Discovery and Identification of Three Homocysteine Metabolites by Chemical Derivatization and Mass Spectrometry Fragmentation

Authors: Agongo, Julius, Grady, Scott F., Cho, Kevin, Patti, Gary J., Bythell, Benjamin J., Arnatt, Christopher K., Edwards, James L.

Source: ANALYTICAL CHEMISTRY -WASHINGTON DC-. 96(28):11639-11643

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Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D

Authors: Wang, Lihua ^{1, ∗}, Wang, Siyu ¹, Anema, Jason A. ¹, Moghaddam, Vaha A. ¹, Lu, Yanli ¹, Lin, Shiow ¹, Daw, E. Warwick ¹, Kuipers, Allison L. ², Miljkovic, Iva ², Brent, Michael ³, Patti, Gary J. ⁴, Thygarajan, Bharat ⁵, Zmuda, Joseph M. ², Province, Michael A. ¹, An, Ping ¹

Source: In Journal of Lipid Research January 2025 66(1)

Metabolite signatures of chronological age, aging, survival, and longevity

Authors: Sebastiani, Paola ^{1, 2, 17, ∗}, Monti, Stefano ^{3, 4}, Lustgarten, Michael S. ⁵, Song, Zeyuan ¹, Ellis, Dylan ⁶, Tian, Qu ⁷, Schwaiger-Haber, Michaela ⁸, Stancliffe, Ethan ⁸, Leshchyk, Anastasia ⁴, Short, Meghan I. ^{1, 2}, Ardisson Korat, Andres V. ⁵, Gurinovich, Anastasia ^{1, 2}, Karagiannis, Tanya ^{1, 2}, Li, Mengze ⁴, Lords, Hannah J. ⁴, Xiang, Qingyan ¹, Marron, Megan M. ⁹, Bae, Harold ¹⁰, Feitosa, Mary F. ¹¹, Wojczynski, Mary K. ¹¹, O’Connell, Jeffrey R. ¹², Montasser, May E. ¹², Schupf, Nicole ¹³, Arbeev, Konstantin ¹⁴, Yashin, Anatoliy ¹⁴, Schork, Nicholas ¹⁵, Christensen, Kaare ¹⁶, Andersen, Stacy L. ³, Ferrucci, Luigi ⁷, Rappaport, Noa ⁶, Perls, Thomas T. ³, Patti, Gary J. ⁸

Source: In Cell Reports 26 November 2024 43(11)

Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock

Authors: Sun, Jiameng ¹, Zhang, Yiming ¹, Adams, Joshua A. ¹, Higgins, Cassandra B. ¹, Kelly, Shannon C. ¹, Zhang, Hao ^{2, 3, 4}, Cho, Kevin Y. ^{2, 3, 4}, Johnson, Ulysses G. ^{5, 6}, Swarts, Benjamin M. ^{5, 6}, Wada, Shun-Ichi ⁷, Patti, Gary J. ^{2, 3, 4}, Shriver, Leah P. ^{2, 3, 4}, Finck, Brian N. ⁴, Herzog, Erik D. ⁸, DeBosch, Brian J. ^{1, 9, 10, ∗}

Source: In Cell Reports 22 October 2024 43(10)

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism

Authors: Zhang, Yiming, Higgins, Cassandra B., Tica, Stefani, Adams, Joshua A., Sun, Jiameng, Kelly, Shannon C., Zong, Xiaoyu, Dietzen, Dennis J., Pietka, Terri, Ballentine, Samuel J., Shriver, Leah P., Patti, Gary J., Cao, Yin, DeBosch, Brian J.

Source: In Cell Metabolism 3 September 2024 36(9):2069-2085

Loss of function of FAM177A1, a Golgi complex localized protein, causes a novel neurodevelopmental disorder

Authors: Acosta, Maria T., Adam, Margaret, Adams, David R., Alvarez, Raquel L., Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A., Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennett, Jimmy, Berg-Rood, Beverly, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C., Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Sessions Cole, F., Colley, Heather A., Cope, Heidi, Corner, Brian, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D’Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Dell’Angelica, Esteban C., Dickson, Patricia, Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Ezell, Kimberly, Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Gahl, William A., Glass, Ian, Gochuico, Bernadette, Goddard, Page C., Godfrey, Rena A., Golden-Grant, Katie, Grajewski, Alana, Hadley, Don, Hahn, Sihoun, Halley, Meghan C., Hamid, Rizwan, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jamal, Fariha, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Karaviti, Lefkothea, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Kozuira, Mary, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, AudreyStephannie, Mahoney, Rachel, Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Maravilla, Kenneth, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Mefford, Heather, Lawrence Merritt, J., Might, Matthew, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Mulvihill, John, Nakano-Okuno, Mariko, Nelson, Stanley F., Neumann, Serena, Newman, John H., Nicholas, Sarah K., Nickerson, Deborah, Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Carl Pallais, J., Palmer, Christina G.S., Papp, Jeanette C., Parker, Neil H., Phillips, John A., III, Posey, Jennifer E., Potocki, Lorraine, Pusey Swerdzewski, Barbara N., Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenwasser, Natalie, Rossignol, Francis, Ruzhnikov, Maura, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Ron Scott, C., Seto, Elaine, Shashi, Vandana, Shin, Jimann, Silverman, Edwin K., Sinsheimer, Janet S., Sisco, Kathy, Smith, Edward C., Smith, Kevin S., Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca C., Stoler, Joan M., Sullivan, Kathleen, Sullivan, Jennifer A., Sun, Angela, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L.M., Tarakad, Arjun, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Wallace, Stephanie, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Hubshman, Monika Weisz, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Worley, Kim, Xiao, Changrui, Yamamoto, Shinya, Yang, John, Zhang, Zhe, Zuchner, Stephan, Legro, Nicole R., Bowman, Angela, Ugur, Berrak, Jackstadt, Madelyn M., Shriver, Leah P., Patti, Gary J., Zhang, Bo, Feng, Wenjia, McAdow, Anthony R., Goddard, Pagé, Jensen, Tanner, Fresard, Laure, Alvarez, Raquel, McCormack, Colleen, Holt, James M., Worthey, Elizabeth A., Montgomery, Stephen B., Postlethwait, John, De Camilli, Pietro, Solnica-Krezel, Lila

Source: In Genetics in Medicine September 2024 26(9)

Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A2 and mitochondrial respiration

Authors: Moon, Sung Ho, Liu, Xinping, Jenkins, Christopher M., Dilthey, Beverly Gibson, Patti, Gary J., Gross, Richard W.

Source: In Journal of Lipid Research September 2024 65(9)

PeakDetective: A Semisupervised Deep Learning-Based Approach for Peak Curation in Untargeted Metabolomics

Authors: Stancliffe, Ethan, Patti, Gary J.

Source: Analytical chemistry. 95(25):9397-9403

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632989785&indx=1&recIds=ETOCRN632989785

Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker

Authors: Granados‐Fuentes, Daniel, Cho, Kevin, Patti, Gary J., Costa, Rodolfo, Herzog, Erik D., Montagnese, Sara

Source: Liver international. 43(3):673-683

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178362103.0x000001&indx=1&recIds=ETOCvdc_100178362103.0x000001

The Warburg effect: a signature of mitochondrial overload

Authors: Wang, Yahui, Patti, Gary J.

Source: In Trends in Cell Biology December 2023 33(12):1014-1020

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

Authors: Yiew, Nicole K.H., Deja, Stanislaw, Ferguson, Daniel, Cho, Kevin, Jarasvaraparn, Chaowapong, Jacome-Sosa, Miriam, Lutkewitte, Andrew J., Mukherjee, Sandip, Fu, Xiaorong, Singer, Jason M., Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

Source: In iScience 17 November 2023 26(11)

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

Authors: Ferguson, Daniel, Eichler, Sophie J., Yiew, Nicole K.H., Colca, Jerry R., Cho, Kevin, Patti, Gary J., Shew, Trevor M., Lutkewitte, Andrew J., Mukherjee, Sandip, McCommis, Kyle S., Niemi, Natalie M., Finck, Brian N.

Source: In Molecular Metabolism April 2023 70

Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment

Authors: Sponagel, Jasmin, Jones, Jill K., Frankfater, Cheryl, Zhang, Shanshan, Tung, Olivia, Cho, Kevin, Tinkum, Kelsey L., Gass, Hannah, Nunez, Elena, Spitz, Douglas R., Chinnaiyan, Prakash, Schaefer, Jacob, Patti, Gary J., Graham, Maya S., Mauguen, Audrey, Grkovski, Milan, Dunphy, Mark P., Krebs, Simone, Luo, Jingqin, Rubin, Joshua B., Ippolito, Joseph E.

Source: In Med 11 November 2022 3(11):792-811

An Untargeted Metabolomics Workflow that Scales to Thousands of Samples for Population-Based Studies

Authors: Stancliffe, Ethan, Schwaiger-Haber, Michaela, Sindelar, Miriam, Murphy, Matthew J., Soerensen, Mette, Patti, Gary J.

Source: Analytical chemistry. 94(50):17370-17378

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630952849&indx=1&recIds=ETOCRN630952849

Combining Isotopologue Workflows and Simultaneous Multidimensional Separations to Detect, Identify, and Validate Metabolites in Untargeted Analyses

Authors: Dodds, James N., Wang, Lingjue, Patti, Gary J., Baker, Erin S.

Source: Analytical chemistry. 94(5):2527-2535

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628722160&indx=1&recIds=ETOCRN628722160

Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

Authors: Wang, Yahui, Stancliffe, Ethan, Fowle-Grider, Ronald, Wang, Rencheng, Wang, Cheng, Schwaiger-Haber, Michaela, Shriver, Leah P., Patti, Gary J.

Source: In Molecular Cell 1 September 2022 82(17):3270-3283

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

Authors: Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

Source: In Cell Reports 26 April 2022 39(4)

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

Authors: Hodges, Wesley T., Jarasvaraparn, Chaowapong, Ferguson, Daniel, Griffett, Kristine, Gill, Lauren E., Chen, Yana, Ilagan, Ma. Xenia G., Hegazy, Lamees, Elgendy, Bahaa, Cho, Kevin, Patti, Gary J., McCommis, Kyle S., Finck, Brian N.

Source: In Journal of Biological Chemistry February 2022 298(2)

Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity

Authors: Sindelar, Miriam, Stancliffe, Ethan, Schwaiger-Haber, Michaela, Anbukumar, Dhanalakshmi S., Adkins-Travis, Kayla, Goss, Charles W., O’Halloran, Jane A., Mudd, Philip A., Liu, Wen-Chun, Albrecht, Randy A., García-Sastre, Adolfo, Shriver, Leah P., Patti, Gary J.

Source: In Cell Reports Medicine 17 August 2021 2(8)

Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver

Authors: Naser, Fuad J., Jackstadt, Madelyn M., Fowle-Grider, Ronald, Spalding, Jonathan L., Cho, Kevin, Stancliffe, Ethan, Doonan, Steven R., Kramer, Eva T., Yao, Lijun, Krasnick, Bradley, Ding, Li, Fields, Ryan C., Kaufman, Charles K., Shriver, Leah P., Johnson, Stephen L., Patti, Gary J.

Source: In Cell Metabolism 6 July 2021 33(7):1493-1504