Elevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog

Authors: Neda Kortam, Wenying Liang, Claire Shiple, Suiyuan Huang, Rosemary Gedert, James St. Clair, Cyrus Sarosh, Caroline Foster, Pei-Suen Tsou, John Varga, Jason S. Knight, Dinesh Khanna, Ramadan A. Ali

Source: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)

Subject Terms: Systemic sclerosis, Vascular complications, Neutrophil extracellular traps (NETs), Prostacyclin, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/1e9423ad492e4ec5b83935972b964cf2

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Authors: Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Authors: Souren Paul, Mark H. Kaplan, Dinesh Khanna, Preston M. McCourt, Anjan K. Saha, Pei-Suen Tsou, Mahek Anand, Alexander Radecki, Mohamad Mourad, Amr H. Sawalha, David M. Markovitz, Rafael Contreras-Galindo

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d5eaf6cdd6504e8d8ebc8070af2ffb48

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Authors: Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b780d1905dd3456085e57175c8dc1c29

Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis

Authors: Enze Xing, Feiyang Ma, Rachael Wasikowski, Allison C. Billi, Mehrnaz Gharaee-Kermani, Jennifer Fox, Craig Dobry, Amanda Victory, Mrinal K. Sarkar, Xianying Xing, Olesya Plazyo, Henry W. Chen, Grant Barber, Heidi Jacobe, Pei-Suen Tsou, Robert L. Modlin, John Varga, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Dinesh Khanna

Source: JCI Insight, Vol 8, Iss 16 (2023)

Subject Terms: Dermatology, Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/40503665b3474f938f778ca913681263

Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis

Authors: Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga

Source: JCI Insight, Vol 8, Iss 14 (2023)

Subject Terms: Autoimmunity, Dermatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/b5bda06bbf254b1d930547a5f45e0f51

Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis

Authors: Wenxia Wang, Swarna Bale, Bharath Yalavarthi, Priyanka Verma, Pei-Suen Tsou, Ken M. Calderone, Dibyendu Bhattacharyya, Gary J. Fisher, John Varga, Swati Bhattacharyya

Source: JCI Insight, Vol 7, Iss 21 (2022)

Subject Terms: Autoimmunity, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/a9a1c3f128b146f981dd7f3db1b53149

Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

Authors: Seok-Jo Kim, Swarna Bale, Priyanka Verma, Qianqian Wan, Feiyang Ma, Johann E. Gudjonsson, Stanley L. Hazen, Paul W. Harms, Pei-Suen Tsou, Dinesh Khanna, Lam C. Tsoi, Nilaksh Gupta, Karen J. Ho, John Varga

Source: iScience, Vol 25, Iss 7, Pp 104669- (2022)

Subject Terms: Cell biology, Microbial metabolism, Microbiome, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222009415; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/f9eca232c9634042bf6a7b0a0699f25c

Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1

Authors: Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L. Campbell, Qi Wu, Ellen N. Model, Matthew E. Lind, Sirapa Vichaikul, Megan N. Mattichak, William D. Brodie, Jonatan L. Hervoso, Sarah Ory, Camila I. Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M. O’Mara, Jeffrey H. Ruth, Aaron M. Robida, Andrew J. Alt, Chengxin Zhang, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, Tristan Maerz, Thomas L. Saunders, Vincent E. Groppi, David A. Fox, M. Asif Amin

Source: The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)

Subject Terms: Autoimmunity, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/e5e9835fa1944ab4a428208a7bd7d3dd

Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma

Authors: Sirapa Vichaikul, Mikel Gurrea-Rubio, M. Asif Amin, Phillip L. Campbell, Qi Wu, Megan N. Mattichak, William D. Brodie, Pamela J. Palisoc, Mustafa Ali, Sei Muraoka, Jeffrey H. Ruth, Ellen N. Model, Dallas M. Rohraff, Jonatan L. Hervoso, Yang Mao-Draayer, David A. Fox, Dinesh Khanna, Amr H. Sawalha, Pei-Suen Tsou

Source: JCI Insight, Vol 7, Iss 9 (2022)

Subject Terms: Autoimmunity, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/144c5e7d2e6a41519ccf4095bccbb0c0

Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Authors: Pamela J. Palisoc, Leah Vaikutis, Mikel Gurrea-Rubio, Ellen N. Model, Morgan M. O’mara, Sarah Ory, Sirapa Vichaikul, Dinesh Khanna, Pei-Suen Tsou, Amr H. Sawalha

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: scleroderma, fibrosis, dermal fibroblasts, GPNMB, autoimmunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.814533/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8403e7a4f4b34bbc8160d24bb65ecf5b

Author Correction: Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Authors: Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/de33bf0fed064aa3affe26473be697d4

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

Authors: Vivek Nagaraja, Cathie Spino, Erica Bush, Pei-Suen Tsou, Robyn T. Domsic, Robert Lafyatis, Tracy Frech, Jessica K. Gordon, Virginia D. Steen, Dinesh Khanna

Source: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)

Subject Terms: Systemic sclerosis, Digital ulcers, Riociguat, Clinical trial, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13075-019-1979-7; https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/002748e02921434a8e70ce32c1c61b89

Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

Authors: Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey, Jason S. Knight

Source: JCI Insight, Vol 6, Iss 17 (2021)

Subject Terms: Inflammation, Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/841d7563afdf4a2684c13199b322ad80

CD6 is a target for cancer immunotherapy

Authors: Jeffrey H. Ruth, Mikel Gurrea-Rubio, Kalana S. Athukorala, Stephanie M. Rasmussen, Daniel P. Weber, Peggy M. Randon, Rosemary J. Gedert, Matthew E. Lind, M. Asif Amin, Phillip L. Campbell, Pei-Suen Tsou, Yang Mao-Draayer, Qi Wu, Thomas M. Lanigan, Venkateshwar G. Keshamouni, Nora G. Singer, Feng Lin, David A. Fox

Source: JCI Insight, Vol 6, Iss 5 (2021)

Subject Terms: Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/f287e4446e9b405d899bf9971cadfab5

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Authors: Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin

Source: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13075-018-1519-x; https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/4f63b3bffec345f58497e6ec184a9263

Hypomethylation of and is associated with type-I interferon-dependent expression in lupus CD8+ T cells.

Authors: Miller, Shaylynn, Pei-Suen Tsou, Coit, Patrick, Gensterblum-Miller, Elizabeth, Renauer, Paul, Rohraff, Dallas M., Kilian, Nathan C., Schonfeld, Mark, Sawalha, Amr H., Tsou, Pei-Suen

Source: Annals of the Rheumatic Diseases; Apr2019, Vol. 78 Issue 4, p519-528, 10p, 1 Chart, 4 Graphs

Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma.

Authors: Pei-Suen Tsou¹, Campbell, Phillip¹, Amin, M. Asif¹, Coit, Patrick¹, Miller, Shaylynn¹, Fox, David A.¹, Khanna, Dinesh^1,2, Sawalha, Amr H.^1,3 asawalha@umich.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 2/26/2019, Vol. 116 Issue 9, p3695-3702. 8p.

Subject Terms: *SCLERODERMA (Disease), *COLLAGEN diseases, *FIBROSIS, *GENE expression, *MOLECULAR genetics

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

Authors: Sarkar, Mrinal K., Hile, Grace A., Lam C. Tsoi, Xianying Xing, Jianhua Liu, Yun Liang, Berthier, Celine C., Swindell, William R., Patrick, Matthew T., Shuai Shao, Pei-Suen Tsou, Uppala, Ranjitha, Beamer, Maria A., Srivastava, Anshika, Bielas, Stephanie L., Harms, Paul W., Getsios, Spiro, Elder, James T., Voorhees, John J., Gudjonsson, Johann E.

Source: Annals of the Rheumatic Diseases; Nov2018, Vol. 77 Issue 11, p1653-1664, 12p, 1 Diagram, 5 Graphs

Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts.

Authors: Ye He, Pei-Suen Tsou, Khanna, Dinesh, Sawalha, Amr H., He, Ye, Tsou, Pei-Suen

Source: Annals of the Rheumatic Diseases; Aug2018, Vol. 77 Issue 8, p1209-1219, 11p, 6 Graphs