Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates

Authors: Haddijatou Mbye, Fatoumata Bojang, Fatou Kene Jaiteh, Aminata Jawara, Bekai Njie, Simon Correa, Umberto D'Alessandro, Alfred Amambua-Ngwa

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 81-87 (2023)

Subject Terms: Plasmodium falciparum, Malaria, Medicine for Malaria Venture (MMV), Pathogen box, Antimalarial drug susceptibility, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320723000209; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/a7739edf62074e69a4d9c65b096f3f09

Unveiling the antimicrobial action of MMV676501, MMV687807, and MMV102872 against Staphylococcus aureus: A mechanistic investigation

Authors: Akash Suresh, Umarani Brahma, Vasundhra Bhandari, Paresh Sharma

Source: Current Research in Biotechnology, Vol 8, Iss , Pp 100245- (2024)

Subject Terms: MMV Pathogen Box, Microarray, Mode of Action, Antimicrobial Resistance, Staphylococcus aureus, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590262824000716; https://doaj.org/toc/2590-2628

Access URL: https://doaj.org/article/e92a106213c14a619ab7a327f50c3397

MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes

Authors: Prasanna Babu Araveti, Macha Vijay, Prajna Parimita Kar, Shalu Varunan, Anand Srivastava

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 18, Iss , Pp 20-31 (2022)

Subject Terms: Theileria annulata, Pathogen box, Anti-theilerial, Drug, Therapeutics, Medicine for Malaria Venture (MMV), Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320721000567; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/49baacc906e1402a8b823ec42f89fbc2

In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica

Authors: Markos Tadele, Solomon M. Abay, Peter Asaga, Eyasu Makonnen, Asrat Hailu

Source: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)

Subject Terms: Leishmania aethiopica, Cutaneous leishmaniasis, Pathogen box, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://doaj.org/toc/2050-6511

Access URL: https://doaj.org/article/4ce5311b3d59402a85464c4df73eb191

The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis

Authors: Emily Puumala, Olga Zaslaver, Amy Chen, Dustin Duncan, Meea Fogal, Rebecca S. Shapiro, Mohammad T. Mazhab-Jafari, Luke Whitesell, J. Rafael Montenegro-Burke, Nicole Robbins, Leah E. Cowen

Source: mBio, Vol 13, Iss 6 (2022)

Subject Terms: Candida albicans, Candida auris, HAL9, HSP12, Pathogen Box, experimental evolution, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/1c5467aeaa4947168dabf4b8f207fb82

Identification of Compounds With Antiviral Activity Against SARS-CoV-2 in the MMV Pathogen Box Using a Phenotypic High-Throughput Screening Assay

Authors: Laís D. Coimbra, Alexandre Borin, Marina Fontoura, Humberto D. Gravina, Alice Nagai, Jacqueline Farinha Shimizu, Karina Bispo-dos-Santos, Fabiana Granja, Paulo S. L. Oliveira, Kleber G. Franchini, Kirandeep Samby, Marjorie Bruder, José Luiz Proença-Módena, Daniela B. B. Trivella, Juliana H. C. Smetana, Artur T. Cordeiro, Rafael Elias Marques

Source: Frontiers in Virology, Vol 2 (2022)

Subject Terms: SARS-CoV-2, biosafety level 3, MMV pathogen box, antivirals, drug repositioning, high-throughput screening, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fviro.2022.854363/full; https://doaj.org/toc/2673-818X

Access URL: https://doaj.org/article/a5ef3494e053423bab15254c1229c102

Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors

Authors: Thales do Valle Moreira, Luan Carvalho Martins, Lucas Abreu Diniz, Talita Cristina Diniz Bernardes, Renata Barbosa de Oliveira, Rafaela Salgado Ferreira

Source: Pathogens, Vol 12, Iss 2, p 251 (2023)

Subject Terms: Chagas disease, cruzain, screening, drug discovery, small molecule inhibitors, Pathogen Box, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/12/2/251; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/5bad3c30008a49dc88e5462e499397fc

Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae

Authors: Haeun Kim, Brianne J. Burkinshaw, Linh G. Lam, Kevin Manera, Tao G. Dong

Source: Microbiology Spectrum, Vol 9, Iss 3 (2021)

Subject Terms: antibiotics, Pathogen Box, cholera, AMR, small molecule, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/c660b948f543459d970eb5036b75fc47

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

Authors: Tadele M, Abay SM, Makonnen E, Hailu A

Source: Drug Design, Development and Therapy, Vol Volume 14, Pp 1307-1317 (2020)

Subject Terms: leishmania donovani, pathogen box compounds, medicines for malaria venture, drug discovery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/leishmania-donovani-growth-inhibitors-from-pathogen-box-compounds-of-m-peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/e55eec0449ec410b971cbcc36dde5023

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

Authors: Martina Maccesi, Pedro H. N. Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki, Sandro Montefusco, Ruben Abagyan, Jennifer Keiser, Marina M. Mourão, Conor R. Caffrey

Source: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)

Subject Terms: Schistosoma, Schistosomiasis, Drug discovery, Phenotypic screen, Pathogen Box, MMV, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13071-019-3747-6; https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/409ebe9371c34ff0b5f701fa37ac4641

Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei

Authors: Darline Dize, Rolland Bantar Tata, Rodrigue Keumoe, Rufin Marie Kouipou Toghueo, Mariscal Brice Tchatat, Cyrille Ngansop Njanpa, Vianey Claire Tchuenguia, Lauve Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Benoît Laleu, James Duffy, Ozlem Tastan Bishop, Fabrice Fekam Boyom

Source: Molecules, Vol 27, Iss 19, p 6574 (2022)

Subject Terms: Trypanosoma brucei brucei, MMV Pathogen Box, antitrypanosomal, MMV675968 (2,4-diaminoquinazoline), in silico, structure–activity relationship, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/19/6574; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/d92679b19d0d465db813d3ac915bd143

A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase

Authors: Warangkhana Songsungthong, Sunisa Prasopporn, Louise Bohan, Potjanee Srimanote, Ubolsree Leartsakulpanich, Suganya Yongkiettrakul

Source: PeerJ, Vol 9, p e10743 (2021)

Subject Terms: Streptococcus suis, Antibiotics, Antifolate, Dihydrofolate reductase, Pathogen Box, Diaminopyrimidine, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/10743.pdf; https://peerj.com/articles/10743/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/5b295c73e8484157a5a6d39a09d24248

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

Authors: Melissa L. Sykes, Emily K. Kennedy, Kevin D. Read, Marcel Kaiser, Vicky M. Avery

Source: Microorganisms, Vol 10, Iss 7, p 1287 (2022)

Subject Terms: MMV Pathogen Box, Human African Trypanosomiasis, Chagas disease, Trypanosoma cruzi, Trypanosoma brucei, image-based assays, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/10/7/1287; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/c9eba067cf6a428696091151793d2dc6

Discovery of New Chemical Tools against Leishmania amazonensis via the MMV Pathogen Box

Authors: Atteneri López-Arencibia, Ines Sifaoui, María Reyes-Batlle, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Jacob Lorenzo-Morales, José E. Piñero

Source: Pharmaceuticals, Vol 14, Iss 12, p 1219 (2021)

Subject Terms: Leishmania amazonensis, screening, chemotherapy, Pathogen Box, hits, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/12/1219; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/a763800dda984c78a6b3646b4df70ee0

Identification of Promising Antifungal Drugs against Scedosporium and Lomentospora Species after Screening of Pathogen Box Library

Authors: Rodrigo Rollin-Pinheiro, Luana Pereira Borba-Santos, Mariana Ingrid Dutra da Silva Xisto, Yuri de Castro-Almeida, Victor Pereira Rochetti, Sonia Rozental, Eliana Barreto-Bergter

Source: Journal of Fungi, Vol 7, Iss 10, p 803 (2021)

Subject Terms: Pathogen Box, Scedosporium, antifungal drugs, drug repurposing, biofilm, fungal growth, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2309-608X/7/10/803; https://doaj.org/toc/2309-608X

Access URL: https://doaj.org/article/082f47a1ad56486e92576361bdd046f4

Preclinical Studies in Anti-Trypanosomatidae Drug Development

Authors: Cintya Perdomo, Elena Aguilera, Ileana Corvo, Paula Faral-Tello, Elva Serna, Carlos Robello, Shane R. Wilkinson, Gloria Yaluff, Guzmán Alvarez

Source: Pharmaceuticals, Vol 14, Iss 7, p 644 (2021)

Subject Terms: anti-trypanosomatid, arylidene ketones, thiazolidene hydrazines, Pathogen box, veterinary isolates, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/7/644; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/412137f8cd824fe4af8561229996da07

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

Authors: Sarah Preston, Yaqing Jiao, Abdul Jabbar, Sean L. McGee, Benoît Laleu, Paul Willis, Timothy N.C. Wells, Robin B. Gasser

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 329-334 (2016)

Subject Terms: Haemonchus contortus, Anthelmintic screening, Pathogen Box, Tolfenpyrad, Mitochondrial respiratory chain, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320716300525; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/db3a431160a7488cabe0d23839f5dadc

Evaluating New Compounds to Treat Burkholderia pseudomallei Infections

Authors: Brittany N. Ross, Julia N. Myers, Laura A. Muruato, Daniel Tapia, Alfredo G. Torres

Source: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Subject Terms: Burkholderia, antibiotic resistance, persistence, pathogen box, treatment, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2018.00210/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/bb85445d0678490093a0f4b64a6f2f6a

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

Authors: Jian Liang Low, Mu-Lu Wu, Dinah Binte Aziz, Benoît Laleu, Thomas Dick

Source: Frontiers in Microbiology, Vol 8 (2017)

Subject Terms: pathogen box, NTM, Mycobacterium avium, Mycobacterium abscessus, drug screening, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2017.01539/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/bb67ccc7c43a475a89bcd5150a68470c

Discovery of a Novel Antifungal Agent in the Pathogen Box

Authors: François L. Mayer, James W. Kronstad

Source: mSphere, Vol 2, Iss 2 (2017)

Subject Terms: antifungal drug, Candida albicans, Cryptococcus gattii, Cryptococcus neoformans, Pathogen Box, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/217d8ba7035a4a5caea4d88acd988b93