Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection

Authors: Chetty, Alisha, Darby, Matthew G., Vornewald, Pia M., Martín-Alonso, Mara, Filz, Anna, Ritter, Manuel, McSorley, Henry J., Masson, Lindi, Smith, Katherine, Brombacher, Frank, O’Shea, Matthew K., Cunningham, Adam F., Ryffel, Bernhard, Oudhoff, Menno J., Dewals, Benjamin G., Layland, Laura E., Horsnell, William G.C.

Source: In Cell Host & Microbe 14 April 2021 29(4):579-593

Helminths get MIFfed by the tuft cell – ILC2 circuit

Authors: Vornewald, Pia M, Oudhoff, Menno J

Source: Immunology and cell biology. 100(5):301-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150123803.0x000001&indx=1&recIds=ETOCvdc_100150123803.0x000001

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential

Authors: Judson, Robert N., Quarta, Marco, Oudhoff, Menno J., Soliman, Hesham, Yi, Lin, Chang, Chih Kai, Loi, Gloria, Vander Werff, Ryan, Cait, Alissa, Hamer, Mark, Blonigan, Justin, Paine, Patrick, Doan, Linda T.N., Groppa, Elena, He, WenJun, Su, Le, Zhang, Regan H., Xu, Peter, Eisner, Christine, Low, Marcela, Barta, Ingrid, Lewis, Coral-Ann B., Zaph, Colby, Karimi, Mohammad M., Rando, Thomas A., Rossi, Fabio M.

Source: In Cell Stem Cell 1 February 2018 22(2):177-190

LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model.

Authors: Díez-Sánchez, Alberto, Lindholm, Håvard T., Vornewald, Pia M., Ostrop, Jenny, Yao, Rouan, Single, Andrew B., Marstad, Anne, Parmar, Naveen, Shaw, Tovah N., Martín-Alonso, Mara, Oudhoff, Menno J.

Source: Nature Communications; 4/22/2024, Vol. 15 Issue 1, p1-20, 20p

Subject Terms: INTESTINAL mucosa, INNATE lymphoid cells, GASTROINTESTINAL system, INTESTINES, HOMEOSTASIS, SMALL intestine, IMMUNOLOGICAL tolerance, CHEMOKINE receptors

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Authors: Oudhoff, Menno J., Braam, Mitchell J.S., Freeman, Spencer A., Wong, Denise, Rattray, David G., Wang, Jia, Antignano, Frann, Snyder, Kimberly, Refaeli, Ido, Hughes, Michael R., McNagny, Kelly M., Gold, Michael R., Arrowsmith, Cheryl H., Sato, Toshiro, Rossi, Fabio M.V., Tatlock, John H., Owen, Dafydd R., Brown, Peter J., Zaph, Colby

Source: In Developmental Cell 4 April 2016 37(1):47-57

Helminths are positively AMPing up gut de-bugging

Authors: Horsnell, William G.C., Oudhoff, Menno J.

Source: Cell host & microbe. 30(1):1-2

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152868300.0x000001&indx=1&recIds=ETOCvdc_100152868300.0x000001

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Authors: Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Sep 01. 111(35), 12853-12858.

Access URL: https://www.jstor.org/stable/43043421

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program

Authors: Antignano, Frann, Braam, Mitchell, Hughes, Michael R., Chenery, Alistair L., Burrows, Kyle, Gold, Matthew J., Oudhoff, Menno J., Rattray, David, Halim, Timotheus Y., Cait, Alissa

Source: Journal of experimental medicine. 213(7):1153-1162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606996675&indx=1&recIds=ETOCRN606996675

Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection.

Authors: Vornewald, Pia M., Forman, Ruth, Rouan Yao, Parmar, Naveen, Lindholm, Håvard T., Lee, Lilith S. K., Martín-Alonso, Mara, Else, Kathryn J., Oudhoff, Menno J.

Source: Frontiers in Immunology; 2023, p1-16, 16p

Subject Terms: WHIPWORMS, MATRIX metalloproteinases, HELMINTHIASIS, DRUG resistance in bacteria, SMOOTH muscle

Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

Authors: Drurey, Claire, Lindholm, Håvard T., Coakley, Gillian, Poveda, Marta Campillo, Löser, Stephan, Doolan, Rory, Gerbe, François, Jay, Philippe, Harris, Nicola, Oudhoff, Menno J.

Source: Journal of experimental medicine. 219(1):e20211140-e20211140

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628390471&indx=1&recIds=ETOCRN628390471

Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.

Authors: Parmar, Naveen¹, Burrows, Kyle^2,3, Vornewald, Pia M.¹, Lindholm, Håvard T.¹, Zwiggelaar, Rosalie T.¹, Díez-Sánchez, Alberto¹, Martín-Alonso, Mara¹, Fosslie, Madeleine⁴, Vallance, Bruce A.⁵, Dahl, John Arne⁴, Zaph, Colby⁶, Oudhoff, Menno J.¹, menno.oudhoff@ntnu.no

Source: PLoS Pathogens; 3/31/2021, Vol. 17 Issue 3, p1-24, 24p

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia.

Authors: Lindholm, Håvard T., Parmar, Naveen, Drurey, Claire, Campillo Poveda, Marta, Vornewald, Pia M., Ostrop, Jenny, Díez-Sanchez, Alberto, Maizels, Rick M., Oudhoff, Menno J.

Source: Science Immunology; 2022, Vol. 7 Issue 71, p1-14, 14p

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

Authors: Oudhoff, Menno J.^1,2 menno.oudhoff@ntnu.no, Antignano, Frann¹, Chenery, Alistair L.¹, Burrows, Kyle¹, Redpath, Stephen A.³, Braam, Mitchell J.¹, Perona-Wright, Georgia³, Zaph, Colby^1,4,5 colby.zaph@monash.edu

Source: PLoS Pathogens. 9/6/2016, Vol. 12 Issue 9, p1-16. 16p.

Subject Terms: *EPITHELIAL cells, *IMMUNITY, *HELMINTHIASIS, *IMMUNE response, *METHYLTRANSFERASES, *LYSINE, *VERTEPORFIN, *PREVENTION

Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.

Authors: Martín-Alonso, Mara, Iqbal, Sharif, Vornewald, Pia M., Lindholm, Håvard T., Damen, Mirjam J., Martínez, Fernando, Hoel, Sigrid, Díez-Sánchez, Alberto, Altelaar, Maarten, Katajisto, Pekka, Arroyo, Alicia G., Oudhoff, Menno J.

Source: Nature Communications; 11/18/2021, Vol. 12 Issue 1, p1-17, 17p

Subject Terms: STEM cell niches, MATRIX metalloproteinases, SMOOTH muscle, PERIOSTIN, REGENERATION (Biology), INTESTINES, SMALL intestine

Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.

Authors: Roberts, Luke B., Schnoeller, Corinna, Berkachy, Rita, Darby, Matthew, Pillaye, Jamie, Oudhoff, Menno J., Parmar, Naveen, Mackowiak, Claire, Sedda, Delphine, Quesniaux, Valerie, Ryffel, Bernhard, Vaux, Rachel, Gounaris, Kleoniki, Berrard, Sylvie, Withers, David R., Horsnell, William G. C., Selkirk, Murray E.

Source: Science Immunology; 2021, Vol. 6 Issue 57, p1-14, 14p

Requirement for Core 2 O-Glycans for Optimal Resistance to Helminth Infection.

Authors: Mullaly, Sarah C.¹, Oudhoff, Menno J.¹, Min, Paul H.¹, Burrows, Kyle¹, Antignano, Frann¹, Rattray, David G.¹, Chenery, Alistair¹, McNagny, Kelly M.^1,2, Ziltener, Hermann J.^1,3, Zaph, Colby^1,3 colby@brc.ubc.ca

Source: PLoS ONE. Mar2013, Vol. 8 Issue 3, p1-7. 7p.

Subject Terms: *HELMINTHIASIS, *GLYCANS, *IMMUNOLOGY, *IMMUNE response, *VIRUS research, *TRICHURIASIS, *MEDICAL research

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Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

Authors: Oudhoff, Menno J., Freeman, Spencer A., Couzens, Amber L., Antignano, Frann, Kuznetsova, Ekaterina, Min, Paul H., Northrop, Jeffrey P., Lehnertz, Bernhard, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Arrowsmith, Cheryl H., Nishina, Hiroshi, Gold, Michael R., Rossi, Fabio M.V., Gingras, Anne-Claude, Zaph, Colby

Source: In Developmental Cell 29 July 2013 26(2):188-194

E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.

Authors: Go'mez-Escudero, Jesu's, Moreno, Vanessa, Martín-Alonso, Mara, Herna'ndez-Riquer, M. Victoria, Feinberg, Tamar, Colmenar, Ángel, Calvo, Enrique, Camafeita, Emilio, Martínez, Fernando, Oudhoff, Menno J., Weiss, Stephen J., Arroyo, Alicia G.

Source: Journal of Cell Science; Dec2017, Vol. 130 Issue 23, p4013-4027, 15p

Subject Terms: CADHERINS, HOMEOSTASIS, CELL adhesion molecules

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