Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: Applications to cardiovascular medicine

Authors: Jyh-Ming Jimmy Juang, Tzu-Pin Lu, Ming-Wei Su, Chien-Wei Lin, Jenn-Hwai Yang, Hou-Wei Chu, Chien-Hsiun Chen, Yi-Wen Hsiao, Chien-Yueh Lee, Li-Mei Chiang, Qi-You Yu, Chuhsing Kate Hsiao, Ching-Yu Julius Chen, Pei-Ei Wu, Chien-Hua Pai, Eric Y. Chuang, Chen-Yang Shen

Source: Journal of Advanced Research, Vol 30, Iss , Pp 147-158 (2021)

Subject Terms: Taiwan Biobank, Extensive whole-genome sequencing, De novo mutations, Cardiovascular diseases, Medicine (General), R5-920, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2090123220302538; https://doaj.org/toc/2090-1232

Access URL: https://doaj.org/article/9022988ea22547ef96ec142bdbfe0cc8

Increased Cellular Levels of MicroRNA-9 and MicroRNA-221 Correlate with Cancer Stemness and Predict Poor Outcome in Human Breast Cancer

Authors: Chun-Wen Cheng, Jyh-Cherng Yu, Yi-Hsien Hsieh, Wen-Ling Liao, Jia-Ching Shieh, Chung-Chin Yao, Huei-Jane Lee, Po-Ming Chen, Pei-Ei Wu, Chen-Yang Shen

Source: Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 2205-2218 (2018)

Subject Terms: Breast cancer, MiR-9, MiR-221, Prognosis, Stemness, Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/492561; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778

Access URL: https://doaj.org/article/8f92b1caff4e4672928fa9c831d5d613

Blood multiomics reveal insights into population clusters with low prevalence of diabetes, dyslipidemia and hypertension.

Authors: Ming-Wei Su, Chung-Ke Chang, Chien-Wei Lin, Shiu-Jie Ling, Chia-Ni Hsiung, Hou-Wei Chu, Pei-Ei Wu, Chen-Yang Shen

Source: PLoS ONE, Vol 15, Iss 3, p e0229922 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/547d102859864d9db8c4687d91dffee6

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

Authors: Tomotaka Ugai, Roger L. Milne, Hidemi Ito, Kristan J. Aronson, Manjeet K. Bolla, Tsun Chan, Ching W. Chan, Ji‐Yeob Choi, Don M. Conroy, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Valerie Gaborieau, Anna Gonzalez‐Neira, Mikael Hartman, Catherine S. Healey, Motoki Iwasaki, Esther M. John, Daehee Kang, Sung‐Won Kim, Ava Kwong, Artitaya Lophatananon, Kyriaki Michailidou, Nur Aishah Mohd Taib, Kenneth Muir, Sue K. Park, Paul D. P. Pharoah, Suleeporn Sangrajrang, Chen‐Yang Shen, Xiao‐Ou Shu, John J. Spinelli, Soo H. Teo, Daniel C. Tessier, Chiu‐Chen Tseng, Shoichiro Tsugane, Daniel Vincent, Qin Wang, Anna H. Wu, Pei‐Ei Wu, Wei Zheng, Keitaro Matsuo

Source: Molecular Genetics & Genomic Medicine, Vol 7, Iss 6, Pp n/a-n/a (2019)

Subject Terms: acetaldehyde, alcohol drinking, aldehyde dehydrogenase‐2, breast cancer, single nucleotide polymorphism, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2324-9269

Access URL: https://doaj.org/article/95859b0ff9884bb8bd4211022b94e362

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

Authors: Tomas Kirchhoff, Mia M Gaudet, Antonis C Antoniou, Lesley McGuffog, Manjeet K Humphreys, Alison M Dunning, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Thilo Dork, Peter Schürmann, Johann H Karstens, Peter Hillemanns, Fergus J Couch, Janet Olson, Celine Vachon, Xianshu Wang, Angela Cox, Ian Brock, Graeme Elliott, Malcolm W R Reed, Barbara Burwinkel, Alfons Meindl, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, GENICA Network, Annegien Broeks, Marjanka K Schmidt, Laura J Van 't Veer, Linde M Braaf, Nichola Johnson, Olivia Fletcher, Lorna Gibson, Julian Peto, Clare Turnbull, Sheila Seal, Anthony Renwick, Nazneen Rahman, Pei-Ei Wu, Jyh-Cherng Yu, Chia-Ni Hsiung, Chen-Yang Shen, Melissa C Southey, John L Hopper, Fleur Hammet, Thijs Van Dorpe, Anne-Sophie Dieudonne, Sigrid Hatse, Diether Lambrechts, Irene L Andrulis, Natalia Bogdanova, Natalia Antonenkova, Juri I Rogov, Daria Prokofieva, Marina Bermisheva, Elza Khusnutdinova, Christi J van Asperen, Robert A E M Tollenaar, Maartje J Hooning, Peter Devilee, Sara Margolin, Annika Lindblom, Roger L Milne, José Ignacio Arias, M Pilar Zamora, Javier Benítez, Gianluca Severi, Laura Baglietto, Graham G Giles, kConFab, AOCS Study Group, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, Helene Holland, Sue Healey, Shan Wang-Gohrke, Jenny Chang-Claude, Arto Mannermaa, Veli-Matti Kosma, Jaana Kauppinen, Vesa Kataja, Bjarni A Agnarsson, Maria A Caligo, Andrew K Godwin, Heli Nevanlinna, Tuomas Heikkinen, Zachary Fredericksen, Noralane Lindor, Katherine L Nathanson, Susan M Domchek, SWE-BRCA, Niklas Loman, Per Karlsson, Marie Stenmark Askmalm, Beatrice Melin, Anna von Wachenfeldt, HEBON, Frans B L Hogervorst, Martijn Verheus, Matti A Rookus, Caroline Seynaeve, Rogier A Oldenburg, Marjolijn J Ligtenberg, Margreet G E M Ausems, Cora M Aalfs, Hans J P Gille, Juul T Wijnen, Encarna B Gómez García, EMBRACE, Susan Peock, Margaret Cook, Clare T Oliver, Debra Frost, Craig Luccarini, Gabriella Pichert, Rosemarie Davidson, Carol Chu, Diana Eccles, Kai-Ren Ong, Jackie Cook, Fiona Douglas, Shirley Hodgson, D Gareth Evans, Rosalind Eeles, Bert Gold, Paul D P Pharoah, Kenneth Offit, Georgia Chenevix-Trench, Douglas F Easton, BCAC/CIMBA

Source: PLoS ONE, Vol 7, Iss 6, p e35706 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768030/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1433592c7c844e02a12dd57e5bf1a0a8

Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.

Authors: Jirong Long, Qiuyin Cai, Hyuna Sung, Jiajun Shi, Ben Zhang, Ji-Yeob Choi, Wanqing Wen, Ryan J Delahanty, Wei Lu, Yu-Tang Gao, Hongbing Shen, Sue K Park, Kexin Chen, Chen-Yang Shen, Zefang Ren, Christopher A Haiman, Keitaro Matsuo, Mi Kyung Kim, Ui Soon Khoo, Motoki Iwasaki, Ying Zheng, Yong-Bing Xiang, Kai Gu, Nathaniel Rothman, Wenjing Wang, Zhibin Hu, Yao Liu, Keun-Young Yoo, Dong-Young Noh, Bok-Ghee Han, Min Hyuk Lee, Hong Zheng, Lina Zhang, Pei-Ei Wu, Ya-Lan Shieh, Sum Yin Chan, Shenming Wang, Xiaoming Xie, Sung-Won Kim, Brian E Henderson, Loic Le Marchand, Hidemi Ito, Yoshio Kasuga, Sei-Hyun Ahn, Han Sung Kang, Kelvin Y K Chan, Hiroji Iwata, Shoichiro Tsugane, Chun Li, Xiao-Ou Shu, Dae-Hee Kang, Wei Zheng

Source: PLoS Genetics, Vol 8, Iss 2, p e1002532 (2012)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22383897/pdf/?tool=EBI; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/f75dd7743701428380d28e90b5183179

Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.

Authors: Simon N Stacey, Patrick Sulem, Carlo Zanon, Sigurjon A Gudjonsson, Gudmar Thorleifsson, Agnar Helgason, Aslaug Jonasdottir, Soren Besenbacher, Jelena P Kostic, James D Fackenthal, Dezheng Huo, Clement Adebamowo, Temidayo Ogundiran, Janet E Olson, Zachary S Fredericksen, Xianshu Wang, Maxime P Look, Anieta M Sieuwerts, John W M Martens, Isabel Pajares, Maria D Garcia-Prats, Jose M Ramon-Cajal, Ana de Juan, Angeles Panadero, Eugenia Ortega, Katja K H Aben, Sita H Vermeulen, Fatemeh Asadzadeh, K C Anton van Engelenburg, Sara Margolin, Chen-Yang Shen, Pei-Ei Wu, Asta Försti, Per Lenner, Roger Henriksson, Robert Johansson, Kerstin Enquist, Göran Hallmans, Thorvaldur Jonsson, Helgi Sigurdsson, Kristin Alexiusdottir, Julius Gudmundsson, Asgeir Sigurdsson, Michael L Frigge, Larus Gudmundsson, Kristleifur Kristjansson, Bjarni V Halldorsson, Unnur Styrkarsdottir, Jeffrey R Gulcher, Kari Hemminki, Annika Lindblom, Lambertus A Kiemeney, Jose I Mayordomo, John A Foekens, Fergus J Couch, Olufunmilayo I Olopade, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Oskar T Johannsson, Kari Stefansson

Source: PLoS Genetics, Vol 6, Iss 7, p e1001029 (2010)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2908678?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/5c1f5cacc7d24dc18072e623caa67329

SUMOylation of XRCC1 activated by poly (ADP-ribosyl)ation regulates DNA repair.

Authors: Ling-Yueh Hu, Che-Chang Chang, Yen-Sung Huang, Wen-Cheng Chou, Ying-Mei Lin, Chun-Chen Ho, Wei-Ting Chen, Hsiu-Ming Shih, Chia-Ni Hsiung, Pei-Ei Wu, Chen-Yang Shen

Source: Human Molecular Genetics; 7/1/2018, Vol. 27 Issue 13, p2306-2317, 12p

Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project.

Authors: Chien-Hsiun Chen, Jenn-Hwai Yang, Charleston W.K. Chiang, Chia-Ni Hsiung, Pei-Ei Wu, Li-Ching Chang, Hou-Wei Chu, Josh Chang, I-Wen Song, Show-Ling Yang, Yuan-Tsong Chen, Fu-Tong Liu, Chen-Yang Shen

Source: Human Molecular Genetics; 12/15/2016, Vol. 25 Issue 24, p5321-5331, 11p

Fanconi anemia genes in lung adenocarcinoma-a pathway-wide study on cancer susceptibility.

Authors: Shi-Yi Yang, Chia-Ni Hsiung, Yao-Jen Li, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao A. Hsiung, Pan-Chyr Yang, Chien-Jen Chen, Pei-Ei Wu, Jyh-Cherng Yu, Chen-Yang Shen, Huan-Ming Hsu

Source: Journal of Biomedical Science; 2/3/2016, Vol. 23, p1-11, 11p, 1 Color Photograph, 1 Black and White Photograph, 4 Charts

Subject Terms: FANCONI'S anemia, APLASTIC anemia, GENETIC disorders, ADENOCARCINOMA, CARCINOMA

Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements.

Authors: Chia-Ni Hsiung, Hou-Wei Chu, Yuan-Ling Huang, Wen-Cheng Chou, Ling-Yueh Hu, Huan-Ming Hsu, Pei-Ei Wu, Ming-Feng Hou, Jyh-Cherng Yu, Chen-Yang Shen

Source: Breast Cancer Research; 2014, Vol. 16 Issue 5, p1-25, 25p, 1 Diagram, 1 Chart, 5 Graphs

Subject Terms: BREAST cancer, DISEASE progression, GENOMES, ESTROGEN, BIOINFORMATICS

Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians.

Authors: Xiangyu Ma, Beeghly-Fadiel, Alicia, Wei Lu, Jiajun Shi, Yong-Bing Xiang, Qiuyin Cai, Hongbing Shen, Chen-Yang Shen, Zefang Ren, Keitaro Matsuo, Ui Soon Khoo, Motoki Iwasaki, Jirong Long, Ben Zhangi, Bu-Tian Ji, Ying Zheng, Wenjing Wang, Zhibin Hu, Pei-Ei Wu, Ya-Lan Shieh

Source: Cancer Epidemiology, Biomarkers & Prevention; Jul2012, Vol. 21 Issue 7, p1176-1184, 9p

Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development.

Authors: Jyh-Cherng Yu, Chia-Ni Hsiung, Huan-Ming Hsu, Bo-Ying Bao, Shou-Tung Chen, Giu-Cheng Hsu, Wen-Cheng Chou, Ling-Yueh Hu, Shian-Ling Ding, Chun-Wen Cheng, Pei-Ei Wu, Chen-Yang Shen

Source: Breast Cancer Research; 2012, Vol. 13 Issue 1, p1-8, 8p, 1 Black and White Photograph, 1 Diagram, 1 Chart, 1 Graph

Subject Terms: BREAST cancer, HUMAN genetic variation, CELL adhesion, BIOLOGICAL variation, CANCER patients

Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes.

Authors: Jyh-Cherng Yu, Shian-ling Ding, Chih-Hao Chang, Shu-Hsin Kuo, Shou-Tung Chen, Giu-Cheng Hsu, Huan-Ming Hsu, Ming-Feng Hou, Lin Yi Jung, Chun-Wen Cheng, Pei-Ei Wu, Chen-Yang Shen

Source: Carcinogenesis; Sep2009, Vol. 30 Issue 9, p1562-1570, 9p, 3 Diagrams, 3 Charts, 2 Graphs

Subject Terms: BREAST cancer, GENETIC polymorphisms, UBIQUITIN, LIGASES, CARCINOGENESIS, GENES

Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan.

Authors: Chun-Wen Cheng, Jyh-Cherng Yu, Chiun-Sheng Huang, Jia-Ching Shieh, Yi-Ping Fu, Hsiao-Wei Wang, Pei-Ei Wu

Source: Breast Cancer Research & Treatment; Sep2008, Vol. 111 Issue 1, p145-155, 11p, 1 Diagram, 4 Charts

Subject Terms: DNA repair, CANCER in women, BREAST cancer research, GENETIC polymorphisms

DNA double-strand break repair capacity and risk of breast cancer.

Authors: Da-Tian Bau, Yi-Chien Mau, Shian-ling Ding, Pei-Ei Wu, Chen-Yang Shen

Source: Carcinogenesis; Aug2007, Vol. 28 Issue 8, p1726-1730, 5p, 1 Chart, 2 Graphs

Subject Terms: CARCINOGENESIS, BREAST cancer, CANCER risk factors, EPSTEIN-Barr virus diseases, CANCER in women

Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility.

Authors: Jyh-Cherng Yu, Huan-Ming Hsu, Shou-Tung Chen, Giu-Cheng Hsu, Chiun-Sheng Huang, Ming-Feng Hou, Yi-Ping Fu, Ting-Chih Cheng, Pei-Ei Wu, Chen-Yang Shen

Source: Journal of Biomedical Science; May2006, Vol. 13 Issue 3, p419-432, 14p, 1 Diagram, 5 Charts

Subject Terms: HORMONES, ESTROGEN, BREAST cancer, GENES, CANCER in women

High‐resolution 19p13.2–13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity.

Authors: Tseng‐Long Yang, Yen‐Rey Su, Chiun‐Sheng Huang, Jyh‐Cherng Yu, Yen‐Li Lo, Pei‐Ei Wu, Chen‐Yang Shen

Source: Genes, Chromosomes & Cancer; Nov2004, Vol. 41 Issue 3, p250-256, 7p

Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.

Authors: Shian-ling Ding, Jyh-Cherng Yu, Shou-Tung Chen, Giu-Cheng Hsu, Shou-Jen Kuo, Yu Hsin Lin, Pei-Ei Wu, Chen-Yang Shen

Source: Carcinogenesis; Jan2009, Vol. 30 Issue 1, p43-43, 1p

Subject Terms: GENETICS of breast cancer, BRCA genes, PROTEIN-protein interactions, CARCINOGENESIS, DNA helicases, DISEASE susceptibility, FAMILIAL diseases, GENETIC polymorphisms