Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling

Authors: Parra‐Guillen, Zinnia P., Sancho‐Araiz, Aymara, Mayawala, Kapil, Zalba, Sara, Garrido, Maria J., Alwis, Dinesh, Troconiz, Iñaki F., Freshwater, Tomoko

Source: Clinical pharmacology & therapeutics. 114(3):623-632

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Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation

Authors: Riva, Natalia, Ibarra, Manuel, Parra‐Guillen, Zinnia P., Galván, Maria Eugenia, Pérez, Erika, Trezeguet Renatti, Guido, Cáceres Guido, Paulo, Lopez, Clarisa, Licciardone, Nieves, Halac, Esteban, Dip, Marcelo, Cruz, Alejandro, Imventarza, Oscar, Buamscha, Daniel, Troconiz, Iñaki F., Schaiquevich, Paula

Source: British journal of clinical pharmacology. 89(3):1115-1126

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Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer

Authors: Vera‐Yunca, Diego, Parra‐Guillen, Zinnia P., Girard, Pascal, Trocóniz, Iñaki F., Terranova, Nadia

Source: British journal of clinical pharmacology. 88(1):166-177

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Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria

Authors: Vera‐Yunca, Diego, Córdoba, Karol M., Parra‐Guillen, Zinnia P., Jericó, Daniel, Fontanellas, Antonio, Trocóniz, Iñaki F.

Source: British journal of pharmacology. 179(14):3815-3830

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Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies.

Authors: Lefèvre, Apolline, Parra-Guillen, Zinnia P., Trocóniz, Iñaki F., Boetsch, Christophe, Frances, Nicolas

Source: Frontiers in Immunology; 2025, p1-11, 11p

Subject Terms: CYTOKINE release syndrome, IMMUNE system, T cells, CYTOKINES, CD3 antigen

Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment.

Authors: Sancho-Araiz, Aymara^1,2 (AUTHOR), Parra-Guillen, Zinnia P.^1,2 (AUTHOR), Bragard, Jean^3,4 (AUTHOR), Ardanza, Sergio^3,4 (AUTHOR), Mangas-Sanjuan, Victor^5,6 (AUTHOR), Trocóniz, Iñaki F.^1,2,4 (AUTHOR) itroconiz@unav.es

Source: PLoS Computational Biology. 10/4/2023, Vol. 19 Issue 10, p1-18. 18p. 1 Diagram, 1 Chart, 8 Graphs.

Subject Terms: *TUMOR microenvironment, *TUMOR growth, *CELL anatomy, *CANCER cells, *CANCER treatment

A quantitative systems pharmacology model for acute viral hepatitis B

Authors: Asín-Prieto, Eduardo, Parra-Guillen, Zinnia P., Gómez Mantilla, José David, Vandenbossche, Joris, Stuyckens, Kim, de Trixhe, Xavier Woot, Perez-Ruixo, Juan José, Troconiz, Iñaki F.

Source: In Computational and Structural Biotechnology Journal 2021 19:4997-5007

Pharmacodynamic Model of the Hemodynamic Effects of Propofol and Remifentanil and Their Interaction with Noxious Stimulation †.

Authors: Garraza-Obaldia, Maite, Jaramillo, Sebastian, Parra-Guillen, Zinnia P., Valencia, José F., Gambús, Pedro L., Trocóniz, Iñaki F.

Source: Pharmaceutics; Dec2024, Vol. 16 Issue 12, p1615, 15p

Subject Terms: LARYNGEAL masks, HEART beat, REMIFENTANIL, PROPOFOL, HYPERTENSION

Disentangling Anti‐Tumor Response of Immunotherapy Combinations: A Physiologically Based Framework for V937 Oncolytic Virus and Pembrolizumab.

Authors: Sancho‐Araiz, Aymara, Parra‐Guillen, Zinnia P., Troconiz, Iñaki F., Freshwater, Tomoko

Source: Clinical Pharmacology & Therapeutics; Nov2024, Vol. 116 Issue 5, p1304-1313, 10p

Subject Terms: IMMUNE checkpoint inhibitors, TUMOR treatment, CANCER cells, CANCER treatment, CD8 antigen

A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease

Authors: Balbas-Martinez, Violeta, Asin-Prieto, Eduardo, Parra-Guillen, Zinnia P., Troconiz, Iñaki F. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics March 2020 372(3):299-307

Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model

Authors: Vera-Yunca, Diego, Serrano-Mendioroz, Irantzu, Sampedro, Ana, Jericó, Daniel, Trocóniz, Iñaki F., Fontanellas, Antonio, Parra-Guillén, Zinnia P.

Source: In Molecular Genetics and Metabolism November 2019 128(3):367-375

Immune network for viral hepatitis B: Topological representation

Authors: Asín-Prieto, Eduardo, Parra-Guillen, Zinnia P., Mantilla, José David Gómez, Vandenbossche, Joris, Stuyckens, Kim, de Trixhe, Xavier Woot, Perez-Ruixo, Juan José, Troconiz, Iñaki F.

Source: In European Journal of Pharmaceutical Sciences 1 August 2019 136

Disease pharmacokinetic–pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA‐based therapies

Authors: Parra‐Guillen, Zinnia P., Fontanellas, Antonio, Jiang, Lei, Jericó, Daniel, Martini, Paolo, Vera‐Yunca, Diego, Hard, Marjie, Guey, Lin T., Troconiz, Iñaki F.

Source: British journal of pharmacology. 177(14):3168-3182

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Model‐Informed Dose Selection for Xentuzumab, a Dual Insulin‐Like Growth Factor‐I/II—Neutralizing Antibody

Authors: Parra‐Guillen, Zinnia P., Schmid, Ulrike, Janda, Alvaro, Freiwald, Matthias, Troconiz, Iñaki F.

Source: Clinical pharmacology & therapeutics. 107(3):597-606

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Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts

Authors: Parra-Guillen, Zinnia P. ¹, Mangas-Sanjuan, Victor ^{1, 2}, Garcia-Cremades, Maria ³, Troconiz, Iñaki F., Mo, Gary, Pitou, Celine, Iversen, Philip W., Wallin, Johan E. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics July 2018 366(1):96-104

The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing

Authors: Melin, Johanna, Hartung, Niklas, Parra‐Guillen, Zinnia P., Whitaker, Martin J., Ross, Richard J., Kloft, Charlotte

Source: Clinical endocrinology. 91(1):33-40

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Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer – Proof of concept towards a systems pharmacology approach

Authors: Saafan, Hisham, Foerster, Sarah, Parra-Guillen, Zinnia P., Hammer, Elke, Michaelis, Martin, Cinatl, Jindrich, Jr., Völker, Uwe, Fröhlich, Holger, Kloft, Charlotte, Ritter, Christoph A.

Source: In European Journal of Pharmaceutical Sciences 30 October 2016 94:20-32

Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults

Authors: Melin, Johanna, Parra-Guillen, Zinnia P., Hartung, Niklas, Huisinga, Wilhelm, Ross, Richard J., Whitaker, Martin J., Kloft, Charlotte

Source: Clinical pharmacokinetics. 57(4):515-527

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Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients

Authors: Klopp-Schulze, Lena, Joerger, Markus, Wicha, Sebastian G., ter Heine, Rob, Csajka, Chantal, Parra-Guillen, Zinnia P., Kloft, Charlotte

Source: Clinical pharmacokinetics. 57(2):229-242

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Modeling Tumor Response after Combined Administration of Different Immune-Stimulatory Agents

Authors: Parra-Guillen, Zinnia P., Berraondo, Pedro, Ribba, Benjamin, Trocóniz, Iñaki F. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2013 346(3):432-442