Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer

Authors: Inoue, Akira, Robinson, Frederick S., Minelli, Rosalba, Tomihara, Hideo, Rizi, Bahar Salimian, Rose, Johnathon L., Kodama, Takahiro, Srinivasan, Sanjana, Harris, Angela L., Zuniga, Andy M., Mullinax, Robert A., Ma, Xiaoyan, Seth, Sahil, Daniele, Joseph R., Peoples, Michael D., Loponte, Sara, Akdemir, Kadir C., Khor, Tin Oo, Feng, Ningping, Roszik, Jason, Sobieski, Mary M., Brunell, David, Stephan, Clifford, Giuliani, Virginia, Deem, Angela K., Shingu, Takashi, Deribe, Yonathan Lissanu, Menter, David G., Heffernan, Timothy P., Viale, Andrea, Bristow, Christopher A., Kopetz, Scott, Draetta, Giulio F., Genovese, Giannicola, Carugo, Alessandro

Source: In Gastroenterology July 2021 161(1):196-210

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Authors: Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

Source: In Cell Metabolism 1 May 2018 27(5):977-987

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

Authors: Manshouri, Roxsan, Coyaud, Etienne, Kundu, Samrat T., Peng, David H., Stratton, Sabrina A., Alton, Kendra, Bajaj, Rakhee, Fradette, Jared J., Minelli, Rosalba, Peoples, Michael D., Carugo, Alessandro, Chen, Fengju, Bristow, Christopher, Kovacs, Jeffrey J., Barton, Michelle C., Heffernan, Tim, Creighton, Chad J., Raught, Brian, Gibbons, Don L.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131103588.0x000001&indx=1&recIds=ETOCvdc_100131103588.0x000001

SMARCB1 regulates the hypoxic stress response in sickle cell trait.

Authors: Melinda Soeung, Perelli, Luigi, Ziheng Chen, Dondossola, Eleonora, I-Lin Ho, Carbone, Federica, Li Zhang, Khan, Hania, Le, Courtney N., Cihui Zhu, Peoples, Michael D., Ningping Feng, Shan Jiang, Zacharias, Niki Millward, Minelli, Rosalba, Shapiro, Daniel D., Deem, Angela K., Sisi Gao, Cheng, Emily H., Lucchetti, Donatella

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/23/2023, Vol. 120 Issue 21, p1-11, 33p

Subject Terms: SICKLE cell trait, KIDNEY tumors, ERYTHROCYTES, RENAL cancer

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.

Authors: Giuliani, Virginia, Miller, Meredith A., Liu, Chiu-Yi, Hartono, Stella R., Class, Caleb A., Bristow, Christopher A., Suzuki, Erika, Sanz, Lionel A., Gao, Guang, Gay, Jason P., Feng, Ningping, Rose, Johnathon L., Tomihara, Hideo, Daniele, Joseph R., Peoples, Michael D., Bardenhagen, Jennifer P., Geck Do, Mary K., Chang, Qing E., Vangamudi, Bhavatarini, Vellano, Christopher

Source: Nature Communications; 7/30/2021, Vol. 12 Issue 1, p1-19, 19p

Subject Terms: METABOLIC regulation, DNA damage, PROTEIN arginine methyltransferases, FUNCTIONAL genomics, RNA splicing, RNA metabolism

Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1mutations

Authors: Shariati, Maryam, Evans, Kurt W., Zheng, Xiaofeng, Bristow, Christopher A., Ng, Patrick Kwok-Shing, Rizvi, Yasmeen Q., Tapia, Coya, Yang, Fei, Carugo, Alessandro, Heffernan, Timothy P., Peoples, Michael D., Tripathy, Debu, Meric-Bernstam, Funda

Source: Oncogene; July 2021, Vol. 40 Issue: 26 p4425-4439, 15p

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Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.

Authors: Invrea, Federica, Punzi, Simona, Petti, Consalvo, Minelli, Rosalba, Peoples, Michael D., Bristow, Christopher A., Vurchio, Valentina, Corrado, Alessia, Bragoni, Alberto, Marchiò, Caterina, Bertotti, Andrea, Trusolino, Livio, Bardelli, Alberto, Isella, Claudio, Carugo, Alessandro, Draetta, Giulio F., Medico, Enzo

Source: Cancers; Aug2021, Vol. 13 Issue 15, p3805-3805, 1p

Subject Terms: HIGH throughput screening (Drug development), IN vitro studies, GENETIC mutation, IN vivo studies, ONCOGENES, ANIMAL experimentation, CELL receptors, ANTINEOPLASTIC agents, COLORECTAL cancer, CELLULAR signal transduction, TRANSFERASES, DESCRIPTIVE statistics, MEMBRANE proteins, CELL lines, ENZYME inhibitors, MICE, DRUG resistance in cancer cells, PHARMACODYNAMICS

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Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.

Authors: Konen, Jessica M., Rodriguez, B. Leticia, Fradette, Jared J., Gibson, Laura, Davis, Denali, Minelli, Rosalba, Peoples, Michael D., Kovacs, Jeffrey, Carugo, Alessandro, Bristow, Christopher, Heffernan, Timothy, Gibbons, Don L.

Source: Cancers; Apr2019, Vol. 11 Issue 4, p462, 1p

Subject Terms: ANTINEOPLASTIC agents, LUNG cancer treatment, ANIMAL experimentation, ANTIGENS, CELL lines, CELL receptors, GENES, IMMUNOLOGICAL adjuvants, IMMUNOTHERAPY, LUNG tumors, EVALUATION of medical care, MICE

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.

Authors: Kundu, Samrat T., Fradette, Jared J., Byers, Lauren A., Peng, David H., Gibbons, Don L., Diao, Lixia, Tong, Pan, Wang, Jing, Canales, Jaime Rodriguez, Villalobos, Pamela A., Mino, Barbara, Wistuba, Ignacio I., Yang, Yanan, Minelli, Rosalba, Peoples, Michael D., Bristow, Christopher A., Heffernan, Timothy P., Carugo, Alessandro

Source: Science Translational Medicine; 3/13/2019, Vol. 11 Issue 483, pN.PAG-N.PAG, 1p

Subject Terms: ZINC-finger proteins, LUNG cancer treatment, MITOGEN-activated protein kinases

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

Authors: Peng, David H., Kundu, Samrat T., Fradette, Jared J., Diao, Lixia, Tong, Pan, Byers, Lauren A., Wang, Jing, Canales, Jaime Rodriguez, Villalobos, Pamela A., Mino, Barbara, Yang, Yanan, Minelli, Rosalba, Peoples, Michael D., Bristow, Christopher A., Heffernan, Timothy P., Carugo, Alessandro, Wistuba, Ignacio I., Gibbons, Don L.

Source: Science Translational Medicine; March 2019, Vol. 11 Issue: 483