Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue

Authors: Melanie Modder, Claudia P. Coomans, Dirk-Jan Saaltink, Mayke M. H. Tersteeg, Janna Hoogduin, Leonie Scholten, Amanda C. M. Pronk, Reshma A. Lalai, Anita Boelen, Andries Kalsbeek, Patrick C. N. Rensen, Erno Vreugdenhil, Sander Kooijman

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Doublecortin-like, β-Tanycytes, Body weight control, Energy expenditure, White adipose tissue browning, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/dfe49dbfc38e4ce386cd77ee4e307ebf

Butyrate Prevents Obesity Accompanied by HDAC9-Mediated Browning of White Adipose Tissue

Authors: Jing Yang, Guoli Li, Shan Wang, Mingqian He, Sijing Dong, Ting Wang, Binyin Shi, Patrick C. N. Rensen, Yanan Wang

Source: Biomedicines, Vol 13, Iss 2, p 260 (2025)

Subject Terms: obesity, butyrate, thermogenesis, HDAC9, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/13/2/260; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/76ac7575fee14d0cb61bff63d53da5fe

Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes

Authors: Rosalie G. J. Rietjens, Gangqi Wang, Anouk I. M. van der Velden, Angela Koudijs, M. Cristina Avramut, Sander Kooijman, Patrick C. N. Rensen, Johan van der Vlag, Ton J. Rabelink, Bram Heijs, Bernard M. van den Berg

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b63da834cde7487bb1afc2fd5be2ce99

Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans

Authors: Anna Borup, Ida Donkin, Mariëtte R. Boon, Martin Frydland, Borja Martinez-Tellez, Annika Loft, Sune H. Keller, Andreas Kjaer, Jesper Kjaergaard, Christian Hassager, Romain Barrès, Patrick C. N. Rensen, Christina Christoffersen

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ac928242ef3141f18c4d97ecb075955f

No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Authors: Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Francisco M. Acosta, Juan M. A. Alcantara, Francisco J. Amaro-Gahete, Wendy D. Martinez-Avila, Elisa Merchan-Ramirez, Victoria Muñoz-Hernandez, Francisco J. Osuna-Prieto, Lucas Jurado-Fasoli, Huiwen Xu, Lourdes Ortiz-Alvarez, María J. Arias-Tellez, Andrea Mendez-Gutierrez, Idoia Labayen, Francisco B. Ortega, Milena Schönke, Patrick C. N. Rensen, Concepción M. Aguilera, José M. Llamas-Elvira, Ángel Gil, Jonatan R. Ruiz

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/423225690a6c49afaa79539a8376bd23

Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus

Authors: Lushun Yuan, Aswin Verhoeven, Niek Blomberg, Huub J. van Eyk, Maurice B. Bizino, Patrick C. N. Rensen, Ingrid M. Jazet, Hildo J. Lamb, Ton J. Rabelink, Martin Giera, Bernard M. van den Berg

Source: Metabolites, Vol 14, Iss 1, p 33 (2024)

Subject Terms: lipidomics, Dutch South Asian, Dutch white Caucasian, type 2 diabetes mellitus, diabetic nephropathy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/14/1/33; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/ad85c4ff28364256bcca523ac38df8bc

Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes

Authors: Saeed Katiraei, Janna A. van Diepen, Luciana P. Tavares, Lisa R. Hoving, Amanda Pronk, Ineke Verschueren, Patrick C. N. Rensen, Jaap Jan Zwaginga, Sarantos Kostidis, Martin Giera, Mauro Teixera, Ko Willems van Dijk, Mihai G. Netea, Jimmy F. P. Berbée, Vanessa van Harmelen

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cc4da25ea14d4d3fafb29c84e5ac24db

Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice

Authors: Menno Hoekstra, Baoyan Ren, Pirkka-Pekka Laurila, Reeni B. Hildebrand, Jarkko Soronen, Vanessa Frodermann, Zhuang Li, Mariëtte R. Boon, Janine J. Geerling, Patrick C. N. Rensen, Matti Jauhiainen, Miranda Van Eck

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/17a14d3adad549cc9cc447dc81e3bc71

Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

Authors: Francisco J. Osuna-Prieto, Borja Martinez-Tellez, Lourdes Ortiz-Alvarez, Xinyu Di, Lucas Jurado-Fasoli, Huiwen Xu, Victoria Ceperuelo-Mallafré, Catalina Núñez-Roa, Isabelle Kohler, Antonio Segura-Carretero, José V. García-Lario, Angel Gil, Concepción M. Aguilera, Jose M. Llamas-Elvira, Patrick C. N. Rensen, Joan Vendrell, Jonatan R. Ruiz, Sonia Fernández-Veledo

Source: Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021)

Subject Terms: Obesity, Visceral adiposity, Inflammation, Oxylipins, Succinate, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/fb1bf7ad288e4c6ab546b24aea75d0c6

Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone

Authors: Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sánchez-López, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: Aldosterone, corticosterone, dexamethasone, eplerenone, glucocorticoid receptor, mineralocorticoid receptor, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.960279/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/5db24c94244c410bb742c1672b9f6255

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

Authors: Maxime M. Bos, Neil J. Goulding, Matthew A. Lee, Amy Hofman, Mariska Bot, René Pool, Lisanne S. Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R. Biermasz, Dorret I. Boomsma, Irene de Boer, Constantinos Christodoulides, Abbas Dehghan, Ko Willems van Dijk, Ian Ford, Mohsen Ghanbari, Bastiaan T. Heijmans, M. Arfan Ikram, J. Wouter Jukema, Dennis O. Mook-Kanamori, Fredrik Karpe, Annemarie I. Luik, L. H. Lumey, Arn M. J. M. van den Maagdenberg, Simon P. Mooijaart, Renée de Mutsert, Brenda W. J. H. Penninx, Patrick C. N. Rensen, Rebecca C. Richmond, Frits R. Rosendaal, Naveed Sattar, Robert A. Schoevers, P. Eline Slagboom, Gisela M. Terwindt, Carisha S. Thesing, Kaitlin H. Wade, Carolien A. Wijsman, Gonneke Willemsen, Aeilko H. Zwinderman, Diana van Heemst, Raymond Noordam, Deborah A. Lawlor

Source: BMC Medicine, Vol 19, Iss 1, Pp 1-20 (2021)

Subject Terms: Mendelian randomization, Metabolomics, Sleep, Epidemiology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/3a4e89b02a4e4bc9b561d382d0215d2b

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Authors: Raymond Noordam, Maxime M. Bos, Heming Wang, Thomas W. Winkler, Amy R. Bentley, Tuomas O. Kilpeläinen, Paul S. de Vries, Yun Ju Sung, Karen Schwander, Brian E. Cade, Alisa Manning, Hugues Aschard, Michael R. Brown, Han Chen, Nora Franceschini, Solomon K. Musani, Melissa Richard, Dina Vojinovic, Stella Aslibekyan, Traci M. Bartz, Lisa de las Fuentes, Mary Feitosa, Andrea R. Horimoto, Marjan Ilkov, Minjung Kho, Aldi Kraja, Changwei Li, Elise Lim, Yongmei Liu, Dennis O. Mook-Kanamori, Tuomo Rankinen, Salman M. Tajuddin, Ashley van der Spek, Zhe Wang, Jonathan Marten, Vincent Laville, Maris Alver, Evangelos Evangelou, Maria E. Graff, Meian He, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Pedro Marques-Vidal, Ilja M. Nolte, Nicholette D. Palmer, Rainer Rauramaa, Xiao-Ou Shu, Harold Snieder, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Correa Adolfo, Christie Ballantyne, Larry Bielak, Nienke R. Biermasz, Eric Boerwinkle, Niki Dimou, Gudny Eiriksdottir, Chuan Gao, Sina A. Gharib, Daniel J. Gottlieb, José Haba-Rubio, Tamara B. Harris, Sami Heikkinen, Raphaël Heinzer, James E. Hixson, Georg Homuth, M. Arfan Ikram, Pirjo Komulainen, Jose E. Krieger, Jiwon Lee, Jingmin Liu, Kurt K. Lohman, Annemarie I. Luik, Reedik Mägi, Lisa W. Martin, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Mike A. Nalls, Jeff O’Connell, Annette Peters, Patricia Peyser, Olli T. Raitakari, Alex P. Reiner, Patrick C. N. Rensen, Treva K. Rice, Stephen S. Rich, Till Roenneberg, Jerome I. Rotter, Pamela J. Schreiner, James Shikany, Stephen S. Sidney, Mario Sims, Colleen M. Sitlani, Tamar Sofer, Konstantin Strauch, Morris A. Swertz, Kent D. Taylor, André G. Uitterlinden, Cornelia M. van Duijn, Henry Völzke, Melanie Waldenberger, Robert B. Wallance, Ko Willems van Dijk, Caizheng Yu, Alan B. Zonderman, Diane M. Becker, Paul Elliott, Tõnu Esko, Christian Gieger, Hans J. Grabe, Timo A. Lakka, Terho Lehtimäki, Kari E. North, Brenda W. J. H. Penninx, Peter Vollenweider, Lynne E. Wagenknecht, Tangchun Wu, Yong-Bing Xiang, Wei Zheng, Donna K. Arnett, Claude Bouchard, Michele K. Evans, Vilmundur Gudnason, Sharon Kardia, Tanika N. Kelly, Stephen B. Kritchevsky, Ruth J. F. Loos, Alexandre C. Pereira, Mike Province, Bruce M. Psaty, Charles Rotimi, Xiaofeng Zhu, Najaf Amin, L. Adrienne Cupples, Myriam Fornage, Ervin F. Fox, Xiuqing Guo, W. James Gauderman, Kenneth Rice, Charles Kooperberg, Patricia B. Munroe, Ching-Ti Liu, Alanna C. Morrison, Dabeeru C. Rao, Diana van Heemst, Susan Redline

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7a287494756c4fbcb7eb0688fb50e01b

A double-blind, placebo-controlled, randomised trial to assess the effect of liraglutide on ectopic fat accumulation in South Asian type 2 diabetes patients

Authors: Huub J. van Eyk, Elisabeth H. M. Paiman, Maurice B. Bizino, Paul de Heer, Petronella H. Geelhoed-Duijvestijn, Aan V. Kharagjitsingh, Johannes W. A. Smit, Hildo J. Lamb, Patrick C. N. Rensen, Ingrid M. Jazet

Source: Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)

Subject Terms: South Asian, Diabetes mellitus type 2, Ectopic fat, GLP-1 analogue, Liraglutide, Randomised clinical trial, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12933-019-0890-5; https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/8192e95d0a7f403ab3e6c270721e4b7a

A simplified procedure to trace triglyceride‐rich lipoprotein metabolism in vivo

Authors: Zhixiong Ying, Mariëtte R. Boon, Tamer Coskun, Sander Kooijman, Patrick C. N. Rensen

Source: Physiological Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

Subject Terms: lipoprotein kinetics, lipoprotein metabolism, lipoproteins, plasma triglyceride metabolism, VLDL, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/38f1e8aff2a54dfaa282f8228a5d1400

A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3‐Leiden.CETP mice

Authors: Xiang Zhang, Yared Paalvast, Yanan Wang, Patrick C. N. Rensen, Albert K. Groen

Source: Physiological Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

Subject Terms: feed efficiency, liver, metabolic syndrome, RNA‐Seq, transgenic mice, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/cea33f784fc84c64a64799cc0a881649

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism

Authors: Xiao-Lan Wang, Samantha E. C. Wolff, Nikita Korpel, Irina Milanova, Cristina Sandu, Patrick C. N. Rensen, Sander Kooijman, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: inflammation, palmitic acid, cellular metabolism, oxidative stress, microglia, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.586399/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b87e7dd86024424987a6511a2b35f12c

Editorial: Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity

Authors: Takeshi Yoneshiro, Rosalía Rodríguez-Rodríguez, Matthias Johannes Betz, Patrick C. N. Rensen

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: brown adipose tissue, beige adipocytes, energy metabolism, thermogenesis, obesity, type 2 diabetes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2020.600341/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/2d21785d3bae4e239abf77406bc69176

Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis

Authors: Zhuang Li, Wouter J. de Jonge, Yanan Wang, Patrick C. N. Rensen, Sander Kooijman

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: brown adipose tissue, neurostimulation, thermogenesis, beta-3 adrenergic receptor signaling, brown adipose tissue temperature, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2020.567545/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/7b4075c4398140b2955879d0af61e185

Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1

Authors: Maaike E. Straat, Mink S. Schinkelshoek, Rolf Fronczek, Gerrit Jan Lammers, Patrick C. N. Rensen, Mariëtte R. Boon

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: brown adipose tissue, energy metabolism, hypothalamus, narcolepsy type 1, obesity, orexin, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2020.00145/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/182e0b41683146e0957ede1bd8d9317d

Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet

Authors: Dicky L. Tahapary, Karin de Ruiter, Farid Kurniawan, Yenny Djuardi, Yanan Wang, Siti M. E. Nurdin, Elisa Iskandar, Dominggus Minggu, Em Yunir, Bruno Guigas, Taniawati Supali, Patrick C. N. Rensen, Erliyani Sartono, Pradana Soewondo, Dante S. Harbuwono, Johannes W. A. Smit, Maria Yazdanbakhsh

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f0aadfa327ef4384bf168fe6d66930fd