Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells

Authors: Elisa Persiani, Antonella Cecchettini, Sofia Amato, Elisa Ceccherini, Ilaria Gisone, Agnese Sgalippa, Chiara Ippolito, Valter Castelvetro, Tommaso Lomonaco, Federico Vozzi

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Microplastics, Vascular smooth muscle cells, Phenotypic switch, Polyethylene, Polystyrene, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/87733bc425b04576beaa604bd9bf15a0

Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection

Authors: Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

Source: Journal of Inflammation Research, Vol Volume 18, Pp 1719-1738 (2025)

Subject Terms: mr-1, rock1, aortic dissection, inflammation, phenotypic switch, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/myofibrillogenesis-regulator-1-in-smooth-muscle-cells-modulates-inflam-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/75f92f0c966741309e21f2a0118c8cfe

3D-printing hydrogel programmed released exosomes to restore aortic medial degeneration through inhibiting VSMC ferroptosis in aortic dissection

Authors: Weitie Wang, Qing Liu, Qiwei Yang, Songning Fu, Dongdong Zheng, Yale Su, Jinyu Xu, Yong Wang, Hulin Piao, Kexiang Liu

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)

Subject Terms: 3D-printed technolgy, Gelma, Mesenchymal stem cell, Exosome, Vascular smooth muscle cells, Phenotypic switch, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/cad2f79da05d4a34a1660b646405d689

ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch

Authors: Liqing Jiang, Linhe Lu, Chao Xue, He Sun, Kai Ren, Liyun Zhang, Hanzhao Zhu, Bin Zhang, Xiaoya Wang, Xinan Qiao, Xiangyan Peng, Jincheng Liu, Weixun Duan

Source: Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)

Subject Terms: Thoracic aortic dissection, ACE2, SIRT3, Vascular smooth muscle cell, Phenotypic switch, Inflammation, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

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Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/2a03e87d8c944a6cbcf280f8c75aadc1

Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway

Authors: Zhou, Hui ^{a, 1}, Lai, Yingying ^{b, 1}, Zhu, Yuanyuan ^a, Shao, Feng ^c, Ma, Guangqiang ^a, Yang, Ningning ^{d, e, f}, Ma, Xianhui ^{d, e, f}, Sun, Yinxiang ^{g, ⁎}, Shi, Qiang ^{g, ⁎}

Source: In Phytomedicine April 2025 139

F-53B stimulated vascular smooth muscle cell phenotypic switch and vascular remodeling via ferroptosis-related pathway

Authors: Zhang, Min ^{a, ⁎, 1}, Shi, Jun ^{b, 1}, Pan, Huichao ^{a, 1}, Zhu, Jie ^c, Wang, Xueting ^a, Zhou, Jun ^a, Deng, Huiping ^b

Source: In Science of the Total Environment 1 December 2024 954

Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response

Authors: Kim Denise Fischer, Shashank Tiwari, Beatrice Thier, Lin Christina Qiu, Tzu-Chen Lin, Annette Paschen, Jochen Imig

Source: Frontiers in Molecular Biosciences, Vol 11 (2024)

Subject Terms: melanoma, lncRNA, phenotypic switch, differentiation, IFNγ response, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2024.1471100/full; https://doaj.org/toc/2296-889X

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Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways

Authors: Wei Liu, Jing Han, Qiuping Yang, Luoxing Xia, Cheng Chen, Jie Song, Yao Cai

Source: Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101591- (2024)

Subject Terms: Intimal hyperplasia, ARHGAP24, Vascular smooth muscle cell, Phenotypic switch, Proliferation, Differentiation, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580823001723; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/0c001eb0fb2141c19db5e1d6d309cfb2

Biologics-induced immunophenotypic cross-switching in patients with psoriasis and atopic dermatitis

Authors: Yanyan Li, Hong Liu, Furen Zhang

Source: Indian Journal of Dermatology, Vol 68, Iss 2, Pp 186-191 (2023)

Subject Terms: biological agents, eczematous paradoxical reactions, phenotypic switch, psoriasiform paradoxical reactions, Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=186;epage=191;aulast=Li; https://doaj.org/toc/0019-5154; https://doaj.org/toc/1998-3611

Access URL: https://doaj.org/article/841e011c25e64cd8a4f6a8868f6960c6

Deciphering the Mechanism of Wogonin, a Natural Flavonoid, on the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Integrating Network Pharmacology and In Vitro Validation

Authors: Lidan Cui, Zuomei Zeng, Xinyue Wang, Tianyi Yuan, Can Wang, Dianlong Liu, Jian Guo, Yucai Chen

Source: Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 555-570 (2023)

Subject Terms: network pharmacology, pulmonary hypertension, cell proliferation, phenotypic switch, HIF-1α, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/45/1/37; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/42aab5df46284f8b829ca03bebac348c

Arteriogenesis and Therapeutic Angiogenesis

Contributors: Quax, Paul, Deindl, Elisabeth

Subject Terms: angiogenesis, vessel maturity, vessel permeability, hemorrhage, atherosclerosis, two-photon intravital microscopy, transforming growth factor-β, endoglin, neovascularization, tissue repair, myocardial infarction, hind limb ischemia, critical limb ischemia, arteriogenesis, cell therapy, secretomes, AP-1 transcription factors, JunB, tip cell specification, vascular development, neurovascular interactions, peripheral arterial disease, biomarkers, inflammation, coagulation, extracellular vesicles, microRNAs, machine learning, gene therapy, stem cells, clinical trials, bioengineering, gene expression, non-viral vectors, 2A-peptides, growth factors, tube formation, VEGF, FGF2, cytokines, animal model, Matrigel plug assay, cold-inducible RNA-binding protein, extracellular cold-inducible RNA-binding protein, CIRP, eCIRP, neutrophil extracellular traps, NETs, macrophage polarization, apoptosis, ischemia, vascular smooth muscle cell, phenotypic switch, collateral arteries, C57BL/6J mice, SV-129 mice, leukocytes, macrophages, neutrophils, C57BL6, 129S1/Sv, CIRBP, 14q32 microRNAs, HUVECs, Medicine and Nursing

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Access URL: https://directory.doabooks.org/handle/20.500.12854/78741
https://mdpi.com/books/pdfview/book/4832

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Authors: Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang, Jing Zhang

Source: Molecular Medicine, Vol 28, Iss 1, Pp 1-20 (2022)

Subject Terms: Single-cell RNA sequencing, Acute thoracic aortic dissection, Cell differentiation trajectory, CXCL12, Cell–cell interaction, Phenotypic switch, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1076-1551; https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/85a5dcdd78924fa2bb8aed58d563770d

miR-335-5p regulates the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1

Authors: Ma Runwei, Zhang Dayong, Song Yi, Kong Jichang, Mu Chunjie, Shen Pin, Gui Wenting

Source: Acta Biochimica et Biophysica Sinica, Vol 54, Pp 961-973 (2022)

Subject Terms: aortic dissection, miR-335-5p, phenotypic switch, vascular smooth muscle cells, Biochemistry, QD415-436, Genetics, QH426-470

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Relation: https://doaj.org/toc/1672-9145

Access URL: https://doaj.org/article/fdbc613a3c324d4da444779cac32e992

Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria

Authors: Yan Zhong Liu, Zong Xiang Li, Lin Lin Zhang, Dan Wang, Yi Ping Liu

Source: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Subject Terms: vascular calcification, vascular smooth muscle cell (VSMC), mitochondria, phenotypic switch, cardiovascular disease, Diseases of the circulatory (Cardiovascular) system, RC666-701

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Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2022.972836/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/32e433b2ce864a3294a1ad41048feb63

Establishing a Macrophage Phenotypic Switch-Associated Signature-Based Risk Model for Predicting the Prognoses of Lung Adenocarcinoma

Authors: Jun Chen, Chao Zhou, Ying Liu

Source: Frontiers in Oncology, Vol 11 (2022)

Subject Terms: lung adenocarcinoma, tumor-associated macrophages, macrophage phenotypic switch, macrophage phenotypic switch-related gene, MRG signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.771988/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/7a8f34dd178243e4a8e7bb5acf6c189a

Sphingosine-1-phosphate type 1 receptor aggravates neointimal hyperplasia after carotid artery injury in mice

Authors: REN Hongqiang, LIU Yijun, LUO Guiquan, ZHAO Li

Source: Di-san junyi daxue xuebao, Vol 43, Iss 3, Pp 202-210 (2021)

Subject Terms: intimal hyperplasia, sphingosine 1-phosphate receptor, phenotypic switch, proliferation, migration, Medicine (General), R5-920

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Relation: https://aammt.tmmu.edu.cn/Upload/rhtml/202009032.htm; https://doaj.org/toc/1000-5404

Access URL: https://doaj.org/article/b0e7a26b0f0945a5ba488108610f8b64

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells

Authors: Hui Zheng, Zhihuang Qiu, Tianci Chai, Jian He, Yuling Zhang, Chaoyun Wang, Jianqiang Ye, Xiaohui Wu, Yumei Li, Li Zhang, Liangwan Chen

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2022)

Subject Terms: insulin resistance, phenotypic switch, aortic dissection, vascular smooth muscle cells, promotes, Diseases of the circulatory (Cardiovascular) system, RC666-701

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Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.732122/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/c112dbd13a1a4f61bfdf01aa44f2df5e

Downregulation of miRNA-1-3p modulates cyclic stretch-mediated proliferation of vascular smooth muscle cells through regulation of ETS-1

Authors: Wang Xizhen, Li Aihua, Duan Ruikang, Zhang Bin

Source: Archives of Biological Sciences, Vol 72, Iss 4, Pp 587-598 (2020)

Subject Terms: mirna-1-3p, cell proliferation, phenotypic switch, cyclic stretch, vascular smooth muscle cells, Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/0354-4664; https://doaj.org/toc/1821-4339

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Positive Association of Leptin and Artery Calcification of Lower Extremity in Patients With Type 2 Diabetes Mellitus: A Pilot Study

Authors: SanBao Chai, Yao Chen, SiXu Xin, Ning Yuan, YuFang Liu, JianBin Sun, XiangYu Meng, YongFen Qi

Source: Frontiers in Endocrinology, Vol 12 (2021)

Subject Terms: leptin, type 2 diabetes mellitus, VSMC, artery calcification, phenotypic switch, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

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Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.583575/full; https://doaj.org/toc/1664-2392

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Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm

Authors: Liren Duan, Shenli Li, Lei Wang, Yuchen Jing, Guangxin Li, Yaodong Sun, Weifeng Sun, Yalun Li, Lin Zhao, Shijie Xin

Source: Frontiers in Physiology, Vol 11 (2020)

Subject Terms: melatonin, nicotine, abdominal aortic aneurysm, vascular smooth muscle cell, phenotypic switch, Physiology, QP1-981

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Relation: https://www.frontiersin.org/article/10.3389/fphys.2020.00866/full; https://doaj.org/toc/1664-042X

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