Physiologically-based pharmacokinetic/pharmacodynamic modeling of meropenem in critically ill patients

Authors: Yujie Yang, Yirong Wang, Wei Zeng, Jinhua Zhou, Min Xu, Ying Lan, Lvye Liu, Jian Shen, Chuan Zhang, Qin He

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Subject Terms: Meropenem, PBPK/PD, Critically ill patients, PK-Sim, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d85e00cfbc944feeabe5746ecd2e650f

Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Authors: Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

Source: Pharmaceutics, Vol 17, Iss 1, p 69 (2025)

Subject Terms: siRNA, physiologically based pharmacokinetic modeling, PK-Sim, ASGPR, RISC, GalNAc, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/1/69; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/0827e8c2d925411b9765d742aeff88e5

Prediction of pediatric dose of tirzepatide from the reference adult dose using physiologically based pharmacokinetic modelling

Authors: Ruifang Guan, Xuening Li, Guo Ma

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: physiologically based pharmacokinetic (PBPK) modelling, tirzepatide, PK-Sim, MoBi, pediatric dose, diabetes, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1326373/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/013ec681a4734a3c8ebd813398a34070

Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing

Authors: Fawaz Alasmari, Mohammed S. Alasmari, Hussa Mubarak Muwainea, Hatun A. Alomar, Abdullah F. Alasmari, Sary Alsanea, Aws Alshamsan, Muhammad F. Rasool, Faleh Alqahtani

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: PBPK, Pk-sim®, CKD, ceftriaxone, PK parameters, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1200828/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/e8f478ff905347a2be120a7457a58fd1

A Comprehensive Physiologically Based Pharmacokinetic Model of Nadolol in Adults with Renal Disease and Pediatrics with Supraventricular Tachycardia

Authors: Samia Kalsoom, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Tanveer Ahmad, Faleh Alqahtani

Source: Pharmaceuticals, Vol 17, Iss 2, p 265 (2024)

Subject Terms: nadolol, physiologically based pharmacokinetic, PK-Sim, pharmacokinetic, renal impairment, pediatrics, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/2/265; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/eeade3b2b9e24dbbb81eeb91e6c38def

A generic avian physiologically-based kinetic (PBK) model and its application in three bird species

Authors: Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey J. Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt, David Heckmann

Source: Environment International, Vol 169, Iss , Pp 107547- (2022)

Subject Terms: PBPK model, Wild animals, Pesticides, Birds, Chemical risk assessment, PK-Sim MoBi, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412022004743; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/538906f5c3854aa58c32c8940c07db7d

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

Authors: Chaozhuang Shen, Dahu Liang, Xiaohu Wang, Wenxin Shao, Kuo Geng, Xingwen Wang, Hua Sun, Haitang Xie

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: propylthiouracil (PTU), PBPK, PK-sim®, extrapolation, elderly, pediatric, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1013432/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/85bc310349f5475a91a69e2fc10e6398

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Authors: Memoona Rashid, Muhammad Sarfraz, Mosab Arafat, Amjad Hussain, Nasir Abbas, Muhammad Waqas Sadiq, Muhammad Fawad Rasool, Nadeem Irfan Bukhari

Source: BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-14 (2020)

Subject Terms: Lisinopril, PBPK, Pediatric, PK-Sim MoBI®, Area under the curve, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40360-020-00429-y; https://doaj.org/toc/2050-6511

Access URL: https://doaj.org/article/f51ff2e5f81f48c48fc4b0d11b500dfe

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations

Authors: Mohammed S. Alasmari, Fawaz Alasmari, Abdullah F. Alasmari, Aws Alshamsan, Sary Alsanea, Muhammad F. Rasool, Faleh Alqahtani

Source: Pharmaceutics, Vol 14, Iss 9, p 1795 (2022)

Subject Terms: PBPK, PK-Sim®, haloperidol, psychosis, personalized medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/9/1795; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/21af96fb8558416d9977ffb9f34dbe8e

Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

Authors: Sumit Basu, Yi Ting (Kayla) Lien, Valvanera Vozmediano, Jan-Frederik Schlender, Thomas Eissing, Stephan Schmidt, Christoph Niederalt

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: physiologically based pharmacokinetic (PBPK) modeling, PK-Sim, monoclonal antibodies, pediatrics, children, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00868/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/288902e7c998413bb6490a1f965d1cd0

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