A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance

Authors: Lei Sun, Arabella H. Wan, Shijia Yan, Ruonian Liu, Jiarui Li, Zhuolong Zhou, Ruirui Wu, Dongshi Chen, Xianzhang Bu, Jingxing Ou, Kai Li, Xiongbin Lu, Guohui Wan, Zunfu Ke

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 223-240 (2024)

Subject Terms: Lenvatinib, Drug resistance, High-throughput screening, Drug discovery, Patient-derived model, Romidepsin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523003684; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/6fd491e1a58a4961a1629f26aa3391ae

MRI radiomics captures early treatment response in patient-derived organoid endometrial cancer mouse models

Authors: Heidi Espedal, Kristine E. Fasmer, Hege F. Berg, Jenny M. Lyngstad, Tomke Schilling, Camilla Krakstad, Ingfrid S. Haldorsen

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: patient-derived organoids, MRI radiomics, endometrial cancer, preclinical imaging, patient-derived model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1334541/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e403cc20888a4c6e8e9d0b08de4af815

Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells

Authors: Xiaoying Hou, Cong Du, Ligong Lu, Shengtao Yuan, Meixiao Zhan, Pengtao You, Hongzhi Du

Source: World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-9 (2022)

Subject Terms: Patient-derived model, Patient-derived xenograft (PDX), Patient-derived organoid (PDO), Patient-derived cell (PDC), NCI-60, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1477-7819

Access URL: https://doaj.org/article/132ce0fe1c194eb1bbb678f648559b5a

Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

Authors: Pengfei Xu, Joy C. Yang, Shu Ning, Bo Chen, Christopher Nip, Qiang Wei, Liangren Liu, Oleta T. Johnson, Allen C. Gao, Jason E. Gestwicki, Christopher P. Evans, Chengfei Liu

Source: Pharmacological Research, Vol 189, Iss , Pp 106692- (2023)

Subject Terms: Prostate cancer, Enzalutamide resistance, HSP70, STUB1, Androgen receptor variant, Patient-derived model, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661823000488; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/0aa5beefd47948149ef46484906a60a3

Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids

Authors: Minsuh Kim, Ji Min Kim, Eun Jeong Cho, Chang Ohk Sung, Joon Kim, Se Jin Jang

Source: Data in Brief, Vol 44, Iss , Pp 108506- (2022)

Subject Terms: β-arrestin 2, Yes-associated protein (YAP), Hippo pathway, Cancer organoid, Patient-derived model, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352340922007004; https://doaj.org/toc/2352-3409

Access URL: https://doaj.org/article/45da6c5b3d634aabab25753595b45f23

Patient-derived cancer models: Valuable platforms for anticancer drug testing

Authors: Sofia Genta, Bryan Coburn, David W. Cescon, Anna Spreafico

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: patient-derived model, PDO, drug-testing, co-clinical trial, PDX, cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.976065/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/19744ed92fed4a89a5a9f95141c34d16

RNA Sequencing Reveals Alterations and Similarities in Cell Metabolism, Hypoxia and Immune Evasion in Primary Cell Cultures of Clear Cell Renal Cell Carcinoma

Authors: Adrian Georg Simon, Laura Kristin Esser, Jörg Ellinger, Manuel Ritter, Glen Kristiansen, Michael H. Muders, Thomas Mayr, Marieta Ioana Toma

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: in vitro model, cell culture conditions, ccRCC, RNA-Seq, renal cancer, patient-derived model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.883195/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/323f3dd02fd647e4b4cee5131361c30d

Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis

Authors: Se-Young Jo, Eunyoung Kim, Sangwoo Kim

Source: Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)

Subject Terms: Benchmark, Patient-derived model, Genomic analysis, Mouse contamination, Best practice, Read filtering, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-019-1849-2; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/ff9da52be4a84c0285e009c0370de591

Conditional reprogramming: Modeling urological cancer and translation to clinics

Authors: Wei Liu, Lingao Ju, Songtao Cheng, Gang Wang, Kaiyu Qian, Xuefeng Liu, Yu Xiao, Xinghuan Wang

Source: Clinical and Translational Medicine, Vol 10, Iss 2, Pp n/a-n/a (2020)

Subject Terms: conditional reprogramming, patient‐derived model, precision medicine, urological cancer, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/9fd3b6414a184d23a8b4af7deba9c07b

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