Insights into the inhibition mechanisms of MERS-CoV and SARS-CoV2 papain-like proteases by inhibitors from Crinum distichum: In vitro and in silico analysis

Authors: Kouam, Arnaud Fondjo, Mabou, Florence Déclaire, Fu, Lifeng, Koagne, Roméol Romain, Li, Yan, Owona, Brice Ayissi, Zeuko'o, Elisabeth Menkem, Fepa, Armelle Gaelle Kwesseu, Galani, Borris Rosnay Tietcheu, Reyes, Fernando, Njayou, Frédéric Nico, Moundipa, Paul Fewou, Gao, George Fu

Source: In South African Journal of Botany February 2024 165:290-306

Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation.

Authors: Owona, Brice Ayissi, Mary, Arnaud, Messi, Angelique N., Ravichandran, Kishore Aravind, Mbing, Josephine Ngo, Pegnyemb, Emmanuel, Moundipa, Paul F., Heneka, Michael T.

Source: Molecular Neurobiology; Feb2025, Vol. 62 Issue 2, p1605-1619, 15p

Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity

Authors: Kouam, Arnaud Fondjo, Owona, Brice Ayissi, Fifen, Rodrigue, Njayou, Frédéric Nico, Moundipa, Paul Fewou

Source: In Heliyon August 2020 6(8)

Natural compounds flavonoids as modulators of inflammasomes in chronic diseases

Authors: Owona, Brice Ayissi, Abia, Wilfred Angie, Moundipa, Paul Fewou

Source: In International Immunopharmacology July 2020 84

Withaferin A modulates AIM2 inflammasome and caspase-1 expression in THP-1 polarized macrophages

Authors: Ngoungoure, Florence Pare, Owona, Brice Ayissi

Source: In Experimental Cell Research 15 October 2019 383(2)

In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from Ochna rhizomatosa on HIV-1 Integrase and Plasmodium falciparum.

Authors: Messi, Angélique Nicolas, Bonnet, Susan Lucia, Owona, Brice Ayissi, Wilhelm, Anke, Kamto, Eutrophe Le Doux, Ndongo, Joseph Thierry, Siwe-Noundou, Xavier, Poka, Madan, Demana, Patrick H., Krause, Rui W. M., Ngo Mbing, Joséphine, Pegnyemb, Dieudonné Emmanuel, Bochet, Christian G.

Source: Pharmaceutics; Aug2022, Vol. 14 Issue 8, p1701-1701, 17p

Subject Terms: PLASMODIUM falciparum, HIV, MOLECULAR docking, METABOLITES, FLAVONOIDS, PLASMODIUM, PARASITES

Khaya grandifoliola active fraction as a source of therapeutic compounds for Alzheimer's disease treatment: In silico validation of identified compounds.

Authors: Owona, Brice Ayissi¹ (AUTHOR) briceayissi03@yahoo.fr, Njayou, Frederic N.¹ (AUTHOR), Mkounga, Pierre² (AUTHOR), Moundipa, Paul F.¹ (AUTHOR)

Source: In Silico Pharmacology. 7/4/2022, Vol. 10 Issue 1, p1-13. 13p.

Subject Terms: *ALZHEIMER'S disease, *THERAPEUTICS, *MICROGLIA, *CARBAMIC acid, *GENE expression, *DRUG development

Molecular Insight in the Multifunctional Effects of Oridonin.

Authors: Owona, Brice Ayissi¹ briceayissi03@yahoo.fr, Schluesener, Herman J.¹

Source: Drugs in R&D. Sep2015, Vol. 15 Issue 3, p233-244. 12p.

Subject Terms: *PHARMACOKINETICS, *TUMOR treatment, *CANCER treatment, *DRUG side effects, *CHINESE medicine

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Amelioration of Behavioral Impairments and Neuropathology by Antiepileptic Drug Topiramate in a Transgenic Alzheimer's Disease Model Mice, APP/PS1.

Authors: Owona, Brice Ayissi¹ (AUTHOR) briceayissi03@yahoo.fr, Zug, Caroline¹ (AUTHOR), Schluesener, Hermann J.¹ (AUTHOR), Zhang, Zhi-Yuan¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Jun2019, Vol. 20 Issue 12, p3003. 1p. 2 Diagrams, 3 Graphs.

Subject Terms: *ALZHEIMER'S disease, *ANTICONVULSANTS, *TOPIRAMATE, *MOUSE diseases, *MEDICAL model, *NEUROPROTECTIVE agents, *DONEPEZIL

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Entada africana fraction CH2Cl2/MEOH 5% inhibits inducible nitric oxide synthase and proinflammatory cytokines gene expression induced by lipopolysaccharide in microglia.

Authors: Owona, Brice Ayissi, Njayou, Nico Frederic, Laufer, Stefan A., Schluesener, Hermann J., Moundipa, Paul Fewou

Source: BMC Complementary & Alternative Medicine; 2013, Vol. 13 Issue 1, p254-260, 7p, 1 Chart, 4 Graphs

Subject Terms: ANIMAL experimentation, BARK, BIOLOGICAL assay, BIOLOGICAL models, CELL physiology, CHROMATOGRAPHIC analysis, CULTURE media (Biology), CYTOKINES, ENZYME-linked immunosorbent assay, GENE expression, MEDICINAL plants, MICE, NITRIC oxide, POLYMERASE chain reaction, RESEARCH funding, TOXICITY testing, PLANT extracts, REVERSE transcriptase polymerase chain reaction, LIPOPOLYSACCHARIDES, IN vitro studies

Geographic Terms: CAMEROON