Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications

Authors: Gomez, Ivana M., Uriarte, Maia, Fernandez, Gimena, Barrile, Franco, Castrogiovanni, Daniel, Cantel, Sonia, Fehrentz, Jean-Alain, De Francesco, Pablo N., Perello, Mario

Source: In Molecular Metabolism December 2024 90

The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life

Authors: Kruger, Ana Luz, Malpeli, Agustina, Sala, Marisa, Casado, Carla, Mendez, Ignacio, Fotia, Lucrecia, López, Mercedes, Tournier, Andrea, Castrogiovanni, Daniel, Heredia, Florencia, Llovera, Ramiro, Schiöth, Helgi B, Perelló, Mario, Andreoli, María F

Source: In The Journal of Nutrition November 2024 154(11):3388-3399

New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract

Authors: Sancho-Alonso, María, Sarriés-Serrano, Unai, Miquel-Rio, Lluis, Yanes Castilla, Claudia, Paz, Verónica, Meana, José Javier, Perello, Mario, Bortolozzi, Analia

Source: In Spanish Journal of Psychiatry and Mental Health July 2024

Systemic Ghrelin Treatment Induces Rapid, Transient, and Asymmetric Changes in the Metabolic Activity of the Mouse Brain

Authors: De Francesco, Pablo Nicolás, Fernandez, Gimena, Uriarte, Maia, Urrutia, Leandro, Ponce de León, Magdalena, Fehrentz, Jean-Alain, Falasco, German, Perello, Mario

Source: Neuroendocrinology. 113(1):64-79

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170742448.0x000001&indx=1&recIds=ETOCvdc_100170742448.0x000001

Ghrelin’s orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Authors: Barrile, Franco, Cassano, Daniela, Fernandez, Gimena, De Francesco, Pablo N., Reynaldo, Mirta, Cantel, Sonia, Fehrentz, Jean-Alain, Donato, José, Jr, Schiöth, Helgi B., Zigman, Jeffrey M., Perello, Mario

Source: In Psychoneuroendocrinology October 2023 156

Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Authors: Fittipaldi, Antonela S., Castrogiovanni, Daniel, Lufrano, Daniela, Saenz, Camila, De Francesco, Pablo N., Lalonde, Tyler, Luyt, Leonard G., Cantel, Sonia, Fehrentz, Jean-Alain, Andreoli, María F., Perello, Mario

Source: In Life Sciences 15 January 2023 313

Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Authors: Péraldi-Roux, Sylvie, Bayle, Morgane, M'Kadmi, Céline, Damian, Marjorie, Vaillé, Justine, Fernandez, Gimena, Cornejo, Maria Paula, Marie, Jacky, Banères, Jean-Louis, Ben Haj Salah, Khoubaib, Fehrentz, Jean-Alain, Cantel, Sonia, Perello, Mario, Denoyelle, Séverine, Oiry, Catherine, Neasta, Jérémie

Source: In Biochemical Pharmacology August 2022 202

The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond

Authors: Perelló, Mario, Cornejo, María P., De Francesco, Pablo N., Fernandez, Gimena, Gautron, Laurent, Valdivia, Lesly S.

Source: In IBRO Neuroscience Reports June 2022 12:228-239

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Authors: Aguggia, Julieta P., Cornejo, María P., Fernandez, Gimena, De Francesco, Pablo N., Mani, Bharath K., Cassano, Daniela, Cabral, Agustina, Valdivia, Spring, García Romero, Guadalupe, Reynaldo, Mirta, Fehrentz, Jean-Alain, Zigman, Jeffrey M., Perello, Mario

Source: In Psychoneuroendocrinology May 2022 139

ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors

Authors: Portales, Andrea Estefanía, Mustafá, Emilio Román, McCarthy, Clara Inés, Cornejo, María Paula, Couto, Paula Monserrat, Gironacci, Mariela Mercedes, Caramelo, Julio Javier, Perelló, Mario, Raingo, Jesica

Source: In Life Sciences 15 March 2022 293

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Authors: Uriarte, Maia, De Francesco, Pablo N., Fernández, Gimena, Castrogiovanni, Daniel, D'Arcangelo, Micaela, Imbernon, Mónica, Cantel, Sonia, Denoyelle, Severine, Fehrentz, Jean-Alain, Praetorius, Jeppe, Prevot, Vincent, Perello, Mario

Source: In Molecular and Cellular Endocrinology 1 December 2021 538

THE INTRIGUING LIGAND-DEPENDENT AND LIGAND-INDEPENDENT ACTIONS OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR ON REWARD-RELATED BEHAVIORS

Authors: Cornejo, María P., Mustafá, Emilio R., Barrile, Franco, Cassano, Daniela, De Francesco, Pablo N., Raingo, Jesica, Perello, Mario ^*

Source: In Neuroscience and Biobehavioral Reviews January 2021 120:401-416

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.

Authors: Aguggia, Julieta, Fernandez, Gimena, Cassano, Daniela, Mustafá, Emilio R, Rodríguez, Silvia S, Cantel, Sonia, Fehrentz, Jean-Alain, Raingo, Jesica, Schiöth, Helgi B, Habib, Abdella M, Francesco, Pablo N De, Perello, Mario

Source: Endocrinology; Jan2025, Vol. 166 Issue 1, p1-16, 16p

Subject Terms: GLUCAGON-like peptide-1 receptor, G protein coupled receptors, CALCIUM channels, GHRELIN, NEURONS

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain.

Authors: Saenz, Camila, Fernandez, Gimena, Llovera, Ramiro, Tolosa, María J., Cantel, Sonia, Fehrentz, Jean-Alain, Mackie, Kenneth, Leggio, Lorenzo, Zigman, Jeffrey, De Francesco, Pablo N., Perello, Mario

Source: Brain Structure & Function; Jan2025, Vol. 230 Issue 1, p1-25, 25p

The ups and downs of growth hormone secretagogue receptor signaling

Authors: Cornejo, María P., Mustafá, Emilio R., Cassano, Daniela, Banères, Jean‐Louis, Raingo, Jesica, Perello, Mario

Source: FEBS journal. 288(24):7213-7229

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137347708.0x000001&indx=1&recIds=ETOCvdc_100137347708.0x000001

Metabolic insights from a GHSR-A203E mutant mouse model

Authors: Torz, Lola J., Osborne-Lawrence, Sherri, Rodriguez, Juan, He, Zhenyan, Cornejo, María Paula, Mustafá, Emilio Román, Jin, Chunyu, Petersen, Natalia, Hedegaard, Morten A., Nybo, Maja, Damonte, Valentina Martínez, Metzger, Nathan P., Mani, Bharath K., Williams, Kevin W., Raingo, Jesica, Perello, Mario, Holst, Birgitte, Zigman, Jeffrey M.

Source: In Molecular Metabolism September 2020 39

Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice

Authors: Cornejo, María Paula, Barrile, Franco, Cassano, Daniela, Aguggia, Julieta Paola, García Romero, Guadalupe, Reynaldo, Mirta, Andreoli, María Florencia, De Francesco, Pablo Nicolás, Perello, Mario ^*

Source: In Psychoneuroendocrinology September 2020 119

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor–dependent manner

Authors: Cabral, Agustina, Fernandez, Gimena, Tolosa, María J., Rey Moggia, Ángeles, Calfa, Gastón, De Francesco, Pablo N., Perello, Mario

Source: In Molecular Metabolism February 2020 32:69-84

Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region

Authors: Barrile, Franco, M'Kadmi, Céline, De Francesco, Pablo N., Cabral, Agustina, García Romero, Guadalupe, Mustafá, Emilio R., Cantel, Sonia, Damian, Marjorie, Mary, Sophie, Denoyelle, Séverine, Banères, Jean-Louis, Marie, Jacky, Raingo, Jesica, Fehrentz, Jean-Alain, Perelló, Mario

Source: In Molecular and Cellular Endocrinology 1 December 2019 498

LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans.

Authors: Andreoli, María F., Kruger, Ana Luz, Sokolov, Aleksandr V., Rukh, Gull, De Francesco, Pablo N., Perello, Mario, Schiöth, Helgi B.

Source: Diabetes, Obesity & Metabolism; Oct2024, Vol. 26 Issue 10, p4734-4743, 10p

Subject Terms: REWARD (Psychology), ANTIMICROBIAL peptides, SINGLE nucleotide polymorphisms, FOOD consumption, BODY mass index