Comparative in vitro immunoreactivity and protein analysis of Trimeresurus albolabris and Tropidolaemus wagleri venoms.

Authors: Reamtong, Onrapak¹ (AUTHOR), Pearngam, Phorutai² (AUTHOR), Laoungbua, Panithi³ (AUTHOR), Sitprija, Siravit⁴ (AUTHOR), Thiangtrongjit, Tipparat¹ (AUTHOR), Srisuk, Godchakorn⁴ (AUTHOR), Vasaruchapong, Taksa³ (AUTHOR), Khow, Orawan⁵ (AUTHOR), Noiphrom, Jureeporn⁵ (AUTHOR), Chaiyabutr, Narongsak^3,5 (AUTHOR), Chanhome, Lawan³ (AUTHOR) lchanhome@yahoo.com, Kumkate, Supeecha⁴ (AUTHOR) supeecha.kum@mahidol.edu

Source: Scientific Reports. 4/12/2025, Vol. 15 Issue 1, p1-20. 20p.

Subject Terms: *SNAKE venom, *SERINE proteinases, *ANTIVENINS, *CYTOLOGY, *VENOM, *LIFE sciences, *HYDROPHILIC interactions

NbPIRIN promotes the protease activity of papain-like cysteine protease NbRD21 to inhibit Chinese wheat mosaic virus infection.

Authors: Zhong, Kaili¹ (AUTHOR), Xu, Gecheng¹ (AUTHOR), Shi, Jingjing¹ (AUTHOR), Liu, Peng¹ (AUTHOR), Tu, Aizhu¹ (AUTHOR), Wu, Mila¹ (AUTHOR), Liu, Jiaqian¹ (AUTHOR), Chen, Jianping¹ (AUTHOR) jpchen2001@126.com, Yang, Jian¹ (AUTHOR) nather2008@163.com

Source: PLoS Pathogens. 4/2/2025, Vol. 21 Issue 4, p1-28. 28p.

Subject Terms: *CYSTEINE proteinase inhibitors, *CYSTEINE proteinases, *MOSAIC viruses, *PLANT viruses, *DISEASE resistance of plants

Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization.

Authors: Kublicka, Agata¹ (AUTHOR), Lorek, Daria² (AUTHOR), Mikołajczyk-Martinez, Agata³ (AUTHOR), Chodaczek, Grzegorz⁴ (AUTHOR), Chwirot, Aleksandra¹ (AUTHOR), Bażanów, Barbara¹ (AUTHOR), Matczuk, Anna Karolina¹ (AUTHOR) anna.matczuk@upwr.edu.pl

Source: Scientific Reports. 1/25/2025, Vol. 15 Issue 1, p1-13. 13p.

Subject Terms: *MEDICAL sciences, *SERINE proteinases, *FLOW cytometry, *LIFE sciences, *CYTOLOGY

Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging.

Authors: Zhang, Congying¹ (AUTHOR), Wang, Jinlong¹ (AUTHOR), Yao, Tianzhao¹ (AUTHOR), Hu, Jiaxin¹ (AUTHOR), Sun, Feifei¹ (AUTHOR), Feng, Chunlu¹ (AUTHOR), Sun, Zhendong¹ (AUTHOR), Shao, Yuzhuo¹ (AUTHOR), Wang, Zhu¹ (AUTHOR), Wu, Jiarui^1,2 (AUTHOR), Huang, Yunpeng^1,2 (AUTHOR) huangyp@ucas.ac.cn

Source: Aging Cell. Jan2025, Vol. 24 Issue 1, p1-24. 24p.

Subject Terms: *MODEL organisms, *SERINE proteinases, *INSULIN receptors, *CENTRAL nervous system, *HOMEOSTASIS

Papain‐Like Cysteine Proteases Contribute to Functional Cleavage of Begomoviral V2 Effector Required for Relevant Virulences.

Authors: Zhang, Jie^1,2 (AUTHOR), Shang, Pengxiang^1,2 (AUTHOR), Yuan, Linkai^1,2 (AUTHOR), Li, Dingshan^1,2 (AUTHOR), Liu, Shunmin^1,2 (AUTHOR), Du, Zhenguo^1,2 (AUTHOR), Zhuang, Jun^1,2 (AUTHOR) fafuzj@126.com, Wu, Zujian^1,2 (AUTHOR) wuzujian@126.com

Source: Molecular Plant Pathology. Jan2025, Vol. 26 Issue 1, p1-7. 7p.

Subject Terms: *CYSTEINE proteinases, *NICOTIANA benthamiana, *PLANT diseases, *BEGOMOVIRUSES, *PROTEOLYSIS, *PATHOGENIC viruses, *POLYPEPTIDES

Antimicrobial activity of yellow tabebuia flower extract (Tabebuia aurea) against drug-resistant microbes.

Authors: Wijayanti, Ernanin Dyah¹ ernanindyahw@poltekkespim.ac.id, Rahayu, Lina Oktavia¹, Raharjo, Sentot Joko^1,2, Hayuningtyas, Dimastika Purihita¹, Yumnadifa S., Azhaar Ramadhaniar¹, Wulandari, Dita¹, Maharani, Ajensha Diva¹, Maulidina, Intan¹, Febrianti, Rizqi¹

Source: Journal of Biological Researches. Dec2024, Vol. 30 Issue 3, p144-151. 8p.

Subject Terms: *ASPARTIC proteinases, *DISC diffusion tests (Microbiology), *BACTERIAL enzymes, *FLOWER shows, *STREPTOCOCCUS mutans

Antibiofilm Activity of Epinecidin-1 and Its Variants Against Drug-Resistant Candida krusei and Candida tropicalis Isolates from Vaginal Candidiasis Patients.

Authors: Jeyarajan, Sivakumar^1,2 (AUTHOR) jeyaraja@umich.edu, Ranjith, Sukumar¹ (AUTHOR) starsukumar1996@gmail.com, Veerapandian, Raja^3,4 (AUTHOR) director-rmrcne@icmr.gov.in, Natarajaseenivasan, Kalimuthusamy^4,5 (AUTHOR), Chidambaram, Prahalathan⁶ (AUTHOR) prahalath@bdu.ac.in, Kumarasamy, Anbarasu¹ (AUTHOR) anbumbt@bdu.ac.in

Source: Infectious Disease Reports. Dec2024, Vol. 16 Issue 6, p1214-1229. 16p.

Subject Terms: *MEMBRANE proteins, *ASPARTIC proteinases, *ANTIMICROBIAL peptides, *CANDIDA tropicalis, *VULVOVAGINAL candidiasis, *INTRAUTERINE contraceptives

Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis.

Authors: Nemčovičová, Ivana¹ (AUTHOR), Lopušná, Katarína¹ (AUTHOR), Štibrániová, Iveta¹ (AUTHOR), Benedetti, Fabio² (AUTHOR), Berti, Federico² (AUTHOR), Felluga, Fulvia² (AUTHOR), Drioli, Sara² (AUTHOR), Vidali, Mattia² (AUTHOR), Katrlík, Jaroslav³ (AUTHOR), Pažitná, Lucia³ (AUTHOR), Holazová, Alena³ (AUTHOR), Blahutová, Jana³ (AUTHOR), Lenhartová, Simona¹ (AUTHOR), Sláviková, Monika¹ (AUTHOR), Klempa, Boris¹ (AUTHOR), Ondrejovič, Miroslav^4,5 (AUTHOR), Chmelová, Daniela⁴ (AUTHOR), Legerská, Barbora⁴ (AUTHOR), Miertuš, Stanislav^4,5 (AUTHOR), Klacsová, Mária⁶ (AUTHOR)

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-16. 16p.

Subject Terms: *CYSTEINE proteinases, *SARS-CoV-2, *CORONAVIRUSES, *VIRAL genomes, *ANTIVIRAL agents

Mass Spectrometric Based Metabolomics of the Saudi Cultivar of Fenugreek (Trigonella foenum-graecum L.): A Combined GC-MS, Antimicrobial and Computational Approach.

Authors: Almuzaini, Nujud A. M.¹ (AUTHOR) n.alenezy@uoh.edu.sa, Sulieman, Abdel Moneim E.¹ (AUTHOR) badraouir@yahoo.fr, Alanazi, Naimah A.¹ (AUTHOR), Badraoui, Riadh^1,2 (AUTHOR), Abdallah, Emad M.³ (AUTHOR) 140208@qu.edu.sa

Source: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1733. 19p.

Subject Terms: *ASPARTIC proteinases, *PHYTOCHEMICALS, *FENUGREEK, *ANTIBACTERIAL agents, *BLOOD-brain barrier, *BIOACTIVE compounds

Use of temporary immersion systems for the micropropagation of Puya alpestris (Poepp.) Gay as a source to produce proteolytic enzymes: TEMPORARY IMMERSION MICROPROPAGATION PUYA ALPESTRIS PROTEOLYTIC ENZYMES: CABRERA ET AL.

Authors: Cabrera, Inelvis Castro¹ (AUTHOR) inelvis90@gmail.com, Hernández, Karel Vives² (AUTHOR), Burgos, Luciano Sotomayor² (AUTHOR), de la Torre, Martha Hernández¹ (AUTHOR)

Source: In Vitro Cellular & Developmental Biology Plant. Dec2024, Vol. 60 Issue 6, p880-890. 11p.

Subject Terms: *CYSTEINE proteinases, *LIFE sciences, *GERMPLASM, *PLANT growing media, *BOTANY

Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases.

Authors: Denesyuk, Alexander I.¹ (AUTHOR) alexandre.denesyuk@abo.fi, Denessiouk, Konstantin¹ (AUTHOR) mark.s.johnson@abo.fi, Johnson, Mark S.¹ (AUTHOR), Uversky, Vladimir N.² (AUTHOR) alexandre.denesyuk@abo.fi

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p11858. 14p.

Subject Terms: *PROTEINASES, *PROTEINS, *SERINE proteinases

Ecotin protects Salmonella Typhimurium against the microbicidal activity of host proteases.

Authors: Saposnik, Lucas^1,2, Coria, Lorena M.^1,2, Bruno, Laura^1,2, Guaimas, Fracisco^1,2, Pandolfi, Julieta³, Pol, Melina³, Urga, Maria Eugenia³, Sabbione, Florencia⁴, McClelland, Michael⁵, Trevani, Analia⁴, Pasquevich, Karina A.^1,2, Cassataro, Juliana^1,2, jucassataro@iib.unsam.edu.ar

Source: PLoS Pathogens; 3/28/2025, Vol. 21 Issue 3, p1-21, 21p

Novel Hybrid Catalysts of Cysteine Proteases Enhanced by Chitosan and Carboxymethyl Chitosan Micro- and Nanoparticles.

Authors: Holyavka, Marina¹ (AUTHOR) holyavka@rambler.ru, Redko, Yulia¹ (AUTHOR) olshannikovas@gmail.com, Goncharova, Svetlana¹ (AUTHOR) maria.lavlinskaya@gmail.com, Lavlinskaya, Maria¹ (AUTHOR) andrew.v.sorokin@gmail.com, Sorokin, Andrey¹ (AUTHOR) ma-ko@bk.ru, Kondratyev, Maxim^1,2 (AUTHOR) artyukhov@bio.vsu.ru, Artyukhov, Valery¹ (AUTHOR)

Source: Polymers (20734360). Nov2024, Vol. 16 Issue 22, p3111. 18p.

Subject Terms: *CYSTEINE proteinases, *BINDING sites, *AMINO acid residues, *HYDROGEN bonding interactions, *MULTIENZYME complexes

ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization.

Authors: Zhang, Lu^1,2 (AUTHOR), Cheng, Hsiu-Hsin^1,2 (AUTHOR), Krüger, Nadine³ (AUTHOR), Hörnich, Bojan⁴ (AUTHOR), Graichen, Luise^1,2 (AUTHOR), Hahn, Alexander S.⁴ (AUTHOR), Schulz, Sebastian R.⁵ (AUTHOR), Jäck, Hans-Martin⁵ (AUTHOR), Stankov, Metodi V.⁶ (AUTHOR), Behrens, Georg M. N.^6,7 (AUTHOR), Müller, Marcel A.^8,9 (AUTHOR), Drosten, Christian^8,9 (AUTHOR), Mörer, Onnen¹⁰ (AUTHOR), Winkler, Martin Sebastian¹⁰ (AUTHOR), Qian, ZhaoHui¹¹ (AUTHOR), Pöhlmann, Stefan^1,2 (AUTHOR) spoehlmann@dpz.eu, Hoffmann, Markus^1,2 (AUTHOR) mhoffmann@dpz.eu

Source: PLoS Pathogens. 11/13/2024, Vol. 20 Issue 11, p1-33. 33p.

Subject Terms: *SERINE proteinases, *HORSESHOE bats, *CARRIER proteins, *RACCOON dog, *PROTEIN receptors

Interaction Dynamics of Plant-Specific Insert Domains from Cynara cardunculus : A Study of Homo- and Heterodimer Formation.

Authors: Sampaio, Miguel¹ (AUTHOR) up201503801@edu.fc.up.pt, Santos, Sofia¹ (AUTHOR) soliveirasofia13@gmail.com, Jesus, Ana Marta¹ (AUTHOR) up201905096@edu.fc.up.pt, Pissarra, José¹ (AUTHOR) jpissarr@fc.up.pt, Di Sansebastiano, Gian Pietro² (AUTHOR) gp.disansebastiano@unisalento.it, Alvim, Jonas³ (AUTHOR) jonas.alvim@glasgow.ac.uk, Pereira, Cláudia¹ (AUTHOR) cpereira@fc.up.pt

Source: Molecules. Nov2024, Vol. 29 Issue 21, p5139. 15p.

Subject Terms: *CARDOON, *ASPARTIC proteinases, *CARRIER proteins, *DIMERIZATION, *PROTEINS

Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview.

Authors: Vidal, Julia F. D.¹ (AUTHOR), Schwartz, Matheus F.¹ (AUTHOR), Garay, Aisel V.¹ (AUTHOR), Valadares, Napoleão F.¹ (AUTHOR), Bueno, Renata V.¹ (AUTHOR), Monteiro, Ana Carolina L.¹ (AUTHOR), Freitas, Sônia Maria de¹ (AUTHOR), Barbosa, João Alexandre R. G.¹ (AUTHOR) joaobarbosa@unb.br

Source: Toxins. Oct2024, Vol. 16 Issue 10, p428. 38p.

Subject Terms: *SNAKE venom, *SERINE proteinases, *BLOOD platelet activation, *BIOCHEMICAL substrates, *BIOTECHNOLOGY

New Pipeline for Analysing Fruit Proteolytic Products Used as Digestive Health Nutraceuticals.

Authors: Benito-Vázquez, Iván^1,2 (AUTHOR) ivan.benito@pharmactive.eu, Muñoz-Labrador, Ana¹ (AUTHOR) ana.munoz@csic.es, Garrido-Romero, Manuel^1,2 (AUTHOR) manuel.garrido@pharmactive.eu, Hontoria-Caballo, Gema² (AUTHOR), García-García, Carlos³ (AUTHOR) cgarcia@cbm.csic.es, Diez-Municio, Marina² (AUTHOR) mdiez@pharmactive.eu, Moreno, F. Javier¹ (AUTHOR) mdiez@pharmactive.eu

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10315. 19p.

Subject Terms: *CYSTEINE proteinases, *PROTEOLYSIS, *MUSCLE proteins, *PROTEIN stability, *PROTEOMICS, *KIWIFRUIT, *PINEAPPLE

Tetraspanin-enriched microdomains play an important role in pathogenesis in the protozoan parasite Entamoeba histolytica.

Authors: Jiang, Han¹ (AUTHOR), Santos, Herbert J.¹ (AUTHOR), Nozaki, Tomoyoshi¹ (AUTHOR) nozaki@m.u-tokyo.ac.jp

Source: PLoS Pathogens. 10/3/2024, Vol. 20 Issue 10, p1-25. 25p.

Subject Terms: *CYSTEINE proteinases, *ENTAMOEBA histolytica, *CARRIER proteins, *INTESTINAL parasites, *PARASITIC protozoa

Aspergillus Fumigatus Spore Proteases Alter the Respiratory Mucosa Architecture and Facilitate Equine Herpesvirus 1 Infection.

Authors: Portaels, Joren¹ (AUTHOR) joren.portaels@ugent.be, Van Crombrugge, Eline¹ (AUTHOR) esvcromb.vancrombrugge@ugent.be, Van Den Broeck, Wim² (AUTHOR) wim.vandenbroeck@ugent.be, Lagrou, Katrien³ (AUTHOR) katrien.lagrou@uzleuven.be, Laval, Kathlyn¹ (AUTHOR) kathlyn.laval@ugent.be, Nauwynck, Hans¹ (AUTHOR) kathlyn.laval@ugent.be

Source: Viruses (1999-4915). Aug2024, Vol. 16 Issue 8, p1208. 15p.

Subject Terms: *SERINE proteinases, *POLLUTANTS, *RESPIRATORY mucosa, *CELL junctions, *HERPESVIRUS diseases

Computational screening combined with well-tempered metadynamics simulations identifies potential TMPRSS2 inhibitors.

Authors: Sharanya, C. S.¹ (AUTHOR), Wilbee, D. Sasikala^1,2 (AUTHOR), Sathi, Shijulal Nelson³ (AUTHOR), Natarajan, Kathiresan¹ (AUTHOR) kathiresan@rgcb.res.in

Source: Scientific Reports. 7/13/2024, Vol. 14 Issue 1, p1-15. 15p.

Subject Terms: *GIBBS' energy diagram, *SERINE proteinases, *LIFE cycles (Biology), *VIRAL proteins, *BINDING energy, *NARINGIN, *PROTEIN-ligand interactions