Pharmacokinetics of Asfotase Alfa in Adult Patients With Pediatric‐Onset Hypophosphatasia

Authors: Pan, Wei‐Jian, Pradhan, Rajendra, Pelto, Ryan, Seefried, Lothar

Source: Journal of clinical pharmacology. 61(10):1334-1343

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139506030.0x000001&indx=1&recIds=ETOCvdc_100139506030.0x000001

Safety, pharmacokinetics, and pharmacodynamics of efzimfotase alfa, a second-generation enzyme replacement therapy: phase 1, dose-escalation study in adults with hypophosphatasia.

Authors: Dahir, Kathryn M, Shannon, Amy, Dunn, Derek, Voegtli, Walter, Dong, Qunming, Hasan, Jawad, Pradhan, Rajendra, Pelto, Ryan, Pan, Wei-Jian

Source: Journal of Bone & Mineral Research; Oct2024, Vol. 39 Issue 10, p1412-1423, 12p

A Population Pharmacokinetic Assessment of the Effect of Food on Selumetinib in Patients with Neurofibromatosis Type 1‐Related Plexiform Neurofibromas and Healthy Volunteers.

Authors: Zuo, Peiying, Arefayene, Million, Pan, Wei‐Jian, Freshwater, Tomoko, Monteleone, Jonathan

Source: Clinical Pharmacology in Drug Development; Jul2024, Vol. 13 Issue 7, p770-781, 12p

Subject Terms: NEUROFIBROMATOSIS, PHARMACOKINETICS, NEUROFIBROMATOSIS 1, CHILD patients, VOLUNTEERS

Deep learning-based segmentation, quantification and modeling of expansive soil cracks.

Authors: Hu, Qi-cheng, Ye, Wei-min, Pan, Wei-jian, Wang, Qiong, Chen, Yong-gui

Source: Acta Geotechnica; Jan2024, Vol. 19 Issue 1, p455-473, 19p

Subject Terms: SWELLING soils, SOIL cracking, CONVOLUTIONAL neural networks, X-ray imaging

Geographic Terms: CHINA

Pharmacokinetics/Pharmacodynamics Model-Supported Early Drug Development

Authors: Chen, Bin, Q. Dong, Jennifer, Pan, Wei-Jian, Ruiz, Ana

Source: Current pharmaceutical biotechnology. 13(7):1360-1375

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083442759.0x000001&indx=1&recIds=ETOCvdc_100083442759.0x000001

Development and validation of a novel ICP-MS method to quantify different copper species in human plasma from patients with Wilson disease

Authors: Liang, Tao, Zhang, Haiting, Zhang, Linwen, Moseley, Scott, Guo, Ping, Chen, Meng, Hall, Tracey, Li, Ming, Swenson, Eugene, Pan, Wei-Jian, Meltzer, Brian, Pelto, Ryan, Ma, Mark

Source: Journal of hepatology. 77(S1):S526-S526

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167018190.0x000001&indx=1&recIds=ETOCvdc_100167018190.0x000001

Pharmacokinetics of Murine p75-Fc Fusion Protein and MP6-XT22 Anti-Murine TNF-α mAb in Mice

Authors: Filler, Scott G. ^*, Solis, Norma V., Guo, Jane, Doellgast, George, Ruiz-Garcia, Ana, Pan, Wei-Jian

Source: In Journal of Investigative Dermatology Symposium Proceedings May 2007 12(1):52-56

Comparison of the pharmacokinetics of lansoprazole 15- and 30-mg sachets for suspension versus intact capsules

Authors: Amer, Fouad, Karol, Michael D., Pan, Wei-Jian, Griffin, Janice S., Lukasik, Nancy L., Locke, Charles S., Chiu, Yi-Lin

Source: In Clinical Therapeutics 2004 26(12):2076-2083

FRI268 - Development and validation of a novel ICP-MS method to quantify different copper species in human plasma from patients with Wilson disease

Authors: Liang, Tao, Zhang, Haiting, Zhang, Linwen, Moseley, Scott, Guo, Ping, Chen, Meng, Hall, Tracey, Li, Ming, Swenson, Eugene, Pan, Wei-Jian, Meltzer, Brian, Pelto, Ryan, Ma, Mark

Source: In Journal of Hepatology July 2022 77 Supplement 1:S526-S526

Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously

Authors: Freston, James ^*, Chiu, Yi-Lin, Pan, Wei-Jian, Lukasik, Nancy, Täubel, Jörg

Source: In The American Journal of Gastroenterology 2001 96(7):2058-2065

Cocaine and alcohol interactions in the rat: Effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics

Authors: Pan, Wei-Jian ^*, Hedaya, Mohsen A.

Source: In Journal of Pharmaceutical Sciences December 1999 88(12):1266-1274

Cocaine and alcohol interactions in the rat: Effect on cocaine pharmacokinetics and pharmacodynamics

Authors: Pan, Wei-Jian, Hedaya, Mohsen A.

Source: In Journal of Pharmaceutical Sciences April 1999 88(4):459-467

Cocaine and alcohol interactions in the rat: Contribution of cocaine metabolites to the pharmacological effects

Authors: Pan, Wei-Jian, Hedaya, Mohsen A.

Source: In Journal of Pharmaceutical Sciences April 1999 88(4):468-476

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Prediction of clinical pharmacokinetics of AMG 181, a human anti- α4 β7 monoclonal antibody for treating inflammatory bowel diseases.

Authors: Li, Hong, Köck, Kathleen, Wisler, John A., Rees, William A., Prince, Peter J., Reynhardt, Kai O., Hsu, Hailing, Yu, Zhigang, Borie, Dominic C., Salinger, David H., Pan, Wei ‐ Jian

Source: Pharmacology Research & Perspectives; Feb2015, Vol. 3 Issue 1, pn/a-N.PAG, 13p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, INFLAMMATORY bowel disease treatment, PHARMACOKINETICS, PHARMACODYNAMICS, KRA, PHARMACEUTICAL research

Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases.

Authors: Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang

Source: British Journal of Clinical Pharmacology; Dec2014, Vol. 78 Issue 6, p1315-1333, 19p, 4 Charts, 8 Graphs

Subject Terms: CLINICAL pharmacology, MONOCLONAL antibodies, INFLAMMATORY bowel diseases, PHARMACOKINETICS, PHARMACODYNAMICS

Sa1207 Pharmacokinetics/Pharmacodynamics (PK/PD), Efficacy, and Safety of AMG 181 in Subjects With Active, Mild to Moderate Ulcerative Colitis - An Initial Assessment

Authors: Pan, Wei-Jian, Radford-Smith, Graham, Andrews, Jane M., Schwartz, Howard I., Sullivan, Barbara A., Evangelista, Christine M., Rees, William A., Doherty, David R., Prince, Peter J., Reynhardt, Kai O., Zhou, Kefei, Johnson, Justo Sierra, Treacy, Anthony M., Lee, Jonathan, Yu, Zhigang, Borie, Dominique C.

Source: In Gastroenterology May 2013 144(5) Supplement 1:S