α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studies.

Authors: Esposito, Fabio¹ (AUTHOR), Pala, Nicolino¹ (AUTHOR), Carcelli, Mauro² (AUTHOR), Boateng, Samuel T.³ (AUTHOR), D'Aquila, Paolo S.⁴ (AUTHOR), Mariani, Alberto⁵ (AUTHOR), Satta, Sandro⁶ (AUTHOR), Chamcheu, Jean Christopher³ (AUTHOR), Sechi, Mario¹ (AUTHOR) mario.sechi@uniss.it, Sanna, Vanna⁷ (AUTHOR) sanna.nanomater@gmail.com

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-10. 10p.

Subject Terms: *GREEN tea, *TEA, *CATECHIN, *ACARBOSE

Company/Entity: UNITED States. Food & Drug Administration

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

Authors: Esposito, Francesca, Sechi, Mario, Pala, Nicolino, Sanna, Adele, Koneru, Pratibha Chowdary, Kvaratskhelia, Mamuka, Naesens, Lieve, Corona, Angela, Grandi, Nicole, di Santo, Roberto, D'Amore, Vincenzo Maria, Di Leva, Francesco Saverio, Novellino, Ettore, Cosconati, Sandro, Tramontano, Enzo

Source: In Antiviral Research February 2020 174

Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities

Authors: Sechi, Mario, Syed, Deeba N., Pala, Nicolino, Mariani, Alberto, Marceddu, Salvatore, Brunetti, Antonio, Mukhtar, Hasan, Sanna, Vanna

Source: In Materials Science & Engineering C 1 November 2016 68:594-602

An Integrated Biological Approach to Guide the Development of Metal-Chelating Inhibitors of Influenza Virus PA Endonuclease

Authors: Stevaert, Annelies, Nurra, Salvatore, Pala, Nicolino, Carcelli, Mauro, Rogolino, Dominga, Shepard, Caitlin, Domaoal, Robert A., Kim, Baek, Alfonso-Prieto, Mercedes, Marras, Salvatore A.E., Sechi, Mario, Naesens, Lieve ^*

Source: In Molecular Pharmacology February 2015 87(2):323-337

Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol

Authors: Sanna, Vanna, Roggio, Anna Maria, Pala, Nicolino, Marceddu, Salvatore, Lubinu, Giuseppe, Mariani, Alberto, Sechi, Mario

Source: In International Journal of Biological Macromolecules January 2015 72:531-536

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Authors: Trabocchi, Andrea, Pala, Nicolino, Krimmelbein, Ilga, Menchi, Gloria, Guarna, Antonio, Sechi, Mario, Dreker, Tobias, Scozzafava, Andrea, Supuran, Claudiu T., Carta, Fabrizio

Source: Journal of enzyme inhibition and medicinal chemistry. 30(3):466-471

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105822025.0x000001&indx=1&recIds=ETOCvdc_100105822025.0x000001

Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors

Authors: Sechi, Mario, Rizzi, Giuseppe, Bacchi, Alessia, Carcelli, Mauro, Rogolino, Dominga, Pala, Nicolino, Sanchez, Tino W., Taheri, Laleh, Dayam, Raveendra, Neamati, Nouri

Source: In Bioorganic & Medicinal Chemistry 2009 17(7):2925-2935

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.

Authors: Pala, Nicolino¹ nikpal@uniss.it, Esposito, Francesca² francescaesposito@unica.it, Rogolino, Dominga³ dominga.rogolino@unipr.it, Carcelli, Mauro³ mauro.carcelli@unipr.it, Sanna, Vanna¹ vsanna@uniss.it, Palomba, Michele¹ mpalomba@uniss.it, Naesens, Lieve⁴ lieve.naesens@kuleuven.be, Corona, Angela² angela.corona@unica.it, Grandi, Nicole² nicole.grandi2@gmail.com, Tramontano, Enzo^2,5 tramon@unica.it, Sechi, Mario¹ mario.sechi@uniss.it

Source: International Journal of Molecular Sciences. Aug2016, Vol. 17 Issue 8, p1371. 18p. 6 Diagrams, 3 Charts, 1 Graph.

Subject Terms: *RIBONUCLEASE H, *REVERSE transcriptase, *HYDROLYSIS, *CATALYTIC activity, *MOLECULAR docking

Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches.

Authors: Pagnozzi, Daniela, Pala, Nicolino, Biosa, Grazia, Dallocchio, Roberto, Dessì, Alessandro, Singh, Pankaj Kumar, Rogolino, Dominga, Di Fiore, Anna, De Simone, Giuseppina, Supuran, Claudiu T., Sechi, Mario

Source: ACS Medicinal Chemistry Letters; 2/10/2022, Vol. 13 Issue 2, p271-277, 7p

Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus‑1 Integrase Capture.

Authors: Pala, Nicolino, Esposito, Francesca, Tramontano, Enzo, Singh, Pankaj Kumar, Sanna, Vanna, Carcelli, Mauro, Haigh, Lisa D., Satta, Sandro, Sechi, Mario

Source: ACS Medicinal Chemistry Letters; 10/8/2020, Vol. 11 Issue 10, p1986-1992, 7p

Design and synthesis of novel polycycles based on the 3 H-pyrrolo/6,7-dihydropyrido[1,2- a]indole scaffold as templates for pharmaceutical development.

Authors: Derudas, Marco¹, Pala, Nicolino², Sanna, Vanna³, Dallocchio, Roberto⁴, Dessì, Alessandro⁴, Roggio, Anna Maria³, Sechi, Mario²

Source: Journal of Heterocyclic Chemistry. Sep2011, Vol. 48 Issue 5, p1161-1168. 8p. 11 Diagrams, 1 Graph.

Subject Terms: *DRUG development, *HETEROCYCLIC compounds, *POLYCYCLIC compounds, *INORGANIC cyclic compounds, *DRUG design, *DNA topoisomerases, *DNA polymerases

Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors.

Authors: Gomaa, Mohamed F. Y.¹, Pala, Nicolino², Derudas, Marco³, Hasanen, Jehan Abd-Elrazik¹, El-Tamany, El-Sayed H.¹, Casule, Paola², Mariani, Alberto⁴, Sechi, Mario² mario.sechi@uniss.it

Source: ARKIVOC: Online Journal of Organic Chemistry. 2011, p1-14. 14p.

Subject Terms: *PYRIDAZINONES, *SUBSTRATES (Materials science), *HIV, *INTEGRASE inhibitors, *RING formation (Chemistry), *ENZYME inhibitors

ZnO nanoparticles with high degradation efficiency of organic dyes under sunlight irradiation

Authors: Sanna, Vanna, Pala, Nicolino, Alzari, Valeria, Nuvoli, Daniele, Carcelli, Mauro

Source: In Materials Letters 1 January 2016 162:257-260

Chapter 3 - Carbonic Anhydrase I

Authors: Pala, Nicolino, Cadoni, Roberta, Sechi, Mario

Source: In Carbonic Anhydrases as Biocatalysts 2015:31-49

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Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: New isoform-I selective nanomolar inhibitors

Authors: Sechi, Mario, Innocenti, Alessio, Pala, Nicolino, Rogolino, Dominga, Carcelli, Mauro, Scozzafava, Andrea, Supuran, Claudiu T.

Source: In Bioorganic & Medicinal Chemistry Letters 15 September 2012 22(18):5801-5806

HIV-1 IN Strand Transfer Chelating Inhibitors: A Focus on Metal Binding

Authors: Bacchi, Alessia, Carcelli, Mauro, Compari, Carlotta, Fisicaro, Emilia, Pala, Nicolino, Rispoli, Gabriele, Rogolino, Dominga, Sanchez, Tino W., Sechi, Mario, Neamati, Nouri

Source: Molecular Pharmaceutics; 20240101, Issue: Preprints

Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore

Authors: Pala, Nicolino, Dallocchio, Roberto, Dessì, Alessandro, Brancale, Andrea, Carta, Fabrizio, Ihm, Simone, Maresca, Alfonso, Sechi, Mario, Supuran, Claudiu T.

Source: In Bioorganic & Medicinal Chemistry Letters 2011 21(8):2515-2520