CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

Authors: Pusapati, Ganesh V., Kong, Jennifer H., Patel, Bhaven B., Krishnan, Arunkumar, Sagner, Andreas, Kinnebrew, Maia, Briscoe, James, Aravind, L., Rohatgi, Rajat

Source: In Developmental Cell 8 January 2018 44(1):113-129

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

Authors: Patel, Bhaven B.^1,2, Lebensohn, Andres M.^1,2 andres.lebensohn@nih.gov, Pusapati, Ganesh V.¹, Carette, Jan E.³, Salzman, Julia^1,4 julia.salzman@stanford.edu, Rohatgi, Rajat^1,2 rrohatgi@stanford.edu

Source: PLoS ONE. 1/29/2019, Vol. 14 Issue 1, p1-21. 21p.

Subject Terms: *HAPLOIDY, *BIOINFORMATICS, *GENETIC regulation, *NON-coding RNA, *WNT signal transduction

Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.

Authors: Kong, Jennifer H., Young, Cullen B., Pusapati, Ganesh V., Espinoza, F. Hernán, Patel, Chandni B., Beckert, Francis, Ho, Sebastian, Patel, Bhaven B., Gabriel, George C., Aravind, L., Bazan, J. Fernando, Gunn, Teresa M., Lo, Cecilia W., Rohatgi, Rajat

Source: Development (09501991); Oct2021, Vol. 148 Issue 19, p1-17, 17p

Subject Terms: HEDGEHOG signaling proteins, HUMAN abnormalities, MULTIPLE birth, MEMBRANE proteins, SMALL molecules

Avoidable Serum Potassium Testing in the Cardiac ICU: Development and Testing of a Machine-Learning Model.

Authors: Patel, Bhaven B., Sperotto, Francesca, Molina, Mathieu, Kimura, Satoshi, Delgado, Marlon I., Santillana, Mauricio, Kheir, John N.

Source: Pediatric Critical Care Medicine; Apr2021, Vol. 22 Issue 4, p392-400, 9p

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Title: Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Authors: Lebensohn, Andres M., Dubey, Ramin, Neitzel, Leif R., Tacchelly-Benites, Ofelia, Eungi Yang, Marceau, Caleb D., Davis, Eric M., Patel, Bhaven B., Bahrami-Nejad, Zahra, Travaglini, Kyle J., Ahmed, Yashi, Lee, Ethan, Carette, Jan E., Rohatgi, Rajat

Source: eLife; 2016, following p1-115, 129p

Direct ionic stress sensing and mitigation by the transcription factor NFAT5.

Authors: Khandwala, Chandni B.¹, Sarkar, Parijat¹, Schmidt, H. Broder¹, Mengxiao Ma¹, Pusapati, Ganesh V.¹, Lamoliatte, Frederic², Kinnebrew, Maia¹, Patel, Bhaven B.¹, Tillo, Desiree³, Lebensohn, Andres M.⁴, Rohatgi, Rajat¹ rrohatgi@stanford.edu

Source: Science Advances. 2/21/2025, Vol. 11 Issue 8, p1-24. 24p.

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