A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects with secondary progressive multiple sclerosis: evaluation of cerebrospinal fluid penetration and the effects on exploratory biomarkers

Authors: Edwards, Keith R., Kamath, Aneesh, Button, Judy, Kamath, Vineetha, Mendoza, Jason P., Zhu, Bing, Plavina, Tatiana, Woodward, Caroline, Penner, Natalia

Source: In Multiple Sclerosis and Related Disorders June 2021 51

Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist

Authors: Ghosal, Anima ^*, Lu, Xiaowen, Penner, Natalia, Gao, Lan, Ramanathan, Ragu, Chowdhury, Swapan K., Kishnani, Narendra S., Alton, Kevin B.

Source: In Drug Metabolism and Disposition January 2011 39(1):30-38

Identification of Two Novel Metabolites of SCH 486757, a Nociceptin/Orphanin FQ Peptide Receptor Agonist, in Humans

Authors: Penner, Natalia A. ¹, Ho, Ginny, Bercovici, Ana, Chowdhury, Swapan K. ^*, Alton, Kevin B.

Source: In Drug Metabolism and Disposition November 2010 38(11):2067-2074

Active metabolite of a thrombin receptor antagonist

Sampling BIAS at channel junctions in gated flow injection on chips.

Authors: Slentz, Benjamin E., Penner, Natalia A., Regnier, Fred

Source: Analytical Chemistry; September 15 2002, Vol. 74 Issue 18, p4835-4840, 6p

Contributions of commercial sorbents to the selectivity in immobilized metal affinity chromatography with Cu(II)

Authors: Ren, Diya, Penner, Natalia A., Slentz, Benjamin E., Inerowicz, Halina D., Rybalko, Marina, Regnier, Fred E.

Source: In Journal of Chromatography A 2004 1031(1):87-92

Protein proteolysis and the multi-dimensional electrochromatographic separation of histidine-containing peptide fragments on a chip

Authors: Slentz, Benjamin E, Penner, Natalia A, Regnier, Fred E ^∗

Source: In Journal of Chromatography A 2003 984(1):97-107

Capillary electrochromatography of peptides on microfabricated poly(dimethylsiloxane) chips modified by cerium(IV)-catalyzed polymerization

Authors: Slentz, Benjamin E, Penner, Natalia A, Regnier, Fred E ^∗

Source: In Journal of Chromatography A 2002 948(1):225-233

Application of neutral hydrophobic hypercrosslinked polystyrene to the separation of inorganic anions by ion chromatography

Authors: Penner, Natalia A., Nesterenko, Pavel N. ^*

Source: In Journal of Chromatography A 2000 884(1):41-51

Phase II Dose Selection for Alpha Synuclein–Targeting Antibody Cinpanemab (BIIB054) Based on Target Protein Binding Levels in the Brain.

Authors: Kuchimanchi, Mita, Monine, Michael, Kandadi Muralidharan, Kumar, Woodward, Caroline, Penner, Natalia

Source: CPT: Pharmacometrics & Systems Pharmacology; Sep2020, Vol. 9 Issue 9, p515-522, 8p

Subject Terms: PROTEIN binding, EXTRACELLULAR fluid, PARKINSON'S disease, MONOCLONAL antibodies, INTRAVENOUS therapy, IMMUNOGLOBULINS

Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054.

Authors: Brys, Miroslaw, Fanning, Laura, Hung, Serena, Ellenbogen, Aaron, Penner, Natalia, Yang, Minhua, Welch, Mackenzie, Koenig, Erica, David, Eric, Fox, Tara, Makh, Shavy, Aldred, Jason, Goodman, Ira, Pepinsky, Blake, Liu, YuTing, Graham, Danielle, Weihofen, Andreas, Cedarbaum, Jesse M.

Source: Movement Disorders; Aug2019, Vol. 34 Issue 8, p1154-1163, 10p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, DRUG therapy for Parkinson's disease, COMPARATIVE studies, IMMUNOLOGICAL adjuvants, RESEARCH methodology, MEDICAL cooperation, MONOCLONAL antibodies, NERVE tissue proteins, RESEARCH, RESEARCH funding, EVALUATION research, BLIND experiment

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Geometric effects of collocated monolithic support structures on separation performance in microfabricated systems.

Authors: Slentz, Benjamin E., Penner, Natalia A., Regnier, Fred

Source: Journal of Separation Science; 2002, Vol. 25 Issue 15/17, p1011-1018, 8p

Nanoliter capillary electrochromatography columns based on collocated monolithic support structures molded in poly(dimethyl siloxane).

Authors: Slentz, Benjamin E., Penner, Natalia A., Lugowska, Emilia, Regnier, Fred

Source: Electrophoresis; Sep2001, Vol. 22 Issue 17, p3736-3743, 8p

Simultaneous determination of dihydroxybenzenes, aminophenols and phenylenediamines in hair dyes by high-performance liquid chromatography on hypercross-linked polystyrene.

Authors: Penner, Natalia A., Nesterenko, Pavel N.

Source: Analyst; 2000, Issue 7, p1249-1254, 6p

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Tissue distribution of 35S-metabolically labeled neublastin (BG00010) in rats.

Authors: Penner, Natalia¹ (AUTHOR) natasha.penner@biogen.com, Purushothama, Shobha¹ (AUTHOR), Pepinsky, Blake¹ (AUTHOR)

Source: Journal of Pharmaceutical & Biomedical Analysis. May2020, Vol. 184, pN.PAG-N.PAG. 1p.

Subject Terms: *CARRIER proteins, *MOLECULAR weights, *RADICULOPATHY, *TISSUES, *RATS, *PROXIMAL kidney tubules, *PAIN management

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