Mpox infection protects against re-challenge in rhesus macaques

Authors: Aid, Malika, Sciacca, Michaela, McMahan, Katherine, Hope, David, Liu, Jinyan, Jacob-Dolan, Catherine, Powers, Olivia, Barrett, Julia, Wu, Cindy, Mutoni, Audrey, Murdza, Tetyana, Richter, Hannah, Velasco, Jason, Teow, Elyse, Boursiquot, Mona, Cook, Anthony, Orekov, Tatyana, Hamilton, Melissa, Pessaint, Laurent, Ryan, Alaina, Hayes, Tammy, Martinot, Amanda J., Seaman, Michael S., Lewis, Mark G., Andersen, Hanne, Barouch, Dan H.

Source: In Cell 12 October 2023 186(21):4652-4661

Use of a Multiplex Immunoassay Platform to Investigate Multifaceted Antibody Responses in SARS-CoV-2 Vaccinees with and Without Prior Infection.

Authors: Odo, Troy, Haun, Brien K., Williams, Caitlin A., Ball, Aquena, To, Albert, Wong, Teri Ann S., Ching, Lauren, Nakano, Eileen, Van Ry, Alex, Pessaint, Laurent, Andersen, Hanne, Donini, Oreola, Nerurkar, Vivek R., Lehrer, Axel T.

Source: COVID; Apr2025, Vol. 5 Issue 4, p44, 19p

Subject Terms: SARS-CoV-2 Delta variant, ANTIBODY diversity, COVID-19 vaccines, ANTIBODY formation, BREAKTHROUGH infections

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Authors: Gagne, Matthew, Moliva, Juan I., Foulds, Kathryn E., Andrew, Shayne F., Flynn, Barbara J., Werner, Anne P., Wagner, Danielle A., Teng, I-Ting, Lin, Bob C., Moore, Christopher, Jean-Baptiste, Nazaire, Carroll, Robin, Foster, Stephanie L., Patel, Mit, Ellis, Madison, Edara, Venkata-Viswanadh, Maldonado, Nahara Vargas, Minai, Mahnaz, McCormick, Lauren, Honeycutt, Christopher Cole, Nagata, Bianca M., Bock, Kevin W., Dulan, Caitlyn N.M., Cordon, Jamilet, Flebbe, Dillon R., Todd, John-Paul M., McCarthy, Elizabeth, Pessaint, Laurent, Van Ry, Alex, Narvaez, Brandon, Valentin, Daniel, Cook, Anthony, Dodson, Alan, Steingrebe, Katelyn, Nurmukhambetova, Saule T., Godbole, Sucheta, Henry, Amy R., Laboune, Farida, Roberts-Torres, Jesmine, Lorang, Cynthia G., Amin, Shivani, Trost, Jessica, Naisan, Mursal, Basappa, Manjula, Willis, Jacquelyn, Wang, Lingshu, Shi, Wei, Doria-Rose, Nicole A., Zhang, Yi, Yang, Eun Sung, Leung, Kwanyee, O’Dell, Sijy, Schmidt, Stephen D., Olia, Adam S., Liu, Cuiping, Harris, Darcy R., Chuang, Gwo-Yu, Stewart-Jones, Guillaume, Renzi, Isabella, Lai, Yen-Ting, Malinowski, Agata, Wu, Kai, Mascola, John R., Carfi, Andrea, Kwong, Peter D., Edwards, Darin K., Lewis, Mark G., Andersen, Hanne, Corbett, Kizzmekia S., Nason, Martha C., McDermott, Adrian B., Suthar, Mehul S., Moore, Ian N., Roederer, Mario, Sullivan, Nancy J., Douek, Daniel C., Seder, Robert A.

Source: In Cell 28 April 2022 185(9):1556-1571

Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

Authors: Chandrashekar, Abishek, Yu, Jingyou, McMahan, Katherine, Jacob-Dolan, Catherine, Liu, Jinyan, He, Xuan, Hope, David, Anioke, Tochi, Barrett, Julia, Chung, Benjamin, Hachmann, Nicole P., Lifton, Michelle, Miller, Jessica, Powers, Olivia, Sciacca, Michaela, Sellers, Daniel, Siamatu, Mazuba, Surve, Nehalee, VanWyk, Haley, Wan, Huahua, Wu, Cindy, Pessaint, Laurent, Valentin, Daniel, Van Ry, Alex, Muench, Jeanne, Boursiquot, Mona, Cook, Anthony, Velasco, Jason, Teow, Elyse, Boon, Adrianus C.M., Suthar, Mehul S., Jain, Neharika, Martinot, Amanda J., Lewis, Mark G., Andersen, Hanne, Barouch, Dan H.

Source: In Cell 28 April 2022 185(9):1549-1555

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Authors: Gagne, Matthew, Corbett, Kizzmekia S., Flynn, Barbara J., Foulds, Kathryn E., Wagner, Danielle A., Andrew, Shayne F., Todd, John-Paul M., Honeycutt, Christopher Cole, McCormick, Lauren, Nurmukhambetova, Saule T., Davis-Gardner, Meredith E., Pessaint, Laurent, Bock, Kevin W., Nagata, Bianca M., Minai, Mahnaz, Werner, Anne P., Moliva, Juan I., Tucker, Courtney, Lorang, Cynthia G., Zhao, Bingchun, McCarthy, Elizabeth, Cook, Anthony, Dodson, Alan, Teng, I-Ting, Mudvari, Prakriti, Roberts-Torres, Jesmine, Laboune, Farida, Wang, Lingshu, Goode, Adrienne, Kar, Swagata, Boyoglu-Barnum, Seyhan, Yang, Eun Sung, Shi, Wei, Ploquin, Aurélie, Doria-Rose, Nicole, Carfi, Andrea, Mascola, John R., Boritz, Eli A., Edwards, Darin K., Andersen, Hanne, Lewis, Mark G., Suthar, Mehul S., Graham, Barney S., Roederer, Mario, Moore, Ian N., Nason, Martha C., Sullivan, Nancy J., Douek, Daniel C., Seder, Robert A.

Source: In Cell 6 January 2022 185(1):113-130

Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Authors: Lai, Chih-Yun, To, Albert, Wong, Teri Ann S., Lieberman, Michael M., Clements, David E., Senda, James T., Ball, Aquena H., Pessaint, Laurent, Andersen, Hanne, Furuyama, Wakako, Marzi, Andrea, Donini, Oreola, Lehrer, Axel T.

Source: In Vaccine: X December 2021 9

Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques

Authors: He, Xuan, Chandrashekar, Abishek, Zahn, Roland, Wegmann, Frank, Yu, Jingyou, Mercado, Noe B., McMahan, Katherine, Martinot, Amanda J., Piedra-Mora, Cesar, Beecy, Sidney, Ducat, Sarah, Chamanza, Ronnie, Huber, Sietske Rosendahl, van Heerden, Marjolein, van der Fits, Leslie, Borducchi, Erica N., Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H., Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G., Schuitemaker, Hanneke, Barouch, Dan H.

Source: In Cell 24 June 2021 184(13):3467-3473

Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways.

Authors: Gagne, Matthew, Flynn, Barbara J., Honeycutt, Christopher Cole, Flebbe, Dillon R., Andrew, Shayne F., Provost, Samantha J., McCormick, Lauren, Van Ry, Alex, McCarthy, Elizabeth, Todd, John-Paul M., Bao, Saran, Teng, I-Ting, Marciano, Shir, Rudich, Yinon, Li, Chunlin, Jain, Shilpi, Wali, Bushra, Pessaint, Laurent, Dodson, Alan, Cook, Anthony

Source: Nature Communications; 8/12/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: RHESUS monkeys, VACCINE approval, DRUG efficacy, ANTIVIRAL agents, ANGIOTENSIN converting enzyme, MACAQUES

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates.

Authors: Zhu, Daniel Y.¹, Gorman, Matthew J.², Yuan, Dansu², Yu, Jingyou³, Mercado, Noe B.³, McMahan, Katherine³, Borducchi, Erica N.³, Lifton, Michelle³, Liu, Jinyan³, Nampanya, Felix³, Patel, Shivani³, Peter, Lauren³, Tostanoski, Lisa H.³, Pessaint, Laurent⁴, Van Ry, Alex⁴, Finneyfrock, Brad⁴, Velasco, Jason⁴, Teow, Elyse⁴, Brown, Renita⁴, Cook, Anthony⁴

Source: PLoS Biology; 5/5/2022, Vol. 20 Issue 5, p1-25, 25p, 1 Diagram, 6 Graphs

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques.

Authors: Rosati, Margherita¹, Agarwal, Mahesh², Hu, Xintao², Devasundaram, Santhi², Stellas, Dimitris¹, Chowdhury, Bhabadeb¹, Bear, Jenifer², Burns, Robert², Donohue, Duncan³, Pessaint, Laurent⁴, Andersen, Hanne⁴, Lewis, Mark G.⁴, Terpos, Evangelos⁵, Dimopoulos, Meletios Athanasios⁵, Wlodawer, Alexander⁶, Mullins, James I.^7,8,9, Venzon, David J.¹⁰, Pavlakis, George N.¹, Felber, Barbara K.², Barbara.felber@nih.gov

Source: PLoS Pathogens; 9/22/2021, Vol. 17 Issue 9, p1-23, 23p

The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects

Authors: Attardi, Barbara J., Hild, Sheri A., Koduri, Sailaja, Pham, Trung, Pessaint, Laurent, Engbring, Jean, Till, Bruce, Gropp, David, Semon, Anne, Reel, Jerry R.

Source: In Journal of Steroid Biochemistry and Molecular Biology 2010 122(4):212-218

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Authors: Laczkó, Dorottya, Hogan, Michael J., Toulmin, Sushila A., Hicks, Philip, Lederer, Katlyn, Gaudette, Brian T., Castaño, Diana, Amanat, Fatima, Muramatsu, Hiromi, Oguin, Thomas H., III, Ojha, Amrita, Zhang, Lizhou, Mu, Zekun, Parks, Robert, Manzoni, Tomaz B., Roper, Brianne, Strohmeier, Shirin, Tombácz, István, Arwood, Leslee, Nachbagauer, Raffael, Karikó, Katalin, Greenhouse, Jack, Pessaint, Laurent, Porto, Maciel, Putman-Taylor, Tammy, Strasbaugh, Amanda, Campbell, Tracey-Ann, Lin, Paulo J.C., Tam, Ying K., Sempowski, Gregory D., Farzan, Michael, Choe, Hyeryun, Saunders, Kevin O., Haynes, Barton F., Andersen, Hanne, Eisenlohr, Laurence C., Weissman, Drew, Krammer, Florian, Bates, Paul, Allman, David, Locci, Michela, Pardi, Norbert

Source: In Immunity 13 October 2020 53(4):724-732

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2.

Authors: Tioni, Mariana F., Jordan, Robert, Pena, Angie Silva, Garg, Aditya, Wu, Danlu, Phan, Shannon I., Weiss, Christopher M., Cheng, Xing, Greenhouse, Jack, Orekov, Tatyana, Valentin, Daniel, Kar, Swagata, Pessaint, Laurent, Andersen, Hanne, Stobart, Christopher C., Bloodworth, Melissa H., Stokes Peebles, R., Liu, Yang, Xie, Xuping, Shi, Pei-Yong

Source: NPJ Vaccines; 7/29/2022, Vol. 7 Issue 1, p1-13, 13p

Subject Terms: SARS-CoV-2, CHIMERIC proteins, COVID-19 vaccines, IMMUNOGLOBULINS, RESPIRATORY syncytial virus, COVID-19 pandemic, IMMUNOGLOBULIN A, VIRAL envelope proteins

A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant.

Authors: Albert To¹, Wong, Teri Ann S.¹, Lieberman, Michael M.¹, Thompson, Karen², Ball, Aquena H.¹, Pessaint, Laurent³, Greenhouse, Jack³, Daham, Nisrine³, Cook, Anthony³, Narvaez, Brandon³, Flinchbaugh, Zack³, Van Ry, Alex³, Yalley-Ogunro, Jake³, Andersen Elyard, Hanne³, Chih-Yun Lai¹, Donini, Oreola⁴, Lehrer, Axel T.¹ lehrer@hawaii.edu

Source: ACS Infectious Diseases. 4/8/2022, Vol. 8 Issue 4, p825-840. 16p.

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine.

Authors: Gebre, Makda S., Rauch, Susanne, Roth, Nicole, Yu, Jingyou, Chandrashekar, Abishek, Mercado, Noe B., He, Xuan, Liu, Jinyan, McMahan, Katherine, Martinot, Amanda, Martinez, David R., Giffin, Victoria, Hope, David, Patel, Shivani, Sellers, Daniel, Sanborn, Owen, Barrett, Julia, Liu, Xiaowen, Cole, Andrew C., Pessaint, Laurent

Source: Nature; 1/20/2022, Vol. 601 Issue 7893, p410-414, 5p

Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2.

Authors: Lassaunière, Ria, Polacek, Charlotta, Gram, Gregers J., Frische, Anders, Tingstedt, Jeanette Linnea, Krüger, Maren, Dorner, Brigitte G., Cook, Anthony, Brown, Renita, Orekov, Tatyana, Putmon-Taylor, Tammy, Campbell, Tracey-Ann, Greenhouse, Jack, Pessaint, Laurent, Andersen, Hanne, Lewis, Mark G., Fomsgaard, Anders

Source: NPJ Vaccines; 12/20/2021, Vol. 6 Issue 1, p1-13, 13p

Subject Terms: DNA vaccines, COVID-19 vaccines, VACCINE trials, RHESUS monkeys, IMMUNOGLOBULINS

One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization.

Authors: Gu, Maggie, Torres, Jonathan L., Li, Yijia, Van Ry, Alex, Greenhouse, Jack, Wallace, Shannon, Chiang, Chi-I, Pessaint, Laurent, Jackson, Abigail M., Porto, Maciel, Kar, Swagata, Li, Yuxing, Ward, Andrew B., Wang, Yimeng

Source: Emerging Microbes & Infections; Dec 2021, Vol. 10 Issue 1, p2016-2029, 14p

Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern.

Authors: Tostanoski, Lisa H., Yu, Jingyou, Mercado, Noe B., McMahan, Katherine, Jacob-Dolan, Catherine, Martinot, Amanda J., Piedra-Mora, Cesar, Anioke, Tochi, Chang, Aiquan, Giffin, Victoria M., Hope, David L., Wan, Huahua, Bondzie, Esther A., Mahrokhian, Shant H., Wrijil, Linda M., Bauer, Katherine, Pessaint, Laurent, Porto, Maciel, Piegols, Joseph, Faudree, Andrew

Source: Science Translational Medicine; 11/3/2021, Vol. 13 Issue 618, p1-8, 8p

Subject Terms: HAMSTERS, SARS-CoV-2, COVID-19, GOLDEN hamster, NATURAL immunity, VACCINATION, VACCINE effectiveness, RHESUS monkeys

Correlates of protection against SARS-CoV-2 in rhesus macaques.

Authors: McMahan, Katherine, Yu, Jingyou, Mercado, Noe B., Loos, Carolin, Tostanoski, Lisa H., Chandrashekar, Abishek, Liu, Jinyan, Peter, Lauren, Atyeo, Caroline, Zhu, Alex, Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Jacob-Dolan, Catherine, Li, Zhenfeng, Nampanya, Felix, Patel, Shivani, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin

Source: Nature; 2/25/2021, Vol. 590 Issue 7847, p630-634, 5p

CoVaccine HT™ Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 Immunization.

Authors: Haun, Brien K., Lai, Chih-Yun, Williams, Caitlin A., Wong, Teri Ann S., Lieberman, Michael M., Pessaint, Laurent, Andersen, Hanne, Lehrer, Axel T.

Source: Frontiers in Immunology; 10/30/2020, Vol. 11, pN.PAG-N.PAG, 10p

Subject Terms: SARS-CoV-2, IMMUNE response, COVID-19 pandemic, ANTIBODY titer, VIRAL antibodies