Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis

Authors: Diehl, Carina ^{1, 2, 20}, Soberón, Valeria ^{1, 2, 3, 4, 20}, Baygün, Seren ^{1, 2, 3, 20}, Chu, Yuanyuan ^{1, 4, 20}, Mandelbaum, Jonathan ⁵, Kraus, Laura ^{1, 2}, Engleitner, Thomas ^{2, 3, 6}, Rudelius, Martina ⁷, Fangazio, Marco ⁵, Daniel, Christoph ⁸, Bortoluzzi, Sabrina ^{1, 2}, Helmrath, Sabine ^{1, 2}, Singroul, Pankaj ^{1, 2}, Gölling, Vanessa ^{1, 2}, Osorio Barrios, Francisco ^{1, 2}, Seyhan, Gönül ^{1, 2}, Oßwald, Lena ^{1, 2, 9}, Kober-Hasslacher, Maike ^{1, 4}, Zeng, Theodor ^{1, 2}, Öllinger, Rupert ^{2, 3, 6}, Afzali, Ali M. ¹⁰, Korn, Thomas ¹⁰, Honarpisheh, Mohsen ¹¹, Lech, Maciej ¹¹, Ul Ain, Qurrat ¹², Pircher, Joachim ^{12, 13}, Imširović, Vanna ¹⁴, Jelenčić, Vedrana ¹⁴, Wensveen, Felix M. ¹⁴, Passerini, Verena ¹⁵, Bärthel, Stefanie ^{2, 3, 16}, Bhagat, Govind ¹⁷, Dominguez-Sola, David ¹⁸, Saur, Dieter ^{2, 3, 16}, Steiger, Katja ^{3, 19}, Rad, Roland ^{2, 3, 6}, Pasqualucci, Laura ^{5, 17}, Weigert, Oliver ^{3, 15}, Schmidt-Supprian, Marc ^{1, 2, 3, 4, 21, ∗}

Source: In Immunity 14 January 2025 58(1):124-142

Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4 + T-Cells to Infiltrate the Colonic Mucosa.

Authors: Campos, Javier¹ (AUTHOR) jvrcamposa@gmail.com, Osorio-Barrios, Francisco² (AUTHOR), Villanelo, Felipe^1,3 (AUTHOR) felipe@dlab.cl, Gutierrez-Maldonado, Sebastian E.^1,3 (AUTHOR) sebastian.gutierrez@uss.cl, Vargas, Pablo^4,5 (AUTHOR) pablo.vargas@inserm.fr, Pérez-Acle, Tomás^1,3 (AUTHOR) tperezacle@cienciavida.org, Pacheco, Rodrigo^1,6 (AUTHOR) rpacheco@cienciavida.org

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10022. 15p.

Subject Terms: *INFLAMMATORY bowel diseases, *G protein coupled receptors, *CHEMOKINE receptors, *T cells, *GASTROINTESTINAL system, *DOPAMINE, *DOPAMINE receptors, *VIRAL tropism

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

Authors: Marino, Franca, Pinoli, Monica, Rasini, Emanuela, Martini, Stefano, Luini, Alessandra, Pulze, Laura, Dalla Gasperina, Daniela, Grossi, Paolo, Legnaro, Massimiliano, Ferrari, Marco, Congiu, Terenzio, Pacheco, Rodrigo, Osorio‐Barrios, Francisco, Eguileor, Magda, Cosentino, Marco

Source: Immunology. 167(4):508-527

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165872893.0x000001&indx=1&recIds=ETOCvdc_100165872893.0x000001

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Authors: Bararia, Deepak, Hildebrand, Johannes A., Stolz, Sebastian, Haebe, Sarah, Alig, Stefan, Trevisani, Christopher P., Osorio-Barrios, Francisco, Bartoschek, Michael D., Mentz, Michael, Pastore, Alessandro, Gaitzsch, Erik, Heide, Michael, Jurinovic, Vindi, Rautter, Katharina, Gunawardana, Jay, Sabdia, Muhammed B., Szczepanowski, Monika, Richter, Julia, Klapper, Wolfram, Louissaint, Abner, Jr., Ludwig, Christina, Bultmann, Sebastian, Leonhardt, Heinrich, Eustermann, Sebastian, Hopfner, Karl-Peter, Hiddemann, Wolfgang, von Bergwelt-Baildon, Michael, Steidl, Christian, Kridel, Robert, Tobin, Joshua W.D., Gandhi, Maher K., Weinstock, David M., Schmidt-Supprian, Marc, Sárosi, Menyhárt B., Rudelius, Martina, Passerini, Verena, Mautner, Josef, Weigert, Oliver

Source: In Cell Reports 5 May 2020 31(5)

The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

Authors: Doñas, Cristian, Carrasco, Macarena, Fritz, Macarena, Prado, Carolina, Tejón, Gabriela, Osorio-Barrios, Francisco, Manríquez, Valeria, Reyes, Paz, Pacheco, Rodrigo, Bono, María Rosa, Loyola, Alejandra, Rosemblatt, Mario

Source: In Journal of Autoimmunity December 2016 75:105-117

Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity.

Authors: Prado, Carolina^1,2 (AUTHOR), Osorio-Barrios, Francisco¹ (AUTHOR), Falcón, Paulina¹ (AUTHOR), Espinoza, Alexandra¹ (AUTHOR), Saez, Juan José³ (AUTHOR), Yuseff, María Isabel³ (AUTHOR), Pacheco, Rodrigo^1,2 (AUTHOR) rpachecr@gmail.com

Source: Journal of Neuroinflammation. 12/17/2021, Vol. 18 Issue 1, p1-20. 20p.

Subject Terms: *B cells, *DOPAMINE receptors, *CENTRAL nervous system, *REGULATORY B cells, *MYELIN oligodendrocyte glycoprotein, *BONE marrow transplantation, *ANTIGENS, *T cells, *DOPAMINE, *CELL culture, *DEMYELINATION, *CELL receptors, *IMMUNITY, *AMINO acids, *MICE, *ANIMALS

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Authors: Doñas, Cristian, Neira, Jocelyn, Osorio-Barrios, Francisco, Carrasco, Macarena, Fernández, Dominique, Prado, Carolina, Loyola, Alejandra, Pacheco, Rodrigo, Rosemblatt, Mario

Source: Scientific reports. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191457673.0x000001&indx=1&recIds=ETOCvdc_100191457673.0x000001

Dopamine Receptor D3 Signaling on CD4^+ T Cells Favors Th1- and Th17-Mediated Immunity

Authors: Contreras, Francisco, Prado, Carolina, González, Hugo, Franz, Dafne, Osorio-Barrios, Francisco, Osorio, Fabiola, Ugalde, Valentina, Lopez, Ernesto, Elgueta, Daniela, Figueroa, Alicia

Source: Journal of immunology. 196(10):4143-4149

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606080138&indx=1&recIds=ETOCRN606080138

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Dopaminergic Stimulation of Myeloid Antigen-Presenting Aells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis.

Authors: Prado, Carolina, Gaiazzi, Michela, González, Hugo, Ugalde, Valentina, Figueroa, Alicia, Osorio-Barrios, Francisco J., López, Ernesto, Lladser, Alvaro, Rasini, Emanuela, Marino, Franca, Zaffaroni, Mauro, Cosentino, Marco, Pacheco, Rodrigo

Source: Frontiers in Immunology; 3/21/2018, p1-N.PAG, 16p

Subject Terms: ENCEPHALOMYELITIS, DOPAMINERGIC mechanisms, STAT proteins

Cathepsin SAlterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Authors: Bararia, Deepak, Hildebrand, Johannes A., Stolz, Sebastian, Haebe, Sarah, Alig, Stefan, Trevisani, Christopher P., Osorio-Barrios, Francisco, Bartoschek, Michael D., Mentz, Michael, Pastore, Alessandro, Gaitzsch, Erik, Heide, Michael, Jurinovic, Vindi, Rautter, Katharina, Gunawardana, Jay, Sabdia, Muhammed B., Szczepanowski, Monika, Richter, Julia, Klapper, Wolfram, Louissaint, Abner, Ludwig, Christina, Bultmann, Sebastian, Leonhardt, Heinrich, Eustermann, Sebastian, Hopfner, Karl-Peter, Hiddemann, Wolfgang, von Bergwelt-Baildon, Michael, Steidl, Christian, Kridel, Robert, Tobin, Joshua W.D., Gandhi, Maher K., Weinstock, David M., Schmidt-Supprian, Marc, Sárosi, Menyhárt B., Rudelius, Martina, Passerini, Verena, Mautner, Josef, Weigert, Oliver

Source: Cell Reports; May 2020, Vol. 31 Issue: 5