Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil

Authors: Monique Cristina dos Santos, Natalia Fintelman-Rodrigues, Aline de Paula Dias da Silva, Rodolfo Leandro Nascimento Silva, Victor Corrêa Seixas, Amanda A. Batista-da-Silva, Marcelo Alves Ferreira, Patrícia T. Bozza, Fernando A. Bozza, Thiago Moreno L. Souza

Source: Frontiers in Microbiology, Vol 16 (2025)

Subject Terms: COVID-19, SARS-CoV-2, slum, Rio de Janeiro, Brazil, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2025.1483895/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/84727634585d475382707e1b8f3bc574

Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice

Authors: Mayara Mattos, Carolina Q. Sacramento, André C. Ferreira, Natalia Fintelman-Rodrigues, Filipe S. Pereira-Dutra, Caroline Souza de Freitas, João S. M. Gesto, Jairo R. Temerozo, Aline de Paula Dias Da Silva, Mariana T. G. Moreira, Rafael S. C. Silva, Gabriel P. E. Silveira, Douglas P. Pinto, Heliana M. Pereira, Laís B. Fonseca, Marcelo Alves Ferreira, Camilla Blanco, João P. B. Viola, Dumith Chequer Bou-Habib, Patrícia T. Bozza, Thiago Moreno L. Souza

Source: Viruses, Vol 16, Iss 12, p 1856 (2024)

Subject Terms: SARS-CoV-2, anti-HCV drugs, exonuclease, error prone, K18-hACE2 mice, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/12/1856; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/51b59679bfcd43f8b39448b4729181d7

Prevention of lipid droplet accumulation by DGAT1 inhibition ameliorates sepsis-induced liver injury and inflammation

Authors: Lívia Teixeira, Filipe S. Pereira-Dutra, Patrícia A. Reis, Tamires Cunha-Fernandes, Marcos Y. Yoshinaga, Luciana Souza-Moreira, Ellen K. Souza, Ester A. Barreto, Thiago P. Silva, Hugo Espinheira-Silva, Tathiany Igreja, Maísa M. Antunes, Ana Cristina S. Bombaça, Cassiano F. Gonçalves-de-Albuquerque, Gustavo B. Menezes, Eugênio D. Hottz, Rubem F.S. Menna-Barreto, Clarissa M. Maya-Monteiro, Fernando A. Bozza, Sayuri Miyamoto, Rossana C.N. Melo, Patrícia T. Bozza

Source: JHEP Reports, Vol 6, Iss 2, Pp 100984- (2024)

Subject Terms: immunometabolism, inflammation, sepsis, MODS, steatosis, lipid peroxidation, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923003154; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/78f65ec2abf54078b0c5adb7c1518e41

Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation

Authors: Thiago Moreno L. Souza, Vagner D. Pinho, Cristina F. Setim, Carolina Q. Sacramento, Rodrigo Marcon, Natalia Fintelman-Rodrigues, Otavio A. Chaves, Melina Heller, Jairo R. Temerozo, André C. Ferreira, Mayara Mattos, Patrícia B. Momo, Suelen S. G. Dias, João S. M. Gesto, Filipe Pereira-Dutra, João P. B. Viola, Celso Martins Queiroz-Junior, Lays Cordeiro Guimarães, Ian Meira Chaves, Pedro Pires Goulart Guimarães, Vivian Vasconcelos Costa, Mauro Martins Teixeira, Dumith Chequer Bou-Habib, Patrícia T. Bozza, Anderson R. Aguillón, Jarbas Siqueira-Junior, Sergio Macedo-Junior, Edineia L. Andrade, Guilherme P. Fadanni, Sara E. L. Tolouei, Francine B. Potrich, Adara A. Santos, Naiani F. Marques, João B. Calixto, Jaime A. Rabi

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7d55dbfc83a94333a82eee70353ce909

Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19

Authors: Monique R. O. Trugilho, Isaclaudia G. Azevedo-Quintanilha, João S. M. Gesto, Emilly Caroline S. Moraes, Samuel C. Mandacaru, Mariana M. Campos, Douglas M. Oliveira, Suelen S. G. Dias, Viviane A. Bastos, Marlon D. M. Santos, Paulo C. Carvalho, Richard H. Valente, Eugenio D. Hottz, Fernando A. Bozza, Thiago Moreno L. Souza, Jonas Perales, Patrícia T. Bozza

Source: Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/872ce91a2be0406f806e073372def0cc

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology

Authors: Jairo R. Temerozo, Natalia Fintelman-Rodrigues, Monique Cristina dos Santos, Eugenio D. Hottz, Carolina Q. Sacramento, Aline de Paula Dias da Silva, Samuel Coelho Mandacaru, Emilly Caroline dos Santos Moraes, Monique R. O. Trugilho, João S. M. Gesto, Marcelo Alves Ferreira, Felipe Betoni Saraiva, Lohanna Palhinha, Remy Martins-Gonçalves, Isaclaudia Gomes Azevedo-Quintanilha, Juliana L. Abrantes, Cássia Righy, Pedro Kurtz, Hui Jiang, Hongdong Tan, Carlos Morel, Dumith Chequer Bou-Habib, Fernando A. Bozza, Patrícia T. Bozza, Thiago Moreno L. Souza

Source: Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)

Subject Terms: Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2049-2618

Access URL: https://doaj.org/article/6e852a90651e4bdaae661b0aaad38148

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

Authors: Xuanting Wang, Carolina Q. Sacramento, Steffen Jockusch, Otávio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R. Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, Patrícia T. Bozza, James J. Russo, Thiago Moreno L. Souza, Jingyue Ju

Source: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/421885d8a61b464da42eeec94cc924d8

Platelet–leukocyte interactions in the pathogenesis of viral infections

Authors: Eugenio D. Hottz, Anna Cecíllia Quirino-Teixeira, Laura Botelho Merij, Mariana Brandi Mendonça Pinheiro, Stephane Vicente Rozini, Fernando A. Bozza, Patrícia T. Bozza

Source: Platelets, Vol 33, Iss 2, Pp 200-207 (2022)

Subject Terms: platelets, platelet-leukocyte aggregates, covid-19, dengue, hiv, influenza, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/199a9192445443388d00e3d6a559134a

Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages

Authors: André C. Ferreira, Carolina Q. Sacramento, Filipe S. Pereira-Dutra, Natália Fintelman-Rodrigues, Priscila P. Silva, Mayara Mattos, Caroline S. de Freitas, Andressa Marttorelli, Gabrielle R. de Melo, Mariana M. Campos, Isaclaudia G. Azevedo-Quintanilha, Aluana S. Carlos, João Vítor Emídio, Cristiana C. Garcia, Patrícia T. Bozza, Fernando A. Bozza, Thiago M. L. Souza

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: influenza virus, necroptosis, TNF, etanercept, macrophages, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1067285/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/0836dd826fee4902a18acb63980080a8

Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R

Authors: Mariana Brandi Mendonça Pinheiro, Stephane Vicente Rozini, Anna Cecíllia Quirino-Teixeira, Giselle Barbosa-Lima, Juliana F. Lopes, Carolina Q. Sacramento, Fernando A. Bozza, Patrícia T. Bozza, Eugenio D. Hottz

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: platelets, nitric oxide, iNOS, IL-1R, dengue, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1029213/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ef1eec77d1c54e9fa5dc0b041e0a59ea

Integrated NMR and MS Analysis of the Plasma Metabolome Reveals Major Changes in One-Carbon, Lipid, and Amino Acid Metabolism in Severe and Fatal Cases of COVID-19

Authors: Marcos C. Gama-Almeida, Gabriela D. A. Pinto, Lívia Teixeira, Eugenio D. Hottz, Paula Ivens, Hygor Ribeiro, Rafael Garrett, Alexandre G. Torres, Talita I. A. Carneiro, Bianca de O. Barbalho, Christian Ludwig, Claudio J. Struchiner, Iranaia Assunção-Miranda, Ana Paula C. Valente, Fernando A. Bozza, Patrícia T. Bozza, Gilson C. dos Santos, Tatiana El-Bacha

Source: Metabolites, Vol 13, Iss 7, p 879 (2023)

Subject Terms: SARS-CoV-2, metabolomics, 1H-NMR, high-resolution mass spectrometry, fatal COVID-19, virus-host interactions, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/7/879; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/ee864e801ccb463f89651876d0b39350

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Authors: Natalia Fintelman-Rodrigues, Aline P.D. da Silva, Monique Cristina dos Santos, Felipe B. Saraiva, Marcelo A. Ferreira, João Gesto, Danielle A.S. Rodrigues, André M. Vale, Isaclaudia G. de Azevedo, Vinícius C. Soares, Hui Jiang, Hongdong Tan, Diogo A. Tschoeke, Carolina Q. Sacramento, Fernando A. Bozza, Carlos M. Morel, Patrícia T. Bozza, Thiago Moreno L. Souza

Source: Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1446-1453 (2021)

Subject Terms: COVID-19, coronavirus disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/012ca42c98e74c1197d39a712f22fc7d

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

Authors: André C. Ferreira, Vinicius Cardoso Soares, Isaclaudia G. de Azevedo-Quintanilha, Suelen da Silva Gomes Dias, Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Mayara Mattos, Caroline S. de Freitas, Jairo R. Temerozo, Lívia Teixeira, Eugenio Damaceno Hottz, Ester A. Barreto, Camila R. R. Pão, Lohanna Palhinha, Milene Miranda, Dumith Chequer Bou-Habib, Fernando A. Bozza, Patrícia T. Bozza, Thiago Moreno L. Souza

Source: Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/7f1d84675e3f4ca48d979b928e9f0e90

Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report

Authors: Joanna Bokel, Daniela P. Mendes-de-Almeida, Remy Martins-Gonçalves, Lohanna Palhinha, Alexandre G. Vizzoni, Danusa Ferreira Correa, Luciana Gomes Pedro Brandão, Patrícia T. Bozza, Beatriz Grinsztejn

Source: Frontiers in Public Health, Vol 10 (2022)

Subject Terms: generalized edema, pseudothrombocytopenia, spurious thrombocytopenia, COVID-19 vaccine safety, vaccine-induced pseudothrombocytopenia, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpubh.2022.907652/full; https://doaj.org/toc/2296-2565

Access URL: https://doaj.org/article/8a326e00dfd648c8833c6b225725f18a

Platelet‐leukocyte interactions in COVID‐19: Contributions to hypercoagulability, inflammation, and disease severity

Authors: Eugenio D. Hottz, Patrícia T. Bozza

Source: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 3, Pp n/a-n/a (2022)

Subject Terms: COVID‐19, monocytes, neutrophils, platelets, thromboinflammation, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/7c3ea392694944a99264443037a2bc06

Fundamentals in Covid-19-Associated Thrombosis: Molecular and Cellular Aspects

Authors: Daniella M. Mizurini, Eugenio D. Hottz, Patrícia T. Bozza, Robson Q. Monteiro

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Subject Terms: COVID-19, thrombosis, platelets, monocytes, neutrophil extracellular trap, endothelium, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.785738/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/610721cce71744868827a1f39a177ba7

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating

Authors: José Alexandre Salerno, Thayana Torquato, Jairo R. Temerozo, Livia Goto-Silva, Karina Karmirian, Mayara A. Mendes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Letícia R Q. Souza, Isis M. Ornelas, Carla P. Veríssimo, Luiz Guilherme H S. Aragão, Gabriela Vitória, Carolina S G. Pedrosa, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Teresa Puig-Pijuan, Vinícius Salazar, Rafael Dariolli, Diogo Biagi, Daniel R. Furtado, Luciana Barreto Chiarini, Helena L. Borges, Patrícia T. Bozza, Marilia Zaluar P. Guimarães, Thiago M.L. Souza, Stevens K. Rehen

Source: PeerJ, Vol 9, p e12595 (2021)

Subject Terms: Sigma-1 Receptor, IPSC, Cardiomyocyte, SARS-CoV-2, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/12595.pdf; https://peerj.com/articles/12595/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/654771cd45c94c0ebd7a55057203f3db

WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2

Authors: Luiz Guilherme H. S. Aragão, Júlia T. Oliveira, Jairo R. Temerozo, Mayara A. Mendes, José Alexandre Salerno, Carolina S. G. Pedrosa, Teresa Puig-Pijuan, Carla P. Veríssimo, Isis M. Ornelas, Thayana Torquato, Gabriela Vitória, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Letícia R. Q. Souza, Karina Karmirian, Livia Goto-Silva, Diogo Biagi, Estela M. Cruvinel, Rafael Dariolli, Daniel R. Furtado, Patrícia T. Bozza, Helena L. Borges, Thiago M. L. Souza, Marília Zaluar P. Guimarães, Stevens K. Rehen

Source: PeerJ, Vol 9, p e12262 (2021)

Subject Terms: Cannabinoids, SARS-Cov-2, COVID-19, Human iPSC-derived cardiomyocytes, WIN 55,212-2, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/12262.pdf; https://peerj.com/articles/12262/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/ce3f2fb7034a4198b040ce2921144372

Non-permissive SARS-CoV-2 infection in human neurospheres

Authors: Carolina da S.G. Pedrosa, Livia Goto-Silva, Jairo R. Temerozo, Leticia R.Q. Souza, Gabriela Vitória, Isis M. Ornelas, Karina Karmirian, Mayara A. Mendes, Ismael C. Gomes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Vinicius Cardoso Soares, Suelen da Silva Gomes Dias, José A. Salerno, Teresa Puig-Pijuan, Julia T. Oliveira, Luiz G.H.S. Aragão, Thayana C.Q. Torquato, Carla Veríssimo, Diogo Biagi, Estela M. Cruvinel, Rafael Dariolli, Daniel R. Furtado, Helena L. Borges, Patrícia T. Bozza, Stevens Rehen, Thiago Moreno L. Souza, Marília Zaluar P. Guimarães

Source: Stem Cell Research, Vol 54, Iss , Pp 102436- (2021)

Subject Terms: New coronavirus, Brain, Neurospheres, SARS-CoV-2, iPS, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S187350612100283X; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/ab1ba8301e984f0faf1cf30367661855

Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia following ChAdOx1 nCOVID-19 vaccine in a pregnant woman

Authors: Daniela P. Mendes-de-Almeida, Remy Martins-Gonçalves, Renata Morato-Santos, Gustavo Adolpho C. de Carvalho, Silas A. Martins, Lohanna Palhinha, Vanessa Sandim, Elyzabeth Avvad-Portari, Fernando A. Bozza, Robson Q. Monteiro, Patrícia T. Bozza, Pedro Kurtz

Source: Haematologica, Vol 106, Iss 11 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10335; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/bff960f88b2e4f2a8465231fc2a34776