Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells

Authors: Matthew Holmes, Gina B. Scott, Samuel Heaton, Tyler Barr, Basem Askar, Louise M.E. Müller, Victoria A. Jennings, Christy Ralph, Cathy Burton, Alan Melcher, Peter Hillmen, Christopher Parrish, Fiona Errington-Mais

Source: Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 17-29 (2023)

Subject Terms: B cell neoplasm, drug resistance, oncolytic virus, coxsackievirus A21, tumor microenvironment, Chronic Lymphocytic Leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770523000244; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/5203c050e9894f55a9405ad6fce9ab42

P786: THROMBOSIS AND MENINGOCOCCAL INFECTION RATES IN PEGCETACOPLAN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA IN THE CLINICAL TRIAL AND POST-MARKETING SETTINGS

Authors: Richard Kelly, Hisakazu Nishimori, Regina Horneff, Peter Hillmen, Jessica Savage, Mohammed Al-Adhami, Stacie Lallier, Gloria Gerber

Source: HemaSphere, Vol 7, p e66610c4 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970048.66610.c4; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/45057cbce2b34ab3b9c8abb2425525ca

Real‐world treatment patterns, adverse events and clinical outcomes in patients with chronic lymphocytic leukaemia treated with ibrutinib in the UK

Authors: Peter Hillmen, Jing Xie, Alan S. M. Yong, Catherine Waweru, Thuy Anh Sorof, Ravi K. Goyal, Keith L. Davis

Source: eJHaem, Vol 2, Iss 2, Pp 219-227 (2021)

Subject Terms: Bruton tyrosine kinase, chronic lymphocytic leukaemia, ibrutinib, tyrosine kinase inhibitor, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/64a0d007117945a597b923277fa9e33d

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia

Authors: Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan

Source: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/326c1d18f1cc498d8b36824ed27e2e04

A platform trial in practice: adding a new experimental research arm to the ongoing confirmatory FLAIR trial in chronic lymphocytic leukaemia

Authors: Dena R. Howard, Anna Hockaday, Julia M. Brown, Walter M. Gregory, Susan Todd, Tahla Munir, Jamie B. Oughton, Claire Dimbleby, Peter Hillmen

Source: Trials, Vol 22, Iss 1, Pp 1-13 (2021)

Subject Terms: Adding treatment arms, Platform trial, Flexible design, Chronic lymphocytic leukaemia, Complex innovative design, Randomised controlled trial, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/f5a4a538c4cd4e3c8cd38fb1ff778296

DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia

Authors: Fraser Thomas, Katie B. Holmes, Sarah Kreuz, Peter Hillmen, Pascal F. Lefevre

Source: Molecular Oncology, Vol 14, Iss 6, Pp 1268-1281 (2020)

Subject Terms: CLL, DAPK3, H3T11, histone phosphorylation, Ibrutinib, mRNA processing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/e1a16b42b1b04727afc2b91d8753eff2

Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials

Authors: Tomasz K. Wojdacz, Harindra E. Amarasinghe, Latha Kadalayil, Alice Beattie, Jade Forster, Stuart J. Blakemore, Helen Parker, Dean Bryant, Marta Larrayoz, Ruth Clifford, Pauline Robbe, Zadie A. Davis, Monica Else, Dena R. Howard, Basile Stamatopoulos, Andrew J. Steele, Richard Rosenquist, Andrew Collins, Andrew R. Pettitt, Peter Hillmen, Christoph Plass, Anna Schuh, Daniel Catovsky, David G. Oscier, Matthew J.J. Rose-Zerilli, Christopher C. Oakes, Jonathan C. Strefford

Source: Blood Advances, Vol 3, Iss 16, Pp 2474-2481 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920300288; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/cd01b8a978aa4041a72a417cc4cb4fcc

The STELLAR trial protocol: a prospective multicentre trial for Richter’s syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease

Authors: Niamh Appleby, Toby A. Eyre, Maite Cabes, Aimee Jackson, Rebecca Boucher, Francesca Yates, Sonia Fox, Andrew Rawstron, Peter Hillmen, Anna Schuh

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Subject Terms: Richter syndrome, Richter transformation, acalabrutinib, BTK inhibitor, chronic lymphocytic leukaemia, CHOP-R, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5717-y; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/15ead9c66a094069a1a882e50217e02a

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients

Authors: Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

Source: Haematologica, Vol 107, Iss 6 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10414; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/539d278310f84aa3955bb4b7eb5f3b1d

Zanubrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia and 17p deletion

Authors: Constantine S. Tam, Tadeusz Robak, Paolo Ghia, Brad S. Kahl, Patricia Walker, Wojciech Janowski, David Simpson, Mazyar Shadman, Peter S. Ganly, Luca Laurenti, Stephen Opat, Monica Tani, Hanna Ciepluch, Emma Verner, Martin Šimkovič, Anders Österborg, Marek Trněný, Alessandra Tedeschi, Jason C. Paik, Sowmya B. Kuwahara, Shibao Feng, Vanitha Ramakrishnan, Aileen Cohen, Jane Huang, Peter Hillmen, Jennifer R. Brown

Source: Haematologica, Vol 106, Iss 9 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10050; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/8f75524183cd439aaa1541ae95718eb4

How We Manage Patients With Chronic Lymphocytic Leukemia During the SARS-CoV-2 Pandemic

Authors: Davide Rossi, Mazyar Shadman, Adalgisa Condoluci, Jennifer R. Brown, John C. Byrd, Gianluca Gaidano, Michael Hallek, Peter Hillmen, Anthony Mato, Emili Montserrat, Paolo Ghia

Source: HemaSphere, Vol 4, Iss 4, p e432 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000432; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/625f1593a816404b8d6b26698be15c38

An increased fraction of circulating miR-363 and miR-16 is particle bound in patients with chronic lymphocytic leukaemia as compared to normal subjects

Authors: Afaf Alharthi, Daniel Beck, Dena R. Howard, Peter Hillmen, Melanie Oates, Andrew Pettitt, Simon D. Wagner

Source: BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)

Subject Terms: Chronic lymphocytic leukaemia, miRNA, Extracellular vesicle, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13104-018-3391-9; https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/8f9e8e4f749d4fa48ebb6c549b1aba2e

GA101 (obinutuzumab) monocLonal Antibody as Consolidation Therapy In CLL (GALACTIC) trial: study protocol for a phase II/III randomised controlled trial

Authors: Jamie B. Oughton, Laura Collett, Dena R. Howard, Anna Hockaday, Talha Munir, Kathryn McMahon, Lucy McParland, Claire Dimbleby, David Phillips, Andy C. Rawstron, Peter Hillmen

Source: Trials, Vol 18, Iss 1, Pp 1-12 (2017)

Subject Terms: Chronic lymphocytic leukaemia (CLL), Obinutuzumab, GA-101, Consolidation, Phase II/III trial, Minimal residual disease (MRD), Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-017-2107-0; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/85a3ae6118144f27ac5415aae69c87c7

Impact of idelalisib on health-related quality of life in patients with relapsed chronic lymphocytic leukemia in a phase III randomized trial

Authors: Paolo Ghia, Steven E. Coutre, Bruce D. Cheson, Jacqueline C. Barrientos, Peter Hillmen, Andrew R. Pettitt, Andrew D. Zelenetz, Sanatan Shreay, Michael Hallek, Richard R. Furman

Source: Haematologica, Vol 105, Iss 10 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9652; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/9855e6dd543348bdb5a1554b9616880d

Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial

Authors: Andrew R. Pettitt, Richard Jackson, Silvia Cicconi, Fotis Polydoros, Christina Yap, James Dodd, Matthew Bickerstaff, Michael Stackpoole, Umair T. Khan, Stacey Carruthers, Melanie Oates, Ke Lin, Sarah E. Coupland, Geetha Menon, Nagesh Kalakonda, Helen McCarthy, Adrian Bloor, Anna Schuh, Andrew Duncombe, Claire Dearden, Christopher Fegan, Ben Kennedy, Renata Walewska, Scott Marshall, Christopher P. Fox, Peter Hillmen

Source: Haematologica, Vol 105, Iss 12 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9646; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/53bc7354a2964c36992d8813be0e32a7

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria

Authors: Robert A. Brodsky, Régis Peffault de Latour, Scott T. Rottinghaus, Alexander Röth, Antonio M. Risitano, Ilene C. Weitz, Peter Hillmen, Jaroslaw P. Maciejewski, Jeff Szer, Jong Wook Lee, Austin G. Kulasekararaj, Lori Volles, Andrew I. Damokosh, Stephan Ortiz, Lori Shafner, Peng Liu, Anita Hill, Hubert Schrezenmeier

Source: Haematologica, Vol 106, Iss 1 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9614; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/e3c0bd580d374332a80ee7518eb29f3a

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1

Authors: Eugen Tausch, Philipp Beck, Richard F. Schlenk, Billy J. Jebaraj, Anna Dolnik, Deyan Y. Yosifov, Peter Hillmen, Fritz Offner, Ann Janssens, K. Govind Babu, Sebastian Grosicki, Jiri Mayer, Panagiotis Panagiotidis, Astrid McKeown, Ira V. Gupta, Alexandra Skorupa, Celine Pallaud, Lars Bullinger, Daniel Mertens, Hartmut Döhner, Stephan Stilgenbauer

Source: Haematologica, Vol 105, Iss 10 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9598; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/36cf02f355d94d7a8bdbd704903512c5

Clinical and morphological predictors of outcome in older aplastic anemia patients treated with eltrombopag

Authors: Bruno Fattizzo, Austin G. Kulasekararaj, Anita Hill, Nana Benson-Quarm, Morag Griffin, Talha Munir, Louise Arnold, Kathryn Riley, Robin Ireland, Hugues De Lavallade, Victoria Potter, Dario Consonni, Peter Hillmen, Ghulam J. Mufti, Wilma Barcellini, Judith C. W. Marsh

Source: Haematologica, Vol 104, Iss 11 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9136; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/afbb1a7b67a04e4691e516000cf260fe

Significant hemolysis is not required for thrombosis in paroxysmal nocturnal hemoglobinuria

Authors: Morag Griffin, Peter Hillmen, Talha Munir, Stephen Richards, Louise Arnold, Kathryn Riley, Anita Hill

Source: Haematologica, Vol 104, Iss 3 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8832; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/c2d0fed74efd48a9ac7871492d577e71

Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2

Authors: Paul M. Barr, Tadeusz Robak, Carolyn Owen, Alessandra Tedeschi, Osnat Bairey, Nancy L. Bartlett, Jan A. Burger, Peter Hillmen, Steven Coutre, Stephen Devereux, Sebastian Grosicki, Helen McCarthy, Jianyong Li, David Simpson, Fritz Offner, Carol Moreno, Cathy Zhou, Lori Styles, Danelle James, Thomas J. Kipps, Paolo Ghia

Source: Haematologica, Vol 103, Iss 9 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8589; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/379cf031951e46cc9409fd9b6d097879