Phase 2 study of the antitumour activity and safety of simlukafusp alfa (FAP-IL2v) combined with atezolizumab in patients with recurrent and/or metastatic cervical squamous cell carcinoma

Authors: Verlingue, Loic, Italiano, Antoine, Prenen, Hans, Guerra Alia, Eva Maria, Tosi, Diego, Perets, Ruth, Lugowska, Iwona, Moiseyenko, Vladimir, Gumus, Mahmut, Arslan, Cagatay, Lindsay, Colin R., Deva, Sanjeev, Taus, Álvaro, Oaknin, Ana, Rottey, Sylvie, Cicin, Irfan, Goksu, Sema Sezgin, Smolin, Alexey, Roselló-Keränen, Susana, Habigt, Christin, Marbach, Daniel, Boetsch, Christophe, Dejardin, David, Sleiman, Nassim, Evers, Stefan, Richard, Muriel, Ardeshir, Caroline, Charo, Jehad, Kraxner, Anton, Teichgräber, Volker, Keshelava, Nino, Dziadziuszko, Rafal

Source: In eBioMedicine November 2024 109

A preceding low-virulence strain pandemic inducing immunity against COVID-19

Authors: Perets, Hagai B., Perets, Ruth

Subject Terms: Quantitative Biology - Populations and Evolution, Physics - Physics and Society

Access URL: http://arxiv.org/abs/2007.07154

Genomic alterations in circulating tumor DNA (ctDNA) and response to telisotuzumab adizutecan (ABBV-400) treatment in patients (pts) with colorectal cancer (CRC).

Authors: Cecchini, Michael, Sharma, Manish R, Kuboki, Yasutoshi, Perets, Ruth, Cohen, Jonathan, Raimbourg, Judith, Nakajima, Takako Eguchi, Cruz-Correa, Marcia, Ghiringhelli, François, Raghav, Kanwal Pratap Singh, Vasilopoulos, Athanasios, Luo, Xizhi, Neagu Aristide, Martha Raluca, Morrison Thiele, Gladys, Hunter, Zoe, Burns, Michael Charles, Roberts-Rapp, Lisa, Strickler, John H

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p258-258, 307p

Anti–cytotoxic T-lymphocyte–associated antigen-4 monoclonal antibody quavonlimab in combination with pembrolizumab: Safety and efficacy from a phase I study in previously treated extensive-stage small cell lung cancer

Authors: Cho, Byoung Chul, Yoh, Kiyotaka, Perets, Ruth, Nagrial, Adnan, Spigel, David R., Gutierrez, Martin, Kim, Dong-Wan, Kotasek, Dusan, Rasco, Drew, Niu, Jiaxin, Satouchi, Miyako, Ahn, Myung-Ju, Lee, Dae Ho, Maurice-Dror, Corinne, Siddiqi, Shabana, Ren, Yixin, Altura, Rachel A., Bar, Jair

Source: In Lung Cancer September 2021 159:162-170

DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer

Authors: Moskovich, Dotan, Alfandari, Adi, Finkelshtein, Yael, Weisz, Avivit, Katzav, Aviva, Kidron, Debora, Edelstein, Evgeny, Veroslavski, Daniel, Perets, Ruth, Arbib, Nissim, Kadan, Yfat, Fishman, Ami, Lerer, Bernard, Ellis, Martin, Ashur-Fabian, Osnat

Source: In Cancer Letters 31 March 2021 501:224-233

The KEYVIBE program: vibostolimab and pembrolizumab for the treatment of advanced malignancies.

Authors: Shapira-Frommer, Ronnie, Niu, Jiaxin, Perets, Ruth, Peters, Solange, Shouse, Geoffrey, Lugowska, Iwona, Garassino, Marina C., Sands, Jacob, Keenan, Tanya, Zhao, Bin, Healy, Jane, Ahn, Myung-Ju

Source: Future Oncology; 2024, Vol. 20 Issue 27, p1983-1991, 9p

Safety and clinical activity of JNJ-78306358, a human leukocyte antigen-G (HLA-G) x CD3 bispecific antibody, for the treatment of advanced stage solid tumors.

Authors: Geva, Ravit, Vieito, Maria, Ramon, Jorge, Perets, Ruth, Pedregal, Manuel, Corral, Elena, Doger, Bernard, Calvo, Emiliano, Bardina, Jorge, Garralda, Elena, Brown, Regina J., Greger, James G., Wu, Shujian, Steinbach, Douglas, Yao, Tsun-Wen Sheena, Cao, Yu, Lauring, Josh, Chaudhary, Ruchi, Patel, Jaymala, Patel, Bharvin

Source: Cancer Immunology, Immunotherapy; Oct2024, Vol. 73 Issue 10, p1-14, 14p

Corrigendum to 'DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer' [Canc. Lett. 501 224–233]

Authors: Moskovich, Dotan, Alfandari, Adi, Finkelshtein, Yael, Weisz, Avivit, Katzav, Aviva, Kidron, Debora, Edelstein, Evgeny, Veroslavski, Daniel, Perets, Ruth, Arbib, Nissim, Kadan, Yfat, Fishman, Ami, Lerer, Bernard, Ellis, Martin, Ashur-Fabian, Osnat

Source: Cancer letters. 563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190028824.0x000001&indx=1&recIds=ETOCvdc_100190028824.0x000001

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

Authors: Maniati, Eleni, Berlato, Chiara, Gopinathan, Ganga, Heath, Owen, Kotantaki, Panoraia, Lakhani, Anissa, McDermott, Jacqueline, Pegrum, Colin, Delaine-Smith, Robin M., Pearce, Oliver M.T., Hirani, Priyanka, Joy, Joash D., Szabova, Ludmila, Perets, Ruth, Sansom, Owen J., Drapkin, Ronny, Bailey, Peter, Balkwill, Frances R.

Source: In Cell Reports 14 January 2020 30(2):525-540

Checkpoint Inhibitors in Gynecological Malignancies: Are we There Yet?

Authors: Taha, Tarek, Reiss, Ari, Amit, Amnon, Perets, Ruth

Source: BioDrugs. 34(6):749-762

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187030261.0x000001&indx=1&recIds=ETOCvdc_100187030261.0x000001

Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients

Authors: Gabizon, Alberto A., Tahover, Esther, Golan, Talia, Geva, Ravit, Perets, Ruth, Amitay, Yasmine, Shmeeda, Hilary, Ohana, Patricia

Source: Investigational new drugs. 38(5):1411-1420

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171295567.0x000001&indx=1&recIds=ETOCvdc_100171295567.0x000001

Glucocorticoids as an adjunct to oncologic treatment in solid malignancies – Not an innocent bystander

Authors: Maurice-Dror, Corinne, Perets, Ruth, Bar-Sela, Gil

Source: In Critical Reviews in Oncology / Hematology June 2018 126:37-44

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

Authors: Eckert, Mark, Coscia, Fabian, Chryplewicz, Agnieszka, Chang, Jae, Hernandez, Kyle, Pan, Shawn, Tienda, Samantha, Nahotko, Dominik, Li, Gang, Blaženović, Ivana, Lastra, Ricardo, Curtis, Marion, Yamada, S., Perets, Ruth, McGregor, Stephanie, Andrade, Jorge, Fiehn, Oliver, Moellering, Raymond, Mann, Matthias, Lengyel, Ernst

Source: Nature. 569(7758):723-728

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153455238.0x000001&indx=1&recIds=ETOCvdc_100153455238.0x000001

Interim results of the randomized phase 2 cohort of study FW-2020-01 assessing the efficacy, safety and pharmacodynamics of CM24 in combination with nivolumab and chemotherapy in advanced/metastatic pancreatic cancer.

Authors: Macarulla, Teresa, Cecchini, Michael, Garcia-Carbonero, Rocio, Golan, Talia, Perets, Ruth, Borazanci, Erkut Hasan, Pedregal, Manuel, Ponz-Sarvise, Mariano, Al Hallak, Mohammed Najeeb, Pant, Shubham, Boni, Valentina, Saavedra, Omar, de Miguel, Maria J., Leal, Alexis Diane, Muñoz Martín, Andrés J., Sauri, Tamara, Schickler, Michael

Source: Journal of Clinical Oncology; 2024 Supplement 17, Vol. 42, pLBA4143-LBA4143, 83p

PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma

Authors: Ghannam-Shahbari, Dima, Jacob, Eyal, Kakun, Reli, Wasserman, Tanya, Korsensky, Lina, Sternfeld, Ofir, Kagan, Juliana, Bublik, Debora, Aviel-Ronen, Sarit, Levanon, Keren, Sabo, Edmond, Larisch, Sarit, Oren, Moshe, Hershkovitz, Dov, Perets, Ruth

Source: Oncogene. 37(17):2213-2224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111749354.0x000001&indx=1&recIds=ETOCvdc_100111749354.0x000001

Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study

Authors: Geva, Ravit, Lopez, Juanita, Danson, Sarah, Joensuu, Heikki, Peer, Avivit, Harris, Samuel J., Souza, Fabricio, Pereira, Kaline M. C., Perets, Ruth

Source: European journal of nuclear medicine and molecular imaging. 46(5):1092-1101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125527888.0x000001&indx=1&recIds=ETOCvdc_100125527888.0x000001

Mutant KRAS Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring

Authors: Perets, Ruth, Greenberg, Orli, Shentzer, Talia, Semenisty, Valeria, Epelbaum, Ron, Bick, Tova, Sarji, Shada, Ben‐Izhak, Ofer, Sabo, Edmond, Hershkovitz, Dov

Source: Oncologist. 23(5):566-572

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082764537.0x000001&indx=1&recIds=ETOCvdc_100082764537.0x000001

A phase 1, open-label, multicenter study evaluating MK-1084 as monotherapy and in combination with other therapies in patients with KRAS G12C mutant advanced solid tumors.

Authors: Lugowska, Iwona A., Rojas, Carlos, Stathis, Anastasios, Weindler, Susanne, Pal, Abhijit, Castanon Alvarez, Eduardo, Mackiewicz, Jacek, Garrido, Marcelo, Sendur, Mehmet Ali Nahit, Lakhani, Nehal J., Frentzas, Sophia, Dziadziuszko, Rafal, Sacher, Adrian G., Wakuda, Kazushige, Kato, Terufumi, Perets, Ruth, Castillo Fernandez, Omar Orlando, Jemielita, Thomas, Choi, Yewon, Juergens, Rosalyn A.

Source: Journal of Clinical Oncology; 2024 Supplement 3, Vol. 42, pTPS232-TPS232, 235p

PRKCI promotes immune suppression in ovarian cancer

Authors: Sarkar, Sharmistha, Bristow, Christopher A., Dey, Prasenjit, Rai, Kunal, Perets, Ruth, Ramirez-Cardenas, Alejandra, Malasi, Shruti, Huang-Hobbs, Emmet, Haemmerle, Monika, Wu, Sherry Y.

Source: Genes & development. 31(11):1109-1121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612646695&indx=1&recIds=ETOCRN612646695

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

Authors: Perets, Ruth, Wyant, Gregory A., Muto, Katherine W., Bijron, Jonathan G., Poole, Barish B., Chin, Kenneth T., Chen, Jin Yun H., Ohman, Anders W., Stepule, Corey D., Kwak, Soongu, Karst, Alison M., Hirsch, Michelle S., Setlur, Sunita R., Crum, Christopher P., Dinulescu, Daniela M., Drapkin, Ronny

Source: In Cancer Cell 9 December 2013 24(6):751-765