An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Authors: Zhou, Nian E. ^{1, 9}, Tang, Su ^{1, 9}, Bian, Xuelin ^{1, 9}, Parai, Maloy K. ¹, Krieger, Inna V. ¹, Flores, Armando ¹, Jaiswal, Pradeep K. ¹, Bam, Radha ¹, Wood, Jeremy L. ¹, Shi, Zhe ¹, Stevens, Laura J. ², Scobey, Trevor ³, Diefenbacher, Meghan V. ³, Moreira, Fernando R. ³, Baric, Thomas J. ³, Acharya, Arjun ¹, Shin, Joonyoung ¹, Rathi, Manish M. ¹, Wolff, Karen C. ⁴, Riva, Laura ⁴, Bakowski, Malina A. ⁴, McNamara, Case W. ⁴, Catanzaro, Nicholas J. ³, Graham, Rachel L. ³, Schultz, David C. ⁵, Cherry, Sara ^{5, 6}, Kawaoka, Yoshihiro ⁷, Halfmann, Peter J. ⁷, Baric, Ralph S. ^{3, 8}, Denison, Mark R. ², Sheahan, Timothy P. ^{3, 8, ∗}, Sacchettini, James C. ^{1, 10, ∗∗}

Source: In Cell Reports 26 November 2024 43(11)

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Authors: Aggarwal, Anup, Parai, Maloy K., Shetty, Nishant, Wallis, Deeann, Woolhiser, Lisa, Hastings, Courtney, Dutta, Noton K., Galaviz, Stacy, Dhakal, Ramesh C., Shrestha, Rupesh, Wakabayashi, Shoko, Walpole, Chris, Matthews, David, Floyd, David, Scullion, Paul, Riley, Jennifer, Epemolu, Ola, Norval, Suzanne, Snavely, Thomas, Robertson, Gregory T., Rubin, Eric J., Ioerger, Thomas R., Sirgel, Frik A., van der Merwe, Ruben, van Helden, Paul D., Keller, Peter, Böttger, Erik C., Karakousis, Petros C., Lenaerts, Anne J., Sacchettini, James C.

Source: In Cell 13 July 2017 170(2):249-259

Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange

Authors: Huang, Hsiao-Ling, Krieger, Inna V., Parai, Maloy K., Gawandi, Vijay B., Sacchettini, James C.

Source: In Journal of Biological Chemistry December 2016 291(53):27421-27432

An unexpected reaction of phosphorous tribromide on chromanone, thiochromanone, 3,4-dihydro-2 H-benzo[ b]thiepin-5-one, 3,4-dihydro-2 H-benzo[ b]oxepin-5-one and tetralone derived allylic alcohols: a case study

Authors: Parai, Maloy K., Shagufta, Srivastava, Ajay K., Kassack, Matthias, Panda, Gautam

Source: In Tetrahedron 2008 64(42):9962-9976

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Authors: Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K., Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer

Source: Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p409-423, 15p

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ChemInform Abstract: An Unexpected Reaction of Phosphorous Tribromide on Chromanone, Thiochromanone, 3,4-Dihydro-2H-benzo[b]thiepin-5-one, 3,4-Dihydro-2H-benzo[b]oxepin-5-one and Tetralone Derived Allylic Alcohols: A Case Study.

Authors: Parai, Maloy K., Shagufta, Shagufta, Srivastava, Ajay K., Kassack, Matthias, Panda, Gautam

Source: ChemInform; Feb2009, Vol. 40 Issue 7, pno-no, 1p