Low-Density Lipoprotein Receptor-Related Protein 1 as a Potential Therapeutic Target in Alzheimer's Disease.

Authors: Petralla, Sabrina¹ (AUTHOR), Panayotova, Maria¹ (AUTHOR), Franchina, Elisa¹ (AUTHOR) s.petralla@uni-heidelberg.de, Fricker, Gert¹ (AUTHOR), Puris, Elena¹ (AUTHOR) elena.puris@uni-heidelberg.de

Source: Pharmaceutics. Jul2024, Vol. 16 Issue 7, p948. 21p.

Subject Terms: *ALZHEIMER'S disease, *NEURODEGENERATION, *DRUG target, *DISEASE progression, *AMYLOID

Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells

Authors: Puris, Elena, Petralla, Sabrina, Auriola, Seppo, Kidron, Heidi, Fricker, Gert, Gynther, Mikko

Source: Journal of pharmaceutical sciences. 112(9):2581-2590

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195392420.0x000001&indx=1&recIds=ETOCvdc_100195392420.0x000001

Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats

Authors: Boi, Laura, Petralla, Sabrina, Monti, Barbara, Talani, Giuseppe, Sanna, Enrico, Pisu, Maria Giuseppina, Calderisi, Giulia, Maciocco, Elisabetta, Serra, Mariangela, Concas, Alessandra, Porcu, Patrizia

Source: In Hormones and Behavior August 2022 144

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Authors: Puris, Elena, Auriola, Seppo, Petralla, Sabrina, Hartman, Robin, Gynther, Mikko, de Lange, Elizabeth C.M., Fricker, Gert

Source: In Neurobiology of Disease July 2022 169

Turning Donepezil into a Multi‐Target‐Directed Ligand through a Merging Strategy

Authors: Perone, Rosaria, Albertini, Claudia, Uliassi, Elisa, Di Pietri, Flaminia, Sena Murteira Pinheiro, Pedro, Petralla, Sabrina, Rizzardi, Nicola, Fato, Romana, Pulkrabkova, Lenka, Soukup, Ondrej, Tramarin, Anna, Bartolini, Manuela, Bolognesi, Maria Laura

Source: ChemMedChem. 16(1):187-198

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114578672.0x000001&indx=1&recIds=ETOCvdc_100114578672.0x000001

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Authors: Marques, Carolina S., López, Óscar, Bagetta, Donatella, Carreiro, Elisabete P., Petralla, Sabrina, Bartolini, Manuela, Hoffmann, Matthias, Alcaro, Stefano, Monti, Barbara, Bolognesi, Maria Laura, Decker, Michael, Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Bioorganic Chemistry May 2020 98

Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors

Authors: Roldán-Peña, Jesús M., Romero-Real, Valle, Hicke, Javier, Maya, Inés, Franconetti, Antonio, Lagunes, Irene, Padrón, José M., Petralla, Sabrina, Poeta, Eleonora, Naldi, Marina, Bartolini, Manuela, Monti, Barbara, Bolognesi, Maria L., López, Óscar, Fernández-Bolaños, José G.

Source: In European Journal of Medicinal Chemistry 1 November 2019 181

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

Authors: Montanari, Serena, Mahmoud, Ali Mokhtar, Pruccoli, Letizia, Rabbito, Alessandro, Naldi, Marina, Petralla, Sabrina, Moraleda, Ignacio, Bartolini, Manuela, Monti, Barbara, Iriepa, Isabel, Belluti, Federica, Gobbi, Silvia, Di Marzo, Vincenzo, Bisi, Alessandra, Tarozzi, Andrea, Ligresti, Alessia, Rampa, Angela

Source: In European Journal of Medicinal Chemistry 15 September 2019 178:243-258

Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer's Disease Is Associated with Activation of HIF-1 Signaling Pathway.

Authors: Petralla, Sabrina, Saveleva, Liudmila, Kanninen, Katja M., Oster, Julia S., Panayotova, Maria, Fricker, Gert, Puris, Elena

Source: Molecular Neurobiology; Sep2024, Vol. 61 Issue 9, p6383-6394, 12p

Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose

Authors: Massenzio, Francesca, Peña-Altamira, Emiliano, Petralla, Sabrina, Virgili, Marco, Zuccheri, Giampaolo, Miti, Andrea, Polazzi, Elisabetta, Mengoni, Ilaria, Piffaretti, Deborah, Monti, Barbara

Source: In BBA - Molecular Basis of Disease December 2018 1864(12):3771-3785

Ketone bodies resume mitochondrial respiration in neuronal progenitors from iPSCs of patients with AGC1 deficiency

Authors: Lasorsa, Francesco M., Barile, Simona N., Magnifico, Maria C., Distelmaier, Felix, Poeta, Eleonora, Viggiano, Luigi, Pignataro, Antonella, Antonicelli, Marica, Palmieri, Luigi, Petralla, Sabrina, Hentschel, Julia, Porcelli, Vito, Tioli, Gaia, Pisano, Isabella, Porcelli, Anna Maria, Fiermonte, Giuseppe, Palmieri, Ferdinando, Anderson, Stewart A., Iommarini, Luisa, Wallace, Douglas C., Monti, Barbara

Source: In BBA - Bioenergetics 1 September 2024 1865 Supplement

Impaired mitochondrial respiration in neuron progenitor cells from IPSCs of patients affected by AGC1 deficiency

Authors: Lasorsa, Francesco M., Magnifico, Maria C., Barile, Simona N., Distelmaier, Felix, Viggiano, Luigi, Petralla, Sabrina, Porcelli, Vito, Pignataro, Antonella, Poeta, Eleonora, Pisano, Isabella, Fiermonte, Giuseppe, Palmieri, Luigi, Anderson, Stewart A., Wallace, Douglas C., Hentschel, Julia, Monti, Barbara

Source: Biochimica et biophysica acta. 1863(S)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168839487.0x000001&indx=1&recIds=ETOCvdc_100168839487.0x000001

Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells

Authors: Profilo, Emanuela, Peña-Altamira, Luis Emiliano, Corricelli, Mariangela, Castegna, Alessandra, Danese, Alberto, Agrimi, Gennaro, Petralla, Sabrina, Giannuzzi, Giulia, Porcelli, Vito, Sbano, Luigi, Viscomi, Carlo, Massenzio, Francesca, Palmieri, Erika Mariana, Giorgi, Carlotta, Fiermonte, Giuseppe, Virgili, Marco, Palmieri, Luigi, Zeviani, Massimo, Pinton, Paolo, Monti, Barbara, Palmieri, Ferdinando, Lasorsa, Francesco Massimo

Source: In BBA - Molecular Basis of Disease June 2017 1863(6):1422-1435

Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids.

Authors: Albertini, Claudia, Petralla, Sabrina, Massenzio, Francesca, Monti, Barbara, Rizzardi, Nicola, Bergamini, Christian, Uliassi, Elisa, Borges, Fernanda, Chavarria, Daniel, Fricker, Gert, Goettert, Marcia, Kronenberger, Thales, Gehringer, Matthias, Laufer, Stefan, Bolognesi, Maria L.

Source: Archiv der Pharmazie; Jun2024, Vol. 357 Issue 6, p1-11, 11p

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

Authors: Jeřábek, Jakub, Uliassi, Elisa, Guidotti, Laura, Korábečný, Jan, Soukup, Ondřej, Sepsova, Vendula, Hrabinova, Martina, Kuča, Kamil, Bartolini, Manuela, Peña-Altamira, Luis Emiliano, Petralla, Sabrina, Monti, Barbara, Roberti, Marinella, Bolognesi, Maria Laura

Source: In European Journal of Medicinal Chemistry 15 February 2017 127:250-262

N-1, 2, 3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Authors: Marques, Carolina S., López, Óscar, Bagetta, Donatella, Carreiro, Elisabete P., Petralla, Sabrina, Bartolini, Manuela, Hoffmann, Matthias, Alcaro, Stefano, Monti, Barbara, Bolognesi, Maria Laura, Decker, Michael, Fernández-Bolaños, José G., Burke, Anthony J.

Source: Bioorganic chemistry. 98

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114252133.0x000001&indx=1&recIds=ETOCvdc_100114252133.0x000001

Neuronal Regulation of Neuroprotective Microglial Apolipoprotein E Secretion in Rat In Vitro Models of Brain Pathophysiology

Authors: Polazzi, Elisabetta, Mengoni, Ilaria, Peña-Altamira, Emiliano, Massenzio, Francesca, Virgili, Marco, Petralla, Sabrina, Monti, Barbara

Source: Journal of neuropathology and experimental neurology. 74(8):818-834

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100034359963.0x000001&indx=1&recIds=ETOCvdc_100034359963.0x000001

TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.

Authors: Nozal, Vanesa, Martínez-González, Loreto, Gomez-Almeria, Marta, Gonzalo-Consuegra, Claudia, Santana, Paula, Chaikuad, Apirat, Pérez-Cuevas, Eva, Knapp, Stefan, Lietha, Daniel, Ramírez, David, Petralla, Sabrina, Monti, Barbara, Carmen Gil, Martín-Requero, Angeles, Palomo, Valle, de Lago, Eva, Martinez, Ana

Source: Journal of Medicinal Chemistry; 1/27/2022, Vol. 65 Issue 2, p1585-1607, 23p

Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency.

Authors: Poeta, Eleonora, Petralla, Sabrina, Babini, Giorgia, Renzi, Brunaldo, Celauro, Luigi, Magnifico, Maria Chiara, Barile, Simona Nicole, Masotti, Martina, De Chirico, Francesca, Massenzio, Francesca, Viggiano, Luigi, Palmieri, Luigi, Virgili, Marco, Lasorsa, Francesco Massimo, Monti, Barbara

Source: Frontiers in Cellular Neuroscience; 1/12/2022, Vol. 15, p1-23, 23p

Subject Terms: HISTONE acetylation, OLIGODENDROGLIA, HISTONES, GENETIC regulation, MITOCHONDRIA, NEUROGLIA, CEREBRAL atrophy

Dietary Protein Source Influences Brain Inflammation and Memory in a Male Senescence-Accelerated Mouse Model of Dementia.

Authors: Petralla, Sabrina, Parenti, Cristina, Ravaioli, Valentina, Fancello, Irene, Massenzio, Francesca, Virgili, Marco, Monti, Barbara, Pena-Altamira, Emiliano

Source: Molecular Neurobiology; Apr2021, Vol. 58 Issue 4, p1312-1329, 18p