Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09–09): a randomised, open-label, multicentre, phase 3 trial

Authors: Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Kühn, Michael W.M., Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Wattad, Mohammad, Götze, Katharina, Fransecky, Lars, Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Ringhoffer, Mark, Greil, Richard, Hertenstein, Bernd, Krauter, Jürgen, Martens, Uwe M., Nachbaur, David, Samra, Maisun Abu, Machherndl-Spandl, Sigrid, Basara, Nadezda, Leis, Claudia, Schrade, Anika, Kapp-Schwoerer, Silke, Cocciardi, Sibylle, Bullinger, Lars, Thol, Felicitas, Heuser, Michael, Paschka, Peter, Gaidzik, Verena I., Saadati, Maral, Benner, Axel, Schlenk, Richard F., Döhner, Konstanze, Ganser, Arnold, Kühn, Michael W M, Wattad, Mohammed, Martens, Uwe M, Gaidzik, Verena I, Schlenk, Richard F

Source: In The Lancet Haematology July 2023 10(7):e495-e509

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications

Authors: Döhner, Hartmut ^*, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald, Salih, Helmut, Lübbert, Michael, Kühn, Michael W.M., Schroeder, Thomas, Salwender, Hans, Götze, Katharina, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I., Theis, Frauke, Thol, Felicitas, Heuser, Michael, Schlenk, Richard F., Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard, Stone, Richard, Döhner, Konstanze, Ganser, Arnold

Source: In Blood Advances 27 September 2022 6(18):5345-5355

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin

Authors: Schmalbrock, Laura K., Dolnik, Anna, Cocciardi, Sibylle, Sträng, Eric, Theis, Frauke, Jahn, Nikolaus, Panina, Ekaterina, Blätte, Tamara J., Herzig, Julia, Skambraks, Sabrina, Rücker, Frank G., Gaidzik, Verena I., Paschka, Peter, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Schroeder, Thomas, Lübbert, Michael, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Larson, Richard A., Ganser, Arnold, Stunnenberg, Hendrik G., Minucci, Saverio, Stone, Richard M., Bloomfield, Clara D., Döhner, Hartmut, Döhner, Konstanze ^{*, *}, Bullinger, Lars ^*

Source: In Blood 3 June 2021 137(22):3093-3104

Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations

Authors: Heuser, Michael ^{*, **}, Heida, Bennet ^*, Büttner, Konstantin, Wienecke, Clara Philine, Teich, Katrin, Funke, Carolin, Brandes, Maximilian, Klement, Piroska, Liebich, Alessandro, Wichmann, Martin, Neziri, Blerina, Chaturvedi, Anuhar, Kloos, Arnold, Mintzas, Konstantinos, Gaidzik, Verena I., Paschka, Peter, Bullinger, Lars, Fiedler, Walter, Heim, Albert, Puppe, Wolfram, Krauter, Jürgen, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Stadler, Michael, Hambach, Lothar, Gabdoulline, Razif, Thol, Felicitas ^*

Source: In Blood Advances 11 May 2021 5(9):2294-2304

The urine light chain/glomerular filtration rate (GFR) quotient shows a high sensitivity and specificity to detect cast nephropathy in monoclonal light chain disease

Authors: Bergner, Raoul, Hoffmann, Martin, Uppenkamp, Michael, Paschka, Peter, Klank, David

Source: European journal of haematology. 106(6):836-841

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122620800.0x000001&indx=1&recIds=ETOCvdc_100122620800.0x000001

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial

Authors: Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze ^*

Source: In Blood 24 December 2020 136(26):3041-3050

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

Authors: Jahn, Nikolaus, Terzer, Tobias, Sträng, Eric, Dolnik, Anna, Cocciardi, Sibylle, Panina, Ekaterina, Corbacioglu, Andrea, Herzig, Julia, Weber, Daniela, Schrade, Anika, Götze, Katharina, Schröder, Thomas, Lübbert, Michael, Wellnitz, Dominique, Koller, Elisabeth, Schlenk, Richard F., Gaidzik, Verena I., Paschka, Peter, Rücker, Frank G., Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Bullinger, Lars ^*, Döhner, Konstanze ^*

Source: In Blood Advances 22 December 2020 4(24):6342-6352

Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Authors: Rücker, Frank G. ^*, Agrawal, Mridul ^*, Corbacioglu, Andrea ^*, Weber, Daniela, Kapp-Schwoerer, Silke, Gaidzik, Verena I., Jahn, Nikolaus, Schroeder, Thomas, Wattad, Mohammed, Lübbert, Michael, Koller, Elisabeth, Kindler, Thomas, Götze, Katharina, Ringhoffer, Mark, Westermann, Jörg, Fiedler, Walter, Horst, Heinz A., Greil, Richard, Schroers, Roland, Mayer, Karin, Heinicke, Thomas, Krauter, Jürgen, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, Döhner, Konstanze

Source: In Blood 7 November 2019 134(19):1608-1618

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Authors: Schlenk, Richard F. ^*, Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, Döhner, Hartmut

Source: In Blood 21 February 2019 133(8):840-851

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Authors: Thol, Felicitas, Gabdoulline, Razif, Liebich, Alessandro, Klement, Piroska, Schiller, Johannes, Kandziora, Christian, Hambach, Lothar, Stadler, Michael, Koenecke, Christian, Flintrop, Madita, Pankratz, Mira, Wichmann, Martin, Neziri, Blerina, Büttner, Konstantin, Heida, Bennet, Klesse, Sabrina, Chaturvedi, Anuhar, Kloos, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Gaidzik, Verena I., Bullinger, Lars, Fiedler, Walter, Heim, Albert, Hamwi, Iyas, Eder, Matthias, Krauter, Jürgen, Schlenk, Richard F., Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Heuser, Michael ^**

Source: In Blood 18 October 2018 132(16):1703-1713

NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Authors: Rudorf, Alina, Müller, Tony Andreas, Klingeberg, Cathrin, Kreutmair, Stefanie, Poggio, Teresa, Gorantla, Sivahari Prasad, Rückert, Tamina, Schmitt-Graeff, Annette, Gengenbacher, Anina, Paschka, Peter

Source: Blood. 134(4):383-388

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620919080&indx=1&recIds=ETOCRN620919080

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

Authors: Cocciardi, Sibylle, Dolnik, Anna, Kapp-Schwoerer, Silke, Rücker, Frank, Lux, Susanne, Blätte, Tamara, Skambraks, Sabrina, Krönke, Jan, Heidel, Florian, Schnöder, Tina, Corbacioglu, Andrea, Gaidzik, Verena, Paschka, Peter, Teleanu, Veronica, Göhring, Gudrun, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Weber, Daniela, Sträng, Eric, Kestler, Hans, Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze

Source: Nature communications. 10(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135459753.0x000001&indx=1&recIds=ETOCvdc_100135459753.0x000001

The Urine Light Chain/eGFR Quotient as a Tool to Rule out Cast Nephropathy in Myeloma-Associated Kidney Failure.

Authors: Klank, David, Löffler, Christian, Friedrich, Julian, Hoffmann, Martin, Paschka, Peter, Bergner, Raoul

Source: Biomedicines; May2024, Vol. 12 Issue 5, p1032, 10p

Subject Terms: QUOTIENT rule, KIDNEY failure, EPIDERMAL growth factor receptors, KIDNEY diseases, RENAL biopsy, GLOMERULAR filtration rate

Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial

Authors: Paschka, Peter, Schlenk, Richard, Weber, Daniela, Benner, Axel, Bullinger, Lars, Heuser, Michael, Gaidzik, Verena, Thol, Felicitas, Agrawal, Mridul, Teleanu, Veronica, Lübbert, Michael, Fiedler, Walter, Radsak, Markus, Krauter, Jürgen, Horst, Heinz-A., Greil, Richard, Mayer, Karin, Kündgen, Andrea, Martens, Uwe, Heil, Gerhard, Salih, Helmut, Hertenstein, Bernd, Schwänen, Carsten, Wulf, Gerald, Lange, Elisabeth, Pfreundschuh, Michael, Ringhoffer, Mark, Girschikofsky, Michael, Heinicke, Thomas, Kraemer, Doris, Göhring, Gudrun, Ganser, Arnold, Döhner, Konstanze, Döhner, Hartmut

Source: Leukemia. 32(7):1621-1630

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132430087.0x000001&indx=1&recIds=ETOCvdc_100132430087.0x000001

Gene expression analysis of decitabine treated AML: high impact of tumor suppressor gene expression changes

Authors: Bohl, Stephan R., Dolnik, Anna, Jensen, Thomas, Lang, Katharina M., Hackanson, Björn, Gaidzik, Verena I., Paschka, Peter, Knudsen, Steen, Döhner, Konstanze, Döhner, Hartmut, Claus, Rainer, Lübbert, Michael, Bullinger, Lars

Source: Leukemia & lymphoma. 58(9):2264-2267

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049436763.0x000001&indx=1&recIds=ETOCvdc_100049436763.0x000001

Palbociclib in Acute Leukemias With KMT2A-rearrangement: Results of AMLSG 23-14 Trial

Authors: Gaidzik, Verena I., Paschka, Peter, Schlenk, Richard F., Weber, Daniela, Fröhling, Stefan, Krämer, Alwin, Wäsch, Ralph, Westermann, Jörg, Mayer, Karin, de Wit, Maike, Fiedler, Walter, Benner, Axel, Heuser, Michael, Thol, Felicitas, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut

Source: HemaSphere. 7(5):e877-e877

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190877401.0x000001&indx=1&recIds=ETOCvdc_100190877401.0x000001

Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation

Authors: Schlenk, Richard F. ^*, Kayser, Sabine, Bullinger, Lars, Kobbe, Guido, Casper, Jochen, Ringhoffer, Mark, Held, Gerhard, Brossart, Peter, Lübbert, Michael, Salih, Helmut R., Kindler, Thomas, Horst, Heinz A., Wulf, Gerald, Nachbaur, David, Götze, Katharina, Lamparter, Alexander, Paschka, Peter, Gaidzik, Verena I., Teleanu, Veronica, Späth, Daniela, Benner, Axel, Krauter, Jürgen, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

Source: In Blood 27 November 2014 124(23):3441-3449

Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

Authors: Tassara, Michela, Döhner, Konstanze, Brossart, Peter, Held, Gerhard, Götze, Katharina, Horst, Heinz-A., Ringhoffer, Mark, Köhne, Claus-Henning, Kremers, Stephan, Raghavachar, Aruna, Wulf, Gerald, Kirchen, Heinz, Nachbaur, David, Derigs, Hans Günter, Wattad, Mohammed, Koller, Elisabeth, Brugger, Wolfram, Matzdorff, Axel, Greil, Richard, Heil, Gerhard, Paschka, Peter, Gaidzik, Verena I., Göttlicher, Martin, Döhner, Hartmut, Schlenk, Richard F. ^*

Source: In Blood 26 June 2014 123(26):4027-4036

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

Authors: Stilgenbauer, Stephan ^*, Schnaiter, Andrea, Paschka, Peter, Zenz, Thorsten, Rossi, Marianna, Döhner, Konstanze, Bühler, Andreas, Böttcher, Sebastian, Ritgen, Matthias, Kneba, Michael, Winkler, Dirk, Tausch, Eugen, Hoth, Patrick, Edelmann, Jennifer, Mertens, Daniel, Bullinger, Lars, Bergmann, Manuela, Kless, Sabrina, Mack, Silja, Jäger, Ulrich, Patten, Nancy, Wu, Lin, Wenger, Michael K., Fingerle-Rowson, Günter, Lichter, Peter, Cazzola, Mario, Wendtner, Clemens M., Fink, Anna M., Fischer, Kirsten, Busch, Raymonde, Hallek, Michael, Döhner, Hartmut

Source: In Blood 22 May 2014 123(21):3247-3254

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA

Authors: Schlenk, Richard F. ^*, Taskesen, Erdogan, van Norden, Yvette, Krauter, Jürgen, Ganser, Arnold, Bullinger, Lars, Gaidzik, Verena I., Paschka, Peter, Corbacioglu, Andrea, Göhring, Gudrun, Kündgen, Andrea, Held, Gerhard, Götze, Katharina, Vellenga, Edo, Kuball, Juergen, Schanz, Urs, Passweg, Jakob, Pabst, Thomas, Maertens, Johan, Ossenkoppele, Gert J., Delwel, Ruud, Döhner, Hartmut, Cornelissen, Jan J., Döhner, Konstanze, Löwenberg, Bob ^*

Source: In Blood 29 August 2013 122(9):1576-1582