Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy

Authors: Benchenouf Feriel, Cuomo Alessandra, Gorth J. Deborah, Normand Corinne, Thuillet Raphaël, Ottaviani Mina, Akamkam Ali, Menager Jean-Baptiste, Fadel Guillaume, Grynblat Julien, Ghigna Maria-Rosa, Fadel Elie, Savale Laurent, Mercier Olaf, Tu Ly, Humbert Marc, Guignabert Christophe

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Chronic thromboembolic pulmonary hypertension, Microvasculopathy, Endothelin-1, Endothelin receptor antagonist, Pulmonary vasculature, Therapeutic target, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/692b8624e8f24a5bafb0489c5106e6e7

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Authors: Robert, Fabien ^{1, 2}, Benchenouf, Feriel ^{1, 2}, Ha, My Ngoc ^{1, 2}, Cuomo, Alessandra ^{1, 3}, Ottaviani, Mina ^{1, 2}, Surbier, Maxime ^{1, 2}, Thuillet, Raphaël ^{1, 2}, Normand, Corinne ^{1, 2}, Dumont, Florent ^{1, 2}, Verstuyft, Céline ⁴, Fiore, Frederic ⁵, Guinut, Frederic ⁶, Humbert, Marc ^{1, 2, 7}, Coilly, Audrey ^{8, 9}, Gonzales, Emmanuel ^{9, 10}, Sitbon, Olivier ^{1, 2, 7}, Tu, Ly ^{1, 2}, Guignabert, Christophe ^{1, 2, †}, Savale, Laurent ^{1, 2, 7, ⁎, †}

Source: In JHEP Reports March 2025 7(3)

Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension

Authors: Jutant, Etienne-Marie, Chelgham, Mustapha K., Ottaviani, Mina, Thuillet, Raphaël, Le Vely, Benjamin, Humbert, Marc, Guignabert, Christophe, Tu, Ly, Huertas, Alice

Source: In Journal of Heart and Lung Transplantation January 2024 43(1):120-133

AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery

Authors: Abdelazeem, Heba, Tu, Ly, Thuillet, Raphaël, Ottaviani, Mina, Boulfrad, Achraf, Beck, Thomas, Senbel, Amira, Mani, Salma, Castier, Yves, Guyard, Alice, Tran-Dinh, Alexy, El-Benna, Jamel, Longrois, Dan, Silverstein, Adam M., Guignabert, Christophe, Norel, Xavier

Source: In European Journal of Pharmacology 5 May 2023 946

Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats

Authors: Tu, Ly, Thuillet, Raphaël, Perrot, Julie, Ottaviani, Mina, Ponsardin, Emy, Kolkhof, Peter, Humbert, Marc, Viengchareun, Say, Lombès, Marc, Guignabert, Christophe

Source: Hypertension. 79(10):2262-2273

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179679608.0x000001&indx=1&recIds=ETOCvdc_100179679608.0x000001

Driving Role of Interleukin‐2–Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis

Authors: Frantz, Camelia, Cauvet, Anne, Durand, Aurélie, Gonzalez, Virginie, Pierre, Rémi, Do Cruzeiro, Marcio, Bailly, Karine, Andrieu, Muriel, Orvain, Cindy, Avouac, Jérôme, Ottaviani, Mina, Thuillet, Raphaël, Tu, Ly, Guignabert, Christophe, Lucas, Bruno, Auffray, Cédric, Allanore, Yannick

Source: Arthritis & rheumatology. 74(8):1387-1398

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173620483.0x000001&indx=1&recIds=ETOCvdc_100173620483.0x000001

Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome.

Authors: Robert, Fabien, Certain, Marie-Caroline, Baron, Audrey, Thuillet, Raphaël, Duhaut, Léa, Ottaviani, Mina, Chelgham, Mustapha Kamel, Normand, Corinne, Berrebeh, Nihel, Ricard, Nicolas, Furlan, Valerie, Desroches-Castan, Agnès, Gonzales, Emmanuel, Jacquemin, Emmanuel, Sitbon, Olivier, Humbert, Marc, Bailly, Sabine, Coilly, Audrey, Guignabert, Christophe, Tu, Ly

Source: American Journal of Respiratory & Critical Care Medicine; 9/1/2024, Vol. 210 Issue 5, p648-661, 14p

Subject Terms: LABORATORY rats, PORTAL hypertension, PORTAL vein, DISEASE complications, BILE ducts

Effects of B Cell Depletion by CD19-Targeted Chimeric Antigen Receptor T Cells in a Murine Model of Systemic Sclerosis.

Authors: Avouac, Jérôme, Cauvet, Anne, Orvain, Cindy, Boulch, Morgane, Tilotta, Françoise, Ly Tu, Thuillet, Raphaël, Ottaviani, Mina, Guignabert, Christophe, Bousso, Philippe, Allanore, Yannick

Source: Arthritis & Rheumatology; Feb2024, Vol. 76 Issue 2, p268-278, 11p

Subject Terms: INFLAMMATION prevention, ANIMAL experimentation, SYSTEMIC scleroderma, CELL receptors, MONOCLONAL antibodies, TREATMENT effectiveness, T cells, PULMONARY fibrosis, ANTIGENS, MICE, VASCULAR remodeling

Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis.

Authors: Cauvet, Anne, Decellas, Arthur, Guignabert, Christophe, Rongvaux-Gaïda, Dominique, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Rieger, François, Avouac, Jérôme, Allanore, Yannick

Source: Arthritis Research & Therapy; 9/12/2023, Vol. 25 Issue 1, p1-12, 12p

Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.

Authors: Guignabert, Christophe, Savale, Laurent, Boucly, Athénaïs, Thuillet, Raphaël, Tu, Ly, Ottaviani, Mina, Rhodes, Christopher J., De Groote, Pascal, Prévot, Grégoire, Bergot, Emmanuel, Bourdin, Arnaud, Howard, Luke S., Fadel, Elie, Beurnier, Antoine, Roche, Anne, Jevnikar, Mitja, Jaïs, Xavier, Montani, David, Wilkins, Martin R., Sitbon, Olivier

Source: Circulation; 6/13/2023, Vol. 147 Issue 24, p1809-1822, 14p

Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats.

Authors: Leuillier, Matthieu, Platel, Valentin, Tu, Ly, Feugray, Guillaume, Thuillet, Raphaël, Groussard, Déborah, Messaoudi, Hind, Ottaviani, Mina, Chelgham, Mustapha, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Morisseau, Christophe, Brunel, Valéry, Duflot, Thomas, Guignabert, Christophe, Bellien, Jérémy

Source: Cells (2073-4409); Feb2023, Vol. 12 Issue 4, p665, 11p

Subject Terms: RATS, EPOXIDE hydrolase, PULMONARY hypertension, ORAL drug administration, RIGHT ventricular dysfunction, PULMONARY artery

Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells.

Authors: Le Vely, Benjamin, Phan, Carole, Berrebeh, Nihel, Thuillet, Raphaël, Ottaviani, Mina, Chelgham, Mustapha Kamel, Chaumais, Marie-Camille, Amazit, Larbi, Humbert, Marc, Huertas, Alice, Guignabert, Christophe, Tu, Ly

Source: American Journal of Respiratory Cell & Molecular Biology; Aug2022, Vol. 67 Issue 2, p215-226, 20p

Subject Terms: VASCULAR endothelial cells, PULMONARY arterial hypertension, PROTEIN-tyrosine kinases, BONE morphogenetic protein receptors, ENDOTHELIUM diseases, PULMONARY hypertension

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.

Authors: Orvain, Cindy, Cauvet, Anne, Prudent, Alexis, Guignabert, Christophe, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Duhalde, Fanny, Nicco, Carole, Batteux, Frédéric, Avouac, Jérôme, Wang, NingXin, Seaberg, Michelle A., Dillon, Stacey R., Allanore, Yannick

Source: Arthritis Research & Therapy; 1/5/2022, Vol. 24 Issue 1, p1-15, 15p