A novel PAK1/TCF1 regulatory axis promotes non-small cell lung cancer progression

Authors: Chuangang Lu, Yuncong Su, Youzhong Xu, Siyuan Sheng, Taiting Chen, Juan Li

Source: Discover Oncology, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: PAK1, TCF1, Non-small cell lung cancer, Carcinogenesis, Therapeutic targets, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/268234f1958a4fd1ba99c272b5eb046f

Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation

Authors: Hui He, Tianyu Jiang, Meng Ding, Yuan Zhu, Xiaoting Xu, Yashuang Huang, Wenfeng Yu, Hailong Ou

Source: Redox Biology, Vol 79, Iss , Pp 103477- (2025)

Subject Terms: NADPH oxidase 1, Abdominal aortic aneurysm, PAK1, Smooth muscle cell, Vascular inflammation, MMP2, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724004555; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/359c0fd003534b14bfe5b6c7f87caff8

RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy

Authors: Shuo Ma, Yanhua Xu, Xinyue Qin, Mei Tao, Xinliang Gu, Lei Shen, Yinhao Chen, Ming Zheng, Shiyi Qin, Guoqiu Wu, Shaoqing Ju

Source: Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-25 (2024)

Subject Terms: circPTPN22, Gastric cancer, Autophagy, miR-6788-5p, PAK1, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/84fd6be42ebf4785908b2392526d6ce5

Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis

Authors: Kirsty M. Ferguson, Carla Blin, Claudia Garcia-Diaz, Harry Bulstrode, Raul Bardini Bressan, Katrina McCarten, Steven M. Pollard

Source: Disease Models & Mechanisms, Vol 17, Iss 12 (2024)

Subject Terms: neural stem cell, quiescence, foxg1, foxo6, pak1, glioblastoma, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/17/12/dmm052005; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/24f34094e5c84ddb88486ed5b9bc5256

Modulating PAK1: Accessory Proteins as Promising Therapeutic Targets

Authors: Amin Mirzaiebadizi, Rana Shafabakhsh, Mohammad Reza Ahmadian

Source: Biomolecules, Vol 15, Iss 2, p 242 (2025)

Subject Terms: PAK1, p21-activated kinase, accessory proteins, scaffold proteins, adaptor proteins, α/βPIX, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/2/242; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/808a7d64b7d44377b9a728c29ad08905

VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

Authors: Natalia Fernández-Parejo, L. Francisco Lorenzo-Martín, Juana M. García-Pedrero, Juan P. Rodrigo, Mercedes Dosil, Xosé R. Bustelo

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: Guanosine nucleotide exchange factors, RHO GTPases, RAC1, RHOA, PAK1, ROCK, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cc4d6834c3764ff9ae00a5011ff571bb

Natural Compounds in Plant-Based Food

Contributors: Eisenreich, Andreas, Schaefer, Bernd

Subject Terms: pyrrolizidine alkaloids, hepatotoxicity, HepaRG, cholestasis, bile acid, turmeric, essential oil composition, α-turmerone, β-turmerone, ar-turmerone, polyunsaturated fatty acids (PUFAs), erucic acid, petroselinic acid, fat quality indices, hypocholesterolemic fatty acids, atherogenic index (AI), structure dependency, bile acids, biodegradation, pyrrolizidine alkaloid (PA), contamination, food chain, compost, plant waste, Lappula squarrosa, Senecio jacobaea, HPLC-ESI-MS/MS, horizontal alkaloid transfer, asarone isomers, human study, metabolites, asarone glucuronides, mustard, Sinapis alba, Brassica nigra, Brassica juncea, glucosinolates, isothiocyanates, bisphenol F, allergy, toxicology, piperine, food safety, drug interaction, reproductive toxicity, bolus administration, alkenylbenzenes, food, consumption, regulation, mixtures, cell cycle, IPA, microRNA, PAK1, senecionine, myristicin, elemicin, safrole, methyleugenol, flavoring, black pepper, cinnamon, health benefits and risks, antioxidant properties, carcinogens, DNA-reactants, epigenetic, risk assessment, polyacetylenes, phytochemicals, anti-inflammatory, anticancer, Medicine and Nursing, Medical toxicology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/113877
https://mdpi.com/books/pdfview/book/7718

ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1

Authors: Kai Wang, Xun Qiu, Zhensheng Zhang, Hanzhi Xu, Yawen Tan, Renyi Su, Fengqiang Gao, Jianyong Zhuo, Wangyao Li, Zhengxing Lian, Hong He, Xiao Xu

Source: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)

Subject Terms: ATRA, Chemoresistance, Hepatocellular carcinom, PAK1, Sorafenib, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/b854af39d4904d43a575104fdc0440da

PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway

Authors: Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)

Subject Terms: COX-2, IPA-3, Merlin, NF-κB, NF2, PAK1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/bcfbb42313e74969939c727a7eea4f8a

BAY 11-7082: An Anti-inflammatory Drug for COVID-19

Authors: Mohadeseh Nemati, Fahima Danesh Pouya, Elmira Roshani Asl, Yousef Rasmi1comma2

Source: Sudan Journal of Medical Sciences, Vol 18, Iss 1, Pp 117-120 (2023)

Subject Terms: bay 11-7082, covid-19, pak1, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1858-5051

Access URL: https://doaj.org/article/2b3686398b6440e299a789aa4e0f78a8

LINC00467 induces melanoma deterioration by targeting miR-485-5p/p21 activated kinase 1

Authors: Ji Zhoujing, Zhang Jie, Zhang Lili, Yang Shengju, Li Yangcheng, Gu Lixiong

Source: Journal of Medical Biochemistry, Vol 42, Iss 2, Pp 282-288 (2023)

Subject Terms: melanoma, linc00467, mir-485-5p, pak1, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302282J.pdf; https://doaj.org/toc/1452-8258; https://doaj.org/toc/1452-8266

Access URL: https://doaj.org/article/dd593c7d9df04aa28ec54ffef3a6ce89

Identification of Genetic Diversity of P21-Activated Kinases (PAK1) Gene in Senduro Goats and Boerawa Goats using PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism)

Authors: Heri Damayanti, Tri Eko Susilorini, Guruh Prasetyo, Nur Hidayah, Ahmad Zarkasi Efendi, Ari Ardiantoro, Wike Andre Septian Septian, Suyadi Suyadi

Source: Jurnal Ilmu-Ilmu Peternakan, Vol 33, Iss 3 (2023)

Subject Terms: senduro goat, boerawa goat, pak1, pcr-rflp, genetic diversity, Animal culture, SF1-1100

File Description: electronic resource

Relation: https://jiip.ub.ac.id/index.php/jiip/article/view/2782; https://doaj.org/toc/0852-3681; https://doaj.org/toc/2443-0765

Access URL: https://doaj.org/article/c399c687292f40c8a61fdf307d2f588c

Editorial: Cell signaling in cancer metastasis and lineage plasticity

Authors: Wei Yang, Kavita Shah, Rong Yang

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: signaling, metastasis, lineage plasticity, ONECUT2, PAK1, network, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1302659/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/7f3605ef99de4bf7a8ad2c390a37d627

Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia

Authors: Zijuan Wu, Luqiao Wang, Lei Fan, Hanning Tang, Xiaoling Zuo, Danling Gu, Xueying Lu, Yue Li, Jiazhu Wu, Shuchao Qin, Yi Xia, Huayuan Zhu, Li Wang, Wei Xu, Jianyong Li, Hui Jin

Source: Molecular Oncology, Vol 16, Iss 16, Pp 2920-2935 (2022)

Subject Terms: chronic lymphocytic leukaemia, ibrutinib resistance, metabolism, PAK1, three‐dimensional genome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/9c293ac4caa34f1b972808bacc774fbd

LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer

Authors: Chen G, Liao J, Xu Y, Chen Y, Li J, Bu G, Li Q

Source: Cancer Management and Research, Vol Volume 14, Pp 1729-1740 (2022)

Subject Terms: gastric cancer, linc01232, mir-506-5p, metastasis, pak1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.dovepress.com/linc01232-promotes-metastasis-and-emt-by-regulating-mir-506-5ppak1-axi-peer-reviewed-fulltext-article-CMAR; https://doaj.org/toc/1179-1322

Access URL: https://doaj.org/article/537b406ad9a2413e86ef7b4709273b24

Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function

Authors: Rekha Balakrishnan, Pablo A. Garcia, Rajakrishnan Veluthakal, Janice M. Huss, Joseph M. Hoolachan, Debbie C. Thurmond

Source: Antioxidants, Vol 12, Iss 9, p 1658 (2023)

Subject Terms: type 2 diabetes, insulin resistance, skeletal muscle, mitochondria, PAK1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/9/1658; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/fa5f47e8f89f4b80a08ae9cc988484c8

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Authors: Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao, Ze-nan Tang

Source: Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-14 (2021)

Subject Terms: Circ-PNPT1, miR-889-3p, PAK1, Gestational diabetes mellitus, Exosomes, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/90cca435f11b42c98e03ef317826c4e7

MiR-7 Regulates Pathogen-Induced Immune Response via PAK1 in the Sea Cucumber Apostichopus japonicus

Authors: Tanjun Zhao, Liyuan Ren, Chengda Li, Li Liu, Yang Zou, Hanyu Yan, Yaoyao Zhan, Yaqing Chang

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: MiR-7, PAK1, Vibrio splendidus, Apostichopus japonicus, innate immune regulation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.927796/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0d421057d03c40208eea4a9d687a16cf

Centchroman prevents metastatic colonization of breast cancer cells and disrupts angiogenesis via inhibition of RAC1/PAK1/β-catenin signaling axis

Authors: Khan, Sajid ^{a, 1}, Shukla, Samriddhi ^{a, 2}, Farhan, Mohammad ^{a, 3}, Sinha, Sonam ^{a, 4}, Lakra, Amar Deep ^a, Penta, Dhanamjai ^b, Kannan, Anbarasu ^c, Meeran, Syed Musthapa ^{a, b, ⁎}

Source: In Life Sciences 1 September 2020 256

Mislocalized cytoplasmic p27 activates PAK1‐mediated metastasis and is a prognostic factor in osteosarcoma

Authors: Xiang Chen, Justin M. M. Cates, Yu-Chen Du, Antrix Jain, Sung Yun Jung, Xiao-Nan Li, John M. Hicks, Tsz‐Kwong Man

Source: Molecular Oncology, Vol 14, Iss 4, Pp 846-864 (2020)

Subject Terms: biomarkers, metastasis, osteosarcoma, p27, PAK1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/abe8194521a84310b6dd257de637971c