LET measurements and simulation modelling of the charged particle field for the Clatterbridge ocular proton therapy beamline

Authors: Yap, Jacinta S. L., Bal, Navrit J. S., Brooke, Mark D., Oancea, Cristina, Granja, Carlos, Kacperek, Andrzej, Jolly, Simon, Heuvel, Frank Van den, Parsons, Jason L., Welsch, Carsten P.

Subject Terms: Physics - Medical Physics, Physics - Instrumentation and Detectors

Access URL: http://arxiv.org/abs/2501.17404

The Potential for Targeting G 2 /M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy.

Authors: Melia, Emma¹ (AUTHOR) exm307@student.bham.ac.uk, Parsons, Jason L.^1,2 (AUTHOR) j.parsons.3@bham.ac.uk

Source: Cancers. Sep2024, Vol. 16 Issue 17, p3016. 23p.

Subject Terms: *PROTEIN kinase inhibitors, *RADIOTHERAPY, *CELL cycle, *CANCER patients, *RADIATION-sensitizing agents, *DNA damage, *CELL death, *DNA repair

KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein–Protein Interactions to Promote Cancer Cell Survival

Authors: Saleh, Hadil, Liloglou, Triantafillos, Rigden, Daniel J., Parsons, Jason L., Grundy, Gabrielle J.

Source: In Journal of Molecular Biology 15 February 2024 436(4)

Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons.

Authors: Melia, Emma, Fisch, Anne-Sophie, Tinhofer, Ingeborg, Parsons, Jason L.

Source: Cell Death & Disease; 2/25/2025, Vol. 16 Issue 1, p1-10, 10p

Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness.

Authors: Punshon, Leah D., Fabbrizi, Maria Rita, Phoenix, Ben, Green, Stuart, Parsons, Jason L.

Source: Cells (2073-4409); Dec2024, Vol. 13 Issue 24, p2065, 26p

Subject Terms: BORON-neutron capture therapy, LINEAR energy transfer, DNA repair, DNA damage, HELIUM ions

HDAC Inhibitors Can Enhance Radiosensitivity of Head and Neck Cancer Cells Through Suppressing DNA Repair.

Authors: Antrobus, Jennifer, Mackinnon, Bethany, Melia, Emma, Hughes, Jonathan R., Parsons, Jason L.

Source: Cancers; Dec2024, Vol. 16 Issue 23, p4108, 14p

Subject Terms: SURVIVAL, DIAGNOSTIC imaging, RESEARCH funding, HEAD & neck cancer, RADIATION, ENZYMES, CELLULAR signal transduction, TREATMENT effectiveness, FLUORESCENT antibody technique, CELL lines, RADIATION-sensitizing agents, DNA repair, DNA damage, MICROSCOPY, HISTONE deacetylase, EPIDERMAL growth factor receptors, CHEMICAL inhibitors

MicroRNA‐184 is induced by store‐operated calcium entry and regulates early keratinocyte differentiation

Authors: Richardson, Adam, Powell, Andrew K., Sexton, Darren W., Parsons, Jason L., Reynolds, Nick J., Ross, Kehinde

Source: Journal of cellular physiology. 235(10):6854-6861

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133141000.0x000001&indx=1&recIds=ETOCvdc_100133141000.0x000001

Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling

Authors: Madders, Eleanor C. E. T., Parsons, Jason L.

Source: Advances in experimental medicine and biology. 1241:59-76

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624201357&indx=1&recIds=ETOCRN624201357

Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage

Authors: Carter, Rachel J., Nickson, Catherine M., Thompson, James M., Kacperek, Andrzej, Hill, Mark A., Parsons, Jason L.

Source: International journal of radiation oncology, biology, physics. 104(3):656-665

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082100932.0x000001&indx=1&recIds=ETOCvdc_100082100932.0x000001

Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia.

Authors: Hill, Rhianna M., Li, Chun, Hughes, Jonathan R., Rocha, Sonia, Grundy, Gabrielle J., Parsons, Jason L.

Source: Journal of Cellular & Molecular Medicine; Jun2024, Vol. 28 Issue 12, p1-11, 11p

Subject Terms: DOUBLE-strand DNA breaks, AUTOPHAGY, HYPOXIA-inducible factors, HYPOXEMIA, SQUAMOUS cell carcinoma

Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation.

Authors: Fabbrizi, Maria Rita, Doggett, Thomas J., Hughes, Jonathan R., Melia, Emma, Dufficy, Elizabeth R., Hill, Rhianna M., Goula, Amalia, Phoenix, Ben, Parsons, Jason L.

Source: Cell Death Discovery; 6/12/2024, Vol. 10 Issue 1, p1-10, 10p

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

Authors: Carter, Rachel J., Nickson, Catherine M., Thompson, James M., Kacperek, Andrzej, Hill, Mark A., Parsons, Jason L.

Source: International journal of radiation oncology, biology, physics. 100(3):776-784

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131612650.0x000001&indx=1&recIds=ETOCvdc_100131612650.0x000001

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.

Authors: Fabbrizi, Maria Rita, Nickson, Catherine M., Hughes, Jonathan R., Robinson, Emily A., Vaidya, Karthik, Rubbi, Carlos P., Kacperek, Andrzej, Bryant, Helen E., Helleday, Thomas, Parsons, Jason L.

Source: Cell Death & Disease; Feb2024, Vol. 15 Issue 2, p1-11, 11p

Regulation of base excision repair proteins by ubiquitylation

Authors: Edmonds, Matthew J., Parsons, Jason L.

Source: In Experimental Cell Research 15 November 2014 329(1):132-138

Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR‐edited cells.

Authors: Guerra Liberal, Francisco D. C.¹ (AUTHOR) f.liberal@qub.ac.uk, Parsons, Jason L.² (AUTHOR), McMahon, Stephen J.¹ (AUTHOR)

Source: Medical Physics. Jan2024, Vol. 51 Issue 1, p591-600. 10p.

Subject Terms: *LINEAR energy transfer, *CRISPRS, *RADIATION tolerance, *DNA repair, *DOUBLE-strand DNA breaks, *ALPHA rays, *HEART beat, *GENE knockout

Co-ordination of base excision repair and genome stability

Authors: Parsons, Jason L., Dianov, Grigory L.

Source: In DNA Repair 1 May 2013 12(5):326-333

DNA damage and repair dependencies of ionising radiation modalities.

Authors: Melia, Emma¹, Parsons, Jason L.¹

Source: Bioscience Reports. Oct2023, Vol. 43 Issue 10, p1-15. 15p.

Subject Terms: *DNA repair, *DNA damage, *PROTON therapy, *LINEAR energy transfer, *DOSE-response relationship (Radiation), *PHOTON emission

Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination

Authors: Markkanen, Enni, van Loon, Barbara, Ferrari, Elena, Parsons, Jason L., Dianov, Grigory L., Hübscher, Ulrich

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Jan 01. 109(2), 437-442.

Access URL: https://www.jstor.org/stable/23075990

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage

Authors: Khoronenkova, Svetlana V., Dianova, Irina I., Ternette, Nicola, Kessler, Benedikt M., Parsons, Jason L., Dianov, Grigory L.

Source: In Molecular Cell 30 March 2012 45(6):801-813

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair

Authors: Ström, Cecilia E., Mortusewicz, Oliver, Finch, David, Parsons, Jason L., Lagerqvist, Anne, Johansson, Fredrik, Schultz, Niklas, Erixon, Klaus, Dianov, Grigory L., Helleday, Thomas

Source: In DNA Repair 2011 10(9):961-969