Clustering analyses of murine bone marrow-derived neutrophils reveal a phenotypic heterogeneity that can respond differentially to stimulation

Authors: Silva, Pedro H. ^{a, b}, Peñaloza, Hernán F. ^{a, b, c}, Cordero, José ^b, Kalergis, Alexis M. ^{a, b, d}, Barrera, Nelson P. ^{b, ⁎⁎}, Bueno, Susan M. ^{a, b, ⁎}

Source: In Heliyon 28 February 2025 11(4)

Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults

Authors: Rojas, Álvaro, Navarrete, María Soledad, Del Río, Constanza, Del Pino, Dinely, Aguirre, Natalia, Salinas, Grecia, Vega, Franco, Salgado, Acsa, Quinteros, Thomas, Ortiz, Marlene, Puente, Marcela, Muñoz, Alma, Astudillo, Patricio, Le Corre, Nicole, Potin, Marcela, Catalán, Juan, Peralta, Melan, Zamanillo, Consuelo, Keller, Nicole, Fernández, Rocío, Aljaro, Sofía, López, Sofía, González, José Tomás, Weil, Tania, Opazo, Luz, Muñoz, Paula, Estay, Inés, Cantillana, Miguel, Carrera, Liliana, Masalleras, Matías, Guzmán, Paula, Aguirre, Francisca, Cortés, Aarón, Bátiz, Luis Federico, Pérez, Javiera, Apablaza, Karen, Yates, Lorena, Valdés, María de los Ángeles, Hurtado, Bernardita, Venteneul, Veronique, Astorga, Constanza, Muñoz-Venturelli, Paula, Vial, Pablo A., Schilling, Andrea, Pavez, Daniela, Pérez, Inia, Riviotta, Amy, González, Francisca, Urrutia, Francisca, Del Río, Alejandra, Asenjo, Claudia, Vargas, Bárbara, Castro, Francisca, Acuña, Alejandra, Guzmán, Javiera, Astudillo, Camila, Pérez, Carlos M., Espinoza, Pilar, Martínez, Andrea, Arancibia, Marcela, Romero, Harold, Bustamante, Cecilia, Pérez, María Loreto, Uribe, Natalia, Silva, Viviana, Morice, Bernardita, Pérez, Marco, González, Marcela, Jensen, Werner, Pasten, Claudia, Aguilera, M. Fernanda, Martínez, Nataly, Molina, Camila, Arrieta, Sebastián, López, Begoña, Ortiz, Claudia, Escobar, Macarena, Bustamante, Camila, Espinoza, Marcia, Pardo, Angela, Carrasco, Alison, Montes, Miguel, Saldías, Macarena, Gutiérrez, Natalia, Sánchez, Juliette, Fuentes, Daniela, Calvo, Yolanda, Cepeda, Mariela, Lemus, Rosario, Suárez, Muriel, Armijo, Mercedes, Monsalves, Shirley, Marucich, Constance, Cornejo, Cecilia, Acosta, Ángela, Prado, Xaviera, Yáñez, Francisca, Barroeta, Marisol, López, Claudia, Donato, Paulina, Lasso, Martin, Iturrieta, María, Giraldo, Juan, Gutiérrez, Francisco, Acuña, María, Cascone, Ada, Rojas, Raymundo, Sepúlveda, Camila, Contreras, Mario, Campisto, Yessica, González, Pablo, Quizhpi, Zoila, López, Mariella, Pizzeghello, Vania, Silva, Stephannie, Méndez, Constanza, Peñaloza, Hernán F., Schultz, Bárbara M., Piña-Iturbe, Alejandro, Ríos, Mariana, Moreno-Tapia, Daniela, Pereira-Sánchez, Patricia, Leighton, Diane, Orellana, Claudia, Covarrubias, Consuelo, Gálvez, Nicolás M.S., Soto, Jorge A., Duarte, Luisa F., Rivera-Pérez, Daniela, Vázquez, Yaneisi, Cabrera, Alex, Bustos, Sergio, Iturriaga, Carolina, Urzua, Marcela, Navarrete, María S., Fasce, Rodrigo A., Fernández, Jorge, Mora, Judith, Ramírez, Eugenio, Gaete-Argel, Aracelly, Acevedo, Mónica, Valiente-Echeverría, Fernando, Soto-Rifo, Ricardo, Weiskopf, Daniela, Grifoni, Alba, Sette, Alessandro, Zeng, Gang, Meng, Weining, González-Aramundiz, José V., González, Pablo A., Abarca, Katia, Melo-González, Felipe, Bueno, Susan M., Kalergis, Alexis M.

Source: In eBioMedicine May 2023 91

Elastase Activity From Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality

Authors: Zupetic, Jill, Peñaloza, Hernán F., Bain, William, Hulver, Mei, Mettus, Roberta, Jorth, Peter, Doi, Yohei, Bomberger, Jennifer, Pilewski, Joseph, Nouraie, Mehdi, Lee, Janet S.

Source: In Chest November 2021 160(5):1624-1633

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype

Authors: Bain, William G., Peñaloza, Hernán F., Ladinsky, Mark S., van der Geest, Rick, Sullivan, Mara, Ross, Mark, Kitsios, Georgios D., Methé, Barbara A., McVerry, Bryan J., Morris, Alison, Watson, Alan M., Watkins, Simon C., St Croix, Claudette M., Stolz, Donna B., Bjorkman, Pamela J., Lee, Janet S.

Source: Chest. 159(3):963-966

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136872252.0x000001&indx=1&recIds=ETOCvdc_100136872252.0x000001

Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury.

Authors: Suber, Tomeka L., Tabary, Mohammadreza, Bain, William, Olonisakin, Tolani, Lockwood, Karina, Xiong, Zeyu, Zhang, Yingze, Kohli, Naina, Furguiele, Lauren, Peñaloza, Hernán, McVerry, Bryan J., Rose, Jason J., Shah, Faraaz, Methé, Barbara, Li, Kelvin, Mallampalli, Rama K., Chen, Kong, Fan, Li, Morris, Alison, Tyurin, Vladimir A.

Source: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: LUNG injuries, E-cigarette or vaping product use-associated lung injuries, PHYSIOLOGICAL oxidation, ARACHIDONIC acid, OLEIC acid

In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.

Authors: Bain, William, Ahn, Brian, Peñaloza, Hernán F, McElheny, Christi L, Tolman, Nathanial, van der Geest, Rick, Gonzalez-Ferrer, Shekina, Chen, Nathalie, An, Xiaojing, Hosuru, Ria, Tabary, Mohammadreza, Papke, Erin, Kohli, Naina, Farooq, Nauman, Bachman, William, Olonisakin, Tolani F, Xiong, Zeyu, Griffith, Marissa P, Sullivan, Mara, Franks, Jonathan

Source: Journal of Infectious Diseases; 7/15/2024, Vol. 230 Issue 1, p209-220, 12p

Subject Terms: PHAGOCYTIC function tests, WHOLE genome sequencing, ENZYME-linked immunosorbent assay, LUNG infections, POLYSACCHARIDES, KLEBSIELLA infections, KLEBSIELLA pneumoniae

Editorial: Immune response to gram-negative bacteria in the lungs.

Authors: Jara-Collao, Agnes, Poli, M Cecilia, Bain, William, Peñaloza, Hernán F.

Source: Frontiers in Cellular & Infection Microbiology; 2024, p1-3, 3p

Subject Terms: SUPPRESSORS of cytokine signaling, CYSTIC fibrosis transmembrane conductance regulator, GRAM-negative bacterial diseases, RESPIRATORY infections, GRAM-negative bacteria, T cells

The role of myeloid‐derived suppressor cells in chronic infectious diseases and the current methodology available for their study

Authors: Peñaloza, Hernán F., Alvarez, Diana, Muñoz‐Durango, Natalia, Schultz, Bárbara M., González, Pablo A., Kalergis, Alexis M., Bueno, Susan M.

Source: Journal of leukocyte biology. 105(5):857-872

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100079878122.0x000001&indx=1&recIds=ETOCvdc_100079878122.0x000001

Opposing roles of IL-10 in acute bacterial infection

Authors: Peñaloza, Hernán F., Schultz, Barbara M., Nieto, Pamela A., Salazar, Geraldyne A., Suazo, Isidora, Gonzalez, Pablo A., Riedel, Claudia A., Alvarez-Lobos, Manuel M., Kalergis, Alexis M., Bueno, Susan M.

Source: In Cytokine and Growth Factor Reviews December 2016 32:17-30

Neutrophils and lymphopenia, an unknown axis in severe COVID-19 disease.

Authors: Peñaloza, Hernán F.¹ (AUTHOR) hep42@pitt.edu, Lee, Janet S.¹ (AUTHOR), Ray, Prabir^1,2 (AUTHOR)

Source: PLoS Pathogens. 9/2/2021, Vol. 17 Issue 9, p1-9. 9p.

Subject Terms: *COVID-19, *MYELOID cells, *MYELOID-derived suppressor cells, *NEUTROPHILS, *ADULT respiratory distress syndrome, *SARS-CoV-2, *T cells

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling

Authors: Kitur, Kipyegon, Wachtel, Sarah, Brown, Armand, Wickersham, Matthew, Paulino, Franklin, Peñaloza, Hernán F., Soong, Grace, Bueno, Susan, Parker, Dane, Prince, Alice

Source: Cell reports. 16(8):2219-2230

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100038611772.0x000001&indx=1&recIds=ETOCvdc_100038611772.0x000001

BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.

Authors: van der Geest, Rick¹, Peñaloza, Hernán F.¹, Zeyu Xiong¹, Gonzalez-Ferrer, Shekina¹, Xiaojing An¹, Huihua Li¹, Hongye Fan¹, Tabary, Mohammadreza¹, Nouraie, S. Mehdi¹, Yanwu Zhao¹, Yingze Zhang¹, Kong Chen¹, Alder, Jonathan K.¹, Bain, William G.^1,2, Lee, Janet S.^1,3,4,5 ljanet@wustl.edu

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology. Nov2023, Vol. 325 Issue 5, pL604-L616. 13p.

Subject Terms: *KLEBSIELLA pneumoniae, *KLEBSIELLA infections, *ALVEOLAR macrophages, *IMMUNE response, *TYPE I interferons, *PHAGOCYTOSIS, *INTERFERON receptors

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates.

Authors: van der Geest, Rick, Hongye Fan, Peñaloza, Hernán F., Bain, William G., Zeyu Xiong, Kohli, Naina, Larson, Emily, Sullivan, Mara L. G., Franks, Jonathan M., Stolz, Donna B., Ryota Ito, Kong Chen, Yohei Doi, Harriff, Melanie J., Lee, Janet S.

Source: Frontiers in Cellular & Infection Microbiology; 3/28/2023, Vol. 13, p1-12, 12p

Subject Terms: PHAGOCYTOSIS, KLEBSIELLA pneumoniae, INFECTION control, BRONCHOALVEOLAR lavage, INFLAMMATION, MACROPHAGES

The matricellular protein thrombospondin-1 in lung inflammation and injury.

Authors: Tabary, Mohammadreza, Gheware, Atish, Peñaloza, Hernán F., Lee, Janet S.

Source: American Journal of Physiology: Cell Physiology; Sep2022, Vol. 323 Issue 3, pC857-C865, 9p

Subject Terms: PNEUMONIA, THROMBOSPONDIN-1, LUNG injuries, EXTRACELLULAR space, PROTEINS, INTEGRINS

Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae.

Authors: Peñaloza, Hernán F.¹, Nieto, Pamela A.¹, Muñoz‐Durango, Natalia¹, Salazar‐Echegarai, Francisco J.¹, Torres, Javiera², Parga, María J.³, Alvarez‐Lobos, Manuel³, Riedel, Claudia A.⁴, Kalergis, Alexis M.^1,5,6, Bueno, Susan M.^1,6

Source: Immunology. Sep2015, Vol. 146 Issue 1, p100-112. 13p.

Subject Terms: *INTERLEUKIN-10, *PNEUMONIA diagnosis, *NEUTROPHILS, *STREPTOCOCCUS pneumoniae, *OTITIS media, *LABORATORY mice

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases.

Authors: Peñaloza, Hernán F., van der Geest, Rick, Ybe, Joel A., Standiford, Theodore J., Lee, Janet S.

Source: Frontiers in Immunology; 11/23/2021, Vol. 12, p1-19, 19p

Subject Terms: NON-communicable diseases, CHRONIC obstructive pulmonary disease, LUNG diseases, PULMONARY fibrosis, CYTOKINES, MYELOID cells

Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infection.

Authors: González, Liliana A., Melo-González, Felipe, Sebastián, Valentina P., Vallejos, Omar P., Noguera, Loreani P., Suazo, Isidora D., Schultz, Bárbara M., Manosalva, Andrés H., Peñaloza, Hernán F., Soto, Jorge A., Parker, Dane, Riedel, Claudia A., González, Pablo A., Kalergis, Alexis M., Bueno, Susan M.

Source: Frontiers in Immunology; 4/28/2021, Vol. 11, pN.PAG-N.PAG, 16p

Subject Terms: MYELOID cells, STREPTOCOCCUS pneumoniae, NEUTROPHILS, CELLULAR recognition

L-Arginine Enhances Intracellular Killing of Carbapenem-Resistant Klebsiella pneumoniae ST258 by Murine Neutrophils.

Authors: Peñaloza, Hernán F., Ahn, Danielle, Schultz, Bárbara M., Piña-Iturbe, Alejandro, González, Liliana A., Bueno, Susan M.

Source: Frontiers in Cellular & Infection Microbiology; 11/13/2020, Vol. 10, pN.PAG-N.PAG, 11p

Subject Terms: CARBAPENEM-resistant bacteria, ARGININE, KLEBSIELLA pneumoniae, REACTIVE oxygen species, DRUG resistance in bacteria, NEUTROPHILS, PHAGOCYTOSIS

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Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniaePathogenesis

Authors: Gonzalez-Ferrer, Shekina, Peñaloza, Hernán F., Budnick, James A., Bain, William G., Nordstrom, Hayley R., Lee, Janet S., Van Tyne, Daria

Source: Infection and Immunity; 2021, Vol. 89 Issue: 4 pe00693-20-e00693-20, 200068628p