Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors.

Authors: Pacaud, Romain, Thomas, Scott, Chaudhuri, Sibapriya, Lazar, Ann, Timmerman, Luika A., Munster, Pamela N.

Source: Breast Cancer Research; 1/16/2025, Vol. 27 Issue 1, p1-15, 15p

Subject Terms: TRIPLE-negative breast cancer, HOMOLOGOUS recombination, MEDICAL sciences, CELL populations, CELL cycle

Synthetic Lethality Beyond BRCA: A Phase I Study of Rucaparib and Irinotecan in Metastatic Solid Tumors With Homologous Recombination-Deficiency Mutations Beyond BRCA1/2.

Authors: Tsang, Erica S., Dhawan, Mallika S., Pacaud, Romain, Thomas, Scott, Grabowsky, Jennifer, Wilch, Lauren, Karipineni, Silpa, Kelley, Robin Kate, Ko, Andrew H., Collisson, Eric, Chapman, Jocelyn S., Ueda, Stefanie, Bergsland, Emily K., Munster, Pamela

Source: JCO Precision Oncology; 12/1/2024, Vol. 8, p1-12, 12p

Subject Terms: POLY(ADP-ribose) polymerase, HOMOLOGOUS recombination, DNA topoisomerase I, PERITONEAL cancer, IRINOTECAN

Méthylation/déméthylation de l’ADN et expression du génome

Alternate Title: DNA methylation/demethylation and genomic expression (English)

Authors: Cartron, Pierre-François ^{a, b, c, d, g, *}, Pacaud, Romain ^{a, b, c, g}, Salbert, Gilles ^{d, e, f}

Source: In Revue Francophone des Laboratoires June 2015 2015(473):37-48

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: Role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1

Authors: Pacaud, Romain, Sery, Quentin, Oliver, Lisa, Vallette, François M., Tost, Jörg, Cartron, Pierre-François

Source: In Biochimie September 2014 104:36-49

Chapter 40 - Clinical Applications of Histone Deacetylase Inhibitors

Authors: Pacaud, Romain ^*, Garcia, Jose, Thomas, Scott ^*, Munster, Pamela N. ^*

Source: In Handbook of Epigenetics Edition: Third Edition. 2023:793-819

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Authors: Cheray, Mathilde, Etcheverry, Amandine, Jacques, Camille, Pacaud, Romain, Bougras-Cartron, Gwenola, Aubry, Marc, Denoual, Florent, Peterlongo, Pierre, Nadaradjane, Arulraj, Briand, Joséphine, Akcha, Farida, Heymann, Dominique, Vallette, François M., Mosser, Jean, Ory, Benjamin, Cartron, Pierre-François

Source: Molecular cancer. 19(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164199090.0x000001&indx=1&recIds=ETOCvdc_100164199090.0x000001

A phase Ib trial of alpelisib and weekly cisplatin in patients with solid tumor malignancies.

Authors: Tsang, Erica S., Aggarwal, Rahul Raj, Dhawan, Mallika Sachdev, Pacaud, Romain, Fattah, Delaire, Thomas, Scott, Grabowsky, Jennifer A., Munster, Pamela N.

Source: Journal of clinical oncology. 39(15 suppl):3134-3134

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173190486.0x000001&indx=1&recIds=ETOCvdc_100173190486.0x000001

List of contributors

Authors: Akimitsu, Nobuyoshi, Alexeeva, Marina, Almeida, Juliana, Ávila-Avilés, Rodolfo Daniel, Berthelier, Jérémy, Bhatnagar, Akanksha, Boskovic, Maria, Carullo, Nancy V.N., Casas-Mollano, J. Armando, Champagne, Frances A., Chen, Taiping, Chhabra, Ravindresh, Curley, James P., Davison, Gareth W., Dunbar, Gary L., Eggermann, Thomas, Elefant, Felice, Fransquet, Peter D., Fujii, Hodaka, Fujita, Toshitsugu, Furci, Leonardo, Garcia, Jose, Ghosh, Balaram, Gillberg, Linn, Giménez-Orenga, Karen, Hanna, Courtney W., Herceg, Zdenko, Hernández-Hernández, J. Manuel, Hjort, Line, Hu, Xiaotong, Ibeagha-Awemu, Eveline M., Jawaid, Ali, Jiang, Wei, Juez, Oscar, Karnay, Ashley M., Kawata, Kentaro, Khatib, Hasan, Klee, Eric W., Klein, Kerstin, Kremer, Eloïse A., Kronholm, Ilkka, Lee, Ho-Sun, Magdinier, Frédérique, Mansuy, Isabelle M., Mashoodh, Rahia, Mezei, Mihaly, Miah, Maria, Miryeganeh, Matin, Mujtaba, Shiraz, Munster, Pamela N., Murr, Rabih, Navakauskienė, Rūta, Negrón-Lomas, Claudia, Nugent, Fereshteh S., Oltra, Elisa, Onoguchi-Mizutani, Rena, Öztürk, Nail Can, Pacaud, Romain, Peedicayil, Jacob, Pethe, Prasad, Pfeifer, Gerd P., Pulya, Sravani, Rauch, Tibor A., Resendiz, Marisol, Roalsø, Marcus, Robin, Jérôme D., Rossignol, Julien, Ryan, Joanne, Santos-Rebouças, Cíntia Barros, Saze, Hidetoshi, Shepard, Ryan D., Silar, Philippe, Sklias, Athena, Slager, Susan L., Søreide, Kjetil, Srinageshwar, Bhairavi, Suter, David M., Taniue, Kenzui, Thomas, Scott, Tian, Shulan, Tollefsbol, Trygve O., van der Giezen, Mark, Vanzan, Ludovica, Vogt, Günter, Watkins, Darryl S., Watson, Martin M., Wei, Loo Keat, Wrigglesworth, Jo, Yamada, Toshimichi, Yan, Huihuang, Yang, Jie, Ying, Zhengzhou, Zacarias, Ericka, Zhou, Feng C.

Source: In Handbook of Epigenetics Edition: Third Edition. 2023:xiii-xv

The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures.

Authors: Pacaud, Romain^1,2, Brocard, Emeline^1,2, Lalier, Lisenn^1,2,3, Hervouet, Eric⁴, Vallette, François M.^1,2,3, Cartron, Pierre-François^1,2,3,5 pierre-francois.cartron@univ-nantes.fr

Source: Scientific Reports. 3/14/2014, p1-9. 9p.

Subject Terms: *NEOPLASTIC cell transformation, *EPIGENETICS, *ASTROCYTOMAS, *DNA methylation, *FIBROBLASTS, *IMMUNOPRECIPITATION

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DNMT Inhibitors in Cancer, Current Treatments and Future Promising Approach: Inhibition of Specific DNMT-Including Complexes

Authors: Cheray, Mathilde, Pacaud, Romain, Hervouet, Eric, Vallette, Francois M., Cartron, Pierre-Francois

Source: Epigenetic Diagnosis and Therapy; April 2015, Vol. 1 Issue: 1 p37-48, 12p