Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension

Authors: Abbate, Antonio, Abo-Auda, Wael, Akhtar, Asif, Arad, Michael, Atar, Shaul, Baibhav, Bipul, Brucato, Antonio, Collins, Sean, Colquhoun, David, Cremer, Paul, Cross, David, Dwivedi, Girish, Eisen, Alon, Freedberg, Nahum, Fuchs, Shmuel, Gaddam, Eliyazar, Gattorno, Marco, Gelfand, Eli, Grena, Paul, Halabi, Majdi, Harris, David, Imazio, Massimo, Insalaco, Antonella, Karim, Amin, Klein, Allan, Knowlton, Kirk, Kontzias, Apostolos, Kornberg, Robert, Latif, Faisal, Leibowitz, David, LeWinter, Martin, Lou, Pey Wen, Lin, David, Luis, S. Allen, Nicholls, Stephen, Petersen, John, Portman, Michael, Roberts-Thomson, Philip, Schiff, Elad, Siegel, Robert, Stokes, Michael, Sutej, Paul, Wittekind, Samuel, Witzling, Valentin, Zukermann, Robert, Trotta, Lucia, Cremer, Paul C., Klutstein, Marc, Luis, Sushil A., Wasserstrum, Yishay, Clair, JoAnn, Wang, Sheldon, Klein, Allan L., Paolini, John F.

Source: In CJC Open June 2024 6(6):805-810

Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report

Authors: Mohiuddin, Muhammad M, Singh, Avneesh K, Scobie, Linda, Goerlich, Corbin E, Grazioli, Alison, Saharia, Kapil, Crossan, Claire, Burke, Allen, Drachenberg, Cinthia, Oguz, Cihan, Zhang, Tianshu, Lewis, Billeta, Hershfeld, Alena, Sentz, Faith, Tatarov, Ivan, Mudd, Sarah, Braileanu, Gheorghe, Rice, Kathryn, Paolini, John F, Bondensgaard, Kent, Vaught, Todd, Kuravi, Kasinath, Sorrells, Lori, Dandro, Amy, Ayares, David, Lau, Christine, Griffith, Bartley P

Source: Lancet. 402(10399):397-410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195808787.0x000001&indx=1&recIds=ETOCvdc_100195808787.0x000001

First-in-Human Phase 1 Randomized Trial with the Anti-CD40 Monoclonal Antibody KPL-404: Safety, Tolerability, Receptor Occupancy, and Suppression of T-Cell–Dependent Antibody Response

Authors: Samant, Manoj, Ziemniak, John, Paolini, John F. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics December 2023 387(3):306-314

Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a study

Authors: Sofen, Howard, Bissonnette, Robert, Yosipovitch, Gil, Silverberg, Jonathan I., Tyring, Stephen, Loo, Wei Jing, Zook, Matthew, Lee, Mark, Zou, Liangxing, Jiang, Guang-Liang, Paolini, John F.

Source: In eClinicalMedicine March 2023 57

Longitudinal cardiac magnetic resonance imaging following clinical response to rilonacept and prior to recurrence upon treatment suspension: a RHAPSODY subgroup analysis.

Authors: Cremer, Paul C, Brucato, Antonio, Insalaco, Antonella, Lin, David, Luis, Sushil A, Kwon, Deborah H, Jellis, Christine L, Clair, JoAnn, Curtis, Allison, Wang, Sheldon, Klein, Allan L, Imazio, Massimo, Paolini, John F

Source: European Heart Journal - Cardiovascular Imaging; Jan2025, Vol. 26 Issue 1, p72-79, 8p

Subject Terms: PREDICTIVE tests, RESEARCH funding, BLIND experiment, STATISTICAL sampling, PERICARDITIS, TREATMENT effectiveness, MAGNETIC resonance imaging, DECISION making in clinical medicine, RANDOMIZED controlled trials, DESCRIPTIVE statistics, RECOMBINANT proteins, DISEASE relapse

Preclinical Immunopharmacologic Assessment of KPL-404, a Novel, Humanized, Non-Depleting Antagonistic Anti-CD40 Monoclonal Antibody

Authors: Muralidharan, Sujatha, Njenga, Moses, Garron, Tracy, Bondensgaard, Kent, Paolini, John F. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2022 381(1):12-21

Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization

Authors: Belzberg, Micah, Alphonse, Martin Prince, Brown, Isabelle, Williams, Kyle A., Khanna, Raveena, Ho, Byron, Wongvibulsin, Shannon, Pritchard, Thomas, Roh, Youkyung Sophie, Sutaria, Nishadh, Choi, Justin, Jedrych, Jaroslaw, Johnston, Andrew D., Sarkar, Kakali, Vasavda, Chirag, Meixiong, Jimmy, Dillen, Carly, Bondesgaard, Kent, Paolini, John F., Chen, Wei, Corcoran, David, Devos, Nicolas, Kwatra, Madan M., Chien, Anna L., Archer, Nathan K., Garza, Luis A., Dong, Xinzhong, Kang, Sewon, Kwatra, Shawn G.

Source: In Journal of Investigative Dermatology September 2021 141(9):2208-2218

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial

Authors: Gladish, Deborah, Myers, Karen, Kuramochi, Yuki, Sewell, Christina, Balog, Craig, Kosty Sweeny, Denise, Kandrac, Jill, Spencer, Stephanie, Goyanes, Alice, Sahoo, Debasis, Dugar, Siddharth, Aguillon Prada, Robier, Nichols, Dave, Celiberti, Jeannie, Partisano, Annie, Fang, Fang, Coehlo, Jennifer, Perrin, Randy, Mandell, Brian, Gordon, Steven, Wiedemann, Herbert, Young, James, Greer, Joan, Ho, Ai-Chen, Ladd, Any, Mihalick, Virginia, Montpetit, Alison, O'Brine, Joyce, Owen, Catherine, Pal, Mary, Priday, Anna, Raj Sedhai, Yub, Wohlford, George, Hummel, Nicole, Korbee, Leslie, Cremer, Paul C ^*, Abbate, Antonio, Hudock, Kristin, McWilliams, Carla, Mehta, Jinesh, Chang, Steven Y, Sheng, Calvin C, Van Tassell, Benjamin, Bonaventura, Aldo, Vecchié, Alessandra, Carey, Brenna, Wang, Qiuqing, Wolski, Katherine E, Rajendram, Prabalini, Duggal, Abhijit, Wang, Tisha S, Paolini, John F, Trapnell, Bruce C

Source: In The Lancet Rheumatology June 2021 3(6):e410-e418

The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches

Authors: Mauro, Adolfo G., Bonaventura, Aldo, Vecchié, Alessandra, Mezzaroma, Eleonora, Carbone, Salvatore, Narayan, Pratyush, Potere, Nicola, Cannatà, Antonio, Paolini, John F., Bussani, Rossana, Montecucco, Fabrizio, Sinagra, Gianfranco, Van Tassel, Benjamin W., Abbate, Antonio, Toldo, Stefano

Source: In JACC: Basic to Translational Science February 2021 6(2):137-150

Itch intensity in prurigo nodularis is closely related to dermal interleukin‐31, oncostatin M, IL‐31 receptor alpha and oncostatin M receptor beta

Authors: Hashimoto, Takashi, Nattkemper, Leigh A., Kim, Hei Sung, Kursewicz, Christina D., Fowler, Emilie, Shah, Serena M., Nanda, Sonali, Fayne, Rachel A., Paolini, John F., Romanelli, Paolo, Yosipovitch, Gil

Source: Experimental dermatology. 30(6):804-810

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122643323.0x000001&indx=1&recIds=ETOCvdc_100122643323.0x000001

Clinical Presentation and Outcomes of Acute Pericarditis in a Large Urban Hospital in the United States of America

Authors: Vecchié, Alessandra, Chiabrando, Juan G., Dell, Megan S., Bonaventura, Aldo, Mauro, Adolfo G., Wohlford, George, Van Tassell, Benjamin W., Berrocal, Daniel H., Montecucco, Fabrizio, Beutler, Anna, Paolini, John F., Gal, Tamas S., Abbate, Antonio

Source: In Chest December 2020 158(6):2556-2567

RHAPSODY: Rationale for and design of a pivotal Phase 3 trial to assess efficacy and safety of rilonacept, an interleukin-1α and interleukin-1β trap, in patients with recurrent pericarditis

Authors: Klein, Allan L., Imazio, Massimo, Brucato, Antonio, Cremer, Paul, LeWinter, Martin, Abbate, Antonio, Lin, David, Martini, Alberto, Beutler, Anna, Chang, Steven, Fang, Fang, Gervais, Anais, Perrin, Randy, Paolini, John F.

Source: In American Heart Journal October 2020 228:81-90

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study

Authors: De Luca, Giacomo, Cavalli, Giulio, Campochiaro, Corrado, Della-Torre, Emanuel, Angelillo, Piera, Tomelleri, Alessandro, Boffini, Nicola, Tentori, Stefano, Mette, Francesca, Farina, Nicola, Rovere-Querini, Patrizia, Ruggeri, Annalisa, D'Aliberti, Teresa, Scarpellini, Paolo, Landoni, Giovanni, De Cobelli, Francesco, Paolini, John F, Zangrillo, Alberto, Tresoldi, Moreno, Trapnell, Bruce C, Ciceri, Fabio, Dagna, Lorenzo ^*

Source: In The Lancet Rheumatology August 2020 2(8):e465-e473

Sustained Pericarditis Recurrence Risk Reduction With Long-Term Rilonacept.

Authors: Imazio, Massimo, Klein, Allan L., Brucato, Antonio, Abbate, Antonio, Arad, Michael, Cremer, Paul C., Insalaco, Antonella, LeWinter, Martin M., Lewis, Basil S., Lin, David, Luis, Sushil A., Nicholls, Stephen J., Sutej, Paul, Wasserstrum, Yishay, Clair, JoAnn, Agarwal, Indra, Wang, Sheldon, Paolini, John F.

Source: Journal of the American Heart Association; 3/19/2024, Vol. 13 Issue 6, p1-10, 10p

The effect of an apolipoprotein A-I–containing high-density lipoprotein–mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study

Authors: Hovingh, G. Kees, Smits, Loek P., Stefanutti, Claudia, Soran, Handrean, Kwok, See, de Graaf, Jacqueline, Gaudet, Daniel, Keyserling, Constance H., Klepp, Heather, Frick, Jennifer, Paolini, John F., Dasseux, Jean-Louis, Kastelein, John J.P., Stroes, Erik S.

Source: In American Heart Journal May 2015 169(5):736-742

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

Authors: Kootte, Ruud S. ^*, Smits, Loek P. ^*, van der Valk, Fleur M. ^*, Dasseux, Jean-Louis ^†, Keyserling, Constance H. ^†, Barbaras, Ronald ^†, Paolini, John F. ^†, Santos, Raul D. ^§, van Dijk, Theo H. ^**, Dallinga-van Thie, Geesje M. ^*, Nederveen, Aart J. ^††, Mulder, WillemJ.M. ^*, Hovingh, G.Kees ^*, Kastelein, JohnJ.P. ^*, Groen, Albert K. ^**, Stroes, ErikS. ^*

Source: In Journal of Lipid Research March 2015 56(3):703-712

CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice

Authors: Tardy, Claudine, Goffinet, Marine, Boubekeur, Nadia, Ackermann, Rose, Sy, Gavin, Bluteau, Alice, Cholez, Guy, Keyserling, Constance, Lalwani, Narendra, Paolini, John F., Dasseux, Jean-Louis, Barbaras, Ronald, Baron, Rudi

Source: In Atherosclerosis January 2014 232(1):110-118

Model-based Dose Selection for Phase III Rivaroxaban Study in Japanese Patients with Non-valvular Atrial Fibrillation

Authors: Tanigawa, Takahiko ^*, Kaneko, Masato, Hashizume, Kensei, Kajikawa, Mariko, Ueda, Hitoshi, Tajiri, Masahiro, Paolini, John F., Mueck, Wolfgang

Source: In Drug Metabolism and Pharmacokinetics 2013 28(1):59-70

Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF

Authors: Hankey, Graeme J, Patel, Manesh R, Stevens, Susanna R, Becker, Richard C, Breithardt, Günter, Carolei, Antonio, Diener, Hans-Christoph, Donnan, Geoffrey A, Halperin, Jonathan L, Mahaffey, Kenneth W, Mas, Jean-Louis, Massaro, Ayrton, Norrving, Bo, Nessel, Christopher C, Paolini, John F, Roine, Risto O, Singer, Daniel E, Wong, Lawrence, Califf, Robert M, Fox, Keith AA, Hacke, Werner

Source: In Lancet Neurology April 2012 11(4):315-322

Reply to Albulushi et al.—Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From RHAPSODY Long-term Extension

Authors: Brucato, Antonio, Klein, Allan L., Imazio, Massimo, Paolini, John F.

Source: In CJC Open August 2024 6(8):1033-1034