Selective Pyk2 inhibition enhances bone restoration through SCARA5-mediated bone marrow remodeling in ovariectomized mice

Authors: Yunqing Liu, Mai Nishiura, Mika Fujii, Sumiti Sandhu, Yasutaka Yawaka, Yutaka Yamazaki, Akira Hasebe, Tadahiro Iimura, Sek Won Kong, Ji-Won Lee

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: Pyk2, Bone, Mesenchymal stem cell, Osteoclast, Osteoblast, Adipocyte, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/6067f1f0488844c1883abcaf1a93aaf9

PYK2 in the dorsal striatum of Huntington's disease R6/2 mouse model

Authors: Omar Al Massadi, Mélody Labarchède, Benoit de Pins, Sophie Longueville, Albert Giralt, Theano Irinopoulou, Mythili Savariradjane, Enejda Subashi, Silvia Ginés, Jocelyne Caboche, Louise-Laure Mariani, Sandrine Betuing, Jean-Antoine Girault

Source: Neurobiology of Disease, Vol 207, Iss , Pp 106840- (2025)

Subject Terms: Huntington's disease, Striatum, Caudate-putamen, PYK2, Non-receptor tyrosine kinase, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996125000567; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/772e3912123c49a1b957988c822ba9b0

Tyrosine kinase as therapeutic target of neurodegenerative disorders

Authors: Dipanjan Karati, Dileep Kumar

Source: Brain Disorders, Vol 17, Iss , Pp 100193- (2025)

Subject Terms: Tyrosine kinase, Neurodegenerative disorders, Pyk2, Ron receptor, Parkin-Beclin-1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666459325000137; https://doaj.org/toc/2666-4593

Access URL: https://doaj.org/article/ca9f184cfa8c4cfb8c83ca0b51a0a4a9

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway

Authors: Xuefei Ding, Xiaohe Li, Rui Fang, Peilin Yue, Yuxuan Jia, Enjie Li, Yayue Hu, Honggang Zhou, Xudong Song

Source: Molecular Medicine, Vol 30, Iss 1, Pp 1-15 (2024)

Subject Terms: Fibrotic cataract, EMT, Entrectinib, TGFβ2, PYK2, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/d82b753279424a38a45ef2909c84d11f

Targeting PYK2 with heterobifunctional T6BP helps mitigate MASLD and MASH-HCC progression

Authors: Xu, Minxuan ^{1, 2, 3, ⁎, †}, Zhao, Junjie ^{3, †}, Zhu, Liancai ^{3, †}, Ge, Chenxu ^{1, 2, 3, †}, Sun, Yan ^{3, †}, Wang, Ranran ^{2, 5, 6}, Li, Yuanyuan ^{1, 2}, Dai, Xianling ^{1, 3}, Kuang, Qin ^{1, 3}, Hu, Linfeng ^{1, 2, 3}, Luo, Jing ^{1, 2}, Kuang, Gang ^{1, 2}, Ren, Yanrong ^{2, 5, ⁎}, Wang, Bochu ^{3, ⁎}, Tan, Jun ^{1, 2, ⁎, †}, Shi, Shengbin ^{4, ⁎}

Source: In Journal of Hepatology February 2025 82(2):277-300

Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis

Authors: Zhengyan Wu, Min Jiao, Chenying Shu, Saiqun Zhang, Jiajia Wang, Jianhong Pu, Jianjie Zhu, Yuanyuan Zeng, Yehan Zhu, Zeyi Liu

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: Non-small-cell lung cancer (NSCLC), PYK2, Nuclear accumulation of p-STAT3(Tyr705), VGF, Integrin αVβ1, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/c2e9657bc91c49e5910edeac744fde7a

Preliminary study of the homeostatic regulation of osseointegration by nanotube topology

Authors: Tao Chen, MingXing Ren, YuZhou Li, Zheng Jing, XinXin Xu, FengYi Liu, DingQiang Mo, WenXue Zhang, Jie Zeng, He Zhang, Ping Ji, Sheng Yang

Source: Materials Today Bio, Vol 26, Iss , Pp 101038- (2024)

Subject Terms: FAK, PYK2, Osteoclasts, Osteoblasts, Bone homeostasis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006424000978; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/14bee497b0c3420e9ca715559924fd42

PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas

Authors: Junling Shen, Jilong Yang, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun

Source: Cancer Biology & Medicine, Vol 19, Iss 8, Pp 1211-1223 (2022)

Subject Terms: stim1, pyk2, invadopodia, invasion, melanoma, vemurafenib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.cancerbiomed.org/content/19/8/1211; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/a4c7194c32844833b7fac0b3b5911027

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Authors: A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter

Source: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-33 (2022)

Subject Terms: Alzheimer’s disease, Fronto-temporal dementia, Tauopathy, PTK2B, Pyk2, C1q, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/07d99d58976b4e01996ddce1ebeeb842

Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC

Authors: Chengmei Huang, Ruizhang Ou, Xiaoning Chen, Yaxin Zhang, Jiexi Li, Yihao Liang, Xiaohui Zhu, Lei Liu, Mingzhou Li, Dagui Lin, Junfeng Qiu, Guanglong Liu, Lingjie Zhang, Yuanyuan Wu, Huiyi Tang, Yanmin Liu, Li Liang, Yanqing Ding, Wenting Liao

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)

Subject Terms: SPON2, Colorectal cancer, Tumor-associated macrophages, Invasion, Metastasis, PYK2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/431411549d9c4db3983cd3fcdca9e855

Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma

Authors: Guiyue Cai, Ruitao Zou, Huizhi yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Chen

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: PCDH9, circRNAs, malignant melanoma, Pyk2, RAC1, apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.891476/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e87d3e45789c4cd9a630921376936f65

Mouse Modeling Dissecting Macrophage–Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis

Authors: Anna‐Katharina Müller, Ulrike A. Köhler, Sébastien Trzebanski, Yaron Vinik, Harsha Mohan Raj, Jean‐Antoine Girault, Nir Ben‐Chetrit, Antonio Maraver, Steffen Jung, Sima Lev

Source: Advanced Science, Vol 9, Iss 9, Pp n/a-n/a (2022)

Subject Terms: breast cancer, crosstalk signaling, Notch1, PYK2, tumor‐associated macrophages, tumor microenvironment, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/36929aef80e942ad9b61fcc1472add8a

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice

Authors: Gustavo Ferreira Alves, Eleonora Aimaretti, Giacomo Einaudi, Raffaella Mastrocola, Junior Garcia de Oliveira, Debora Collotta, Elisa Porchietto, Manuela Aragno, Carlo Cifani, Regina Sordi, Christoph Thiemermann, Daniel Fernandes, Massimo Collino

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: sepsis, NLRP3 inflammasome, inflammation, Focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (PYK2), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.837180/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/00a5468dfbbd46cb88b9cdde5a58d58c

Pyk2 promotes Ang Ⅱ-induced cardiac hypertrophy in rat

Authors: YAN Wen, LIU Li-xin, KONG Xiang-zhao, LUO Yu-chen, LI Zhong-qiu, LI Nan

Source: Jichu yixue yu linchuang, Vol 40, Iss 3, Pp 351-355 (2020)

Subject Terms: cardiac hypertrophy, angiotensin ⅱ(ang ⅱ), proline-rich tyrosine kinase 2 (pyk2), Medicine

File Description: electronic resource

Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190606.pdf; https://doaj.org/toc/1001-6325

Access URL: https://doaj.org/article/2f0adfe0e5464addbd298aa94d060673

Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells

Authors: Keiichi Oono, Kazuo Ohtake, Chie Watanabe, Sachiko Shiba, Takashi Sekiya, Keizo Kasono

Source: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-12 (2020)

Subject Terms: PC3, EPA, ROS, ERK, Pyk2, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1476-511X

Access URL: https://doaj.org/article/f30a32656ac547a88675762458f1d656

Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation

Authors: Xin Zhang, Yonghong Yang, Lina Jing, Weiwei Zhai, Hui Zhang, Qun Ma, Chunxia Li, Fenglian Yan, Dalei Cheng, Junfeng Zhang, Zhaochen Ning, Hui Shi, Changying Wang, Mingsheng Zhao, Jun Dai, Zhihua Li, Jiankuo Ming, Meimei Yu, Haiyan Wang, Hongyan Cheng, Huabao Xiong, Guanjun Dong

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: PKM2, TLR, Pyk2, inflammation, autoimmunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.680068/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a5699781b3aa4c7f978f7872a47d4c5f

MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells

Authors: Kamila Kitowska, Monika Gorska-Arcisz, Dima Antoun, Izabela Zarczynska, Dominika Czaplinska, Adrian Szczepaniak, Andrzej C. Skladanowski, Maciej Wieczorek, Aleksandra Stanczak, Monika Skupinska, Rafal Sadej

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: FGFR, MET, Pyk2, acquired resistance, cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.633410/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b886481cff41457ab09655e07600ec36

Regulation of the Formation of Osteoclastic Actin Rings by Proline-Rich Tyrosine Kinase 2 Interacting with Gelsolin

Authors: Wang, Qiang, Xie, Yi, Du, Quan-Sheng, Wu, Xiao-Jun, Feng, Xu, Mei, Lin, McDonald, Jay M., Xiong, Wen-Cheng

Source: The Journal of Cell Biology, 2003 Feb . 160(4), 565-575.

Access URL: https://www.jstor.org/stable/1621454

Targeting Pyk2 to β1-Integrin-Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase-Null Cells

Authors: Klingbeil, Candice K., Hauck, Christof R., Hsia, Datsun A., Jones, K. C., Reider, Shannon R., Schlaepfer, David D.

Source: The Journal of Cell Biology, 2001 Jan 01. 152(1), 97-110.

Access URL: https://www.jstor.org/stable/1620266

Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, α vβ 3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility

Authors: Sanjay, Archana, Houghton, Adam, Neff, Lynn, DiDomenico, Emilia, Bardelay, Chantal, Antoine, Evelyne, Levy, Joan, Gailit, James, Bowtell, David, Horne, William C., Baron, Roland

Source: The Journal of Cell Biology, 2001 Jan 01. 152(1), 181-195.

Access URL: https://www.jstor.org/stable/1620272