The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes

Authors: Cristina Alarcón-Vila, Laura Hurtado-Navarro, Sandra V Mateo, Alejandro Peñín-Franch, Carlos M Martínez, Cristina Molina-López, María C Baños, Ana I Gómez, Javier Gómez-Román, Alberto Baroja-Mazo, Juan I Arostegui, Natalia Palmou-Fontana, Juan J Martínez-García, Pablo Pelegrin

Source: EMBO Molecular Medicine, Vol 17, Iss 1, Pp 41-53 (2024)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/bedcada951274a02a92ce7ccae66e203

Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

Authors: Cristina Molina-López, Laura Hurtado-Navarro, Carlos J. García, Diego Angosto-Bazarra, Fernando Vallejo, Ana Tapia-Abellán, Joana R. Marques-Soares, Carmen Vargas, Segundo Bujan-Rivas, Francisco A. Tomás-Barberán, Juan I. Arostegui, Pablo Pelegrin

Source: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8fff75ee7c594dc3a2b4f18e746c4a0b

The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsisResearch in context

Authors: Roberto Lozano-Rodríguez, José Avendaño-Ortíz, Karla Montalbán-Hernández, Juan Carlos Ruiz-Rodríguez, Ricardo Ferrer, Alejandro Martín-Quirós, Charbel Maroun-Eid, Juan José González-López, Anna Fàbrega, Verónica Terrón-Arcos, María Gutiérrez-Fernández, Elisa Alonso-López, Carolina Cubillos-Zapata, María Fernández-Velasco, Rebeca Pérez de Diego, Pablo Pelegrin, Carlos García-Palenciano, Francisco J. Cueto, Carlos del Fresno, Eduardo López-Collazo

Source: EBioMedicine, Vol 97, Iss , Pp 104841- (2023)

Subject Terms: Sepsis, Immune checkpoint, SIGLEC5, T-cell exhaustion, Biomarker, HIF1α, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423004073; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3b43bccf46634fe7872802feee4227c8

ASC nanobodies to counteract the consequences of inflammasome activation

Authors: Sahil Adriouch, Pablo Pelegrin

Source: EMBO Molecular Medicine, Vol 14, Iss 6, Pp 1-3 (2022)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/93540582046741f8a1be5d9bafe769fc

Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects

Authors: Susanne Gaul, Karen Marie Schaeffer, Lena Opitz, Christina Maeder, Alexander Kogel, Luisa Uhlmann, Hermann Kalwa, Ulf Wagner, Jan Haas, Amirhossein Behzadi, Pablo Pelegrin, Jes-Niels Boeckel, Ulrich Laufs

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b6bb569c414c44e89dd851a34202c360

Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity

Authors: Julio García-Villalba, Laura Hurtado-Navarro, Alejandro Peñín-Franch, Cristina Molina-López, Laura Martínez-Alarcón, Diego Angosto-Bazarra, Alberto Baroja-Mazo, Pablo Pelegrin

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: COVID-19, SARS-CoV-2, inflammation, P2X7, purinergic receptors, pyroptosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.894470/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/da244b6cdac24de4acfc5751f80b9902

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

Authors: Juan José Martínez-García, Helios Martínez-Banaclocha, Diego Angosto-Bazarra, Carlos de Torre-Minguela, Alberto Baroja-Mazo, Cristina Alarcón-Vila, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Carlos M. Martínez, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Sahil Adriouch, Friedrich Koch-Nolte, Juan Luján, Francisco Acosta-Villegas, Pascual Parrilla, Carlos García-Palenciano, Pablo Pelegrin

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b

CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

Authors: Cristina Alarcón-Vila, Alberto Baroja-Mazo, Carlos de Torre-Minguela, Carlos M Martínez, Juan J Martínez-García, Helios Martínez-Banaclocha, Carlos García-Palenciano, Pablo Pelegrin

Source: eLife, Vol 9 (2020)

Subject Terms: inflammation, sepsis, purinergic signaling, CD14, LPS, cytokines, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/60849; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/860ef86d817641659a509d5f0529c7ab

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Authors: Iva Hafner-Bratkovič, Petra Sušjan, Duško Lainšček, Ana Tapia-Abellán, Kosta Cerović, Lucija Kadunc, Diego Angosto-Bazarra, Pablo Pelegrin, Roman Jerala

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1ef3edb735df4712b0a5732ea7fa1100

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

Authors: Emeline Bon, Virginie Driffort, Frédéric Gradek, Carlos Martinez-Caceres, Monique Anchelin, Pablo Pelegrin, Maria-Luisa Cayuela, Séverine Marionneau-Lambot, Thibauld Oullier, Roseline Guibon, Gaëlle Fromont, Jorge L. Gutierrez-Pajares, Isabelle Domingo, Eric Piver, Alain Moreau, Julien Burlaud-Gaillard, Philippe G. Frank, Stéphan Chevalier, Pierre Besson, Sébastien Roger

Source: Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b868edb8e4164085a3574d6fbc6f262e

Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience

Authors: Dorota M. Rowczenio, Sónia Melo Gomes, Juan I. Aróstegui, Anna Mensa-Vilaro, Ebun Omoyinmi, Hadija Trojer, Anna Baginska, Alberto Baroja-Mazo, Pablo Pelegrin, Sinisa Savic, Thirusha Lane, Rene Williams, Paul Brogan, Helen J. Lachmann, Philip N. Hawkins

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: cryopyrin-associated periodic syndrome, ASC aggregates, AA amyloidosis, NLRP3 somatic mutation, mutant allele, IL-1β, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01410/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/55a8e59f7daa498181d4f19f27b2fc50

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

Authors: Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté

Source: Mediators of Inflammation, Vol 2016 (2016)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/2338f0c2a3cd43f181bb522927ee65df

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

Authors: Mauricio A. Retamal, Michael V. L. Bennett, Pablo Pelegrin, Ricardo Fernandez

Source: Mediators of Inflammation, Vol 2016 (2016)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/13cc008b41c94bcda38eb06d956fb6c6

The total electric charge and time of application of galvanic currents to macrophages can optimize the release of IL-1β with low cell death

Authors: Alejandro Peñin-Franch, José Antonio García-Vidal, Ana Isabel Gómez, Pilar Escolar-Reina, Francesc Medina-Mirapeix, Pablo Pelegrín

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Percutaneous needle electrolysis, Galvanic current, Macrophage, Inflammation, IL-1β, Cell death, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1c8e5dc1c77e4324b47d94d8ecc972e1

Capítulo 2 - Electrolisis e inflamación. Bases biológicas de la electrolisis percutánea

Authors: Franch, Alejandro Peñín, Vidal, José Antonio García, Reina, Pilar Escolar, Mirapeix, Francesc Medina i, Vivancos, Pablo Pelegrín

Source: In Electrolisis percutánea musculoesquelética. Tendón y bursa 2021:25-32

Detection of inflammasome activation in liver tissue during the donation process as potential biomarker for liver transplantation

Authors: Sandra V. Mateo, Daniel Vidal-Correoso, Ana M. Muñoz-Morales, Marta Jover-Aguilar, Felipe Alconchel, Jesús de la Peña, Laura Martínez-Alarcón, Víctor López-López, Antonio Ríos-Zambudio, Pedro Cascales, José A. Pons, Pablo Ramírez, Pablo Pelegrín, Alberto Baroja-Mazo

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/b4d9086cebc5470fa572833926fa03b7

Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients

Authors: Helios Martínez-Banaclocha, Carlos García-Palenciano, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Julio Padilla-Rodríguez, Alberto Baroja-Mazo, Pablo Pelegrín, Juan José Martínez-García

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: sepsis, inflammation, P2X7 receptor, purinergic signaling, danger signals, leukocytes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1297249/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ec9b780387ab4f1893f5def133287807

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Authors: Diego Angosto-Bazarra, Cristina Molina-López, Pablo Pelegrín

Source: Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/ac0c010038dc45f8b61db21a0b4e5dba

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

Authors: Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín

Source: BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)

Subject Terms: Pyroptosis, Gasdermin, Pejvakin, Evolution, Sepsis, Infection, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/13fc3eb2f2734fffa31708fb4f36ce7d

Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantationResearch in context

Authors: Fernando Lucas-Ruiz, Sandra V. Mateo, Marta Jover-Aguilar, Felipe Alconchel, Laura Martínez-Alarcón, Carlos de Torre-Minguela, Daniel Vidal-Correoso, Francisco Villalba-López, Víctor López-López, Antonio Ríos-Zambudio, José A. Pons, Pablo Ramírez, Pablo Pelegrín, Alberto Baroja-Mazo

Source: EBioMedicine, Vol 87, Iss , Pp 104419- (2023)

Subject Terms: DAMPs, NLRP3, Inflammasome, Cold ischemia, DCD, DBD, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422006016; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/2c28ea19bada4e2e8e37f7e5119246df