Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Authors: Baker, Lauren, Barnes, Caroline, Beveridge, Ryan, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Hooks, Yvette, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lafont, David Tino, Lucas, Mark, Maguire, Simon, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Protheroe, Hayley J., Roberson, Laura-Anne, Salsbury, Grace, Sanderson, Mark, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Vancollie, Valerie E., Brackenbury, Lisa, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Liakath-Ali, Kifayathullah, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, Trenchard, Elizabeth, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Woodward, John, Wynn, Elizabeth, Evans, Arthur, Gannon, David, Griffiths, Mark, Holroyd, Simon, Iyer, Vivek, Kipp, Christian, Lewis, Morag, Li, Wei, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Brown, Ellen, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Harrison, James, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Newman, Stuart, Pass, Johanna, Pearson, Laila, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Frost, Carole, Griggs, Nicola, Hrnciarova, Silvia, Kirton, Andrea, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Heath, Emma, Mahajan, Mary Ann, Yalcin, Binnaz, White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Buljan, Marija, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Adams, Niels C., Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Tsang, Stephen H., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Ramirez-Solis, Ramiro, Bradley, Allan, Steel, Karen P.

Source: In Cell 18 July 2013 154(2):452-464

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

Authors: Ingham, Neil J.^1,2, Pearson, Selina A.¹, Vancollie, Valerie E.¹, Rook, Victoria², Lewis, Morag A.^1,2, Chen, Jing^1,2, Buniello, Annalisa^1,2, Martelletti, Elisa², Preite, Lorenzo², Lam, Chi Chung², Weiss, Felix D.², Powis, Zӧe³, Suwannarat, Pim⁴, Lelliott, Christopher J.¹, Dawson, Sally J.⁵, White, Jacqueline K.¹, Steel, Karen P.^1,2 karen.steel@kcl.ac.uk

Source: PLoS Biology. 4/12/2019, Vol. 17 Issue 4, p1-30. 30p. 1 Chart, 6 Graphs.

Subject Terms: *HEARING disorders, *ELECTROPHYSIOLOGY, *PATHOLOGICAL physiology, *GENES, *HETEROGENEITY

AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia

Authors: Wyatt, Christopher N., Mustard, Kirsty J., Pearson, Selina A., Dallas, Mark L, Atkinson, Lucy, Kumar, Prem, Peers, Chris, Hardie, D. Grahame, Evans, A. Mark

Source: In Journal of Biological Chemistry 16 March 2007 282(11):8092-8098

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.

Authors: Lewis, Morag A., Ingham, Neil J., Chen, Jing, Pearson, Selina, Di Domenico, Francesca, Rekhi, Sohinder, Allen, Rochelle, Drake, Matthew, Willaert, Annelore, Rook, Victoria, Pass, Johanna, Keane, Thomas, Adams, David J., Tucker, Abigail S., White, Jacqueline K., Steel, Karen P.

Source: BMC Biology; 3/17/2022, Vol. 20 Issue 1, p1-27, 27p

Subject Terms: EMBRYONIC stem cells, STEM cell culture, GENETIC mutation, HEARING aids

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Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?

Authors: Poulin, Marc J., Wilson, Richard J. A., Wyatt, Christopher N., Pearson, Selina A., Kumar, Prem, Peers, Chris, Hardie, D. Grahame, Evans, A. Mark

Source: Integration in Respiratory Control; 2008, p63-68, 6p

Targeting of Slc25a21 Is Associated with Orofacial Defects and Otitis Media Due to Disrupted Expression of a Neighbouring Gene.

Authors: Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M., Walker, Nicolas, Bussell, James, Chan, Wai-In, Keane, Thomas M., Adams, David J., Scudamore, Cheryl L., Lelliott, Christopher J., Ramírez-Solis, Ramiro, Karp, Natasha A., Steel, Karen P., White, Jacqueline K., Gerdin, Anna-Karin

Source: PLoS ONE; Mar2014, Vol. 9 Issue 3, p1-13, 13p

Subject Terms: HEARING disorders, GENE expression, HOMOZYGOSITY, INFLAMMATION, FACIAL abnormalities, OTITIS media, SYMPTOMS, GENETICS

Peptidergic Activation of Locomotor Pattern Generators in the Neonatal Spinal Cord.

Authors: Pearson, Selina A., Mouihate, Abdeslam, Pittman, Quentin J., Whelan, Patrick J.

Source: Journal of Neuroscience. 11/5/2003, Vol. 23 Issue 31, p10154. 10p.

Subject Terms: *SPINAL cord, *PEPTIDES, *CENTRAL nervous system, *OXYTOCIN, *VASOPRESSIN