REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.

Authors: Ren, Xiaojing¹ (AUTHOR), Teng, Yunfei² (AUTHOR), Xie, Kunxin³ (AUTHOR), He, Xiao^2,4 (AUTHOR), Chen, Gang^2,4 (AUTHOR), Zhang, Kaini⁵ (AUTHOR), Liao, Qingyi⁶ (AUTHOR), Zhang, Jia³ (AUTHOR), Zhou, Xiaohang³ (AUTHOR), Zhu, Yating³ (AUTHOR), Song, Wenyu³ (AUTHOR), Lin, Yuege² (AUTHOR), Zhang, Yi⁷ (AUTHOR), Xu, Zhijian⁶ (AUTHOR), Maeshige, Noriaki⁸ (AUTHOR), Liang, Xiubin⁵ (AUTHOR), Su, Dongming² (AUTHOR) sudongming@njmu.edu.cn, Sun, Peng³ (AUTHOR) sunpeng@njmu.edu.cn, Ding, Ying⁴ (AUTHOR) dingying@njmu.edu.cn

Source: Cell Communication & Signaling. 2/18/2025, Vol. 23 Issue 1, p1-19. 19p.

Subject Terms: *PANCREATIC acinar cells, *MITOGEN-activated protein kinases, *EPIDERMAL growth factor receptors, *LIFE sciences, *CYTOLOGY

Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9.

Authors: Zhou, Cancan^1,2 (AUTHOR), Feng, Zhengyuan^1,2 (AUTHOR), Qian, Weikun^1,2 (AUTHOR), Zhu, Zeen^1,2 (AUTHOR), Cao, Ruiqi^1,2 (AUTHOR), Wang, Qiqi^1,2 (AUTHOR), Zhang, Wunai³ (AUTHOR), Liu, Rujuan^1,2 (AUTHOR), Wu, Shuai^1,2 (AUTHOR), Hao, Jie^1,2 (AUTHOR), Wang, Zheng^1,2 (AUTHOR), Ma, Qingyong^1,2 (AUTHOR), Wu, Zheng^1,2 (AUTHOR) woozheng@xjtu.edu.cn, Li, Xuqi⁴ (AUTHOR) lixuqi@163.com

Source: Biology Direct. 1/14/2025, Vol. 20 Issue 1, p1-14. 14p.

Subject Terms: *STEROL regulatory element-binding proteins, *PANCREATIC acinar cells, *PANCREATIC cancer, *MEDICAL sciences, *TUMOR growth

Knockdown of ORM2 improves cerulein-induced acute pancreatitis in vitro via the p38 MAPK signaling pathway.

Authors: Jie Du¹, Chuanming Zheng¹, Taizhe Zhang¹, Sandang Li¹, Zhong Ji¹, Zhenjie Wang¹ wzj_dr5@163.com

Source: Signa Vitae. Dec2024, Vol. 20 Issue 12, p93-98. 6p.

Subject Terms: *PANCREATIC acinar cells, *MITOGEN-activated protein kinases, *PANCREATIC diseases, *PYROPTOSIS, *PANCREATITIS

Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases.

Authors: Fu, Fei^1,2 (AUTHOR) fufei9940@wchscu.cn, Li, Wanmeng² (AUTHOR) 2023224070047@stu.scu.edu.cn, Zheng, Xiaoyin² (AUTHOR) 2022224070024@stu.scu.edu.cn, Wu, Yaling² (AUTHOR), Du, Dan^1,2 (AUTHOR) dudan@wchscu.cn, Han, Chenxia¹ (AUTHOR) dudan@wchscu.cn

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11474. 25p.

Subject Terms: *PANCREATIC diseases, *PANCREATIC acinar cells, *CHRONIC pancreatitis, *PANCREATIC cancer, *PANCREATITIS

Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation.

Authors: Frost, Fabian¹ (AUTHOR), Weiss, Stefan^1,2 (AUTHOR), Hertel, Johannes³ (AUTHOR), Rühlemann, Malte⁴ (AUTHOR), Bang, Corinna⁴ (AUTHOR), Franke, Andre⁴ (AUTHOR), Nauck, Matthias⁵ (AUTHOR), Dörr, Marcus⁶ (AUTHOR), Völzke, Henry⁷ (AUTHOR), Roggenbuck, Dirk^8,9 (AUTHOR), Schierack, Peter^8,9 (AUTHOR), Völker, Uwe² (AUTHOR), Homuth, Georg² (AUTHOR), Aghdassi, Ali A.¹ (AUTHOR), Sendler, Matthias¹ (AUTHOR), Lerch, Markus M.¹ (AUTHOR), Weiss, Frank U.¹ (AUTHOR) ulrich.weiss@med.uni-greifswald.de

Source: Gut Pathogens. 10/19/2024, Vol. 16 Issue 1, p1-11. 11p.

Subject Terms: *PANCREATIC acinar cells, *SHORT-chain fatty acids, *ENZYME-linked immunosorbent assay, *LACTIC acid, *BODY mass index

Octreotide as prophylaxis against asparaginase-associated pancreatitis: a case series study.

Authors: Hayashi, Hiroshi^1,2 (AUTHOR) hiroshi.273@gmail.com, Morikawa, Yoshihiko² (AUTHOR), Akahoshi, Shogo² (AUTHOR), Ikegawa, Kento² (AUTHOR), Matsui, Motohiro¹ (AUTHOR), Makimoto, Atsushi^1,2 (AUTHOR), Yuza, Yuki¹ (AUTHOR)

Source: Leukemia & Lymphoma. Sep2024, Vol. 65 Issue 9, p1366-1369. 4p.

Subject Terms: *PANCREATIC acinar cells, *DRUG monitoring, *PEDIATRIC intensive care, *LABORATORY rats, *SOMATOSTATIN receptors

Cirsilineol reduces inflammation and apoptosis in an in vitro model of acute pancreatitis.

Authors: Wanqiong Zheng¹ zwq5171717@163.com, Ye Tian², Yiming Zhang¹, Binnan Li¹

Source: Signa Vitae. Sep2024, Vol. 20 Issue 9, p56-62. 7p.

Subject Terms: *PANCREATIC acinar cells, *FLAVONOIDS, *CELL survival, *PANCREATITIS, *APOPTOSIS

Network pharmacology-based investigation and experimental validation of the therapeutic potential and molecular mechanism of Danshen Chuanxiongqin injection in acute pancreatitis.

Authors: Liu, Yining¹ (AUTHOR), Xu, Liming² (AUTHOR), Fang, Qiongyan¹ (AUTHOR), Rong, Hui¹ (AUTHOR), Zheng, Huaiyu¹ (AUTHOR) zsyyyxb123@163.com

Source: Technology & Health Care. 2024, Vol. 32 Issue 4, p2307-2320. 14p.

Subject Terms: *PANCREATIC acinar cells, *TREATMENT effectiveness, *P53 protein, *MOLECULAR docking, *CELL survival

X‐Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells.

Authors: Yang, Zhuo¹ (AUTHOR), Li, Shaojun² (AUTHOR), Zhao, Chuan¹ (AUTHOR), Zhao, Zongzheng¹ (AUTHOR), Tan, Juan¹ (AUTHOR), Zhang, Lu² (AUTHOR), Huang, Yuanqing¹ (AUTHOR) huangyq810314@163.com

Source: Immunity, Inflammation & Disease. Jul2024, Vol. 12 Issue 7, p1-11. 11p.

Subject Terms: *PANCREATIC acinar cells, *CELL physiology, *PANCREATIC duct, *CARRIER proteins, *ENDOPLASMIC reticulum

In vitro effects of Ganoderic acid A on NF-κB-mediated inflammatory response in caerulein-stimulated pancreatic acinar cells.

Authors: Yuzhou Jin¹, Jin Huang¹ jin_huang0713@163.com, Na Ma² mn715292364@sina.com

Source: Signa Vitae. Jun2024, Vol. 20 Issue 6, p93-98. 6p.

Subject Terms: *PANCREATIC acinar cells, *INFLAMMATION, *NF-kappa B, *ENZYME-linked immunosorbent assay, *WESTERN immunoblotting, *REACTIVE oxygen species

Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.

Authors: Araki, Tomoyuki¹ (AUTHOR) arayuki@saitama-med.ac.jp, Miwa, Naofumi² (AUTHOR) nmiwa@saitama-med.ac.jp

Source: BMC Research Notes. 4/15/2024, Vol. 17 Issue 1, p1-6. 6p.

Subject Terms: *PANCREATIC acinar cells, *PANCREATIC cancer, *PANCREATIC enzymes, *EPIGENETICS, *DNA methylation, *GENETIC mutation, *P16 gene

Isorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway.

Authors: Li, Xiaojuan¹ (AUTHOR), Wang, Tao¹ (AUTHOR), Zhou, Qilong¹ (AUTHOR), Li, Fan¹ (AUTHOR), Liu, Ting¹ (AUTHOR), Zhang, Kun¹ (AUTHOR), Wen, Ao¹ (AUTHOR), Feng, Lijuan¹ (AUTHOR), Shu, Xiaoling¹ (AUTHOR), Tian, Simin¹ (AUTHOR), Liu, Yijiang¹ (AUTHOR), Gao, Yu¹ (AUTHOR), Xia, Qing¹ (AUTHOR), Xin, Guang¹ (AUTHOR) xinguang@scu.edu.cn, Huang, Wen¹ (AUTHOR) xinguang@scu.edu.cn

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3784. 18p.

Subject Terms: *PANCREATIC acinar cells, *PANCREATIC enzymes, *MITOCHONDRIA, *CELLULAR signal transduction, *MITOCHONDRIAL DNA, *PANCREATITIS

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis.

Authors: Liu, Jianxing¹ (AUTHOR), Yan, Wenjing¹ (AUTHOR), Chen, Shanshan¹ (AUTHOR), Sun, Yingjie¹ (AUTHOR), Zhang, Fangfang¹ (AUTHOR), Yang, Yue¹ (AUTHOR), Jin, Liang¹ (AUTHOR)

Source: Stem Cells International. 3/21/2024, Vol. 2024, p1-20. 20p.

Subject Terms: *PANCREATIC acinar cells, *PANCREATITIS, *MACROPHAGES, *MESENCHYMAL stem cells, *STEM cells

Ameliorative effects of the melatonin on some cytokine levels, NF-κB immunoreactivity, and apoptosis in rats with cerule-ininduced acute pancreatitis.

Authors: Uluışık, Deniz¹ denizfedai@selcuk.edu.tr, Keskin, Ercan¹, Özaydın, Tuğba², Öznurlu, Yasemin²

Source: Iranian Journal of Basic Medical Sciences. Mar2024, Vol. 27 Issue 3, p279-285. 7p.

Subject Terms: *INTRAPERITONEAL injections, *PANCREATIC acinar cells, *PANCREATITIS, *MELATONIN, *CYTOKINES

β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview.

Authors: Sandoval, Cristian^1,2,3 (AUTHOR) cristian.sandoval@ufrontera.cl, Vera, Angeles⁴ (AUTHOR) a.vera08@ufromail.cl, Birditt, Katherine⁵ (AUTHOR) krb56@cam.ac.uk, Godoy, Karina⁶ (AUTHOR) karina.godoy@ufrontera.cl, Carmine, Florencia⁷ (AUTHOR) f.carmine02@ufromail.cl, Caamaño, José^3,8 (AUTHOR) jose.caamano@ufrontera.cl, Farías, Jorge² (AUTHOR) jose.caamano@ufrontera.cl

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1219. 13p.

Subject Terms: *ISLANDS of Langerhans, *PANCREATIC acinar cells, *CAROTENES, *LIPASES, *PANCREAS, *PANCREATIC duct, *ETHANOL, *LABORATORY mice

The Interaction of Microbiome and Pancreas in Acute Pancreatitis.

Authors: Zhang, Can^1,2 (AUTHOR) zhangcan@hrbmu.edu.cn, Li, Guanqun^1,2 (AUTHOR), Lu, Tianqi^1,2 (AUTHOR), Liu, Liwei^1,2 (AUTHOR), Sui, Yuhang^1,2 (AUTHOR), Bai, Rui¹ (AUTHOR), Li, Le^1,2 (AUTHOR) sunbei70@hrbmu.edu.cn, Sun, Bei^1,2 (AUTHOR) sunbei70@hrbmu.edu.cn

Source: Biomolecules (2218-273X). Jan2024, Vol. 14 Issue 1, p59. 16p.

Subject Terms: *PANCREATIC acinar cells, *PANCREATITIS, *PANCREAS, *ABDOMINAL diseases, *GUT microbiome, *DIGESTIVE enzymes

Natural Antioxidants: New Possibilities For The Treatment and Prevention of Acute Pancreatitis.

Authors: Kňazovický, M.¹ (AUTHOR), Roškovičová, V.¹ (AUTHOR) vroskovicova@gmail.com, Gajdzik, T.¹ (AUTHOR), Hildebrand, T.¹ (AUTHOR), Kaťuchová, J.¹ (AUTHOR)

Source: Bratislava Medical Journal / Bratislavské Lekárske Listy. Feb2025, Vol. 126 Issue 2, p114-126. 13p.

Subject Terms: *PANCREATIC acinar cells, *GASTROINTESTINAL diseases, *DRUG therapy, *OXIDATIVE stress, *PANCREATITIS

Therapeutic potential of plant polyphenols in acute pancreatitis.

Authors: Niu, Chengu¹ (AUTHOR) chenguniu@gmail.com, Zhang, Jing² (AUTHOR), Okolo 3rd, Patrick I.³ (AUTHOR)

Source: Inflammopharmacology. Feb2025, Vol. 33 Issue 2, p785-798. 14p.

Subject Terms: *PLANT polyphenols, *PANCREATIC acinar cells, *PLANT disease treatment, *PANCREATIC enzymes, *ENZYME activation

The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer.

Authors: Tang, Hao-Yu^1,2,3 (AUTHOR), Cao, Yi-Zhi³ (AUTHOR), Zhou, Yi-Wei³ (AUTHOR), Ma, Yu-Shui⁴ (AUTHOR), Jiang, Hong⁵ (AUTHOR), Zhang, Hui² (AUTHOR), Jiang, Lin⁶ (AUTHOR), Yang, Qin-Xin¹ (AUTHOR), Tang, Xiao-Mei³ (AUTHOR), Yang, Chun⁷ (AUTHOR), Liu, Xin-Yun¹ (AUTHOR), Liu, Fu-Xing¹ (AUTHOR), Liu, Ji-Bin^1,2 (AUTHOR) tians2008@ntu.edu.cn, Fu, Da^1,2,3 (AUTHOR) fuda@shsmu.edu.cn, Wang, Yun-Feng^1,8 (AUTHOR) wangyunfeng197911@163.com, Yu, Hong^1,9 (AUTHOR) yuhong@njmu.edu.cn

Source: Journal of Advanced Research. Jan2025, Vol. 67, p253-267. 15p.

Subject Terms: *PANCREATIC acinar cells, *KILLER cells, *KILLER cell receptors, *PANCREATIC cancer, *CHIMERIC antigen receptors

Clinical Outcomes and Molecular Profiling of Pancreatic Acinar Cell Carcinoma: A Retrospective Study.

Authors: Eslinger, Cody¹ (AUTHOR), Seddighzadeh, Bobak¹ (AUTHOR), Yee, Claire² (AUTHOR), Elsabbagh, Zaid¹ (AUTHOR), Pai, Rish³ (AUTHOR), Hartley, Chris⁴ (AUTHOR), Starr, Jason⁵ (AUTHOR), Bekaii-Saab, Tanios¹ (AUTHOR), Halfdanarson, Thorvardur R.⁶ (AUTHOR), Sonbol, Mohamad Bassam¹ (AUTHOR) Sonbol.mohamad@mayo.edu

Source: JCO Precision Oncology. 2025, Vol. 9, p1-10. 10p.

Subject Terms: *PANCREATIC acinar cells, *HOMOLOGOUS recombination, *OVERALL survival, *DRUG target, *NUCLEOTIDE sequencing