Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment

Authors: Patlewicz, G., Judson, R.S., Williams, A.J., Butler, T., Barone, S., Jr., Carstens, K.E., Cowden, J., Dawson, J.L., Degitz, S.J., Fay, K., Henry, T.R., Lowit, A., Padilla, S., Paul Friedman, K., Phillips, M.B., Turk, D., Wambaugh, J.F., Wetmore, B.A., Thomas, R.S.

Source: In Computational Toxicology September 2024 31

A systematic analysis of read-across within REACH registration dossiers

Authors: Patlewicz, G., Karamertzanis, P., Paul Friedman, K., Sannicola, M., Shah, I.

Source: In Computational Toxicology June 2024 30

Quantitative prediction of repeat dose toxicity values using GenRA

Authors: Helman, G., Patlewicz, G., Shah, I.

Source: In Regulatory Toxicology and Pharmacology December 2019 109

An evaluation of selected (Q)SARs/expert systems for predicting skin sensitisation potential

Authors: Fitzpatrick, J. M., Roberts, D. W., Patlewicz, G.

Source: SAR and QSAR in environmental research. 29(6):439-468

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064051206.0x000001&indx=1&recIds=ETOCvdc_100064051206.0x000001

Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset

Authors: Roberts, D.W., Api, A.M., Patlewicz, G., Schultz, T.W.

Source: In Regulatory Toxicology and Pharmacology October 2016 80:247-254

Building scientific confidence in the development and evaluation of read-across

Authors: Patlewicz, G., Ball, N., Boogaard, P.J., Becker, R.A., Hubesch, B.

Source: In Regulatory Toxicology and Pharmacology June 2015 72(1):117-133

Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization

Authors: Fitzpatrick, J. M., Roberts, D. W., Patlewicz, G.

Source: JOURNAL OF APPLIED TOXICOLOGY. 37(1):117-127

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN382724390&indx=1&recIds=ETOCRN382724390

What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis

Authors: Fitzpatrick, J. M., Roberts, D. W., Patlewicz, G.

Source: JOURNAL OF APPLIED TOXICOLOGY. 37(1):105-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN382724366&indx=1&recIds=ETOCRN382724366

Application of IATA – A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization

Authors: Fitzpatrick, J. M., Patlewicz, G.

Source: SAR and QSAR in environmental research. 28(4):297-310

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048519005.0x000001&indx=1&recIds=ETOCvdc_100048519005.0x000001

Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?
Quantitative structure-activity relationships in environmental and health sciences; QSAR2010 workshop

Authors: Patlewicz, G., Mekenyan, O., Dimitrova, G., Kuseva, C., Todorov, M., Kotov, S., Stoeva, S., Donner, E.M.

Source: SAR AND QSAR IN ENVIRONMENTAL RESEARCH. 26(7/8):619-656

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN088071126&indx=1&recIds=ETOCCN088071126

The role of the European Chemicals Bureau in promoting the regulatory use of (Q)SAR methods
Quantitative structure-activity relationships in the human health and environmental toxicology; QSAR 2006 workshop

Authors: Worth, A.P., Bassan, A., De Bruijn, J., Saliner, A.G., Netzeva, T., Patlewicz, G., Pavan, M.

Source: SAR AND QSAR IN ENVIRONMENTAL RESEARCH. 18(1/2):111-125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN086952233&indx=1&recIds=ETOCCN086952233

Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

Authors: Patlewicz, G., Casati, S., Basketter, D. A., Asturiol, D., Roberts, D. W., Lepoittevin, J. P., Worth, A. P., Aschberger, K.

Source: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 82:147-155

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN382095957&indx=1&recIds=ETOCRN382095957

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

Authors: Shah, I., Liu, J., Judson, R. S., Thomas, R. S., Patlewicz, G.

Source: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 79:12-24

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN378713996&indx=1&recIds=ETOCRN378713996

From Knowledge Generation to Knowledge Archive. A General Strategy Using TOPS-MODE with DEREK To Formulate New Alerts for Skin Sensitization
Interfaces among mathematics, chemistry and computer sciences

Authors: Estrada, E., Patlewicz, G., Gutierrez, Y.

Source: JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES. 44(NO 2):688-698

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN051472468&indx=1&recIds=ETOCCN051472468

Mechanism based structure-activity relationships for skin sensitisation-The carbonyl group domain
Quantitative structure-activity relationships in environmental sciences

Authors: Roberts, D. W., Patlewicz, G.

Source: SAR AND QSAR IN ENVIRONMENTAL RESEARCH. 13(NO 1):145-152

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN042981047&indx=1&recIds=ETOCCN042981047

A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity?

Authors: Petkov, P. I., Patlewicz, G., Schultz, T. W., Honma, M., Todorov, M., Kotov, S., Dimitrov, S. D., Donner, E. M., Mekenyan, O. G.

Source: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 72(1):17-25

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN369622120&indx=1&recIds=ETOCRN369622120

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

Authors: Patlewicz, G., Simon, T. W., Rowlands, J. C., Budinsky, R. A., Becker, R. A.

Source: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 71(3):463-477

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN369394871&indx=1&recIds=ETOCRN369394871

An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity�Proof of concept

Authors: Becker, R. A., Friedman, K. P., Simon, T. W., Marty, M. S., Patlewicz, G., Rowlands, J. C.

Source: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 71(3):398-408

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN369394804&indx=1&recIds=ETOCRN369394804

P20-09 Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer Classification Scheme

Authors: Firman, J.W., Boobis, A., Hollnagel, H.M., Kaiser, S., Lovell, D.P., Moretto, A., Müller, S., Ryder, C.V., Schmidt, F., Stice, S., Wijeyesakere, S., Patlewicz, G.

Source: In Toxicology Letters September 2024 399 Supplement 2:S296-S297

High-throughput phenotypic profiling within the NAMs-based, tiered hazard evaluation strategy at the United States Environmental Protection Agency

Authors: Nyffeler, J., Willis, C., Culbreth, M., Brockway, R.E., Everett, L.J., Patlewicz, G., Shah, I., Chang, D., Paul Friedman, K., Wambaugh, J., Harrill, J.A.

Source: Toxicology letters. 350(S):S61-S62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140416412.0x000001&indx=1&recIds=ETOCvdc_100140416412.0x000001