Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis

Authors: Teskey, Grace ¹, Tiwari, Nivedita ¹, Butcko, Andrew J. ^{1, 2}, Kumar, Amit ³, Yadav, Anuradha ³, Huang, Yu-ming M. ³, Kelly, Christopher V. ³, Granneman, James G. ⁴, Perfield, James W. ⁵, Mottillo, Emilio P. ^{1, 2, ∗}

Source: In Journal of Biological Chemistry February 2025 301(2)

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Authors: Anstee, Quentin M, Daly, Ann K, Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J, Day, Christopher P, Wonders, Kristy, Missier, Paolo, McTeer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G, Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M, Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K, Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J, Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, McGlinchey, Aiden, Mato, Jose M, Millet, Óscar, Dufour, Jean-François, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Rasmussen, Daniel Guldager Kring, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattias, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M P, Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andreas, Trautwein, Christian, Reißing, Johanna, Aithal, Guruprasad P, Francis, Susan, Palaniyappan, Naaventhan, Bradley, Christopher, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W, Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, McLeod, Euan James, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Coxson, Harvey, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Kjær, Mette Skalshøi, Harder, Lea Mørch, Davidsen, Peter, Ellegaard, Jens, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Douglas, Shankar, Sudha, Torstenson, Richard, Lindén, Daniel, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D, Billin, Andrew, Doward, Lynda, Twiss, James, Thakker, Paresh, Derdak, Zoltan, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Mózes, Ferenc E, Lee, Jenny A, Alzoubi, Osama, Staufer, Katharina, Trauner, Michael, Paternostro, Rafael, Stauber, Rudolf E, van Dijk, Anne-Marieke, Mak, Anne Linde, de Saint Loup, Marc, Shima, Toshihide, Gaia, Silvia, Shalimar, Lupșor-Platon, Monica, Wong, Vincent Wai-Sun, Li, Guanlin, Wong, Grace Lai-Hung, Karlas, Thomas, Wiegand, Johannes, Sebastiani, Giada, Tsochatzis, Emmanuel, Liguori, Antonio, Yoneda, Masato, Nakajima, Atsushi, Hagström, Hannes, Akbari, Camilla, Hirooka, Masashi, Chan, Wah-Kheong, Mahadeva, Sanjiv, Rajaram, Ruveena, Zheng, Ming-Hua, George, Jacob, Eslam, Mohammed, Viganò, Mauro, Ridolfo, Sofia, Aithal, Guruprasad Padur, Lee, Dae Ho, Nasr, Patrik, Cassinotto, Christophe, de Lédinghen, Victor, Mendoza, Yuly P, Noureddin, Mazen, Truong, Emily, Harrison, Stephen A

Source: In The Lancet Gastroenterology & Hepatology August 2023 8(8):704-713

Characterization of six clinical drugs and dietary intervention in the nonobese CDAA-HFD mouse model of MASH and progressive fibrosis.

Authors: Nielsen, Malte Hasle, Nøhr-Meldgaard, Jacob, Møllerhøj, Mathias Bonde, Oró, Denise, Pors, Susanne E., Andersen, Maja Worm, Kamzolas, Ioannis, Petsalaki, Evangelia, Vacca, Michele, Harder, Lea Mørch, Perfield, James W., Veidal, Sanne, Hansen, Henrik H., Feigh, Michael

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Jan2025, Vol. 328 Issue 1, pG51-G71, 21p

Subject Terms: HEPATIC fibrosis, DRUG discovery, DRUG therapy, HEPATITIS, DRUG efficacy

Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period.

Authors: Hvid, Henning, Hjuler, Sara T., Bedossa, Pierre, Tiniakos, Dina G., Kamzolas, Ioannis, Harder, Lea M., Xue, Yaxin, Perfield, James W., Kirk, Rikke K., Latta, Markus, Mikkelsen, Lars F., Pedersen, Henrik D., Investigators, LITMUS

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Oct2024, Vol. 327 Issue 4, pG571-G585, 15p

Subject Terms: THERAPEUTICS, HIGH-fat diet, WEIGHT gain, LIVER biopsy, RNA sequencing

Perilipin overexpression in mice protects against diet-induced obesity

Authors: Miyoshi, Hideaki ^{∗, †}, Souza, Sandra C. ^{∗, §}, Endo, Mikiko ^†, Sawada, Takashi ^†, Perfield, James W., II ^{∗, ∗∗∗}, Shimizu, Chikara ^†, Stancheva, Zlatina ^∗, Nagai, So ^†, Strissel, Katherine J. ^∗, Yoshioka, Narihito ^†, Obin, Martin S. ^{1, ∗}, Koike, Takao ^†, Greenberg, Andrew S. ^{1, ∗}

Source: In Journal of Lipid Research May 2010 51(5):975-982

Expression of Enzymes and Key Regulators of Lipid Synthesis Is Upregulated in Adipose Tissue during CLA-Induced Milk Fat Depression in Dairy Cows1–3

Authors: Harvatine, Kevin J., Perfield, James W., II, Bauman, Dale E. ^*

Source: In The Journal of Nutrition May 2009 139(5):849-854

Regulation of Fat Synthesis by Conjugated Linoleic Acid: Lactation and the Ruminant Model , ,

Authors: Bauman, Dale E. ^*, Perfield, James W., II, Harvatine, Kevin J., Baumgard, Lance H.

Source: In The Journal of Nutrition February 2008 138(2):403-409

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue

Authors: Souza, Sandra C. ^*, Christoffolete, Marcelo A., Ribeiro, Miriam O., Miyoshi, Hideaki ^{*, **}, Strissel, Katherine J. ^*, Stancheva, Zlatina S. ^*, Rogers, Nicole H. ^*, D'Eon, Tara M. ^*, Perfield, James W., II ^*, Imachi, Hitomi ^*, Obin, Martin S. ^*, Bianco, Antonio C., Greenberg, Andrew S. ^*

Source: In Journal of Lipid Research July 2007 48(6):1273-1279

Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes

Authors: Miyoshi, Hideaki, Perfield, James W., II, Souza, Sandra C., Shen, Wen-Jun, Zhang, Hui-Hong, Stancheva, Zlatina S., Kraemer, Fredric B., Obin, Martin S., Greenberg, Andrew S.

Source: In Journal of Biological Chemistry 12 January 2007 282(2):996-1002

The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis

Authors: Antonellis, Patrick J., Droz, Brian A., Cosgrove, Richard, O'Farrell, Libbey S., Coskun, Tamer, Perfield, James W., II, Bauer, Steven, Wade, Mark, Chouinard, Tara E., Brozinick, Joseph T., Adams, Andrew C., Samms, Ricardo J.

Source: In Molecular Metabolism December 2019 30:131-139

Role of trans-10, cis-12 conjugated linoleic acid (CLA) and other CLA isomers in the regulation of milk fat synthesis and lipid metabolism

Authors: Perfield, James W., 1978

Access URL: http://hdl.handle.net/2027/coo.31924104874049

Fibroblast growth factor-21 improves insulin action in nonlactating ewes.

Authors: Lamb, Cassandra L., Giesy, Sarah L., McGuckin, Molly M., Perfield, James W., Butterfield, Anthony, Moniruzzaman, Mohammed, Haughey, Norman J., McFadden, Joseph W., Boisclair, Yves R.

Source: American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Mar2022, Vol. 322 Issue 3, pR170-R180, 10p

Subject Terms: ADIPOKINES, INSULIN, SOMATOTROPIN, EWES, GLUCOSE tolerance tests, FIBROBLAST growth factors, BLOOD sugar

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

Authors: Samms, Ricardo J., Smith, Dennis P., Cheng, Christine C., Antonellis, Patrick P., Perfield, James W., 2nd, Kharitonenkov, Alexei, Gimeno, Ruth E., Adams, Andrew C.

Source: In Cell Reports 19 May 2015 11(7):991-999

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Loss of ovarian function in mice results in abrogated skeletal muscle PPARδ and FoxO1-mediated gene expression

Authors: Rogers, Nicole H., Perfield, James W., II, Strissel, Katherine J., Obin, Martin S., Greenberg, Andrew S.

Source: In Biochemical and Biophysical Research Communications 2010 392(1):1-3