Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial

Authors: Maria-Luisa Schubert, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Alexander Kunz, Philip Waldhoff, Dominik Vonficht, Schayan Yousefian, Lea Jopp-Saile, Lei Wang, Felix Korell, Anna Keib, Birgit Michels, Dominik Haas, Tim Sauer, Patrick Derigs, Andreas Kulozik, Joachim Kunz, Petra Pavel, Sascha Laier, Patrick Wuchter, Johann Schmier, Gesine Bug, Fabian Lang, Nicola Gökbuget, Jochen Casper, Martin Görner, Jürgen Finke, Andreas Neubauer, Mark Ringhoffer, Denise Wolleschak, Monika Brüggemann, Simon Haas, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt

Source: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-17 (2023)

Subject Terms: Acute lymphoblastic leukemia (ALL), Third-generation chimeric antigen receptor (CAR) T cells, Investigator-initiated trial (IIT), CART-associated toxicities, Cytokine release syndrome (CRS), Cytopenia, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/26e8df351a78481d84b79ca3e21d57c8

Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium

Authors: Eva Altrock, Carla Sens-Albert, Franziska Hofmann, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Johann-Christoph Jann, Felicitas Rapp, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Ali Darwich, Patrick Wuchter, Georgia Metzgeroth, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak

Source: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Bone marrow-derived mesenchymal stromal cells, Myelodysplastic Neoplasms, Xeno-free expansion, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/3d993a6d3dfe43489fb55296d3d2a803

Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies

Authors: Qingyu Xu, Alexander Streuer, Johann-Christoph Jann, Eva Altrock, Nanni Schmitt, Johanna Flach, Carla Sens-Albert, Felicitas Rapp, Julia Wolf, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mariia Kuzina, Ahmed Jawhar, Ali Darwich, Cleo-Aron Weis, Alexander Marx, Patrick Wuchter, Victor Costina, Evelyn Jäger, Elena Sperk, Michael Neumaier, Alice Fabarius, Georgia Metzgeroth, Florian Nolte, Laurenz Steiner, Pavel A. Levkin, Mohamad Jawhar, Wolf-Karsten Hofmann, Vladimir Riabov, Daniel Nowak

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/91b523f59ac547d99572fb13b46e1d2f

ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms

Authors: Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Lyndsey Bolanos, Mark Wunderlich, Johann-Christoph Jann, Alina Wein, Eva Altrock, Marie Demmerle, Sanjay Mukherjee, Abdullah Mahmood Ali, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Azra Raza, Jason M. Foulks, Daniel T. Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak

Source: Haematologica, Vol 109, Iss 5 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11329; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/587fe7bf73e84c44b2b804ab4433a656

AMPLIFY-NEOVAC: a randomized, 3-arm multicenter phase I trial to assess safety, tolerability and immunogenicity of IDH1-vac combined with an immune checkpoint inhibitor targeting programmed death-ligand 1 in isocitrate dehydrogenase 1 mutant gliomas

Authors: Lukas Bunse, Anne-Kathleen Rupp, Isabel Poschke, Theresa Bunse, Katharina Lindner, Antje Wick, Jens Blobner, Martin Misch, Ghazaleh Tabatabai, Martin Glas, Oliver Schnell, Jens Gempt, Monika Denk, Guido Reifenberger, Martin Bendszus, Patrick Wuchter, Joachim P Steinbach, Wolfgang Wick, Michael Platten

Source: Neurological Research and Practice, Vol 4, Iss 1, Pp 1-7 (2022)

Subject Terms: Isocitrate dehydrogenase 1, Peptide vaccine, Astrocytoma, Oligodendroglioma, Recurrent glioma, Window-of-opportunity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2524-3489

Access URL: https://doaj.org/article/4c9969cb47df44d0813e1eae513b7e2a

SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays

Authors: Alina Seidel, Simone Hoffmann, Bernd Jahrsdörfer, Sixten Körper, Carolin Ludwig, Christiane Vieweg, Dan Albers, Pascal von Maltitz, Rebecca Müller, Ramin Lotfi, Patrick Wuchter, Harald Klüter, Frank Kirchhoff, Michael Schmidt, Jan Münch, Hubert Schrezenmeier

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2, vaccination, convalescent plasma, neutralization, omicron, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170759/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/421634f4916d4fde9d8b1c1537f0b244

One-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients

Authors: Sixten Körper, Beate Grüner, Daniel Zickler, Thomas Wiesmann, Patrick Wuchter, Rainer Blasczyk, Kai Zacharowski, Peter Spieth, Torsten Tonn, Peter Rosenberger, Gregor Paul, Jan Pilch, Joachim Schwäble, Tamam Bakchoul, Thomas Thiele, Julian Knörlein, Matthias M. Dollinger, Jörg Krebs, Martin Bentz, Victor M. Corman, Dzenan Kilalic, Gerlinde Schmidtke-Schrezenmeier, Philipp M. Lepper, Lucas Ernst, Hinnerk Wulf, Alexandra Ulrich, Manfred Weiss, Jan Matthias Kruse, Thomas Burkhardt, Rebecca Müller, Harald Klüter, Michael Schmidt, Bernd Jahrsdörfer, Ramin Lotfi, Markus Rojewski, Thomas Appl, Benjamin Mayer, Philipp Schnecko, Erhard Seifried, Hubert Schrezenmeier

Source: The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)

Subject Terms: COVID-19, Therapeutics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/f215c564e7e54be8bf0fb4d93dce1301

Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution

Authors: Sandra Sauer, Petra Pavel, Anita Schmitt, Martin Cremer, Mark Kriegsmann, Thomas Bruckner, Karin Jordan, Patrick Wuchter, Carsten Müller-Tidow, Katharina Kriegsmann

Source: BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)

Subject Terms: Peripheral blood stem cells, Insufficient graft, Autologous stem-cell transplantation, Multiple myeloma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-020-06873-7; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/f6bd1b68eb704a78a1561541eb8610cc

Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia

Authors: Alexander Rühle, Andreas Thomsen, Rainer Saffrich, Maren Voglstätter, Birgit Bieber, Tanja Sprave, Patrick Wuchter, Peter Vaupel, Peter E. Huber, Anca-Ligia Grosu, Nils H. Nicolay

Source: International Journal of Hyperthermia, Vol 37, Iss 1, Pp 430-441 (2020)

Subject Terms: multipotent mesenchymal stromal cells, mesenchymal stem cells, hyperthermia, heat shock proteins, fibroblasts, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157

Access URL: https://doaj.org/article/c9112507ea4a49239560aab55bc92e59

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Authors: Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

Source: Haematologica, Vol 106, Iss 11 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10017; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/937e15b904e943b0be2e3a20014527d8

Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy

Authors: Ramon Lopez Perez, Franziska Münz, Denise Vidoni, Alexander Rühle, Thuy Trinh, Sonevisay Sisombath, Bingwen Zou, Patrick Wuchter, Jürgen Debus, Anca-Ligia Grosu, Rainer Saffrich, Peter E. Huber, Nils H. Nicolay

Source: Stem Cell Research, Vol 40, Iss , Pp - (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506119301667; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/846d40eba8fb4ab0a8ef6f92c9560b88

Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation

Authors: Lorenz Adlung, Sandip Kar, Marie‐Christine Wagner, Bin She, Sajib Chakraborty, Jie Bao, Susen Lattermann, Melanie Boerries, Hauke Busch, Patrick Wuchter, Anthony D Ho, Jens Timmer, Marcel Schilling, Thomas Höfer, Ursula Klingmüller

Source: Molecular Systems Biology, Vol 13, Iss 1, Pp 1-25 (2017)

Subject Terms: 32D‐EpoR, BaF3‐EpoR, CFU‐E, MAPK, PI3K, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/f4655425dbe749a68a27fd0cddb98e78

Shaping of CD56bri Natural Killer Cells in Patients With Steroid-Refractory/Resistant Acute Graft-vs.-Host Disease via Extracorporeal Photopheresis

Authors: Ming Ni, Lei Wang, Mingya Yang, Brigitte Neuber, Leopold Sellner, Angela Hückelhoven-Krauss, Maria-Luisa Schubert, Thomas Luft, Ute Hegenbart, Stefan Schönland, Patrick Wuchter, Bao-an Chen, Volker Eckstein, William Krüger, Ronit Yerushalmi, Katia Beider, Arnon Nagler, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: GvHD, ECP, immunomodulation, natural killer cells, anti-viral effect, anti-leukemia effect, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.00547/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3d6c75863e2c4034873565fb0cd070dc

Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials.

Authors: Birgit Spiess, Sébastien Rinaldetti, Nicole Naumann, Norbert Galuschek, Ute Kossak-Roth, Patrick Wuchter, Irina Tarnopolscaia, Diana Rose, Astghik Voskanyan, Alice Fabarius, Wolf-Karsten Hofmann, Susanne Saußele, Wolfgang Seifarth

Source: PLoS ONE, Vol 14, Iss 3, p e0214305 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9fb29c6c4d2143cf9d629d111cd1c100

Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs.

Authors: Susanne Delecluse, Jiyang Yu, Katharina Bernhardt, Janina Haar, Remy Poirey, Ming-Han Tsai, Rama Kiblawi, Annette Kopp-Schneider, Paul Schnitzler, Martin Zeier, Peter Dreger, Patrick Wuchter, Olcay Cem Bulut, Uta Behrends, Henri-Jacques Delecluse

Source: PLoS ONE, Vol 14, Iss 9, p e0222847 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c25c8cc902184ad4a6e820b29485c313

Modulation of B Cells and Homing Marker on NK Cells Through Extracorporeal Photopheresis in Patients With Steroid-Refractory/Resistant Graft-Vs.-Host Disease Without Hampering Anti-viral/Anti-leukemic Effects

Authors: Lei Wang, Ming Ni, Angela Hückelhoven-Krauss, Leopold Sellner, Jean-Marc Hoffmann, Brigitte Neuber, Thomas Luft, Ute Hegenbart, Stefan Schönland, Christian Kleist, Martin Sill, Bao-an Chen, Patrick Wuchter, Volker Eckstein, William Krüger, Inken Hilgendorf, Ronit Yerushalmi, Arnon Nagler, Carsten Müller-Tidow, Anthony D. Ho, Peter Dreger, Michael Schmitt, Anita Schmitt

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: GvHD, ECP, immunomodulation, regulatory cells, proinflammatory cytokines, effector cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.02207/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/75b380dfc9194cccaf016346c8c83e6e

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

Authors: Jean-Marc Hoffmann, Maria-Luisa Schubert, Lei Wang, Angela Hückelhoven, Leopold Sellner, Sophia Stock, Anita Schmitt, Christian Kleist, Ulrike Gern, Angelica Loskog, Patrick Wuchter, Susanne Hofmann, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt

Source: Frontiers in Immunology, Vol 8 (2018)

Subject Terms: chimeric antigen receptor, immunotherapy, CD19, T cell subpopulations, naive T cells, cytokines, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01956/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8e2683b826d643cab86f401a1ba3bf66

Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia

Authors: Wenwen Wang, Thomas Stiehl, Simon Raffel, Van T. Hoang, Isabel Hoffmann, Laura Poisa-Beiro, Borhan R. Saeed, Rachel Blume, Linda Manta, Volker Eckstein, Tilmann Bochtler, Patrick Wuchter, Marieke Essers, Anna Jauch, Andreas Trumpp, Anna Marciniak-Czochra, Anthony D. Ho, Christoph Lutz

Source: Haematologica, Vol 102, Iss 9 (2017)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8192; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/8b5d4d2146944497bcdbb88a2061a61c

Trabectedin for Metastatic Soft Tissue Sarcoma: A Retrospective Single Center Analysis

Authors: Anthony D. Ho, Patrick Wuchter, Sascha Dietrich, Eva Keller, Thomas Schmitt, Gerlinde Egerer

Source: Marine Drugs, Vol 8, Iss 10, Pp 2647-2658 (2010)

Subject Terms: trabectedin, soft tissue sarcoma, metastatic, advanced, chemotherapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.mdpi.com/1660-3397/8/10/2647/; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/7349895593564acba10df3de11173d6b

Author Correction: Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents

Authors: Cornelia Monzel, Alexandra S. Becker, Rainer Saffrich, Patrick Wuchter, Volker Eckstein, Anthony D. Ho, Motomu Tanaka

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1f7b0f3ef4494f0d87bc3491e4e25ea6