Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons

Authors: Nolan M. Dvorak, Paul A. Wadsworth, Guillermo Aquino-Miranda, Pingyuan Wang, Douglas S. Engelke, Jingheng Zhou, Nghi Nguyen, Aditya K. Singh, Giuseppe Aceto, Zahra Haghighijoo, Isabella I. Smith, Nana Goode, Mingxiang Zhou, Yosef Avchalumov, Evan P. Troendle, Cynthia M. Tapia, Haiying Chen, Reid T. Powell, Timothy J. Baumgartner, Jully Singh, Leandra Koff, Jessica Di Re, Ann E. Wadsworth, Mate Marosi, Marc R. Azar, Kristina Elias, Paul Lehmann, Yorkiris M. Mármol Contreras, Poonam Shah, Hector Gutierrez, Thomas A. Green, Martin B. Ulmschneider, Marcello D’Ascenzo, Clifford Stephan, Guohong Cui, Fabricio H. Do Monte, Jia Zhou, Fernanda Laezza

Source: Nature Communications, Vol 16, Iss 1, Pp 1-27 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5bdbd67a4c3444fa90812b37bab635dc

TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria

Authors: Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi, Jacob Porter, Komi Gbedande, Brendan Prideaux, Thomas A. Green, Erin H. Seeley, Parimal Samir, Kelley T. Dineley, Gracie Vargas, Jia Zhou, Irma Cisneros, Robin Stephens, Fernanda Laezza

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-24 (2023)

Subject Terms: Ion channels, Neuroinflammation, Neuronal excitability, Phosphorylation, Synaptic plasticity, Therapeutic target, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/35303451441c4a8dbc90b35695ec8147

Primary splenic diffuse large B‐cell lymphoma presenting as a splenic abscess

Authors: Paul A. Wadsworth, Roberto N. Miranda, Pooja Bhakta, Peeyush Bhargava, Dylan Weaver, Jianli Dong, Vasily Ovechko, Michael Norman, Palawinnage V. Muthukumarana, Mathew G. Bayes, Jayati Mallick, Kirill A. Lyapichev

Source: eJHaem, Vol 4, Iss 1, Pp 226-231 (2023)

Subject Terms: CD30, Splenic B‐cell lymphoma, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/3f709d82ceb44cf2a7d078ba8c494574

Mobility but Not Balance Limitations Are Associated With Cognitive Decline among Older Hispanics

Authors: Paul A. Wadsworth BS, Nai-Wei Chen PhD, Mukaila Raji MD, Kyriakos S. Markides PhD, Brian Downer PhD

Source: Gerontology and Geriatric Medicine, Vol 6 (2020)

Subject Terms: Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2333-7214

Access URL: https://doaj.org/article/d19366a5767044119008fed7546bfc66

Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

Authors: Aditya K. Singh, Paul A. Wadsworth, Cynthia M. Tapia, Giuseppe Aceto, Syed R. Ali, Haiying Chen, Marcello D'Ascenzo, Jia Zhou, Fernanda Laezza

Source: Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)

Subject Terms: accessory protein, excitability, inactivation, sodium channels, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/69a82b879eaa42cfb0626a46ec32fbf4

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics

Authors: Nolan M. Dvorak, Paul A. Wadsworth, Pingyuan Wang, Haiying Chen, Jia Zhou, Fernanda Laezza

Source: Molecules, Vol 25, Iss 15, p 3365 (2020)

Subject Terms: protein:protein interactions (PPIs), voltage-gated Na+ (Nav) channels, fibroblast growth factor 14 (FGF14), peptidomimetics, molecular docking, neurotherapeutics, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/15/3365; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/251a6d6ae02741e7978c8c9fabb7640d

Intracellular Fibroblast Growth Factor 14: Emerging Risk Factor for Brain Disorders

Authors: Fernanda Laezza, Jessica Di Re, Paul A. Wadsworth

Source: Frontiers in Cellular Neuroscience, Vol 11 (2017)

Subject Terms: neuronal excitability, intracellular signaling, protein-protein interactions, biological psychiatry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fncel.2017.00103/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/e413a0e2fc04466390be73bf6dd2f118

Sex-Specific Proteomic Changes Induced by Genetic Deletion of Fibroblast Growth Factor 14 (FGF14), a Regulator of Neuronal Ion Channels

Authors: Mark L. Sowers, Jessica Di Re, Paul A. Wadsworth, Alexander S. Shavkunov, Cheryl Lichti, Kangling Zhang, Fernanda Laezza

Source: Proteomes, Vol 7, Iss 1, p 5 (2019)

Subject Terms: mass spectroscopy, bioinformatics, FGF14, voltage gated channels, schizophrenia, autism, Alzheimer’s Disease, sex-specific differences, synaptic plasticity, cognitive impairment, excitatory/inhibitory tone, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2227-7382/7/1/5; https://doaj.org/toc/2227-7382

Access URL: https://doaj.org/article/57c1b2e5666345158fce937f9d31edad