A protocol for simultaneous high-sensitivity genotyping and chromatin accessibility profiling in single cells

Authors: Sven Turkalj, Niels Asger Jakobsen, Angus Groom, Felix A. Radtke, Paresh Vyas

Source: STAR Protocols, Vol 4, Iss 4, Pp 102641- (2023)

Subject Terms: Bioinformatics, Cancer, Genetics, Genomics, Molecular Biology, Sequence Analysis, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723006081; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/74639132d5b741ccbc93ab653e811900

Heterogeneous genetic and non‐genetic mechanisms contribute to response and resistance to azacitidine monotherapy

Authors: Vasiliki Symeonidou, Marlen Metzner, Batchimeg Usukhbayar, Aimee E. Jackson, Sonia Fox, Charles F. Craddock, Paresh Vyas

Source: eJHaem, Vol 3, Iss 3, Pp 794-803 (2022)

Subject Terms: acute myeloid leukaemia, azacitidine, clonal evolution, hypomethylating agents, immune microenvironment, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/0ec7692b03e049f3a63341778660afdb

An Overview of Targeted Therapies in Acute Myeloid Leukemia

Authors: Sven Turkalj, Felix A. Radtke, Paresh Vyas

Source: HemaSphere, Vol 7, Iss 6, p e914 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000914; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/0dc4689a331a427bb2fab8c88e7c5729

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

Authors: Thomas R. Jackson, Aini Vuorinen, Laia Josa-Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V.L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony, Deanne Gracias, Lorna McCall, Robert Westwood, Georg C. Terstappen, Stephen G. Davies, Edward W. Tate, Graham M. Wynne, Paresh Vyas, Angela J. Russell, Thomas A. Milne

Source: iScience, Vol 25, Iss 8, Pp 104787- (2022)

Subject Terms: Chemistry, Biological sciences, Molecular biology, Molecular medicine, Cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222010598; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/41383f2f5a8d4ffeb2940ad8bb573d15

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Authors: Ivo S. Muskens, Shaobo Li, Thomas Jackson, Natalina Elliot, Helen M. Hansen, Swe Swe Myint, Priyatama Pandey, Jeremy M. Schraw, Ritu Roy, Joaquin Anguiano, Katerina Goudevenou, Kimberly D. Siegmund, Philip J. Lupo, Marella F. T. R. de Bruijn, Kyle M. Walsh, Paresh Vyas, Xiaomei Ma, Anindita Roy, Irene Roberts, Joseph L. Wiemels, Adam J. de Smith

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/638c652373704f3aa4579682f8dc481e

Entropy Analysis for boundary layer Micropolar fluid flow

Authors: Paresh Vyas, Rajesh Kumar Kasana, Sahanawaz Khan

Source: AIMS Mathematics, Vol 5, Iss 3, Pp 2009-2026 (2020)

Subject Terms: micropolar fluid, porous medium, entropy, Mathematics, QA1-939

File Description: electronic resource

Relation: https://www.aimspress.com/article/10.3934/math.2020133/fulltext.html; https://doaj.org/toc/2473-6988

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DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Authors: Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne

Source: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e4a9cce559524c16a138443251705752

Disease Models & Mechanisms announces a new Editor-in-Chief

Authors: Paresh Vyas

Source: Disease Models & Mechanisms, Vol 13, Iss 12 (2020)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/13/12/dmm048652; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/3d3f6653377c4683956a335df516ba58

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

Authors: Gaëtan Juban, Nathalie Sakakini, Hedia Chagraoui, David Cruz Hernandez, Qian Cheng, Kelly Soady, Bilyana Stoilova, Catherine Garnett, Dominic Waithe, Georg Otto, Jessica Doondeea, Batchimeg Usukhbayar, Elena Karkoulia, Maria Alexiou, John Strouboulis, Edward Morrissey, Irene Roberts, Catherine Porcher, Paresh Vyas

Source: Haematologica, Vol 106, Iss 4 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9780; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/a3502b8fe415487d92a982f33c29512f

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells

Authors: Hedia Chagraoui, Maiken S. Kristiansen, Juan Pablo Ruiz, Ana Serra-Barros, Johanna Richter, Elisa Hall-Ponselé, Nicki Gray, Dominic Waithe, Kevin Clark, Philip Hublitz, Emmanouela Repapi, Georg Otto, Paul Sopp, Stephen Taylor, Supat Thongjuea, Paresh Vyas, Catherine Porcher

Source: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/58afad89e66d460dbd6feaaa3566ef20

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Authors: Laia Josa-Culleré, Thomas J. Cogswell, Irene Georgiou, Morgan Jay-Smith, Thomas R. Jackson, Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell

Source: Molecules, Vol 26, Iss 21, p 6648 (2021)

Subject Terms: acute myeloid leukemia, differentiation, phenotypic screen, CD11b, benzooxazepinones, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/21/6648; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/371c3b38b9e44be49d8dc114324e28ce

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

Authors: Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons, Douglas R. Higgs

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0cd23b9b09ec4af18f7d483a67ceba18

Transient abnormal myelopoiesis without constitutional Down syndrome

Authors: Igne Kairiene, Vaidas Dirse, Ugnius Mickys, Audrone Muleviciene, Paresh Vyas, Jelena Rascon

Source: Journal of Pediatric and Neonatal Individualized Medicine, Vol 9, Iss 1, Pp e090104-e090104 (2019)

Subject Terms: transient abnormal myelopoiesis, congenital leukemia, down syndrome, myelodysplastic syndrome, Medicine, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.jpnim.com/index.php/jpnim/article/view/740; https://doaj.org/toc/2281-0692

Access URL: https://doaj.org/article/6f1934676fe04acbbe7e36199287627e

The Graft-Versus-Leukemia Effect in AML

Authors: Connor Sweeney, Paresh Vyas

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: acute myeloid leukemia, stem cell transplantation, graft-versus-leukemia, graft-versus-host disease, T cells, antigens, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01217/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/dde754b237b74550b873cdc5d22a7322

Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia

Authors: Lynn Quek, Paul Ferguson, Marlen Metzner, Ikhlaaq Ahmed, Alison Kennedy, Catherine Garnett, Sally Jeffries, Claudia Walter, Kim Piechocki, Adele Timbs, Robert Danby, Manoj Raghavan, Andrew Peniket, Mike Griffiths, Andrew Bacon, Janice Ward, Keith Wheatley, Paresh Vyas, Charles Craddock

Source: Blood Advances, Vol 1, Iss 3, Pp 193-204 (2016)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920304250; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/c7aa4ecc15494ffc87dd288a52539336

Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia

Authors: Ross Kinstrie, Dimitris Karamitros, Nicolas Goardon, Heather Morrison, Mike Hamblin, Lisa Robinson, Richard E. Clark, Mhairi Copland, Paresh Vyas

Source: Blood Advances, Vol 1, Iss 3, Pp 160-169 (2016)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920304225; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/cc5b84916719460691ec82068e49351a

Sufficiency criteria for a class of p-valent analytic functions of complex order

Authors: Som Prakash Goyal, Onkar Singh, Paresh Vyas

Source: Le Matematiche, Vol 69, Iss 2, Pp 285-294 (2014)

Subject Terms: Analytic functions, Multivalent functions, starlike function and convex function of complex order, Mathematics, QA1-939

File Description: electronic resource

Relation: http://www.dmi.unict.it/ojs/index.php/lematematiche/article/view/1102; https://doaj.org/toc/0373-3505; https://doaj.org/toc/2037-5298

Access URL: https://doaj.org/article/fe38a9e07abd43cc90d2ddf911070f71

Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

Authors: Kamel El Omari, Sarah J. Hoosdally, Kapil Tuladhar, Dimple Karia, Elisa Hall-Ponselé, Olga Platonova, Paresh Vyas, Roger Patient, Catherine Porcher, Erika J. Mancini

Source: Cell Reports, Vol 4, Iss 1, Pp 135-147 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713002866; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/180f59b26b2445988e1c27f96bd5d220

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Authors: Adam J. Mead, Shabnam Kharazi, Deborah Atkinson, Iain Macaulay, Christian Pecquet, Stephen Loughran, Michael Lutteropp, Petter Woll, Onima Chowdhury, Sidinh Luc, Natalija Buza-Vidas, Helen Ferry, Sally-Ann Clark, Nicolas Goardon, Paresh Vyas, Stefan N. Constantinescu, Ewa Sitnicka, Claus Nerlov, Sten Eirik W. Jacobsen

Source: Cell Reports, Vol 3, Iss 6, Pp 1766-1776 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713002131; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/703445d2063749ebb29c59b6e36d5091

An operational definition of primary refractory acute myeloid leukemia allowing early identification of patients who may benefit from allogeneic stem cell transplantation

Authors: Paul Ferguson, Robert K. Hills, Angela Grech, Sophie Betteridge, Lars Kjeldsen, Michael Dennis, Paresh Vyas, Anthony H. Goldstone, Donald Milligan, Richard E. Clark, Nigel H. Russell, Charles Craddock

Source: Haematologica, Vol 101, Iss 11 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7879; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/f772d011430040108f48560b445e89d7