Suppression of stress granule formation is a vulnerability imposed by mutant p53.

Authors: Thoenen, Elizabeth, Ranjan, Atul, Parrales, Alejandro, Nishikawa, Shigeto, Dixon, Dan A., Oka, Sugako, Iwakuma, Tomoo

Source: Nature Communications; 3/10/2025, Vol. 16 Issue 1, p1-17, 17p

Subject Terms: STRESS granules, DRUG resistance in cancer cells, MEDICAL sciences, MISSENSE mutation, HEPATOCELLULAR carcinoma, P53 antioncogene

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

Authors: Ghosh, Monisankar, Saha, Suchandrima, Bettke, Julie, Nagar, Rachana, Parrales, Alejandro, Iwakuma, Tomoo, van der Velden, Adrianus W.M., Martinez, Luis A.

Source: In Cancer Cell 12 April 2021 39(4):494-508

The interplay between mutant p53 and the mevalonate pathway

Authors: Parrales, Alejandro, Thoenen, Elizabeth, Iwakuma, Tomoo

Source: Cell death and differentiation. 25(3):460-470

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190841502.0x000001&indx=1&recIds=ETOCvdc_100190841502.0x000001

Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways

Authors: Lee-Rivera, Irene, López, Edith, Parrales, Alejandro, Alvarez-Arce, Alejandro, López-Colomé, Ana María

Source: In Experimental Eye Research October 2015 139:81-89

The interplay between mutant p53 and the mevalonate pathway

Authors: Parrales, Alejandro, Thoenen, Elizabeth, Iwakuma, Tomoo

Source: Cell death and differentiation. 25(3):460-470

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129992543.0x000001&indx=1&recIds=ETOCvdc_100129992543.0x000001

ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation

Authors: Parrales, Alejandro, López, Edith, Lee-Rivera, Irene, López-Colomé, Ana María

Source: In Cellular Signalling April 2013 25(4):829-838

Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.

Authors: Gonzalez, Elizabeth, Ahmed, Atif A., McCarthy, Laura, Chastain, Katherine, Habeebu, Sahibu, Zapata-Tarres, Marta, Cardenas-Cardos, Rocio, Velasco-Hidalgo, Liliana, Corcuera-Delgado, Celso, Rodriguez-Jurado, Rodolfo, García-Rodríguez, Lilia, Parrales, Alejandro, Iwakuma, Tomoo, Farooqi, Midhat S., Lee, Brian, Weir, Scott J., Flatt, Terrie G.

Source: Cancers; Apr2023, Vol. 15 Issue 8, p2230, 12p

Subject Terms: RESEARCH, IMMUNOHISTOCHEMISTRY, RNA-binding proteins, HISPANIC Americans, MICRORNA, METASTASIS, RETROSPECTIVE studies, ACQUISITION of data, CANCER relapse, CELL nuclei, RISK assessment, CANCER patients, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, TUMOR markers, PROGRESSION-free survival, EWING'S sarcoma, DISEASE risk factors, CHILDREN, ADOLESCENCE

Geographic Terms: MISSOURI

DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen.

Authors: Nishikawa, Shigeto, Kaida, Atsushi, Parrales, Alejandro, Ranjan, Atul, Alalem, Mohamed, Ren, Hongyi, Schoenen, Frank J., Johnson, David K., Iwakuma, Tomoo

Source: Cell Death Discovery; 10/31/2022, Vol. 8 Issue 1, p1-18, 18p

Comparative oncology approach to drug repurposing in osteosarcoma.

Authors: Parrales, Alejandro¹, McDonald, Peter², Ottomeyer, Megan¹, Roy, Anuradha^2,3, Shoenen, Frank J.^3,4, Broward, Melinda^3,5, Bruns, Tyce⁵, Thamm, Douglas H.^6,7, Weir, Scott J.^3,5,8,9, Neville, Kathleen A.¹⁰, Iwakuma, Tomoo^1,3,11 twakuma@kumc.edu, Fulbright, Joy M.^3,8,11 jmfulbright@cmh.edu

Source: PLoS ONE. 3/26/2018, Vol. 13 Issue 3, p1-16. 16p.

Subject Terms: *OSTEOSARCOMA, *ANTINEOPLASTIC agents, *SURVIVAL analysis (Biometry), *COMPARATIVE studies, *DRUG development, *DRUG interactions, *THERAPEUTICS

Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.

Authors: Alalem, Mohamed, Bhosale, Mrinalini, Ranjan, Atul, Yamamoto, Satomi, Kaida, Atsushi, Nishikawa, Shigeto, Parrales, Alejandro, Farooki, Sana, Anant, Shrikant, Padhye, Subhash, Iwakuma, Tomoo

Source: Cancers; Sep2022, Vol. 14 Issue 17, p4187, 17p

Subject Terms: MOLECULAR structure, CELL lines, CARRIER proteins

p53 as a Regulator of Lipid Metabolism in Cancer.

Authors: Parrales, Alejandro¹ aparrales@kumc.edu, Tomoo Iwakuma¹ tiwakuma@kumc.edu

Source: International Journal of Molecular Sciences. Dec2016, Vol. 17 Issue 12, p2074. 11p. 1 Diagram, 2 Charts.

Subject Terms: *CANCER cells, *LIPID metabolism, *CANCER invasiveness, *DNA repair, *TUMOR suppressor proteins

DNAJA1 promotes cancer metastasis through interaction with mutant p53

Authors: Kaida, Atsushi, Yamamoto, Satomi, Parrales, Alejandro, Young, Eric D., Ranjan, Atul, Alalem, Mohamed A., Morita, Kei-ichi, Oikawa, Yu, Harada, Hiroyuki, Ikeda, Tohru, Thomas, Sufi M., Diaz, Francisco j., Iwakuma, Tomoo

Source: Oncogene; August 2021, Vol. 40 Issue: 31 p5013-5025, 13p

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Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression.

Authors: Iyer, Swathi V., Ranjan, Atul, Elias, Harold K., Parrales, Alejandro, Sasaki, Hiromi, Roy, Badal C., Umar, Shahid, Tawfik, Ossama W., Iwakuma, Tomoo

Source: Nature Communications; Nov2016, Vol. 7 Issue 11, p13561, 1p