Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis

Authors: Xiu-Ya Chan, Kai-Ping Chang, Chia-Yu Yang, Chiao-Rou Liu, Chu-Mi Hung, Chun-Chueh Huang, Hao-Ping Liu, Chih-Ching Wu

Source: Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-25 (2024)

Subject Terms: Protein-enabled homolog (ENAH), Oral cavity squamous cell carcinoma (OSCC), Patient-derived xenograft (PDX), Integrin β5 (ITGB5), Proteomics, GSK3β/β-catenin signaling, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/386a2840509f4202adb4b09360e0f660

Editorial: EBV-induced T cell immunity in cancers

Authors: Baochun Zhang, Josef Mautner, Christian Münz

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Epstein-Barr virus (EBV), T cell, EBV-specific, tumor-associated antigens (TAA), TAA-specific, patient-derived xenograft (PDX), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454792/full; https://doaj.org/toc/1664-3224

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Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma

Authors: Dafu Chen, Chengyue Lei, Weifeng Liu, Meiyu Shao, Meizhou Sun, Jianxun Guo, Jingjing Cao, Jing-Jun Nie, Peng Luo, Yuwen Luo, Bingran Yu, Renxian Wang, Shun Duan, Fu-Jian Xu

Source: Bioactive Materials, Vol 28, Iss , Pp 376-385 (2023)

Subject Terms: Nucleic acid delivery, Nanoparticle, Gene therapy, Osteosarcoma, Responsive, Patient-Derived Xenograft (PDX), Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X23001561; https://doaj.org/toc/2452-199X

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The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model

Authors: Jing-Ren Tseng, Cheng-Lung Hsu, Hsin-Hua Hsieh, Kung-Chu Ho, Yi-Hsiu Chung, Chun-Yi Wu

Source: Biomedical Journal, Vol 47, Iss 3, Pp 100744- (2024)

Subject Terms: Sarcoma, Patient-derived xenograft (PDX), Fibroblast activation protein (FAP), 177Lu-FAPI-46, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2319417024000477; https://doaj.org/toc/2319-4170

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Exploration of Dan-Shen-Yin against pancreatic cancer based on network pharmacology combined with molecular docking and experimental validation

Authors: Gu, Ao ^{a, 1}, Li, Jiatong ^{a, b, c, 1}, Wu, Jian-An ^b, Li, Meng-Yao ^{a, b, ⁎}, Liu, Yingbin ^{a, b, ⁎}

Source: In Current Research in Biotechnology 2024 7

ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors

Authors: Seol Hwa Shin, Eun Jin Ju, Jin Park, Eun Jung Ko, Mi Ri Kwon, Hye Won Lee, Ga Won Son, Yun-Yong Park, Yeon Joo Kim, Si Yeol Song, Sangkwang Lee, Beom Seok Seo, Jin-A Song, Sangbin Lim, Doohwan Jung, Sunyoung Kim, Hyangsook Lee, Seok Soon Park, Seong-Yun Jeong, Eun Kyung Choi

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-15 (2023)

Subject Terms: Antibody-drug conjugate (ADC), B7-H3, Ortho hydroxy-protected aryl sulfate (OHPAS)-linkers, Patient-derived xenograft (PDX), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/143e4bef18f04341876c841b9c2dc509

Patient-derived organoids for precision oncology: a platform to facilitate clinical decision making

Authors: Swati Chitrangi, Pooja Vaity, Aishwarya Jamdar, Shweta Bhatt

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-24 (2023)

Subject Terms: Patient-Derived Organoids (PDOs), Tumor Microenvironment (TME), Patient-derived Xenograft (PDX), Drug efficacy and safety studies, Patient-derived induced pluripotent stem cells (iPSCs), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/7c439c97054f4a7686f41d0c19c3919d

Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models

Authors: Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, Yohei Funakoshi, Yu-Ichiro Koma, Yoji Murata, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami, Hiroshi Yokozaki, Markus G. Manz, Takashi Matozaki

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: humanized mouse, tumor-associated macrophages, SIRP alpha, cancer immunotherapy, patient-derived xenograft (PDX) model, macrophage checkpoint, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294814/full; https://doaj.org/toc/1664-3224

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Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer

Authors: Daniel J. Turnham, Manisha S. Mullen, Nicholas P. Bullock, Kathryn L. Gilroy, Anna E. Richards, Radhika Patel, Marcos Quintela, Valerie S. Meniel, Gillian Seaton, Howard Kynaston, Richard W. E. Clarkson, Toby J. Phesse, Peter S. Nelson, Michael C. Haffner, John N. Staffurth, Helen B. Pearson

Source: Cells, Vol 13, Iss 8, p 673 (2024)

Subject Terms: patient-derived xenograft (PDX), double-negative prostate cancer (DNPC), castration-resistant prostate cancer (CRPC), neuroendocrine (NE), androgen receptor (AR), Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/8/673; https://doaj.org/toc/2073-4409

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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Authors: Claudia Manriquez Roman, author^{1, 2, 3, 4, 5}, R. Leo Sakemura, author^{1, 2}, Brooke L. Kimball, author^{1, 2}, Fang Jin, author⁶, Roman H. Khadka, author⁶, Mohamad M. Adada, author^{1, 2}, Elizabeth L. Siegler, author^{1, 2}, Aaron J. Johnson, author⁶, Saad S. Kenderian, author^{1, 2, 6}

Source: Journal of Visualized Experiments. (192)

Availability: http://www.jove.com/video/64535

Editorial: Patient-derived tumor models for drug development

Authors: Hatim E. Sabaawy, Massimo Broggini, Shiv K. Gupta

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: patient-derived models of cancer, organoid, patient-derived xenograft (PDX), syngeneic graft, pre-clinical drug screen for cancer, immune checkpoint inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1243534/full; https://doaj.org/toc/2234-943X

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Establishment and genetically characterization of patient-derived xenograft models of cervical cancer

Authors: Shuangwei Zou, Miaomiao Ye, Jian-an Zhang, Huihui Ji, Yijie Chen, Xueqiong Zhu

Source: BMC Medical Genomics, Vol 15, Iss 1, Pp 1-11 (2022)

Subject Terms: Patient-derived xenograft (PDX), Cervical cancer, Histological analysis, Genetic stability, Somatic mutations, Whole-genome sequencing (WGS), Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/59e410369f0e4238b93fbd45e5cd03a7

Assessing the performance of different outcomes for tumor growth studies with animal models

Authors: Luke W. Patten, Patrick Blatchford, Matthew Strand, Alexander M. Kaizer

Source: Animal Models and Experimental Medicine, Vol 5, Iss 3, Pp 248-257 (2022)

Subject Terms: mouse model, oncology, outcome selection, patient‐derived xenograft (PDX), statistical analysis, TGII, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2576-2095

Access URL: https://doaj.org/article/af1326699e4448efbdd58f3356f28775

Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions

Authors: Zehui Li, Jin Wang, Zhenning Wang, Yan Xu

Source: EBioMedicine, Vol 92, Iss , Pp 104601- (2023)

Subject Terms: Gastric cancer, Peritoneal metastasis, Animal model, Immunodeficient mouse, Patient-derived xenograft (PDX), Cell line-derived xenograft (CDX), Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423001664; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/9b9d6f7fa83f4f0bbea3f4e707adeb2e

Clinically relevant glioblastoma patient-derived xenograft models to guide drug development and identify molecular signatures

Authors: Joshua Alcaniz, Lars Winkler, Mathias Dahlmann, Michael Becker, Andrea Orthmann, Johannes Haybaeck, Stefanie Krassnig, Christina Skofler, Tobias Kratzsch, Susanne A. Kuhn, Andreas Jödicke, Michael Linnebacher, Iduna Fichtner, Wolfgang Walther, Jens Hoffmann

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: glioblastoma, glioma, patient-derived xenograft (PDX), preclinical oncology, drug efficacy, targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1129627/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/162e4abdb64b415cb7d728a8287cc659

Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells

Authors: Xiaoying Hou, Cong Du, Ligong Lu, Shengtao Yuan, Meixiao Zhan, Pengtao You, Hongzhi Du

Source: World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-9 (2022)

Subject Terms: Patient-derived model, Patient-derived xenograft (PDX), Patient-derived organoid (PDO), Patient-derived cell (PDC), NCI-60, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1477-7819

Access URL: https://doaj.org/article/132ce0fe1c194eb1bbb678f648559b5a

A new intronic quantitative PCR method led to the discovery of transformation from human ascites to murine malignancy in a mouse model

Authors: Jiankang Jin, Longfei Huo, Yibo Fan, Ruiping Wang, Ailing W. Scott, Melissa Pool Pizzi, Xiaodan Yao, Shan Shao, Lang Ma, Matheus S. Da Silva, Kohei Yamashita, Katsuhiro Yoshimura, Boyu Zhang, Jingjing Wu, Linghua Wang, Shumei Song, Jaffer A. Ajani

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: intronic genomic qPCR, authentication and quantification of human and murine samples, patient-derived xenograft (PDX), human-to-murine oncogenic transformation, whole exosome sequencing (WES), tumor microenvironment (TME), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1062424/full; https://doaj.org/toc/2234-943X

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New Therapeutic Perspectives in Prostate Cancer: Patient-Derived Organoids and Patient-Derived Xenograft Models in Precision Medicine

Authors: Vittoria Rago, Anna Perri, Silvia Di Agostino

Source: Biomedicines, Vol 11, Iss 10, p 2743 (2023)

Subject Terms: prostate cancer, patient-derived organoid (PDO), patient-derived xenograft (PDX), precision medicine, targeted therapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/10/2743; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/f833c6e549d34daba298fb263ffcacfe

Enrichment of Deleterious Mutated Genes Involved in Ciliary Function and Histone Modification in Brain Cancer Patient-Derived Xenograft Models

Authors: Hyeongsun Jeong, Hyo Eun Moon, Seongmin Yun, Seung Woo Cho, Hye Ran Park, Sung-Hye Park, Kyungjae Myung, Taejoon Kwon, Sun Ha Paek

Source: Biomedicines, Vol 11, Iss 11, p 2934 (2023)

Subject Terms: patient-derived xenograft (PDX), somatic mutations, histone modification, ciliogenesis, brain tumor, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/11/2934; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/2fb4e78106194fff8c21c55c3f3c5263

Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing

Authors: Martine Charbonneau, Kelly Harper, Karine Brochu-Gaudreau, Alexis Perreault, Patrick P. McDonald, Nadia Ekindi-Ndongo, Claudio Jeldres, Claire M. Dubois

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: ccRCC, chick chorioallantoic membrane, CAM assay, sunitinib, patient-derived xenograft (PDX), animal models, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.1003914/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/d5aaa13b3a744f81922eb52fa8b94ccd