888 An integrative approach to optimize a synthetic EphA2/CD137 agonist: balancing potency, physiochemical properties, and pharmacokinetics to achieve robust anti-tumor activity

Authors: Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Kevin McDonnell, Philip Brandish, Nicholas Keen, Phil Jeffrey

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/6414f70ad96342768354adee2801717c

826 Establishing the preclinical/translational PK/PD relationship for BT7480, a nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

Authors: Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Phil Jeffrey, Hitesh Mistry, Fernando Ortega, Christophe Chassagnole

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/379d284c453b41a4b6783c643e4ce1aa

BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism

Authors: Jun Ma, Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Fanglei You, Mike Kelly, Heather Cohen, Drasti Kanakia, Carly Campbell, David Witty, Stephen Blakemore, Phil Jeffrey

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/11/e002883.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/4724c01b9ec7407d90abf3570e647883

Expression and regulation of drug transporters in vertebrate neutrophils

Authors: Matthew J. Foulkes, Katherine M. Henry, Julien Rougeot, Edward Hooper-Greenhill, Catherine A. Loynes, Phil Jeffrey, Angeleen Fleming, Caroline O. Savage, Annemarie H. Meijer, Simon Jones, Stephen A. Renshaw

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/29c19465e7d54a27a84bf1da012fdddf

Assessment of the blood–brain barrier in CNS drug discovery

Authors: Phil Jeffrey, Scott Summerfield

Source: Neurobiology of Disease, Vol 37, Iss 1, Pp 33-37 (2010)

Subject Terms: Blood–brain barrier, Drug disposition, Drug discovery, CNS, Permeability, Free-fraction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996109002113; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/01b1d732c2bd4e22b73975dee2b5bef5

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability.

Authors: Nicolas Charrier, Brian Clarke, Leanne Cutler, Colin Dingwall, Rachel Dunsdon, Philip East, Julie Hawkins, Colin Howes, Ishrut Hussain, Phil Jeffrey, Graham Maile, Rosalie Matico, Julie Mosley, Alan Naylor, Alistair O’Brien, Sally Redshaw, Paul Rowland, Virginie Soleil, Kathrine J. Smith, Sharon Sweitzer

Source: Journal of Medicinal Chemistry; May2008, Vol. 51 Issue 11, p3313-3317, 5p

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