A phenotypic journey into NT5DC proteins in cancer and other diseases

Authors: Cros-Perrial, Emeline, Jordheim, Lars Petter ^⁎

Source: In Experimental Cell Research 1 March 2025 446(1)

SLX4 and XPF are involved in cell migration and EMT in a cell-specific manner

Authors: Cros-Perrial, Emeline ^a, Beaumel, Sabine ^a, Gimbert, Manon ^a, Camus, Ninon ^a, Vicente, Clara ^a, Sekiou, Imane ^a, Figuet, Léa ^a, Duruisseaux, Michaël ^{a, b}, Dumontet, Charles ^{a, b}, Jordheim, Lars Petter ^{a, ⁎}

Source: In Biochemical Pharmacology June 2025 236

Third‐Generation CD73 Inhibitors Based on a 4,6‐Disubstituted‐2‐Thiopyridine Scaffold.

Authors: Grosjean, Félix, Shaldaeva, Maria, Cros‐Perrial, Emeline, Rodriguez, Céline, Ghoteimi, Rayane, Lebrun, Aurélien, Gao, Zhan‐Guo, Uttaro, Jean‐Pierre, Mathé, Christophe, Jacobson, Kenneth A., Petter Jordheim, Lars, Ménétrier‐Caux, Christine, Chaloin, Laurent, Peyrottes, Suzanne

Source: ChemMedChem; 3/15/2025, Vol. 20 Issue 6, p1-24, 24p

CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells

Authors: Raza, Muhammad-Zawwad, Cadassou, Octavia, Dumontet, Charles, Cros-Perrial, Emeline, Jordheim, Lars Petter

Source: In BBA - General Subjects May 2021 1865(5)

4-Substituted-1,2,3-triazolo nucleotide analogues as CD73 inhibitors, their synthesis, in vitro screening, kinetic and in silico studies

Authors: Ghoteimi, Rayane, Braka, Abdennour, Rodriguez, Céline, Cros-Perrial, Emeline, Tai Nguyen, Van, Uttaro, Jean-Pierre, Mathé, Christophe, Chaloin, Laurent, Ménétrier-Caux, Christine, Jordheim, Lars Petter, Peyrottes, Suzanne

Source: In Bioorganic Chemistry February 2021 107

The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent.

Authors: Ciniero, Gloria, Pedro, Tiago Marques, Dumontet, Charles, Elmenoufy, Ahmed H., West, Frederick G., Weinfeld, Michael, Gentile, Francesco, Tuszynski, Jack A., Cros‐Perrial, Emeline, Jordheim, Lars Petter

Source: Fundamental & Clinical Pharmacology; Feb2025, Vol. 39 Issue 1, p1-9, 9p

Subject Terms: P53 antioncogene, DNA repair, ALKYLATING agents, CANCER treatment, CANCER chemotherapy, BIOCHEMISTRY

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

Authors: Bjånes, Tormod K. ^*, Jordheim, Lars Petter, Schjøtt, Jan, Kamceva, Tina, Cros-Perrial, Emeline, Langer, Anika, Ruiz de Garibay, Gorka, Kotopoulis, Spiros, McCormack, Emmet ¹, Riedel, Bettina ¹

Source: In Drug Metabolism and Disposition March 2020 48(3):153-158

End-of-life management of multiple myeloma patients in the era of CD38 and immunotherapy.

Authors: Sesques, Pierre, Karlin, Lionel, Massy, Emmanuel, Maarek, Alizée, Aussedat, Guillaume, Lazareth, Anne, Golfier, Camille, Bouafia-Sauvy, Fadhela, Lequeu, Helene, Ghergus, Dana, Safar, Violaine, Ferrant, Emmanuelle, Bachy, Emmanuel, Ghesquières, Hervé, Confavreux, Cyrille B., Demangel, Delphine, Perrial, Emeline, Dumontet, Charles

Source: Frontiers in Oncology; 2024, p1-6, 6p

Subject Terms: TIME of death, MULTIPLE myeloma, DISEASE progression, CAUSES of death, KIDNEY failure

Variability in CD39 and CD73 protein levels in uveal melanoma patients.

Authors: Harou, Olivier¹ (AUTHOR), Cros-Perrial, Emeline² (AUTHOR), Alix, Eudeline³ (AUTHOR), Callet-Bauchu, Evelyne³ (AUTHOR), Bertheau, Charlotte¹ (AUTHOR), Dumontet, Charles^2,3 (AUTHOR), Devouassoux-Shisheboran, Mojgan^1,4 (AUTHOR), Jordheim, Lars Petter³ (AUTHOR)

Source: Nucleosides, Nucleotides & Nucleic Acids. 2022, Vol. 41 Issue 11, p1099-1108. 10p.

Subject Terms: *ADENOSINES, *MELANOMA, *PROTEINS, *CANCER cells, *CARCINOGENESIS, *PURINERGIC receptors

Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC–MS/MS in human cancer cells

Authors: Puy, Jean-Yves, Jordheim, Lars Petter, Cros-Perrial, Emeline, Dumontet, Charles, Peyrottes, Suzanne, Lefebvre-Tournier, Isabelle

Source: In Journal of Chromatography B 15 May 2017 1053:101-110

Use of designed experiments for the improvement of pre-analytical workflow for the quantification of intracellular nucleotides in cultured cell lines

Authors: Machon, Christelle, Bordes, Claire, Cros-Perrial, Emeline, Clement, Yohann, Jordheim, Lars Petter, Lanteri, Pierre, Guitton, Jérôme

Source: In Journal of Chromatography A 31 July 2015 1405:116-125

Small Molecule Inhibitors of ERCC1-XPF Protein-Protein Interaction Synergize Alkylating Agents in Cancer Cells

Authors: Jordheim, Lars Petter ^*, Barakat, Khaled H., Heinrich-Balard, Laurence, Matera, Eva-Laure, Cros-Perrial, Emeline, Bouledrak, Karima, El Sabeh, Rana, Perez-Pineiro, Rolando, Wishart, David S., Cohen, Richard, Tuszynski, Jack, Dumontet, Charles

Source: In Molecular Pharmacology July 2013 84(1):12-24

Identification and characterization of inhibitors of cytoplasmic 5′-nucleotidase cN-II issued from virtual screening

Authors: Jordheim, Lars Petter, Marton, Zsuzsanna, Rhimi, Moez, Cros-Perrial, Emeline, Lionne, Corinne, Peyrottes, Suzanne, Dumontet, Charles, Aghajari, Nushin, Chaloin, Laurent

Source: In Biochemical Pharmacology 15 February 2013 85(4):497-506

A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models.

Authors: Chettab, Kamel, Fitzsimmons, Chantel, Novikov, Alexey, Denis, Morgane, Phelip, Capucine, Mathé, Doriane, Antoine Choffour, Pierre, Beaumel, Sabine, Fourmaux, Eric, Norca, Patrick, Kryza, David, Evesque, Anne, Jordheim, Lars Petter, Perrial, Emeline, Matera, Eva-Laure, Caroff, Martine, Kerzerho, Jerome, Dumontet, Charles

Source: Frontiers in Immunology; 2023, p1-18, 18p

Subject Terms: ANTINEOPLASTIC agents, TOLL-like receptors, ANIMAL models in research, INTRAVENOUS therapy, RITUXIMAB

Second‐Generation CD73 Inhibitors Based on a 4,6‐Biaryl‐2‐thiopyridine Scaffold.

Authors: Ghoteimi, Rayane, Braka, Abdennour, Rodriguez, Céline, Cros‐Perrial, Emeline, Duvauchelle, Valentin, Uttaro, Jean‐Pierre, Mathé, Christophe, Ménétrier‐Caux, Christine, Jordheim, Lars Petter, Chaloin, Laurent, Peyrottes, Suzanne

Source: ChemMedChem; 4/3/2023, Vol. 18 Issue 7, p1-16, 16p

A Proposed Methodology to Deal with the Impact of In Vitro Cellular Matrix on the Analytical Performances of a Targeted Metabolomic LC-HRMS Method.

Authors: Guitton, Jérôme, Gavotto, Floriane, Cros-Perrial, Emeline, Jordheim, Lars Petter, Machon, Christelle

Source: International Journal of Molecular Sciences; Feb2023, Vol. 24 Issue 4, p3770, 16p

Subject Terms: METABOLOMICS, MATRIX effect, CELL culture, CELL lines, METABOLITES

Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold.

Authors: Grosjean, Félix¹ (AUTHOR), Cros‐Perrial, Emeline² (AUTHOR), Braka, Abdenour³ (AUTHOR), Uttaro, Jean‐Pierre¹ (AUTHOR), Chaloin, Laurent³ (AUTHOR), Jordheim, Lars Petter² (AUTHOR), Peyrottes, Suzanne¹ (AUTHOR), Mathé, Christophe¹ (AUTHOR) christophe.mathe@umontpellier.fr

Source: European Journal of Organic Chemistry. 6/7/2022, Vol. 2022 Issue 21, p1-8. 8p.

Subject Terms: *TRIAZOLES, *ENZYME inhibitors, *ADENOSINES, *ADENOSINE derivatives, *TRIAZOLE derivatives

Stably transfected adherent cancer cell models with decreased expression of 5′-nucleotidase cN-II.

Authors: Bricard, Gabriel^1,2,3,4 (AUTHOR), Cros-Perrial, Emeline^1,2,3,4 (AUTHOR), Machon, Christelle^1,5 (AUTHOR), Dumontet, Charles^1,2,3,4,5 (AUTHOR), Jordheim, Lars Petter^1,2,3,4 (AUTHOR) lars-petter.jordheim@univ-lyon1.fr

Source: Nucleosides, Nucleotides & Nucleic Acids. 2016, Vol. 35 Issue 10-12, p604-612. 9p.

Subject Terms: *CELL adhesion, *NUCLEOTIDASES, *GENE expression, *CANCER cells, *CYTARABINE

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

Authors: Dumontet, Charles, Peyrottes, Suzanne, Rabeson, Céline, Cros-Perrial, Emeline, Géant, Pierre Yves, Chaloin, Laurent, Jordheim, Lars Petter

Source: In European Journal of Medicinal Chemistry 5 September 2018 157:1051-1055

Netrin-1 expression and targeting in multiple myeloma.

Authors: Fahed, David, Chettab, AbdelKamel, Mathe, Doriane, Denis, Morgane, Traverse-Glehen, Alexandra, Karlin, Lionel, Perrial, Emeline, Dumontet, Charles

Source: Leukemia & Lymphoma; Feb 2022, Vol. 63 Issue 2, p395-403, 9p

Subject Terms: MULTIPLE myeloma, BONE marrow cells, HEMATOLOGIC malignancies, PLASMA cells, COLORECTAL cancer