ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

Authors: Lu, Yuting, Travnickova, Jana, Badonyi, Mihaly, Rambow, Florian, Coates, Andrea, Khan, Zaid, Marques, Jair, Murphy, Laura C., Garcia-Martinez, Pablo, Marais, Richard, Louphrasitthiphol, Pakavarin, Chan, Alex H.Y., Schofield, Christopher J., von Kriegsheim, Alex, Marsh, Joseph A., Pavet, Valeria, Sansom, Owen J., Illingworth, Robert S., Patton, E. Elizabeth

Source: In Cell Reports 23 July 2024 43(7)

PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma

Authors: Polubothu, Satyamaanasa, Bender, Nicole, Muthiah, Siobhan, Zecchin, Davide, Demetriou, Charalambos, Martin, Sara Barberan, Malhotra, Sony, Travnickova, Jana, Zeng, Zhiqiang, Böhm, Markus, Barbarot, Sebastien, Cottrell, Catherine, Davies, Olivia, Baselga, Eulalia, Burrows, Nigel P., Carmignac, Virginie, Diaz, Joey Santiago, Fink, Christine, Haenssle, Holger A., Happle, Rudolf, Harland, Mark, Majerowski, Jacquelyn, Vabres, Pierre, Vincent, Marie, Newton-Bishop, Julia A., Bishop, D. Tim, Siegel, Dawn, Patton, E. Elizabeth, Topf, Maya, Rajan, Neil, Drolet, Beth, Kinsler, Veronica A.

Source: In Journal of Investigative Dermatology June 2023 143(6):1042-1051

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Authors: Brombin, Alessandro, Simpson, Daniel J., Travnickova, Jana, Brunsdon, Hannah, Zeng, Zhiqiang, Lu, Yuting, Young, Adelaide I.J., Chandra, Tamir, Patton, E. Elizabeth

Source: In Cell Reports 11 January 2022 38(2)

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models

Authors: Travnickova, Jana, Patton, E. Elizabeth

Source: In Journal of Investigative Dermatology June 2021 141(6):1389-1394

Melanoma models for the next generation of therapies

Authors: Patton, E. Elizabeth, Mueller, Kristen L., Adams, David J., Anandasabapathy, Niroshana, Aplin, Andrew E., Bertolotto, Corine, Bosenberg, Marcus, Ceol, Craig J., Burd, Christin E., Chi, Ping, Herlyn, Meenhard, Holmen, Sheri L., Karreth, Florian A., Kaufman, Charles K., Khan, Shaheen, Kobold, Sebastian, Leucci, Eleonora, Levy, Carmit, Lombard, David B., Lund, Amanda W., Marie, Kerrie L., Marine, Jean-Christophe, Marais, Richard, McMahon, Martin, Robles-Espinoza, Carla Daniela, Ronai, Ze'ev A., Samuels, Yardena, Soengas, Maria S., Villanueva, Jessie, Weeraratna, Ashani T., White, Richard M., Yeh, Iwei, Zhu, Jiyue, Zon, Leonard I., Hurlbert, Marc S., Merlino, Glenn

Source: In Cancer Cell 10 May 2021 39(5):610-631

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Authors: Johansson, Jeanette A., Marie, Kerrie L., Lu, Yuting, Brombin, Alessandro, Santoriello, Cristina, Zeng, Zhiqiang, Zich, Judith, Gautier, Philippe, von Kriegsheim, Alex, Brunsdon, Hannah, Wheeler, Ann P., Dreger, Marcel, Houston, Douglas R., Dooley, Christopher M., Sims, Andrew H., Busch-Nentwich, Elisabeth M., Zon, Leonard I., Illingworth, Robert S., Patton, E. Elizabeth

Source: In Developmental Cell 10 August 2020 54(3):317-332

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Authors: Louphrasitthiphol, Pakavarin, Siddaway, Robert, Loffreda, Alessia, Pogenberg, Vivian, Friedrichsen, Hans, Schepsky, Alexander, Zeng, Zhiqiang, Lu, Min, Strub, Thomas, Freter, Rasmus, Lisle, Richard, Suer, Eda, Thomas, Benjamin, Schuster-Böckler, Benjamin, Filippakopoulos, Panagis, Middleton, Mark, Lu, Xin, Patton, E. Elizabeth, Davidson, Irwin, Lambert, Jean-Philippe, Wilmanns, Matthias, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.

Source: In Molecular Cell 6 August 2020 79(3):472-487

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Authors: Russo, Mariangela, Chen, Mengnuo, Mariella, Elisa, Peng, Haoning, Rehman, Sumaiyah K., Sancho, Elena, Sogari, Alberto, Toh, Tzen S., Balaban, Nathalie Q., Batlle, Eduard, Bernards, Rene, Garnett, Mathew J., Hangauer, Matthew, Leucci, Eleonora, Marine, Jean-Christophe, O’Brien, Catherine A., Oren, Yaara, Patton, E. Elizabeth, Robert, Caroline, Rosenberg, Susan M., Shen, Shensi, Bardelli, Alberto

Source: Nature Reviews Cancer; October 2024, Vol. 24 Issue: 10 p694-717, 24p

Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development

Authors: Dambroise, Emilie, Ktorza, Ivan, Brombin, Alessandro, Abdessalem, Ghaith, Edouard, Joanne, Luka, Marine, Fiedler, Imke, Binder, Olivia, Pelle, Olivier, Patton, E Elizabeth, Busse, Björn, Menager, Mickaël, Sohm, Frederic, Legeai‐Mallet, Laurence

Source: Journal of bone and mineral research. 35(9):1782-1797

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115037822.0x000001&indx=1&recIds=ETOCvdc_100115037822.0x000001

Spontaneously occurring melanoma in animals and their relevance to human melanoma

Authors: van der Weyden, Louise, Brenn, Thomas, Patton, E Elizabeth, Wood, Geoffrey A, Adams, David J

Source: Journal of pathology. 252(1):4-21

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111911645.0x000001&indx=1&recIds=ETOCvdc_100111911645.0x000001

Melanocyte lineage dynamics in development, growth and disease.

Authors: Brombin, Alessandro^1,2, Patton, E. Elizabeth^1,2 e.patton@ed.ac.uk

Source: Development (09501991). Aug2024, Vol. 151 Issue 15, p1-14. 14p.

Subject Terms: *NEURAL crest, *STEM cells, *SKIN cancer, *MELANOCYTES, *MELANINS, *MELANOMA, *HUMAN skin color

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Authors: Ngeow, Kao Chin, Friedrichsen, Hans J., Li, Linxin, Zeng, Zhiqiang, Andrews, Sarah, Volpon, Laurent, Brunsdon, Hannah, Berridge, Georgina, Picaud, Sarah, Fischer, Roman, Lisle, Richard, Knapp, Stefan, Filippakopoulos, Panagis, Knowles, Helen, Steingrímsson, Eiríkur, Borden, Katherine L. B., Patton, E. Elizabeth, Goding, Colin R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Sep 01. 115(37), E8668-E8677.

Access URL: https://www.jstor.org/stable/26531323

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma

Authors: Soengas, Maria S., Patton, E. Elizabeth

Source: In Cell Stem Cell 2 November 2017 21(5):559-561

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

Authors: Thomas, Anna C., Zeng, Zhiqiang, Rivière, Jean-Baptiste, O’Shaughnessy, Ryan, Al-Olabi, Lara, St.-Onge, Judith, Atherton, David J., Aubert, Hélène, Bagazgoitia, Lorea, Barbarot, Sébastien, Bourrat, Emmanuelle, Chiaverini, Christine, Chong, W. Kling, Duffourd, Yannis, Glover, Mary, Groesser, Leopold, Hadj-Rabia, Smail, Hamm, Henning, Happle, Rudolf, Mushtaq, Imran, Lacour, Jean-Philippe, Waelchli, Regula, Wobser, Marion, Vabres, Pierre, Patton, E. Elizabeth, Kinsler, Veronica A.

Source: In Journal of Investigative Dermatology April 2016 136(4):770-778

MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish

Authors: Lundegaard, Pia R., Anastasaki, Corina, Grant, Nicola J., Sillito, Rowland R., Zich, Judith, Zeng, Zhiqiang, Paranthaman, Karthika, Larsen, Anders Peter, Armstrong, J. Douglas, Porteous, David J., Patton, E. Elizabeth

Source: In Chemistry & Biology 22 October 2015 22(10):1335-1346

Melanoma Regression and Recurrence in Zebrafish

Authors: Wojciechowska, Sonia, Zeng, Zhiqiang, Lister, James A., Ceol, Craig J., Patton, E. Elizabeth

Source: Methods in molecular biology. 1451:143-154

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608743880&indx=1&recIds=ETOCRN608743880

Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration

Authors: Reimer, Michell M., Norris, Anneliese, Ohnmacht, Jochen, Patani, Rickie, Zhong, Zhen, Dias, Tatyana B., Kuscha, Veronika, Scott, Angela L., Chen, Yu-Chia, Rozov, Stanislav, Frazer, Sarah L., Wyatt, Cameron, Higashijima, Shin-ichi, Patton, E. Elizabeth, Panula, Pertti, Chandran, Siddharthan, Becker, Thomas, Becker, Catherina G.

Source: In Developmental Cell 10 June 2013 25(5):478-491

Acetylation reprograms MITF target selectivity and residence time.

Authors: Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.

Source: Nature Communications; 9/28/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: MICROPHTHALMIA-associated transcription factor, HOMEOSTASIS, ACETYLATION, GENETIC regulation, TRANSCRIPTION factors, ONCOGENES, BINDING sites

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

Authors: Zhou, Linna, Ishizaki, Hironori, Spitzer, Michaela, Taylor, Kerrie L., Temperley, Nicholas D., Johnson, Stephen L., Brear, Paul, Gautier, Philippe, Zeng, Zhiqiang, Mitchell, Amy, Narayan, Vikram, McNeil, Ewan M., Melton, David W., Smith, Terry K., Tyers, Mike, Westwood, Nicholas J., Patton, E. Elizabeth

Source: In Chemistry & Biology 27 July 2012 19(7):883-892

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Authors: Sarvi, Sana, Crispin, Richard, Lu, Yuting, Zeng, Lifan, Hurley, Thomas D., Houston, Douglas R., von Kriegsheim, Alex, Chen, Che-Hong, Mochly-Rosen, Daria, Ranzani, Marco, Mathers, Marie E., Xu, Xiaowei, Xu, Wei, Adams, David J., Carragher, Neil O., Fujita, Mayumi, Schuchter, Lynn, Unciti-Broceta, Asier, Brunton, Valerie G., Patton, E. Elizabeth

Source: Cell chemical biology. 25(12):1456-1469.e6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100073945388.0x000001&indx=1&recIds=ETOCvdc_100073945388.0x000001