Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients

Authors: Jochen H. Weishaupt, Péter Körtvélyessy, Peggy Schumann, Ivan Valkadinov, Ute Weyen, Jasper Hesebeck-Brinckmann, Kanchi Weishaupt, Matthias Endres, Peter M. Andersen, Martin Regensburger, Marie Dreger, Jan C. Koch, Julian Conrad, Thomas Meyer

Source: Communications Medicine, Vol 4, Iss 1, Pp 1-5 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/6dd37b8edbb149059b7df64c953bc24a

Antibody Properties Associate with Clinical Phenotype in LGI1 Encephalitis

Authors: Susann Ludewig, Leonie Salzburger, Alexander Goihl, Jana Rohne, Frank Leypoldt, Daniel Bittner, Emrah Düzel, Burkhart Schraven, Dirk Reinhold, Martin Korte, Péter Körtvélyessy

Source: Cells, Vol 12, Iss 2, p 282 (2023)

Subject Terms: LGI1 encephalitis, autoimmune encephalitis, pathophysiology encephalitis, synaptic plasticity, epitope of anti-LGI1 antibodies, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/2/282; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/8e9dd7d9509b40e5b769d3c44285734c

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Provision, cough efficacy and treatment satisfaction of mechanical insufflation-exsufflation in a large multicenter cohort of patients with amyotrophic lateral sclerosis

Authors: André Maier, Dagmar Kettemann, Ute Weyen, Torsten Grehl, Peter Caspar Schulte, Robert Steinbach, Annekathrin Rödiger, Patrick Weydt, Susanne Petri, Joachim Wolf, Julian Grosskreutz, Jan Christoph Koch, Jochen H. Weishaupt, Simone Rosseau, Jenny Norden, Peter Körtvélyessy, Birgit Koch, Teresa Holm, Barbara Hildebrandt, Peggy Schumann, Bertram Walter, Alessio Riitano, Christoph Münch, Thomas Meyer, Susanne Spittel

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e3152c25bfe94af9ae5fab1abc18b80b

Serum neurofilament light chain in COVID-19 and the influence of renal function

Authors: Peter Körtvelyessy, Elena Diekämper, Klemens Ruprecht, Matthias Endres, Paula Stubbemann, Florian Kurth, Jan Adriaan Graw, Mario Menk, Jens Kuhle, Felix Wohlrab

Source: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-7 (2023)

Subject Terms: COVID-19, Neurofilament light chain, Creatinine, Biomarker, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/f273d3422f4f494ab0ce4280f80aa433

Effects of tofersen treatment in patients with SOD1-ALS in a 'real-world' setting – a 12-month multicenter cohort study from the German early access programResearch in context

Authors: Maximilian Wiesenfarth, Johannes Dorst, David Brenner, Zeynep Elmas, Özlem Parlak, Zeljko Uzelac, Katharina Kandler, Kristina Mayer, Ulrike Weiland, Christine Herrmann, Joachim Schuster, Axel Freischmidt, Kathrin Müller, Reiner Siebert, Franziska Bachhuber, Tatiana Simak, Kornelia Günther, Elke Fröhlich, Antje Knehr, Martin Regensburger, Alexander German, Susanne Petri, Julian Grosskreutz, Thomas Klopstock, Peter Reilich, Florian Schöberl, Tim Hagenacker, Ute Weyen, René Günther, Maximilian Vidovic, Martin Jentsch, Thomas Haarmeier, Patrick Weydt, Ivan Valkadinov, Jasper Hesebeck-Brinckmann, Julian Conrad, Jochen Hans Weishaupt, Peggy Schumann, Peter Körtvélyessy, Thomas Meyer, Wolfgang Philipp Ruf, Simon Witzel, Makbule Senel, Hayrettin Tumani, Albert Christian Ludolph

Source: EClinicalMedicine, Vol 69, Iss , Pp 102495- (2024)

Subject Terms: Amyotrophic lateral sclerosis, SOD1, Antisense oligonucleotide, Tofersen, Early access program, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024000749; https://doaj.org/toc/2589-5370

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The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation

Authors: Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kühn, Frank H. Perschel, Matthias Endres, Emrah Düzel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Venø, Bianca Teegen, Winfried Stöcker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jørgen Kjems, Michael Mülleder, Frank Heppner, Peter Körtvelyessy

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)

Subject Terms: COVID-19, Neuroinflammation, Proteomics, RNA, Progranulin, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/2185b49e6e60455db4212f740b0223ba

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Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Authors: Sven Jarius, Florence Pache, Peter Körtvelyessy, Ilijas Jelčić, Mark Stettner, Diego Franciotta, Emanuela Keller, Bernhard Neumann, Marius Ringelstein, Makbule Senel, Axel Regeniter, Rea Kalantzis, Jan F. Willms, Achim Berthele, Markus Busch, Marco Capobianco, Amanda Eisele, Ina Reichen, Rick Dersch, Sebastian Rauer, Katharina Sandner, Ilya Ayzenberg, Catharina C. Gross, Harald Hegen, Michael Khalil, Ingo Kleiter, Thorsten Lenhard, Jürgen Haas, Orhan Aktas, Klemens Angstwurm, Christoph Kleinschnitz, Jan Lewerenz, Hayrettin Tumani, Friedemann Paul, Martin Stangel, Klemens Ruprecht, Brigitte Wildemann, ; in cooperation with the German Society for Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

Source: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-33 (2022)

Subject Terms: Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Neurological symptoms, Lumbar puncture, Cerebrospinal fluid (CSF), Oligoclonal bands, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/e9740832837b4444a94071945a6b71d4

7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer’s disease

Authors: Laura Göschel, Lea Kurz, Andrea Dell'Orco, Theresa Köbe, Peter Körtvélyessy, Ariane Fillmer, Semiha Aydin, Layla Tabea Riemann, Hui Wang, Bernd Ittermann, Ulrike Grittner, Agnes Flöel

Source: NeuroImage: Clinical, Vol 38, Iss , Pp 103439- (2023)

Subject Terms: Amygdala, Hippocampus, 7T MRI, Alzheimer’s disease, SCD, Memory, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158223001286; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/69a8782c5dea4d84a3dbfd46d9611ebe

Ratio and index of Neurofilament light chain indicate its origin in Guillain‐Barré Syndrome

Authors: Peter Körtvelyessy, Jens Kuhle, Emrah Düzel, Stefan Vielhaber, Christian Schmidt, Annika Heinius, Frank Leypoldt, Burkhart Schraven, Dirk Reinhold, David Leppert, Alexander Goihl

Source: Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2213-2220 (2020)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/fad66f697bd8493cba4bccf4592ebfdc

Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy

Authors: Petra Huehnchen, Christian Schinke, Nikola Bangemann, Adam D. Dordevic, Johannes Kern, Smilla K. Maierhof, Lois Hew, Luca Nolte, Peter Körtvelyessy, Jens C. Göpfert, Klemens Ruprecht, Christopher J. Somps, Jens-Uwe Blohmer, Jalid Sehouli, Matthias Endres, Wolfgang Boehmerle

Source: JCI Insight, Vol 7, Iss 6 (2022)

Subject Terms: Neuroscience, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/56592c5cdac2409cbfdeb5a9acd2dfe8

Neurofilament Levels Are Reflecting the Loss of Presynaptic Dopamine Receptors in Movement Disorders

Authors: Elena Diekämper, Britta Brix, Winfried Stöcker, Stefan Vielhaber, Imke Galazky, Michael C. Kreissl, Philipp Genseke, Emrah Düzel, Péter Körtvelyessy

Source: Frontiers in Neuroscience, Vol 15 (2021)

Subject Terms: neurofilament light chain, movement disorders, DaTscan, Parkinson’s Disease, CSF, alpha-synuclein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2021.690013/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/c75d63963c094a3a86857a4e74a006a6

Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons

Authors: Christian Schinke, Valeria Fernandez Vallone, Andranik Ivanov, Yangfan Peng, Péter Körtvelyessy, Luca Nolte, Petra Huehnchen, Dieter Beule, Harald Stachelscheid, Wolfgang Boehmerle, Matthias Endres

Source: Data in Brief, Vol 38, Iss , Pp 107320- (2021)

Subject Terms: Induced pluripotent stem cell derived sensory neurons (iPSC-DSN), Chemotherapy induced neuropathy, 3R, Replacement, Transcriptome, Lithium, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352340921006041; https://doaj.org/toc/2352-3409

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Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons

Authors: Christian Schinke, Valeria Fernandez Vallone, Andranik Ivanov, Yangfan Peng, Péter Körtvelyessy, Luca Nolte, Petra Huehnchen, Dieter Beule, Harald Stachelscheid, Wolfgang Boehmerle, Matthias Endres

Source: Neurobiology of Disease, Vol 155, Iss , Pp 105391- (2021)

Subject Terms: Induced pluripotent stem cell derived sensory neurons (iPSC-DSN), Chemotherapy induced neuropathy, 3R, Replacement, Transcriptome, Lithium, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996121001406; https://doaj.org/toc/1095-953X

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Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus

Authors: Rana Raoof, Eva M. Jimenez-Mateos, Sebastian Bauer, Björn Tackenberg, Felix Rosenow, Johannes Lang, Müjgan Dogan Onugoren, Hajo Hamer, Tessa Huchtemann, Peter Körtvélyessy, Niamh M. C. Connolly, Shona Pfeiffer, Jochen H. M. Prehn, Michael A. Farrell, Donncha F. O’Brien, David C. Henshall, Catherine Mooney

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9b6edaff4d2b4010b13e449a8ada68c7

CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration

Authors: Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: multiple sclerois and neuroimmunology, neurofilament light chain (NFL), amyotrofic lateral sclerosis, primary progressive multiple sclerosis, cerebrospical fluid (CSF), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.01037/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/7c15b80536a74f33aa837dc6df65adfa

Biomarkers of Neurodegeneration in Autoimmune-Mediated Encephalitis

Authors: Peter Körtvelyessy, Harald Prüss, Lorenz Thurner, Walter Maetzler, Deborah Vittore-Welliong, Jörg Schultze-Amberger, Hans-Jochen Heinze, Dirk Reinhold, Frank Leypoldt, Stephan Schreiber, Daniel Bittner

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: progranulin, neurofilament light chain, NMDAR encephalitis, Lgi-1 encephalitis, Caspr2 encephalitis, tau, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.00668/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/3e0c2624f809499dad3490264dd7c954

CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?

Authors: Peter Körtvelyessy, Hans J. Heinze, Johannes Prudlo, Daniel Bittner

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: frontotemporal dementia, cerebrospinal fluid, phospho-tau, tau, amyloid beta, progranulin, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.00504/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/f2c15b201e684606b3552a4c8347a826