Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC

Authors: Piqué-Gili, Marta, Andreu-Oller, Carmen, Mesropian, Agavni, Esteban-Fabró, Roger, Bárcena-Varela, Marina, Ruiz de Galarreta, Marina, Montironi, Carla, Martinez-Quetglas, Iris, Cappuyns, Sarah, Peix, Judit, Keraite, Ieva, Gris-Oliver, Albert, Fernández-Martínez, Elisa, Mauro, Ezequiel, Torres-Martin, Miguel, Abril-Fornaguera, Jordi, Lindblad, Katherine E., Lambrechts, Diether, Dekervel, Jeroen, Thung, Swan N., Sia, Daniela, Lujambio, Amaia, Pinyol, Roser, Llovet, Josep M.

Source: In JHEP Reports November 2024 6(11)

Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

Authors: Cappuyns, Sarah ^{1, 2, 3, 4, 5, †}, Piqué-Gili, Marta ^{5, 6, †}, Esteban-Fabró, Roger ^{5, 6, †}, Philips, Gino ^{3, 4}, Balaseviciute, Ugne ⁶, Pinyol, Roser ⁶, Gris-Oliver, Albert ⁶, Vandecaveye, Vincent ^{7, 8}, Abril-Fornaguera, Jordi ^{5, 6}, Montironi, Carla ^{6, 9}, Bassaganyas, Laia ¹⁰, Peix, Judit ⁶, Zeitlhoefler, Marcus ⁵, Mesropian, Agavni ^{5, 6}, Huguet-Pradell, Júlia ^{5, 6}, Haber, Philipp K. ¹¹, Figueiredo, Igor ¹², Ioannou, Giorgio ¹², Gonzalez-Kozlova, Edgar ¹², D’Alessio, Antonio ¹³, Mohr, Raphael ¹⁴, Meyer, Tim ¹⁵, Lachenmayer, Anja ¹⁶, Marquardt, Jens U. ¹⁷, Reeves, Helen L. ^{18, 19}, Edeline, Julien ²⁰, Finkelmeier, Fabian ²¹, Trojan, Jörg ²¹, Galle, Peter R. ²², Foerster, Friedrich ²², Mínguez, Beatriz ^{23, 24, 25}, Montal, Robert ²⁶, Gnjatic, Sacha ¹², Pinato, David J. ^{13, 27}, Heikenwalder, Mathias ²⁸, Verslype, Chris ^{1, 2}, Van Cutsem, Eric ^{1, 2}, Lambrechts, Diether ^{3, 4}, Villanueva, Augusto ⁵, Dekervel, Jeroen ^{1, 2, ⁎, ‡}, Llovet, Josep M. ^{5, 6, 29, ⁎, ‡}

Source: In Journal of Hepatology December 2024

Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

Authors: Pinyol, Roser, Torrecilla, Sara, Wang, Huan, Montironi, Carla, Piqué-Gili, Marta, Torres-Martin, Miguel, Wei-Qiang, Leow, Willoughby, Catherine E., Ramadori, Pierluigi, Andreu-Oller, Carmen, Taik, Patricia, Lee, Youngmin A., Moeini, Agrin, Peix, Judit, Faure-Dupuy, Suzanne, Riedl, Tobias, Schuehle, Svenja, Oliveira, Claudia P., Alves, Venancio A., Boffetta, Paolo, Lachenmayer, Anja, Roessler, Stephanie, Minguez, Beatriz, Schirmacher, Peter, Dufour, Jean-François, Thung, Swan N., Reeves, Helen L., Carrilho, Flair J., Chang, Charissa, Uzilov, Andrew V., Heikenwalder, Mathias, Sanyal, Arun, Friedman, Scott L., Sia, Daniela, Llovet, Josep M.

Source: In Journal of Hepatology October 2021 75(4):865-878

Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma

Authors: Torrens, Laura, Montironi, Carla, Puigvehí, Marc, Mesropian, Agavni, Leslie, Jack, Haber, Philipp K., Maeda, Miho, Balaseviciute, Ugne, Willoughby, Catherine E., Abril‐Fornaguera, Jordi, Piqué‐Gili, Marta, Torres‐Martín, Miguel, Peix, Judit, Geh, Daniel, Ramon‐Gil, Erik, Saberi, Behnam, Friedman, Scott L., Mann, Derek A., Sia, Daniela, Llovet, Josep M.

Source: Hepatology. 74(5):2652-2669

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135392335.0x000001&indx=1&recIds=ETOCvdc_100135392335.0x000001

DNA Methylation Profiling of Human Hepatocarcinogenesis

Authors: Hernandez‐Meza, Gabriela, Felden, Johann, Gonzalez‐Kozlova, Edgar E., Garcia‐Lezana, Teresa, Peix, Judit, Portela, Anna, Craig, Amanda J., Sayols, Sergi, Schwartz, Myron, Losic, Bojan, Mazzaferro, Vincenzo, Esteller, Manel, Llovet, Josep M., Villanueva, Augusto

Source: Hepatology. 74(1):183-199

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132991628.0x000001&indx=1&recIds=ETOCvdc_100132991628.0x000001

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

Authors: Montal, Robert, Sia, Daniela, Montironi, Carla, Leow, Wei Q., Esteban-Fabró, Roger, Pinyol, Roser, Torres-Martin, Miguel, Bassaganyas, Laia, Moeini, Agrin, Peix, Judit, Cabellos, Laia, Maeda, Miho, Villacorta-Martin, Carlos, Tabrizian, Parissa, Rodriguez-Carunchio, Leonardo, Castellano, Giancarlo, Sempoux, Christine, Minguez, Beatriz, Pawlik, Timothy M., Labgaa, Ismail, Roberts, Lewis R., Sole, Manel, Fiel, Maria I., Thung, Swan, Fuster, Josep, Roayaie, Sasan, Villanueva, Augusto, Schwartz, Myron, Llovet, Josep M.

Source: In Journal of Hepatology August 2020 73(2):315-327

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

Authors: Moeini, Agrin, Torrecilla, Sara, Tovar, Victoria, Montironi, Carla, Andreu-Oller, Carmen, Peix, Judit, Higuera, Mónica, Pfister, Dominik, Ramadori, Pierluigi, Pinyol, Roser, Solé, Manel, Heikenwälder, Mathias, Friedman, Scott L., Sia, Daniela, Llovet, Josep M.

Source: In Gastroenterology November 2019 157(5):1383-1397

Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials

Authors: Montal, Robert, Andreu-Oller, Carmen, Bassaganyas, Laia, Esteban-Fabró, Roger, Moran, Sebastián, Montironi, Carla, Moeini, Agrin, Pinyol, Roser, Peix, Judit, Cabellos, Laia, Villanueva, Augusto, Sia, Daniela, Mazzaferro, Vincenzo, Esteller, Manel, Llovet, Josep

Source: British journal of cancer. 121(4):340-343

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189397220.0x000001&indx=1&recIds=ETOCvdc_100189397220.0x000001

PMEPA1: an oncogene in hepatocellular carcinoma linked to TGF-beta signaling

Authors: Andreu-Oller, Carmen, Piqué-Gili, Marta, Barcena-Varela, Marina, Pinyol, Roser, Esteban-Fabró, Roger, Peix, Judit, Lindblad, Katherine E., Torres-Martín, Miguel, Sia, Daniela, Lujambio, Amaia, Llovet, Josep M.

Source: Journal of hepatology. 77(S1):S45-S46

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167076807.0x000001&indx=1&recIds=ETOCvdc_100167076807.0x000001

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

Authors: Sia, Daniela, Hoshida, Yujin, Villanueva, Augusto, Roayaie, Sasan, Ferrer, Joana, Tabak, Barbara, Peix, Judit, Sole, Manel, Tovar, Victoria, Alsinet, Clara, Cornella, Helena, Klotzle, Brandy, Fan, Jian–Bing, Cotsoglou, Christian, Thung, Swan N., Fuster, Josep, Waxman, Samuel, Garcia–Valdecasas, Juan Carlos, Bruix, Jordi, Schwartz, Myron E., Beroukhim, Rameen, Mazzaferro, Vincenzo, Llovet, Josep M.

Source: In Gastroenterology April 2013 144(4):829-840

TOP-507-YI Single-cell RNA sequencing-derived gene signatures reveal distinct response mechanisms to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

Authors: Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Gris-Oliver, Albert, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Montironi, Carla, Bassaganyas, Laia, Peix, Judit, Zeitlhoefler, Marcus, Mesropian, Agavni, Huguet-Pradell, Júlia, Haber, Philipp, Mohr, Raphael, Meyer, Tim, Reeves, Helen Louise, Edeline, Julien, Finkelmeier, Fabian, Trojan, Jörg, Galle, Peter R., Foerster, Friedrich, Minguez, Beatriz, Montal, Robert, Heikenwälder, Mathias, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep

Source: In Journal of Hepatology June 2024 80 Supplement 1:S411-S412

IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

Authors: Tovar, Victoria, Alsinet, Clara, Villanueva, Augusto, Hoshida, Yujin, Chiang, Derek Y., Solé, Manel, Thung, Swan, Moyano, Susana, Toffanin, Sara, Mínguez, Beatriz, Cabellos, Laia, Peix, Judit, Schwartz, Myron, Mazzaferro, Vincenzo, Bruix, Jordi, Llovet, Josep M.

Source: In Journal of Hepatology 2010 52(4):550-559

Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo

Authors: Newell, Pippa, Toffanin, Sara, Villanueva, Augusto, Chiang, Derek Y., Minguez, Beatriz, Cabellos, Laia, Savic, Radoslav, Hoshida, Yujin, Lim, Kiat Hon, Melgar-Lesmes, Pedro, Yea, Steven, Peix, Judit, Deniz, Kemal, Fiel, M. Isabel, Thung, Swan, Alsinet, Clara, Tovar, Victoria, Mazzaferro, Vincenzo, Bruix, Jordi, Roayaie, Sasan, Schwartz, Myron, Friedman, Scott L., Llovet, Josep M.

Source: In Journal of Hepatology October 2009 51(4):725-733

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

Authors: Villanueva, Augusto, Chiang, Derek Y., Newell, Pippa, Peix, Judit, Thung, Swan, Alsinet, Clara, Tovar, Victoria, Roayaie, Sasan, Minguez, Beatriz, Sole, Manel, Battiston, Carlo, van Laarhoven, Stijn, Fiel, Maria I., Di Feo, Analisa, Hoshida, Yujin, Yea, Steven, Toffanin, Sara, Ramos, Alex, Martignetti, John A., Mazzaferro, Vincenzo, Bruix, Jordi, Waxman, Samuel, Schwartz, Myron, Meyerson, Matthew, Friedman, Scott L., Llovet, Josep M.

Source: In Gastroenterology 2008 135(6):1972-1983

Corrigendum to 'Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis' [J Hepatol 75 (2021) 865–878]

Authors: Pinyol, Roser, Torrecilla, Sara, Wang, Huan, Montironi, Carla, Piqué-Gili, Marta, Torres-Martin, Miguel, Wei-Qiang, Leow, Willoughby, Catherine E., Ramadori, Pierluigi, Andreu-Oller, Carmen, Taik, Patricia, Lee, Youngmin A., Moeini, Agrin, Peix, Judit, Faure-Dupuy, Suzanne, Riedl, Tobias, Schuehle, Svenja, Oliveira, Claudia P., Alves, Venancio A., Boffetta, Paolo, Lachenmayer, Anja, Roessler, Stephanie, Minguez, Beatriz, Schirmacher, Peter, Dufour, Jean-François, Thung, Swan N., Reeves, Helen L., Carrilho, Flair J., Chang, Charissa, Uzilov, Andrew V., Heikenwalder, Mathias, Sanyal, Arun, Friedman, Scott L., Sia, Daniela, Llovet, Josep M.

Source: Journal of hepatology. 75(6):1515-1515

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154497862.0x000001&indx=1&recIds=ETOCvdc_100154497862.0x000001

Cabozantinib enhances the efficacy and immune modulatory activity of anti-PD1 therapy in a syngeneic mouse model of hepatocellular carcinoma

Authors: Esteban-Fabró, Roger, Willoughby, Catherine E., Piqué-Gili, Marta, Peix, Judit, Montironi, Carla, Abril-Fornaguera, Jordi, Torrens, Laura, Pinyol, Roser, Llovet, Josep M.

Source: Journal of hepatology. 73(S1):S40-S40

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136871037.0x000001&indx=1&recIds=ETOCvdc_100136871037.0x000001

OS055 - PMEPA1: an oncogene in hepatocellular carcinoma linked to TGF-beta signaling

Authors: Andreu-Oller, Carmen, Piqué-Gili, Marta, Barcena-Varela, Marina, Pinyol, Roser, Esteban-Fabró, Roger, Peix, Judit, Lindblad, Katherine E., Torres-Martín, Miguel, Sia, Daniela, Lujambio, Amaia, Llovet, Josep M.

Source: In Journal of Hepatology July 2022 77 Supplement 1:S45-S46

AS053 - Cabozantinib enhances the efficacy and immune modulatory activity of anti-PD1 therapy in a syngeneic mouse model of hepatocellular carcinoma

Authors: Esteban-Fabró, Roger, Willoughby, Catherine E., Piqué-Gili, Marta, Peix, Judit, Montironi, Carla, Abril-Fornaguera, Jordi, Torrens, Laura, Pinyol, Roser, Llovet, Josep M.

Source: In Journal of Hepatology August 2020 73 Supplement 1:S40-S40

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