Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

Authors: Akhtar, Shaheen, Anwar, Mohammad, Asgar, Omar, Ashraf, Samina, Bidi, Saeed, Breen, Gerome, Broster, James, Chung, Raymond, Collier, David, Curtis, Charles J, Chaudhary, Shabana, Colligan, Grainne, Deloukas, Panos, Durham, Ceri, Durrani, Faiza, Eto, Fabiola, Finer, Sarah, Gafton, Joseph, Angel, Ana, Griffiths, Chris, Harvey, Joanne, Heng, Teng, Hodgson, Sam, Huang, Qin Qin, Hurles, Matt, Hunt, Karen A, Hussain, Shapna, Islam, Kamrul, Iyer, Vivek, Jacobs, Benjamin M, Kalantzis, Georgios, Khan, Ahsan, Langenberg, Claudia, Lavery, Cath, Lee, Sang Hyuck, MacArthur, Daniel, Malik, Sidra, Malawsky, Daniel, Martin, Hilary, Mason, Dan, Mathur, Rohini, Mazid, Mohammed Bodrul, McDermott, John, Morton, Caroline, Newman, Bill, Owor, Elizabeth, Qureshi, Asma, Ramachandrappa, Shwetha, Raza, Mehru, Russell, Jessry, Safa, Nishat, Samuel, Miriam, Siddiqui, Moneeza, Simpson, Michael, Solly, John, Spreckley, Marie, Stow, Daniel, Taylor, Michael, Trembath, Richard C, Tricker, Karen, van Heel, David A, Walter, Klaudia, Winckley, Caroline, Wood, Suzanne, Wright, John, Zengeya, Ishevanhu, Zöllner, Julia, Schurz, Haiko ¹, Naranbhai, Vivek ^{2, 3, 4, 5, 6}, Yates, Tom A ⁷, Gilchrist, James J ^{2, 8}, Parks, Tom ^{2, 9}, Dodd, Peter J ¹⁰, Möller, Marlo ¹, Hoal, Eileen G ¹, Morris, Andrew P ¹¹, Hill, Adrian V S ^{2, 12}, van Crevel, Reinout ^{13, 14}, van Laarhoven, Arjan ¹³, Ottenhoff, Tom H M ¹⁵, Metspalu, Andres ¹⁶, Magi, Reedik ¹⁶, Meyer, Christian G ¹⁷, Ellis, Magda ¹⁸, Thye, Thorsten ¹⁹, Mahasirimongkol, Surakameth ²⁰, Pasomsub, Ekawat ²¹, Tokunaga, Katsushi ²², Omae, Yosuke ²², Yanai, Hideki ²³, Mushiroda, Taisei ²⁴, Kubo, Michiaki ²⁴, Takahashi, Atsushi ^{25, 26}, Kamatani, Yoichiro ²⁵, Alisjahbana, Bachti ²⁷, Liu, Wei ^{28, 29}, Sheng, A-dong ^{30, 31, 32, 33}, Yang, Yurong ³⁴, Hamilton, Fergus ^{a, ∗}, Ghazal, Peter ^{l, ‡}, Timpson, Nicholas J ^a, Pollara, Gabriele ^{c, ∗∗}

Source: In The Lancet Microbe January 2025 6(1)

Random forest and live single‐cell metabolomics reveal metabolic profiles of human macrophages upon polarization

Authors: Tang, Huaqi, Ali, Ahmed, Abdelazem, Eman, Ottenhoff, Tom H. M., Heeren, Ron M. A., Mashaghi, Alireza

Source: Biotechnology and bioengineering. 120(8):2314-2325

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188521003.0x000001&indx=1&recIds=ETOCvdc_100188521003.0x000001

Extensive flow cytometric immunophenotyping of human PBMC incorporating detection of chemokine receptors, cytokines and tetramers

Authors: Wolfswinkel, Marjolein, Meijgaarden, Krista E., Ottenhoff, Tom H. M., Niewold, Paula, Joosten, Simone A.

Source: Cytometry.Part A. 103(7):600-610

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187363470.0x000001&indx=1&recIds=ETOCvdc_100187363470.0x000001

Thermal‐exchange HLA‐E multimers reveal specificity in HLA‐E and NKG2A/CD94 complex interactions

Authors: Ruibal, Paula, Derksen, Ian, Wolfswinkel, Marjolein, Voogd, Linda, Franken, Kees L. M. C., El Hebieshy, Angela F., Hall, Thorbald, Schoufour, Tom A. W., Wijdeven, Ruud H., Ottenhoff, Tom H. M., Scheeren, Ferenc A., Joosten, Simone A.

Source: Immunology. 168(3):526-537

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176277239.0x000001&indx=1&recIds=ETOCvdc_100176277239.0x000001

Discovery of HLA-E-Presented Epitopes: MHC-E/Peptide Binding and T-Cell Recognition

Authors: Ruibal, Paula, Franken, Kees L. M. C., van Meijgaarden, Krista E., Walters, Lucy C., McMichael, Andrew J., Gillespie, Geraldine M., Joosten, Simone A., Ottenhoff, Tom H. M.

Source: Methods in molecular biology. 2574:15-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630138344&indx=1&recIds=ETOCRN630138344

HLA-E/ Mtb specific CD4⁺ and CD8⁺ T cells have a memory phenotype in individuals with TB infection.

Authors: Voogd, Linda, Riou, Catherine, Scriba, Thomas J., van Wolfswinkel, Marjolein, van Meijgaarden, Krista E., Franken, Kees L. M. C., Wilkinson, Robert J., Ottenhoff, Tom H. M., Joosten, Simone A.

Source: Frontiers in Immunology; 2025, p1-12, 12p

Subject Terms: T cells, IMMUNOLOGIC memory, CELL populations, COMMUNICABLE diseases, ANTIGEN presentation

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Authors: Agnandij, Selidij T, Ahmed, Rafi, Anderson, Jenna, Auderset, Floriane, Bejon, Philip, Borgianni, Luisa, Brosnahan, Jessica, Ciabattini, Annalisa, Engler, Olivier, Haks, Mariëlle C, Harandi, Ali M, Heppner, Donald G, Gerlini, Alice, Huttner, Angela, Kremsner, Peter G, Medaglini, Donata, Monath, Thomas P, Ndungu, Francis M, Njuguna, Patricia, Ottenhoff, Tom H M, Pejoski, David, Page, Mark, Pozzi, Gianni, Santoro, Francesco, Siegrist, Claire-Anne, Dubey, Sheri, Eichberg, Michael, Ndong, Essone P, Lumeka, Kabwende, Nakaya, Helder I, Gonzales Dias Carvalho, Patricia, Rothenberger, Sylvia, Vianello, Eleonora, Nakka, Sravya S, van Veen, Suzanne, Gonzalez-Dias, Patricia, Engele, Carmen G, Quinten, Edwin, Essone, Paulin N, Agnandji, Selidji Todagbe

Source: In The Lancet Microbe February 2022 3(2):e113-e123

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

Authors: Ruibal, Paula, Voogd, Linda, Joosten, Simone A., Ottenhoff, Tom H. M.

Source: Immunological reviews. 301(1):30-47

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125727150.0x000001&indx=1&recIds=ETOCvdc_100125727150.0x000001

Host‐directed therapy to combat mycobacterial infections*

Authors: Kilinç, Gül, Saris, Anno, Ottenhoff, Tom H. M., Haks, Mariëlle C.

Source: Immunological reviews. 301(1):62-83

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125727154.0x000001&indx=1&recIds=ETOCvdc_100125727154.0x000001

A Versatile, Low-Cost Modular Microfluidic System to Prepare Poly(Lactic-co-Glycolic Acid) Nanoparticles With Encapsulated Protein.

Authors: Neustrup, Malene Aaby^1,2 (AUTHOR) maleneaabyneustrup@gmail.com, Ottenhoff, Tom H. M.² (AUTHOR) t.h.m.ottenhoff@lumc.nl, Jiskoot, Wim¹ (AUTHOR), Bouwstra, Joke A.¹ (AUTHOR) bouwstra@lacdr.leidenuniv.nl, van der Maaden, Koen^1,3 (AUTHOR) k.van_der_maaden@lumc.nl

Source: Pharmaceutical Research. Dec2024, Vol. 41 Issue 12, p2347-2361. 15p.

Subject Terms: *PHYSICAL & theoretical chemistry, *MICROFLUIDIC devices, *MATERIALS science, *BIOMACROMOLECULES, *NANOPARTICLES

Mtb -Specific HLA-E-Restricted T Cells Are Induced during Mtb Infection but Not after BCG Administration in Non-Human Primates and Humans.

Authors: Voogd, Linda, van Wolfswinkel, Marjolein, Satti, Iman, White, Andrew D., Dijkman, Karin, Gela, Anele, van Meijgaarden, Krista E., Franken, Kees L. M. C., Marshall, Julia L., Ottenhoff, Tom H. M., Scriba, Thomas J., McShane, Helen, Sharpe, Sally A., Verreck, Frank A. W., Joosten, Simone A.

Source: Vaccines; Oct2024, Vol. 12 Issue 10, p1129, 17p

Subject Terms: T cells, BCG vaccines, TUBERCULOSIS vaccines, MYCOBACTERIUM tuberculosis, RHESUS monkeys

Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

Authors: Eckold, Clare, Doorn, Cassandra L. R., Ruslami, Rovina, Ronacher, Katharina, Riza, Anca‐Lelia, Veen, Suzanne, Lee, Ji‐Sook, Kumar, Vinod, Kerry‐Barnard, Sarah, Malherbe, Stephanus T., Kleynhans, Léanie, Stanley, Kim, Joosten, Simone A., Critchley, Julia A, Hill, Philip C., Crevel, Reinout, Wijmenga, Cisca, Haks, Mariëlle C., Ioana, Mihai, Alisjahbana, Bachti, Walzl, Gerhard, Ottenhoff, Tom H. M., Dockrell, Hazel M., Vianello, Eleonora, Cliff, Jacqueline M.

Source: Clinical and translational medicine. 13(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195104569.0x000001&indx=1&recIds=ETOCvdc_100195104569.0x000001

Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests

Authors: Nathavitharana, Ruvandhi R., Yoon, Christina, MacPherson, Peter, Dowdy, David W., Cattamanchi, Adithya, Somoskovi, Akos, Broger, Tobias, Ottenhoff, Tom H. M., Arinaminpathy, Nimalan, Lonnroth, Knut, Reither, Klaus, Cobelens, Frank, Gilpin, Christopher, Denkinger, Claudia M., Schumacher, Samuel G.

Source: The Journal of Infectious Diseases, 2019 Nov . 220, S116-S125.

Access URL: https://www.jstor.org/stable/26839903

Mobilizing unconventional T cells

Authors: Ottenhoff, Tom H. M., Joosten, Simone A.

Source: Science, 2019 Oct . 366(6463), 302-303.

Access URL: https://www.jstor.org/stable/26843654

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

Authors: Ruibal, Paula, Franken, Kees L. M. C., van Meijgaarden, Krista E., van Loon, Joeri J. F., van der Steen, Dirk, Heemskerk, Mirjam H. M., Ottenhoff, Tom H. M., Joosten, Simone A.

Source: Journal of immunology. 205(10):2861-2872

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625164702&indx=1&recIds=ETOCRN625164702

Betere vaccins tegen tuberculose

Authors: Ottenhoff, Tom H. M.

Source: Nederlands tijdschrift voor geneeskunde. 164(37):29-34

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624461950&indx=1&recIds=ETOCRN624461950

Trends in diagnostic methods and treatment of latent tuberculosis infection in a tertiary care center from 2000 to 2017

Authors: Uzorka, Jonathan W., Duinkerk, Dinah L., Kroft, Lucia J. M., Bakker, Jaap A., Ramai, Rajen S. R. S., Ottenhoff, Tom H. M., Arend, Sandra M.

Source: European journal of clinical microbiology & infectious diseases. 39(7):1329-1337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168187823.0x000001&indx=1&recIds=ETOCvdc_100168187823.0x000001

The Human Pathogen Mycobacterium tuberculosis and the Fish Pathogen Mycobacterium marinum Trigger a Core Set of Late Innate Immune Response Genes in Zebrafish Larvae.

Authors: Dirks, Ron P., Ordas, Anita, Jong-Raadsen, Susanne, Brittijn, Sebastiaan A., Haks, Mariëlle C., Henkel, Christiaan V., Oravcova, Katarina, Racz, Peter I., Tuinhof-Koelma, Nynke, Korzeniowska nee Wiweger, Malgorzata I., Gillespie, Stephen H., Meijer, Annemarie H., Ottenhoff, Tom H. M., Jansen, Hans J., Spaink, Herman P.

Source: Biology (2079-7737); Sep2024, Vol. 13 Issue 9, p688, 20p

Subject Terms: RNA sequencing, MYCOBACTERIUM tuberculosis, MYCOBACTERIAL diseases, FISH pathogens, BACTERIAL diseases, BRACHYDANIO

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria.

Authors: van den Biggelaar, Robin H. G. A., Walburg, Kimberley V., van den Eeden, Susan J. F., van Doorn, Cassandra L. R., Meiler, Eugenia, de Ries, Alex S., Fusco, M. Chiara, Meijer, Annemarie H., Ottenhoff, Tom H. M., Saris, Anno

Source: Scientific Reports; 7/26/2024, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: KINASE inhibitors, SALMONELLA typhimurium, MYCOBACTERIUM tuberculosis, BACTERIA, DRUG resistance in microorganisms, CELL lines

Host Gene Expression Kinetics During Treatment of Tuberculosis in HIV-Coinfected Individuals Is Independent of Highly Active Antiretroviral Therapy

Authors: Gebremicael, Gebremedhin, Kassa, Desta, Quinten, Edwin, Alemayehu, Yodit, Gebreegziaxier, Atsbeha, Belay, Yohannes, van Baarle, Debbie, Ottenhoff, Tom H. M., Cliff, Jacqueline M., Haks, Mariëlle C.

Source: The Journal of Infectious Diseases, 2018 Dec 01. 218(11), 1833-1846.

Access URL: https://www.jstor.org/stable/26748924