Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

Authors: Thomas P Spargo, Lachlan Gilchrist, Guy P Hunt, Richard JB Dobson, Petroula Proitsi, Ammar Al-Chalabi, Oliver Pain, Alfredo Iacoangeli

Source: eLife, Vol 12 (2024)

Subject Terms: fine-mapping, neurodegenerative diseases, colocalisation, local genetic correlation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/88768; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2e888596cf7c481ebf2f63f850e019fc

Marital dissolution and cognition: The mediating effect of Aβ neuropathology

Authors: Avinash Chandra, Rifah Anjum, Sheena Waters, Petroula Proitsi, Laura J. Smith, Charles R. Marshall, for the Alzheimer's Disease Neuroimaging Initiative

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 4, Pp n/a-n/a (2024)

Subject Terms: Alzheimer's disease, amyloid beta, divorce, episodic memory, stress, widowhood, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/8ac07fc944114d90b5174f029f886731

Plasma proteomic profiles of UK Biobank participants with multiple sclerosis

Authors: Benjamin M. Jacobs, Nicola Vickaryous, Gavin Giovannoni, Petroula Proitsi, Sheena Waters, Ruth Dobson

Source: Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 698-709 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/38f9e8643b704256bf2707678525dd96

Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease

Authors: Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, The Insight 46 study team

Source: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)

Subject Terms: Metabolites, Dementia, Brain imaging, Ageing, Polygenic scores, Birth cohort, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/f5a5b80764c34bc1b3fd5049c6dcb527

Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease

Authors: Jodie Lord, Rebecca Green, Shing Wan Choi, Christopher Hübel, Dag Aarsland, Latha Velayudhan, Pak Sham, Cristina Legido-Quigley, Marcus Richards, Richard Dobson, Petroula Proitsi

Source: Biological Psychiatry Global Open Science, Vol 2, Iss 2, Pp 167-179 (2022)

Subject Terms: Biomarkers, Causality, Mediation, Mendelian randomization, Polygenic scores, Psychiatry, RC435-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667174321000872; https://doaj.org/toc/2667-1743

Access URL: https://doaj.org/article/d7d4f99f2fd1491680c7025a8e715b65

Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative

Authors: Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andrea L. Benedet, Thomas K. Karikari, Juan Lantero Rodriguez, the Alzheimer’s Disease Neuroimaging Initiative, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow

Source: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2021)

Subject Terms: Alzheimer’s disease, Polygenic risk score, Plasma phosphorylated tau 181, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/e91414831dd14745b188c7a9293af601

Urinary metabolic phenotyping for Alzheimer’s disease

Authors: Natalja Kurbatova, Manik Garg, Luke Whiley, Elena Chekmeneva, Beatriz Jiménez, María Gómez-Romero, Jake Pearce, Torben Kimhofer, Ellie D’Hondt, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Dag Aarsland, Alejo Nevado-Holgado, Benjamine Liu, Stuart Snowden, Petroula Proitsi, Nicholas J. Ashton, Abdul Hye, Cristina Legido-Quigley, Matthew R. Lewis, Jeremy K. Nicholson, Elaine Holmes, Alvis Brazma, Simon Lovestone

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1bd85f619d574055ba7c1fb49956bdea

Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease

Authors: Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi, Cristina Legido-Quigley, on behalf of the AddNeuroMed Consortium

Source: Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-15 (2020)

Subject Terms: Alzheimer’s disease, Dementia, Brain atrophy, sMRI, Rate of cognitive decline, Lipidomics, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40035-020-00215-0; https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/a1ec73c16aeb4bf59bd98bb02e0536eb

Metabolomic correlates of central adiposity and earlier-life body mass index

Authors: Wahyu Wulaningsih, Petroula Proitsi, Andrew Wong, Diana Kuh, Rebecca Hardy

Source: Journal of Lipid Research, Vol 60, Iss 6, Pp 1136-1143 (2019)

Subject Terms: metabolomics, obesity, nutrition, lipids, epidemiology, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322537; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/b5f192adc2ed45e4b5981766d80149b8

The key role of apolipoprotein B in major vascular diseases and longevity

Authors: Petroula Proitsi

Source: The Lancet. Healthy Longevity, Vol 2, Iss 6, Pp e302-e303 (2021)

Subject Terms: Geriatrics, RC952-954.6, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666756821001203; https://doaj.org/toc/2666-7568

Access URL: https://doaj.org/article/26cda1aa9d4d40899a42f22bb9565e19

Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort

Authors: Jin Xu, Rebecca Green, Min Kim, Jodie Lord, Amera Ebshiana, Sarah Westwood, Alison L. Baird, Alejo J. Nevado-Holgado, Liu Shi, Abdul Hye, Stuart G. Snowden, Isabelle Bos, Stephanie J. B. Vos, Rik Vandenberghe, Charlotte E. Teunissen, Mara Ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen Elisa De Roeck, Sebastiaan Engelborghs, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans R. J. Verhey, Daniel Alcolea, Alberto Lleó, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Giovanni B. Frisoni, José Luis Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone, Petroula Proitsi, Cristina Legido-Quigley, on behalf of the European Medical Information Framework Consortium

Source: Biomedicines, Vol 9, Iss 11, p 1610 (2021)

Subject Terms: sex, Alzheimer’s disease, metabolomics, metabolic pathway, blood, vanillylmandelate, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/11/1610; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/6a6c1bacf1644613b95016a016cd9ea8

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Authors: Peter K. Joshi, Nicola Pirastu, Katherine A. Kentistou, Krista Fischer, Edith Hofer, Katharina E. Schraut, David W. Clark, Teresa Nutile, Catriona L. K. Barnes, Paul R. H. J. Timmers, Xia Shen, Ilaria Gandin, Aaron F. McDaid, Thomas Folkmann Hansen, Scott D. Gordon, Franco Giulianini, Thibaud S. Boutin, Abdel Abdellaoui, Wei Zhao, Carolina Medina-Gomez, Traci M. Bartz, Stella Trompet, Leslie A. Lange, Laura Raffield, Ashley van der Spek, Tessel E. Galesloot, Petroula Proitsi, Lisa R. Yanek, Lawrence F. Bielak, Antony Payton, Federico Murgia, Maria Pina Concas, Ginevra Biino, Salman M. Tajuddin, Ilkka Seppälä, Najaf Amin, Eric Boerwinkle, Anders D. Børglum, Archie Campbell, Ellen W. Demerath, Ilja Demuth, Jessica D. Faul, Ian Ford, Alessandro Gialluisi, Martin Gögele, MariaElisa Graff, Aroon Hingorani, Jouke-Jan Hottenga, David M. Hougaard, Mikko A. Hurme, M. Arfan Ikram, Marja Jylhä, Diana Kuh, Lannie Ligthart, Christina M. Lill, Ulman Lindenberger, Thomas Lumley, Reedik Mägi, Pedro Marques-Vidal, Sarah E. Medland, Lili Milani, Reka Nagy, William E. R. Ollier, Patricia A. Peyser, Peter P. Pramstaller, Paul M. Ridker, Fernando Rivadeneira, Daniela Ruggiero, Yasaman Saba, Reinhold Schmidt, Helena Schmidt, P. Eline Slagboom, Blair H. Smith, Jennifer A. Smith, Nona Sotoodehnia, Elisabeth Steinhagen-Thiessen, Frank J. A. van Rooij, André L. Verbeek, Sita H. Vermeulen, Peter Vollenweider, Yunpeng Wang, Thomas Werge, John B. Whitfield, Alan B. Zonderman, Terho Lehtimäki, Michele K. Evans, Mario Pirastu, Christian Fuchsberger, Lars Bertram, Neil Pendleton, Sharon L. R. Kardia, Marina Ciullo, Diane M. Becker, Andrew Wong, Bruce M. Psaty, Cornelia M. van Duijn, James G. Wilson, J. Wouter Jukema, Lambertus Kiemeney, André G. Uitterlinden, Nora Franceschini, Kari E. North, David R. Weir, Andres Metspalu, Dorret I. Boomsma, Caroline Hayward, Daniel Chasman, Nicholas G. Martin, Naveed Sattar, Harry Campbell, Tōnu Esko, Zoltán Kutalik, James F. Wilson

Source: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/71f6e3ed3cbf4216a67afc3e8eda8b11

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

Authors: Søren D Østergaard, Shubhabrata Mukherjee, Stephen J Sharp, Petroula Proitsi, Luca A Lotta, Felix Day, John R B Perry, Kevin L Boehme, Stefan Walter, John S Kauwe, Laura E Gibbons, Alzheimer’s Disease Genetics Consortium, GERAD1 Consortium, EPIC-InterAct Consortium, Eric B Larson, John F Powell, Claudia Langenberg, Paul K Crane, Nicholas J Wareham, Robert A Scott

Source: PLoS Medicine, Vol 12, Iss 6, p e1001841; discussion e1001841 (2015)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/8e823bfa41d34758a47b666711191f25

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

Authors: Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell

Source: PLoS Medicine, Vol 11, Iss 9, p e1001713 (2014)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/235c99baad1c41dc9d4958467d5a834d

Inflammatory proteins in plasma are associated with severity of Alzheimer's disease.

Authors: Rufina Leung, Petroula Proitsi, Andrew Simmons, Katie Lunnon, Andreas Güntert, Deborah Kronenberg, Megan Pritchard, Magda Tsolaki, Patrizia Mecocci, Iwona Kloszewska, Bruno Vellas, Hilkka Soininen, Lars-Olaf Wahlund, Simon Lovestone

Source: PLoS ONE, Vol 8, Iss 6, p e64971 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3677891?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9192672a6f704feeb27c108bea89de8d

Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.

Authors: Michelle K Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F Powell

Source: PLoS ONE, Vol 6, Iss 2, p e17298 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364883/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/23a00884875846cc8154fa1c9d1e808c

Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease.

Authors: Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams

Source: PLoS ONE, Vol 6, Iss 2 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3039022; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a0c75927ea024e6cbe0463ffa3cddcbf

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

Authors: Lesley Jones, Peter A Holmans, Marian L Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Reinhard Heun, Heike Kölsch, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Eckhard Rüther, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, John Hardy, Michael C O'Donovan, Michael J Owen, Julie Williams

Source: PLoS ONE, Vol 5, Iss 11, p e13950 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21085570/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f60141a186cd4676b259fd600531e266

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